| Pan-cancer analysis of the prognostic significance of ACKR2 expression and the related genetic/epigenetic dysregulations. | Pan-cancer analysis of the prognostic significance of ACKR2 expression and the related genetic/epigenetic dysregulations.
Dong H, Zhou S, Chen X, Deng X, Fang A. | 02/2/2024 |
| The Role of Atypical Chemokine Receptor D6 (ACKR2) in Physiological and Pathological Conditions; Friend, Foe, or Both? | The Role of Atypical Chemokine Receptor D6 (ACKR2) in Physiological and Pathological Conditions; Friend, Foe, or Both?
Gowhari Shabgah A, Jadidi-Niaragh F, Mohammadi H, Ebrahimzadeh F, Oveisee M, Jahanara A, Gholizadeh Navashenaq J., Free PMC Article | 06/18/2022 |
| Biphasic Expression of Atypical Chemokine Receptor (ACKR) 2 and ACKR4 in Colorectal Neoplasms in Association with Histopathological Findings. | Biphasic Expression of Atypical Chemokine Receptor (ACKR) 2 and ACKR4 in Colorectal Neoplasms in Association with Histopathological Findings.
Lewandowska P, Wierzbicki J, Zawadzki M, Agrawal A, Krzystek-Korpacka M., Free PMC Article | 06/26/2021 |
| Expression of ACKR2 in placentas from different types of preeclampsia. | Expression of ACKR2 in placentas from different types of preeclampsia.
Yan S, Cui S, Zhang L, Yang B, Yuan Y, Lv X, Fu H, Li Y, Huang C, Wang P. | 02/6/2021 |
| Abnormal uterine inflammation in obstetric syndromes: molecular insights into the role of chemokine decoy receptor D6 and inflammasome NLRP3. | Abnormal uterine inflammation in obstetric syndromes: molecular insights into the role of chemokine decoy receptor D6 and inflammasome NLRP3.
Tersigni C, Vatish M, D'Ippolito S, Scambia G, Di Simone N. | 02/6/2021 |
| Data suggest that MIRN146b and MIR10b directly bind 3'-untranslated region of ACKR2 and down-regulate expression of ACKR2 in keratinocytes and in lymphatic endothelial cells, respectively. (ACKR2 = atypical chemokine receptor 2) | MicroRNA-146 and cell trauma down-regulate expression of the psoriasis-associated atypical chemokine receptor ACKR2.
Shams K, Kurowska-Stolarska M, Schütte F, Burden AD, McKimmie CS, Graham GJ., Free PMC Article | 12/22/2018 |
| ACKR2 is induced after traumatic brain injuries and has a significant impact on mortality and lesion development acutely following closed head injury. | The scavenging chemokine receptor ACKR2 has a significant impact on acute mortality rate and early lesion development after traumatic brain injury.
Woodcock TM, Frugier T, Nguyen TT, Semple BD, Bye N, Massara M, Savino B, Besio R, Sobacchi C, Locati M, Morganti-Kossmann MC., Free PMC Article | 12/16/2017 |
| ACKR2 is a molecular regulator play a role in inflammatory changes in patients with psoriasis. | ACKR2: Nature's Decoy Receptor Lures Unsuspecting Chemokines in Psoriasis.
Mabuchi T, Hwang ST. | 07/22/2017 |
| Data indicates that D6 is concentrated on trophoblast cell membranes in pre-eclampsia, in line with higher circulating levels of D6-ligand chemokines, but its scavenging activity is affected by trophoblast cytoskeleton disarrangement. | Placental Chemokine Receptor D6 Is Functionally Impaired in Pre-Eclampsia.
Tersigni C, Di Nicuolo F, Maulucci G, Rolfo A, Giuffrida D, Veglia M, De Spirito M, Scambia G, Todros T, Di Simone N., Free PMC Article | 06/24/2017 |
| ACKR2 mediates chemokine scavenging by primary human trophoblasts. | Atypical chemokine receptor ACKR2 mediates chemokine scavenging by primary human trophoblasts and can regulate fetal growth, placental structure, and neonatal mortality in mice.
Teoh PJ, Menzies FM, Hansell CA, Clarke M, Waddell C, Burton GJ, Nelson SM, Nibbs RJ. | 02/28/2015 |
| Data show the structural motifs in the atypical chemokine receptor 2 (ACKR2) are responsible for ligand binding, and suggest ACKR2-derived N-terminal peptides as being of potential therapeutic significance. | The N-terminal region of the atypical chemokine receptor ACKR2 is a key determinant of ligand binding.
Hewit KD, Fraser A, Nibbs RJ, Graham GJ., Free PMC Article | 08/9/2014 |
| Data show that low decoy receptor D6 expression correlated to more invasive tumors and that tumor location influences D6 expression, which is lower in the more distal parts of the colon. | Expression of the chemokine decoy receptor D6 is decreased in colon adenocarcinomas.
Langenes V, Svensson H, Börjesson L, Gustavsson B, Bemark M, Sjöling Å, Quiding-Järbrink M., Free PMC Article | 01/4/2014 |
| engagement of the ACR D6 by its ligands activates a beta-arrestin1-dependent, G protein-independent signaling pathway that results in the phosphorylation of the actin-binding protein cofilin through the Rac1-PAK1-LIMK1 cascade. | β-arrestin-dependent activation of the cofilin pathway is required for the scavenging activity of the atypical chemokine receptor D6.
Borroni EM, Cancellieri C, Vacchini A, Benureau Y, Lagane B, Bachelerie F, Arenzana-Seisdedos F, Mizuno K, Mantovani A, Bonecchi R, Locati M. | 11/16/2013 |
| co-expression of DARC, D6, and CCX-CKR significantly associated with higher survival in gastric cancer | Prognostic impact of atypical chemokine receptor expression in patients with gastric cancer.
Zhu Z, Sun Z, Wang Z, Guo P, Zheng X, Xu H. | 08/31/2013 |
| D6, which is upregulated in both inflammatory and tumor contexts, is an essential regulator of inflammatory leukocyte interactions with lymphatic endothelial cells(LECs) and is required for immature/mature DC discrimination by LECs. | An analysis of the function and expression of D6 on lymphatic endothelial cells.
McKimmie CS, Singh MD, Hewit K, Lopez-Franco O, Le Brocq M, Rose-John S, Lee KM, Baker AH, Wheat R, Blackbourn DJ, Nibbs RJ, Graham GJ. | 07/6/2013 |
| We here summarize the knowledge available today on D6 structural and signaling properties and its essential role for the control of inflammatory cells traffic and proper development of the adaptive immune response. | Review: Structure-function and biological properties of the atypical chemokine receptor D6.
Cancellieri C, Caronni N, Vacchini A, Savino B, Borroni EM, Locati M, Bonecchi R. | 05/18/2013 |
| CCL2 binding to primary adult human astrocytes is CCR2-independent and is likely to be mediated via the D6 decoy. | CCL2 binding is CCR2 independent in primary adult human astrocytes.
Fouillet A, Mawson J, Suliman O, Sharrack B, Romero IA, Woodroofe MN. | 05/4/2013 |
| D6 is expressed in AMs from patients with COPD, and its expression correlates with the degree of functional impairment and markers of immune activation. | Expression of the atypical chemokine receptor D6 in human alveolar macrophages in COPD.
Bazzan E, Saetta M, Turato G, Borroni EM, Cancellieri C, Baraldo S, Savino B, Calabrese F, Ballarin A, Balestro E, Mantovani A, Cosio MG, Bonecchi R, Locati M. | 04/6/2013 |
| These data demonstrate a novel role for D6 as a regulator of the transition from uninvolved to lesional skin in psoriasis. | Elevated expression of the chemokine-scavenging receptor D6 is associated with impaired lesion development in psoriasis.
Singh MD, King V, Baldwin H, Burden D, Thorrat A, Holmes S, McInnes IB, Nicoll R, Shams K, Pallas K, Jamieson T, Lee KM, Carballido JM, Rot A, Graham GJ., Free PMC Article | 02/9/2013 |
| Chemokine decoy receptor D6 limits CC-chemokine-dependent pathogenic inflammation and is required for adequate cardiac remodeling after myocardial infarction. | The chemokine decoy receptor D6 prevents excessive inflammation and adverse ventricular remodeling after myocardial infarction.
Cochain C, Auvynet C, Poupel L, Vilar J, Dumeau E, Richart A, Récalde A, Zouggari Y, Yin KY, Bruneval P, Renault G, Marchiol C, Bonnin P, Lévy B, Bonecchi R, Locati M, Combadière C, Silvestre JS. | 11/3/2012 |
| DARC and D6, the most studied members of this group of molecules, are reviewed. | DARC and D6: silent partners in chemokine regulation?
Hansell CA, Hurson CE, Nibbs RJ., Free PMC Article | 05/28/2011 |
| Chemokne D6 expression is higher in biopsies taken from more severe cardiac allograft rejection. | Cardiac allograft rejection: examination of the expression and function of the decoy chemokine receptor D6.
Bradford L, Marshall H, Robertson H, Kirby JA, Graham G, Ali S, O'Boyle G. | 07/12/2010 |
| D6 protein is found predominantly inside human choriocarcinoma-derived cells with only a small fraction available on the cell surface at any one time, yet it can progressively remove extracellular chemokines, without apparent desensitization. | Chemokine scavenger D6 is expressed by trophoblasts and aids the survival of mouse embryos transferred into allogeneic recipients.
Madigan J, Freeman DJ, Menzies F, Forrow S, Nelson SM, Young A, Sharkey A, Moffett A, Graham GJ, Greer IA, Rot A, Nibbs RJ. | 05/10/2010 |
| D6 cooperates with CD26 in the negative regulation of CCL14 by the selective degradation of its biologically active isoform. | Recognition versus adaptive up-regulation and degradation of CC chemokines by the chemokine decoy receptor D6 are determined by their N-terminal sequence.
Savino B, Borroni EM, Torres NM, Proost P, Struyf S, Mortier A, Mantovani A, Locati M, Bonecchi R., Free PMC Article | 01/21/2010 |
| Immunohistochemistry on lung lymph nodes from patients with pulmonary tuberculosis showed that D6 expression was prominent in lymphatic endothelial cells, while CD68-positive macrophages did not stain for D6. | Role of the chemokine scavenger receptor D6 in balancing inflammation and immune activation.
Borroni EM, Buracchi C, Savino B, Pasqualini F, Russo RC, Nebuloni M, Bonecchi R, Mantovani A, Locati M. | 01/21/2010 |