| A Cryptosporidium parvum vaccine candidate effect on immunohistochemical profiling of CD4[+], CD8[+], Caspase-3 and NF-kappaB in mice. | A Cryptosporidium parvum vaccine candidate effect on immunohistochemical profiling of CD4(+), CD8(+), Caspase-3 and NF-κB in mice.
Aboelsoued D, Toaleb NI, Ibrahim S, Shaapan RM, Megeed KNA., Free PMC Article | 11/1/2023 |
| ThPOK is a critical multifaceted regulator of myeloid lineage development. | ThPOK is a critical multifaceted regulator of myeloid lineage development.
Basu J, Olsson A, Ferchen K, Titerina EK, Chetal K, Nicolas E, Czyzewicz P, Levchenko D, Ge L, Hua X, Grimes HL, Salomonis N, Kappes DJ., Free PMC Article | 08/14/2023 |
| Transfer of mesenchymal stem cell mitochondria to CD4[+] T cells contributes to repress Th1 differentiation by downregulating T-bet expression. | Transfer of mesenchymal stem cell mitochondria to CD4(+) T cells contributes to repress Th1 differentiation by downregulating T-bet expression.
Akhter W, Nakhle J, Vaillant L, Garcin G, Le Saout C, Simon M, Crozet C, Djouad F, Jorgensen C, Vignais ML, Hernandez J., Free PMC Article | 02/4/2023 |
| CD4(+)/IL4(+) lymphocytes of the lamina propria and substance P promote colonic protection during acute stress. | CD4(+)/IL‑4(+) lymphocytes of the lamina propria and substance P promote colonic protection during acute stress.
Arciniega-Martínez IM, Reséndiz Albor AA, Cárdenas Jaramillo LM, Gutiérrez-Meza JM, Falfán-Valencia R, Arroyo BM, Yépez-Ortega M, Pacheco-Yépez J, Abarca-Rojano E., Free PMC Article | 03/12/2022 |
| Bhlhe40 is a key transcription factor that regulates CD4+ T cell-mediated GM-CSF production and pathological damage in the colon in graft-versus-host disease. Bhlhe40 is a key transcription factor that regulates CD4+ T cell-mediated GM-CSF production and pathological damage in the colon in graft-versus-host disease. | Pathogenic Bhlhe40+ GM-CSF+ CD4+ T cells promote indirect alloantigen presentation in the GI tract during GVHD.
Piper C, Zhou V, Komorowski R, Szabo A, Vincent B, Serody J, Alegre ML, Edelson BT, Taneja R, Drobyski WR., Free PMC Article | 07/25/2020 |
| CAF-1 and the DNA methyltransferases cooperate to maintain Cd4 silencing and thereby contribute to CD8+ T-cell function and lineage integrity | The histone chaperone CAF-1 cooperates with the DNA methyltransferases to maintain Cd4 silencing in cytotoxic T cells.
Ng C, Aichinger M, Nguyen T, Au C, Najar T, Wu L, Mesa KR, Liao W, Quivy JP, Hubert B, Almouzni G, Zuber J, Littman DR., Free PMC Article | 09/7/2019 |
| Induction of CD4(+)CD25(+)FOXP3(+) regulatory T cells by mesenchymal stem cells is associated with modulation of ubiquitination factors and Treg-specific demethylated region demethylation. | Induction of CD4(+)CD25(+)FOXP3(+) regulatory T cells by mesenchymal stem cells is associated with modulation of ubiquitination factors and TSDR demethylation.
Khosravi M, Bidmeshkipour A, Cohen JL, Moravej A, Hojjat-Assari S, Naserian S, Karimi MH., Free PMC Article | 03/16/2019 |
| IL-27 induces IL-10 production in CD4 T cells during mouse cytomegalovirus infection. | IL-27 regulates the number, function and cytotoxic program of antiviral CD4 T cells and promotes cytomegalovirus persistence.
Wehrens EJ, Wong KA, Gupta A, Khan A, Benedict CA, Zuniga EI., Free PMC Article | 01/26/2019 |
| Enhancers that regulate Cd4 expression perform multiple functions, including not only direct support of transcriptional activity, but also regulation of the gene's methylation state and entrainment of cis-elements that sustain expression after the cells exit the thymus. | Stage-specific epigenetic regulation of CD4 expression by coordinated enhancer elements during T cell development.
Issuree PD, Day K, Au C, Raviram R, Zappile P, Skok JA, Xue HH, Myers RM, Littman DR., Free PMC Article | 01/19/2019 |
| Study identified the maturation enhancer E4m, validated its role in regulating CD4 expression, and isolate Bcl11b as an important activator for E4m. | Runx-dependent and silencer-independent repression of a maturation enhancer in the Cd4 gene.
Kojo S, Yasmin N, Muroi S, Tenno M, Taniuchi I., Free PMC Article | 01/19/2019 |
| data showed the critical role of the first extracellular domain of CD4, by obtaining mice with a loss of function mutation from Ile to Asn at the position 99 of CD4 (I99N). | A point mutation in the extracellular domain of CD4 completely abolishes CD4 T cell development in C57BL/6 mouse.
Wang H, Li S, Chao T, Wang X, Shi L, Zhang L, Liang Y, Zheng Q, Lu L. | 02/3/2018 |
| results suggest that CD4 CD8 double knockout (DN)T cells can develop efficiently in vivo and chronic exposure to bacterial superantigens may precipitate a lupus-like autoimmune disease through activation of DNT cells | Concomitant Disruption of CD4 and CD8 Genes Facilitates the Development of Double Negative αβ TCR(+) Peripheral T Cells That Respond Robustly to Staphylococcal Superantigen.
Chowdhary VR, Krogman A, Tilahun AY, Alexander MP, David CS, Rajagopalan G., Free PMC Article | 09/23/2017 |
| TCF-1-deficient CD4+ CD8+ double positive thymocytes fail to undergo TCR alpha Valpha14-Jalpha18 rearrangement and produce significantly fewer Natural killer T cells. | T cell factor-1 controls the lifetime of CD4+ CD8+ thymocytes in vivo and distal T cell receptor α-chain rearrangement required for NKT cell development.
Sharma A, Berga-Bolaños R, Sen JM., Free PMC Article | 04/30/2016 |
| High-fat diet - induced type 2 diabetes decreases the number of ileum IL17/RORgammaT CD4 T cells. | The Gut Microbiota Regulates Intestinal CD4 T Cells Expressing RORγt and Controls Metabolic Disease.
Garidou L, Pomié C, Klopp P, Waget A, Charpentier J, Aloulou M, Giry A, Serino M, Stenman L, Lahtinen S, Dray C, Iacovoni JS, Courtney M, Collet X, Amar J, Servant F, Lelouvier B, Valet P, Eberl G, Fazilleau N, Douin-Echinard V, Heymes C, Burcelin R. | 04/2/2016 |
| Results indicate that hypomethylation of Cd4 antigen correlates with stable CD4 expression. | Regulation of DNA methylation dictates Cd4 expression during the development of helper and cytotoxic T cell lineages.
Sellars M, Huh JR, Day K, Issuree PD, Galan C, Gobeil S, Absher D, Green MR, Littman DR., Free PMC Article | 09/26/2015 |
| CD4 is expressed in distinct nanoclusters and does not colocalize with T-cell receptor and active protein tyrosine kinase p56lck | The coreceptor CD4 is expressed in distinct nanoclusters and does not colocalize with T-cell receptor and active protein tyrosine kinase p56lck.
Roh KH, Lillemeier BF, Wang F, Davis MM., Free PMC Article | 06/27/2015 |
| This study establishes an important role of IgE in abdominal aortic aneurysms pathogenesis by activating CD4+ T cells, mast cells, and macrophages. | IgE actions on CD4+ T cells, mast cells, and macrophages participate in the pathogenesis of experimental abdominal aortic aneurysms.
Wang J, Lindholt JS, Sukhova GK, Shi MA, Xia M, Chen H, Xiang M, He A, Wang Y, Xiong N, Libby P, Wang JA, Shi GP., Free PMC Article | 02/14/2015 |
| 5-kb cis-element is required in postselection thymocytes for helper lineage commitment, presumably mediating the maintenance of CD4 expression, and suggest that inactivation of the cis-element by DNA methylation | A silencer-proximal intronic region is required for sustained CD4 expression in postselection thymocytes.
Henson DM, Chou C, Sakurai N, Egawa T., Free PMC Article | 06/28/2014 |
| Both type I CD8+ cytotoxic (Tc1) cells and interleukin (IL)-17-producing CD8+ (Tc17) cells mediate effective antitumor immunity through distinct effector mechanisms, but Tc1 cells are superior to Tc17 cells in mediating tumor regression. | Adoptive transfer of Tc1 or Tc17 cells elicits antitumor immunity against established melanoma through distinct mechanisms.
Yu Y, Cho HI, Wang D, Kaosaard K, Anasetti C, Celis E, Yu XZ., Free PMC Article | 03/30/2013 |
| Accumulation of CD4 positive effector T cells is a critical step in the progression from mild glomerulonephritis to severe crescentic glomerulonephritis accompanied by tubulointerstitial inflammation and loss of kidney function. | Characterization of the renal CD4+ T-cell response in experimental autoimmune glomerulonephritis.
Hopfer H, Holzer J, Hünemörder S, Paust HJ, Sachs M, Meyer-Schwesinger C, Turner JE, Panzer U, Mittrücker HW. | 11/3/2012 |
| CD4-positive cell deficiency impairs IFN-gamma production by CD8-positive effector cells at the site of Mycobacterium tuberculosis infection in mice. | CD4+ T cell-dependent IFN-γ production by CD8+ effector T cells in Mycobacterium tuberculosis infection.
Bold TD, Ernst JD., Free PMC Article | 11/3/2012 |
| Thymic selection does not appear to play an important role in CD4+CD8+ T cell receptor (TCR)beta repertoire overlap between individuals. | Recombinatorial biases and convergent recombination determine interindividual TCRβ sharing in murine thymocytes.
Li H, Ye C, Ji G, Wu X, Xiang Z, Li Y, Cao Y, Liu X, Douek DC, Price DA, Han J. | 11/3/2012 |
| galectin-1 inhibition reduces murine lung metastasis with increased CD4(+) and CD8 (+) T cells and reduced cancer cell adherence | Inhibiting galectin-1 reduces murine lung metastasis with increased CD4(+) and CD8 (+) T cells and reduced cancer cell adherence.
Ito K, Ralph SJ. | 09/22/2012 |
| Mice that lack the ability to make both CD8-positive and CD4-positive induced regulatory T (iTreg) cells have accelerated graft-vs-host-disease mortality compared with animals that are competent to make both iTreg populations. | CD8+ Foxp3+ regulatory T cells are induced during graft-versus-host disease and mitigate disease severity.
Beres AJ, Haribhai D, Chadwick AC, Gonyo PJ, Williams CB, Drobyski WR., Free PMC Article | 09/8/2012 |
| Danazol induced prolonged cardiac allograft survival and generation of regulatory CD4(+) cells. | Induction of regulatory CD4⁺ cells and prolongation of survival of fully allogeneic murine cardiac grafts by danazol.
Uchiyama M, Jin X, Zhang Q, Amano A, Watanabe T, Niimi M. | 09/8/2012 |