| 7SK small nuclear RNA (Rn7SK) induces apoptosis through intrinsic and extrinsic pathways in human embryonic kidney cell line. | 7SK small nuclear RNA (Rn7SK) induces apoptosis through intrinsic and extrinsic pathways in human embryonic kidney cell line.
Abasi M, Ranjbari J, Ghanbarian H. | 01/16/2024 |
| A positive feedback circuit between RN7SK snRNA and m[6]A readers is essential for tumorigenesis. | A positive feedback circuit between RN7SK snRNA and m(6)A readers is essential for tumorigenesis.
Xu X, Ma L, Zhang X, Guo S, Guo W, Wang Y, Qiu S, Tian X, Miao Y, Yu Y, Wang J., Free PMC Article | 06/14/2023 |
| RN7SK small nuclear RNA controls bidirectional transcription of highly expressed gene pairs in skin. | RN7SK small nuclear RNA controls bidirectional transcription of highly expressed gene pairs in skin.
Bandiera R, Wagner RE, Britto-Borges T, Dieterich C, Dietmann S, Bornelöv S, Frye M., Free PMC Article | 11/6/2021 |
| [7SK truncation at 128-179 nt suppresses embryonic stem cell proliferation in vitro by downregulating CDC6]. | [7SK truncation at 128-179 nt suppresses embryonic stem cell proliferation in vitro by downregulating CDC6].
Chen R, Zhang Y, Chen P, Pang Y, Li H, Chen Z, Zhang X, Zhang H, Li W., Free PMC Article | 09/25/2021 |
| Analysis of RNA binding properties of human Ku protein reveals its interactions with 7SK snRNA and protein components of 7SK snRNP complex. | Analysis of RNA binding properties of human Ku protein reveals its interactions with 7SK snRNA and protein components of 7SK snRNP complex.
Shadrina O, Garanina I, Korolev S, Zatsepin T, Van Assche J, Daouad F, Wallet C, Rohr O, Gottikh M. | 12/19/2020 |
| Our results demonstrated the transient knockdown of Rn7SK in mesenchymal stem cells leads to delayed senescence, while its overexpressions shows opposite effects. | Rn7SK small nuclear RNA is involved in cellular senescence.
Musavi M, Kohram F, Abasi M, Bolandi Z, Ajoudanian M, Mohammadi-Yeganeh S, Hashemi SM, Sharifi K, Fathi HR, Ghanbarian H. | 05/30/2020 |
| The 7SK small nuclear RNA is a multifunctional transcriptional regulatory RNA that controls the nuclear activity of the positive transcription elongation factor b (P-TEFb), specifically targets P-TEFb to the promoter regions of selected protein-coding genes and promotes transcription of RNA polymerase II-specific spliceosomal small nuclear RNA genes. | 7SK small nuclear RNA, a multifunctional transcriptional regulatory RNA with gene-specific features.
Egloff S, Studniarek C, Kiss T., Free PMC Article | 11/10/2018 |
| These findings identify a novel role for HIV-1 TAR in the absence of Tat, involving the interference with host cellular immune responses by targeting 7SK RNA-mediated gene expression and P-TEFb inactivation. | Latent HIV-1 TAR Regulates 7SK-responsive P-TEFb Target Genes and Targets Cellular Immune Responses in the Absence of Tat.
Eilebrecht S, Benecke BJ, Benecke AG., Free PMC Article | 02/10/2018 |
| The 7SK small nuclear RNP (snRNP), composed of the 7SK small nuclear RNA (snRNA), MePCE, and Larp7, also functions as a canonical transcription factor that, in collaboration with the little elongation complex (LEC) comprising ELL, Ice1, Ice2, and ZC3H8, promotes transcription of RNAPII-specific spliceosomal snRNA and small nucleolar RNA (snoRNA) genes. | The 7SK snRNP associates with the little elongation complex to promote snRNA gene expression.
Egloff S, Vitali P, Tellier M, Raffel R, Murphy S, Kiss T., Free PMC Article | 07/1/2017 |
| 7SK expression is significantly down-regulated in cancer.7SK transcriptional level decreased in stem cells in comparison with differentiated cell types. | 7SK small nuclear RNA transcription level down-regulates in human tumors and stem cells.
Abasi M, Bazi Z, Mohammadi-Yeganeh S, Soleimani M, Haghpanah V, Zargami N, Ghanbarian H. | 04/29/2017 |
| 7SK physically interacts with the BAF chromatin-remodeling complex, recruits BAF to enhancers and inhibits enhancer transcription by modulating chromatin structure. | 7SK-BAF axis controls pervasive transcription at enhancers.
Flynn RA, Do BT, Rubin AJ, Calo E, Lee B, Kuchelmeister H, Rale M, Chu C, Kool ET, Wysocka J, Khavari PA, Chang HY., Free PMC Article | 07/30/2016 |
| KAP1 controls 7SK snRNP delivery to promoter-proximal regions to facilitate "on-site" P-TEFb activation and Pol II elongation. | KAP1 Recruitment of the 7SK snRNP Complex to Promoters Enables Transcription Elongation by RNA Polymerase II.
McNamara RP, Reeder JE, McMillan EA, Bacon CW, McCann JL, D'Orso I., Free PMC Article | 05/28/2016 |
| results suggest that LARP7 uses both its N- and C-terminal domains to stabilize 7SK in a closed structure, which forms by joining conserved sequences at the 5'-end with the foot of the 3' hairpin and has thus functional implications | Structural insight into the mechanism of stabilization of the 7SK small nuclear RNA by LARP7.
Uchikawa E, Natchiar KS, Han X, Proux F, Roblin P, Zhang E, Durand A, Klaholz BP, Dock-Bregeon AC., Free PMC Article | 06/27/2015 |
| a region in HEXIM1 C-terminal to its previously mapped RNA-binding motif was also required for interactions between HEXIM1 and 7SK. | Genetic analysis of the structure and function of 7SK small nuclear ribonucleoprotein (snRNP) in cells.
Fujinaga K, Luo Z, Peterlin BM., Free PMC Article | 02/14/2015 |
| the release of P-TEFb from the 7SK snRNP led to increased synthesis of HEXIM1 but not HEXIM2 | Release of positive transcription elongation factor b (P-TEFb) from 7SK small nuclear ribonucleoprotein (snRNP) activates hexamethylene bisacetamide-inducible protein (HEXIM1) transcription.
Liu P, Xiang Y, Fujinaga K, Bartholomeeusen K, Nilson KA, Price DH, Peterlin BM., Free PMC Article | 05/31/2014 |
| Bromodomain and extra-terminal (BET) bromodomain inhibition activate transcription via transient release of positive transcription elongation factor b (P-TEFb) from 7SK small nuclear ribonucleoprotein. | Bromodomain and extra-terminal (BET) bromodomain inhibition activate transcription via transient release of positive transcription elongation factor b (P-TEFb) from 7SK small nuclear ribonucleoprotein.
Bartholomeeusen K, Xiang Y, Fujinaga K, Peterlin BM., Free PMC Article | 12/29/2012 |
| 7SK RNA thus establishes gene-dependent plasticity between HMGA1 chromatin remodeling and transcription initiation and P-TEFb transcription elongation. | 7SK snRNA-mediated, gene-specific cooperativity of HMGA1 and P-TEFb.
Eilebrecht S, Benecke BJ, Benecke A. | 09/1/2012 |
| The 7SK snRNP complex acts as a reservoir where active transcription elongation factor P-TEFb can be withdrawn by Tat to stimulate HIV-1 transcription. | New insights into the control of HIV-1 transcription: when Tat meets the 7SK snRNP and super elongation complex (SEC).
He N, Zhou Q., Free PMC Article | 03/24/2012 |
| HMGA1 transcription activity can dependent and independent of 7SK snRNA. | HMGA1-dependent and independent 7SK RNA gene regulatory activity.
Eilebrecht S, Bécavin C, Léger H, Benecke BJ, Benecke A. | 09/17/2011 |
| Tat efficiently replaces HEXIM1 on the 7SK snRNA in vivo and it promotes the disassembly of the 7SK/HEXIM/P-TEFb negative transcriptional regulatory snRNP to augment the nuclear level of active P-TEFb. | Controlling cellular P-TEFb activity by the HIV-1 transcriptional transactivator Tat.
Muniz L, Egloff S, Ughy B, Jády BE, Kiss T., Free PMC Article | 03/12/2011 |
| The configuration of the stem loop 4 of 7SK suggests that the loop is poised to make ternary contacts with P-TEFb and HEXIM or Tat. | Preformed protein-binding motifs in 7SK snRNA: structural and thermodynamic comparisons with retroviral TAR.
Durney MA, D'Souza VM. | 01/1/2011 |
| HIV-1 Tat assembles a multifunctional transcription elongation complex and stably associates with the 7SK snRNP. | HIV-1 Tat assembles a multifunctional transcription elongation complex and stably associates with the 7SK snRNP.
Sobhian B, Laguette N, Yatim A, Nakamura M, Levy Y, Kiernan R, Benkirane M., Free PMC Article | 06/14/2010 |
| T-loop phosphorylated Cdk9 localizes to nuclear speckle domains which may serve as sites of active P-TEFb function and exchange between the Brd4 and 7SK/HEXIM1 regulatory complexes. | T-loop phosphorylated Cdk9 localizes to nuclear speckle domains which may serve as sites of active P-TEFb function and exchange between the Brd4 and 7SK/HEXIM1 regulatory complexes.
Dow EC, Liu H, Rice AP., Free PMC Article | 05/31/2010 |
| PP2B and PP1alpha cooperatively disrupt 7SK snRNP to release P-TEFb for transcription in response to Ca2+ signaling. | PP2B and PP1alpha cooperatively disrupt 7SK snRNP to release P-TEFb for transcription in response to Ca2+ signaling.
Chen R, Liu M, Li H, Xue Y, Ramey WN, He N, Ai N, Luo H, Zhu Y, Zhou N, Zhou Q., Free PMC Article | 01/21/2010 |
| analysis of positive transcription elongation factor - HEXIM1 - 7SK RNA complex | Transcription-dependent association of multiple positive transcription elongation factor units to a HEXIM multimer.
Dulac C, Michels AA, Fraldi A, Bonnet F, Nguyen VT, Napolitano G, Lania L, Bensaude O. | 01/21/2010 |