| CD34 is Expressed in Endothelial Cells in Embryonic Testes and is Additionally Expressed in Non-Endothelial Cells in Postnatal Mouse Testes. | CD34 is Expressed in Endothelial Cells in Embryonic Testes and is Additionally Expressed in Non-Endothelial Cells in Postnatal Mouse Testes.
Abe K, Kameyama H, Abe SI. | 10/15/2022 |
| Lack of CD34 delays bacterial endotoxin-induced lung inflammation. | Lack of CD34 delays bacterial endotoxin-induced lung inflammation.
Aulakh GK, Maltare S, Singh B., Free PMC Article | 11/6/2021 |
| Lack of CD34 produces defects in platelets, microparticles, and lung inflammation. | Lack of CD34 produces defects in platelets, microparticles, and lung inflammation.
Aulakh GK. | 07/17/2021 |
| CD34 and EPCR coordinately enrich functional murine hematopoietic stem cells under normal and inflammatory conditions. | CD34 and EPCR coordinately enrich functional murine hematopoietic stem cells under normal and inflammatory conditions.
Rabe JL, Hernandez G, Chavez JS, Mills TS, Nerlov C, Pietras EM., Free PMC Article | 07/18/2020 |
| In this study, we demonstrate that CD34(+) and CD34(-) subpopulations carrying the BRAF(V600E) mutation confer differential sensitivity to targeted BRAF inhibition. Through elevated KDM5B expression, melanoma cells shift toward a more drug-tolerant, CD34(-) state upon exposure to BRAF inhibitor or combined BRAF inhibitor and MEK inhibitor treatment | KDM5B Promotes Drug Resistance by Regulating Melanoma-Propagating Cell Subpopulations.
Liu X, Zhang SM, McGeary MK, Krykbaeva I, Lai L, Jansen DJ, Kales SC, Simeonov A, Hall MD, Kelly DP, Bosenberg MW, Yan Q., Free PMC Article | 03/14/2020 |
| These results provide evidence that CD34 is required for AHR and airway reactivity maintenance in the early days after an inflammatory episode in asthma. | CD34 Differentially Regulates Contractile and Noncontractile Elements of Airway Reactivity.
Lortie K, Maheux C, Gendron D, Langlois A, Beaulieu MJ, Marsolais D, Bossé Y, Blanchet MR. | 02/24/2018 |
| data suggest that CD34 plays an essential role in maintaining vascular integrity in the lung in response to chemical- and infection-induced tissue damage. | Loss of Vascular CD34 Results in Increased Sensitivity to Lung Injury.
Lo BC, Gold MJ, Scheer S, Hughes MR, Cait J, Debruin E, Chu FSF, Walker DC, Soliman H, Rossi FM, Blanchet MR, Perona-Wright G, Zaph C, McNagny KM. | 12/9/2017 |
| sca-1 antibody reduces both CD34+/c-kit+ progenitor cell surge and vascular restenosis after endoluminal vascular injury in a murine model. | A depleting antibody toward sca-1 mitigates a surge of CD34(+)/c-kit(+) progenitors and reduces vascular restenosis in a murine vascular injury model.
Tillman BW, Kelly J, Richards TD, Chen AF, Donnenberg AD, Donnenberg VS, Tzeng E. | 05/20/2017 |
| Aging induces loss of stemness with concomitant gain of myogenic properties of a pure population of CD34+/CD45- muscle derived stem cells. | Aging induced loss of stemness with concomitant gain of myogenic properties of a pure population of CD34(+)/CD45(-) muscle derived stem cells.
Bose B, Shenoy PS. | 10/8/2016 |
| Stem cell factor is essential for preserving reconstitution capacity of ex vivo expanded cord blood CD34(+) cells in Immunocompromised mice. | Stem cell factor is essential for preserving NOD/SCID reconstitution capacity of ex vivo expanded cord blood CD34(+) cells.
Du Z, Wang Z, Zhang W, Cai H, Tan WS., Free PMC Article | 07/25/2015 |
| combinatorial expression of CD105 and CD34 receptors controls bone morphogenetic protein responsiveness in adipose-derived stem cells | Expression of CD105 and CD34 receptors controls BMP-induced in vitro mineralization of mouse adipose-derived stem cells but does not predict their in vivo bone-forming potential.
Madhu V, Kilanski A, Reghu N, Dighe AS, Cui Q. | 07/4/2015 |
| Our results suggest that CD34+ cells may represent the adipose-derived mesenchymal stem cells which possess stronger multiple differentiation potential during reconstituted skin development | Participation of CD34-enriched mouse adipose cells in hair morphogenesis.
He J, Duan H, Xiong Y, Zhang W, Zhou G, Cao Y, Liu W. | 07/26/2014 |
| Data suggest that CD34 may be a specific marker for functionality, with some specificity for insulin. | Expression profile of a clonal insulin-expressing epithelial cell in the thymus.
Levi D, Polychronakos C., Free PMC Article | 12/21/2013 |
| murine in vitro expanded bone marrow-derived murine mesenchymal stem cells can transform into CD34 expressing cells that induce sarcoma formation in vivo. | In vitro expanded bone marrow-derived murine (C57Bl/KaLwRij) mesenchymal stem cells can acquire CD34 expression and induce sarcoma formation in vivo.
Xu S, De Becker A, De Raeve H, Van Camp B, Vanderkerken K, Van Riet I. | 11/24/2012 |
| Blood-borne CD34(+) endothelial progenitor cells, characterized by active cell division and an amplified transcriptional signature, transition into resident endothelial cells during compensatory lung growth. | CD34+ progenitor to endothelial cell transition in post-pneumonectomy angiogenesis.
Chamoto K, Gibney BC, Lee GS, Lin M, Collings-Simpson D, Voswinckel R, Konerding MA, Tsuda A, Mentzer SJ., Free PMC Article | 04/28/2012 |
| CD34 is necessary for efficient muscle regeneration in adult mice. | CD34 promotes satellite cell motility and entry into proliferation to facilitate efficient skeletal muscle regeneration.
Alfaro LA, Dick SA, Siegel AL, Anonuevo AS, McNagny KM, Megeney LA, Cornelison DD, Rossi FM., Free PMC Article | 03/17/2012 |
| We conclude that CD34 is expressed by mucosal Dendritic Cells and plays an important role in their trafficking through the lung and to the lymph nodes. | CD34 is required for dendritic cell trafficking and pathology in murine hypersensitivity pneumonitis.
Blanchet MR, Bennett JL, Gold MJ, Levantini E, Tenen DG, Girard M, Cormier Y, McNagny KM., Free PMC Article | 01/7/2012 |
| RUNX1 regulates the CD34 gene in haematopoietic stem cells by mediating interactions with a distal regulatory element | RUNX1 regulates the CD34 gene in haematopoietic stem cells by mediating interactions with a distal regulatory element.
Levantini E, Lee S, Radomska HS, Hetherington CJ, Alberich-Jorda M, Amabile G, Zhang P, Gonzalez DA, Zhang J, Basseres DS, Wilson NK, Koschmieder S, Huang G, Zhang DE, Ebralidze AK, Bonifer C, Okuno Y, Gottgens B, Tenen DG., Free PMC Article | 12/24/2011 |
| A novel role for CD34 in both early and late tumor growth, is shown. | Opposing roles for CD34 in B16 melanoma tumor growth alter early stage vasculature and late stage immune cell infiltration.
Maltby S, Freeman S, Gold MJ, Baker JH, Minchinton AI, Gold MR, Roskelley CD, McNagny KM., Free PMC Article | 08/20/2011 |
| study demonstrates a novel role for CD34 in enhancing migration of inflammatory cells and thereby exacerbating host-mediated immunopathology in the intestine of S. Typhimurium-infected mice | CD34 mediates intestinal inflammation in Salmonella-infected mice.
Grassl GA, Faustmann M, Gill N, Zbytnuik L, Merkens H, So L, Rossi FM, McNagny KM, Finlay BB. | 04/30/2011 |
| Data show that high levels of KRT15 expression correlated with a stem cell phenotype and found that KRT15hiITGA6hi stem cells were preserved in bald scalp, while distinct populations of CD200hiITGA6hi and CD34hi cells were markedly diminished. | Bald scalp in men with androgenetic alopecia retains hair follicle stem cells but lacks CD200-rich and CD34-positive hair follicle progenitor cells.
Garza LA, Yang CC, Zhao T, Blatt HB, Lee M, He H, Stanton DC, Carrasco L, Spiegel JH, Tobias JW, Cotsarelis G., Free PMC Article | 04/2/2011 |
| CD133, CD15/SSEA-1, and CD34 do not resume tumor-initiating properties of long-term cultured malignant glio-neuronal stem cells | CD133, CD15/SSEA-1, CD34 or side populations do not resume tumor-initiating properties of long-term cultured cancer stem cells from human malignant glio-neuronal tumors.
Patru C, Romao L, Varlet P, Coulombel L, Raponi E, Cadusseau J, Renault-Mihara F, Thirant C, Leonard N, Berhneim A, Mihalescu-Maingot M, Haiech J, Bièche I, Moura-Neto V, Daumas-Duport C, Junier MP, Chneiweiss H., Free PMC Article | 01/1/2011 |
| CD34 was expressed on colon-infiltrating eosinophils and played a role in eosinophil migration. Further, our findings suggest CD34 is required for efficient eosinophil migration, but not proliferation or expansion in the development of ulcerative colitis. | CD34 is required for infiltration of eosinophils into the colon and pathology associated with DSS-induced ulcerative colitis.
Maltby S, Wohlfarth C, Gold M, Zbytnuik L, Hughes MR, McNagny KM., Free PMC Article | 01/1/2011 |
| Data show that the majority of chondrocyte-like cells are of bone marrow origin, whereas CD34(+)/CD13(+) myeloid precursors appear to infiltrate the plaque actively and transdifferentiate into chondrocyte-like cells in the progression of atherosclerosis. | Myeloid CD34+CD13+ precursor cells transdifferentiate into chondrocyte-like cells in atherosclerotic intimal calcification.
Doehring LC, Heeger C, Aherrahrou Z, Kaczmarek PM, Erdmann J, Schunkert H, Ehlers EM., Free PMC Article | 12/11/2010 |
| Cd34-deficient mice are hypersensitive to autoimmune arthritis, exhibiting an increased vascular leakage at onset of disease which correlates with a subsequent increase in disease severity. | Loss of CD34 leads to exacerbated autoimmune arthritis through increased vascular permeability.
Blanchet MR, Gold M, Maltby S, Bennett J, Petri B, Kubes P, Lee DM, McNagny KM. | 03/15/2010 |