| Plasmodium yoelii surface-related antigen (PySRA) modulates the host pro-inflammatory responses via binding to CD68 on macrophage membrane. | Plasmodium yoelii surface-related antigen (PySRA) modulates the host pro-inflammatory responses via binding to CD68 on macrophage membrane.
Feng X, Yu J-L, Sun Y-F, Du C-Y, Shen Y, Zhang L, Kong W-Z, Han S, Cheng Y., Free PMC Article | 05/30/2024 |
| Microglial CD68 and L-ferritin upregulation in response to phosphorylated-TDP-43 pathology in the amyotrophic lateral sclerosis brain. | Microglial CD68 and L-ferritin upregulation in response to phosphorylated-TDP-43 pathology in the amyotrophic lateral sclerosis brain.
Swanson MEV, Mrkela M, Murray HC, Cao MC, Turner C, Curtis MA, Faull RLM, Walker AK, Scotter EL., Free PMC Article | 08/25/2023 |
| Myeloid-restricted CD68 deficiency attenuates atherosclerosis via inhibition of ROS-MAPK-apoptosis axis. | Myeloid-restricted CD68 deficiency attenuates atherosclerosis via inhibition of ROS-MAPK-apoptosis axis.
Duan L, Zhao Y, Jia J, Chao T, Wang H, Liang Y, Lou Y, Zheng Q, Wang H. | 05/12/2023 |
| Autophagic reprogramming of bone marrow-derived macrophages. | Autophagic reprogramming of bone marrow-derived macrophages.
Mazher M, Moqidem YA, Zidan M, Sayed AA, Abdellatif A., Free PMC Article | 04/5/2023 |
| Scavenger receptor CD68 antigen plays a role in chronic liver injury, which has implications for the design of anti-fibrotic therapies. | The class D scavenger receptor CD68 contributes to mouse chronic liver injury.
Yang L, Yang L, Dong C, Li L. | 04/6/2019 |
| Findings indicate that human CD68 and its mouse ortholog macrosialin located in the lysosomal membrane and share many structural similarities. | CD68/macrosialin: not just a histochemical marker.
Chistiakov DA, Killingsworth MC, Myasoedova VA, Orekhov AN, Bobryshev YV. | 06/24/2017 |
| Myeloid osteoclast precursors do not express CD68. | Osteoclast precursors do not express CD68: results from CD68 promoter-driven RANK transgenic mice.
Jackson MF, Scatena M, Giachelli CM., Free PMC Article | 05/20/2017 |
| CD68, a putative receptor for sporozoite invasion of Kupffer cells that acts as a gateway for malaria infection of the liver. | CD68 acts as a major gateway for malaria sporozoite liver infection.
Cha SJ, Park K, Srinivasan P, Schindler CW, van Rooijen N, Stins M, Jacobs-Lorena M., Free PMC Article | 11/7/2015 |
| Results showed that activated microglia in Alzheimer's disease-like mice showed two-step transition: a CD68-negative activated form at 6-9 months and a CD68-positive form from 12 months of age | Temporal changes of CD68 and α7 nicotinic acetylcholine receptor expression in microglia in Alzheimer's disease-like mouse models.
Matsumura A, Suzuki S, Iwahara N, Hisahara S, Kawamata J, Suzuki H, Yamauchi A, Takata K, Kitamura Y, Shimohama S. | 09/26/2015 |
| Statins promote the beneficial remodeling of plaques in diseased mouse arteries through the stimulation of the CCR7 / CD68 emigration pathway in macrophages | Statins promote the regression of atherosclerosis via activation of the CCR7-dependent emigration pathway in macrophages.
Feig JE, Shang Y, Rotllan N, Vengrenyuk Y, Wu C, Shamir R, Torra IP, Fernandez-Hernando C, Fisher EA, Garabedian MJ., Free PMC Article | 07/21/2012 |
| These findings demonstrate a role for CD68 in the function of osteoclasts. | Genetic ablation of CD68 results in mice with increased bone and dysfunctional osteoclasts.
Ashley JW, Shi Z, Zhao H, Li X, Kesterson RA, Feng X., Free PMC Article | 02/11/2012 |
| CD68-null mononuclear phagocytes exhibited a trend toward enhanced antigen presentation to CD4+ T cells, indicating that CD68 may function to negatively regulate antigen uptake, loading, or major histocompatibility complex class II trafficking. | Deletion of the murine scavenger receptor CD68.
Song L, Lee C, Schindler C., Free PMC Article | 11/12/2011 |
| Atherogenic diet-induced reduction in lipid levels of Reversa model mouse leads to decreased monocyte-derived CD68-positive cells in advanced atherosclerotic plaques and is associated with emigration of these cells from the atherosclerotic plaques. | Reversal of hyperlipidemia with a genetic switch favorably affects the content and inflammatory state of macrophages in atherosclerotic plaques.
Feig JE, Parathath S, Rong JX, Mick SL, Vengrenyuk Y, Grauer L, Young SG, Fisher EA., Free PMC Article | 05/21/2011 |
| Macrosialin does not function as an oxLDL receptor on the cell surface. | Lack of a direct role for macrosialin in oxidized LDL metabolism.
de Beer MC, Zhao Z, Webb NR, van der Westhuyzen DR, de Villiers WJ. | 01/21/2010 |
| Data show that macrosialin (CD68), a macrophage-specific protein, is increased by aging in selected brain regions of male C57BL/6NNia mice. | Macrosialin increases during normal brain aging are attenuated by caloric restriction.
Wong AM, Patel NV, Patel NK, Wei M, Morgan TE, de Beer MC, de Villiers WJ, Finch CE. | 01/21/2010 |