| Infiltrative Vessel Co-optive Growth Pattern Induced by IQGAP3 Overexpression Promotes Microvascular Invasion in Hepatocellular Carcinoma. | Infiltrative Vessel Co-optive Growth Pattern Induced by IQGAP3 Overexpression Promotes Microvascular Invasion in Hepatocellular Carcinoma.
Tang M, Zhang S, Yang M, Feng R, Lin J, Chen X, Xu Y, Yu R, Liao X, Li Z, Li X, Li M, Zhang Q, Chen S, Qian W, Liu Y, Song L, Li J. | 07/8/2024 |
| IQGAP3 Is an Important Mediator of Skin Inflammatory Diseases. | IQGAP3 Is an Important Mediator of Skin Inflammatory Diseases.
Zolotarenko A, Bruskin S., Free PMC Article | 05/20/2024 |
| Identification and validation of non-coding RNA-mediated high expression of IQGAP3 in poor prognosis of lung adenocarcinoma. | Identification and validation of non-coding RNA-mediated high expression of IQGAP3 in poor prognosis of lung adenocarcinoma.
Su Z, Wang Y, Cao J, Ma J, Wang G, Ren H, Zhang Y, Sheng K, Zhu X, Wang Y. | 03/1/2024 |
| IQGAP3 is relevant to prostate cancer: A detailed presentation of potential pathomechanisms. | IQGAP3 is relevant to prostate cancer: A detailed presentation of potential pathomechanisms.
Mei W, Dong Y, Gu Y, Kapoor A, Lin X, Su Y, Vega Neira S, Tang D., Free PMC Article | 12/5/2023 |
| IQGAP3 in clear cell renal cell carcinoma contributes to drug resistance and genome stability. | IQGAP3 in clear cell renal cell carcinoma contributes to drug resistance and genome stability.
Li W, Wang Z, Wang H, Zhang J, Wang X, Xing S, Chen S., Free PMC Article | 01/28/2023 |
| CDC42 Regulates Cell Proliferation and Apoptosis in Bladder Cancer via the IQGAP3-Mediated Ras/ERK Pathway. | CDC42 Regulates Cell Proliferation and Apoptosis in Bladder Cancer via the IQGAP3-Mediated Ras/ERK Pathway.
Li G, Wang Y, Guo XB, Zhao B. | 11/5/2022 |
| Comprehensive Multiomics Analysis Identified IQGAP3 as a Potential Prognostic Marker in Pan-Cancer. | Comprehensive Multiomics Analysis Identified IQGAP3 as a Potential Prognostic Marker in Pan-Cancer.
Wang G, Zhou X, Li Y, Zhao M, Zou Y, Lu Q, Wu Y., Free PMC Article | 10/8/2022 |
| IQGAP3, a YAP Target, Is Required for Proper Cell-Cycle Progression and Genome Stability. | IQGAP3, a YAP Target, Is Required for Proper Cell-Cycle Progression and Genome Stability.
Leone M, Cazorla-Vázquez S, Ferrazzi F, Wiederstein JL, Gründl M, Weinstock G, Vergarajauregui S, Eckstein M, Krüger M, Gaubatz S, Engel FB. | 02/19/2022 |
| Enhancement of Migration and Invasion of Gastric Cancer Cells by IQGAP3. | Enhancement of Migration and Invasion of Gastric Cancer Cells by IQGAP3.
Jinawath N, Shiao MS, Chanpanitkitchote P, Svasti J, Furukawa Y, Nakamura Y., Free PMC Article | 06/19/2021 |
| IQGAP3 interacts with Rad17 to recruit the Mre11-Rad50-Nbs1 complex and contributes to radioresistance in lung cancer. | IQGAP3 interacts with Rad17 to recruit the Mre11-Rad50-Nbs1 complex and contributes to radioresistance in lung cancer.
Zeng Y, Jie X, Wu B, Wu G, Liu L, Xu S. | 03/28/2021 |
| IQGAP3 was upregulated in colorectal cancer at the tissue level and cellular level. Based on immunohistochemistry results of the tissue microarrays, authors demonstrated that higher expression of IQGAP3 was associated with higher tumor node metastasis stage (P = 0.005), higher incidence of lymph node metastasis (P = 0.004), and shorter overall survival (P = 0.022). | High expression of IQGAP3 indicates poor prognosis in colorectal cancer patients.
Wu J, Chen Z, Cao H, Yu Z, Feng J, Wang K, Lu Q, Wu Y. | 05/16/2020 |
| Data found that the IQGAP3/BMP4 ratio in urinary cell-free DNA (ucfDNA) was significantly associated with recurrence-free survival (RFS) and progression-free survival (PFS) in non-muscle-invasive bladder cancer (NMIBC) patients suggesting that the IQGAP3/BMP4 ratio in ucfDNA may be an important independent factor for NMIBC prognosis. | Urinary Cell-Free DNA IQGAP3/BMP4 Ratio as a Prognostic Marker for Non-Muscle-Invasive Bladder Cancer.
Xu Y, Kim YH, Jeong P, Piao XM, Byun YJ, Seo SP, Kang HW, Kim WT, Lee JY, Ryu DH, Choi JW, Kim IY, Moon SK, Choi YH, Yun SJ, Kim WJ. | 03/28/2020 |
| IQGAP3 may be a potential target gene for Kaempferol in the treatment of breast cancer. | IQ Motif Containing GTPase-Activating Protein 3 (IQGAP3) Inhibits Kaempferol-Induced Apoptosis in Breast Cancer Cells by Extracellular Signal-Regulated Kinases 1/2 (ERK1/2) Signaling Activation.
Hu G, Liu H, Wang M, Peng W., Free PMC Article | 02/22/2020 |
| Both IQGAP3/BMP4 and IQGAP3/FAM107A ratios in ucfDNA were significantly higher in patients with BC than in those with hematuria. | Diagnostic value of combined IQGAP3/BMP4 and IQGAP3/FAM107A expression ratios in urinary cell-free DNA for discriminating bladder cancer from hematuria.
Xu Y, Kim YH, Jeong P, Piao XM, Byun YJ, Kang HW, Kim WT, Lee JY, Kim IY, Moon SK, Choi YH, Yun SJ, Kim WJ. | 03/9/2019 |
| These results suggest that IQGAP3 plays an important role in gastric cancer stem cells (CSCs). The location of IQGAP3 on the cell membrane makes it a potential therapeutic target for gastric cancer (GC). | Overexpression of the Transmembrane Protein IQGAP3 Is Associated with Poor Survival of Patients with Gastric Cancer.
Oue N, Yamamoto Y, Oshima T, Asai R, Ishikawa A, Uraoka N, Sakamoto N, Sentani K, Yasui W. | 10/6/2018 |
| IQGAP3 functions as an important regulator of metastasis and epithelial-to-mesenchymal transition by constitutively activating the TGF-beta signaling pathway in Hepatocellular carcinoma. | Role of IQGAP3 in metastasis and epithelial-mesenchymal transition in human hepatocellular carcinoma.
Shi Y, Qin N, Zhou Q, Chen Y, Huang S, Chen B, Shen G, Jia H., Free PMC Article | 05/12/2018 |
| IQGAP2 expression correlated positively with survivability, on the contrary, IQGAP3 expression levels correlated inversely with survivability | Reduced expression of IQGAP2 and higher expression of IQGAP3 correlates with poor prognosis in cancers.
Kumar D, Hassan MK, Pattnaik N, Mohapatra N, Dixit M., Free PMC Article | 11/11/2017 |
| IQGAP3 may be a potential therapeutic target in human breast cancer. | RNA Interference of IQ Motif Containing GTPase-Activating Protein 3 (IQGAP3) Inhibits Cell Proliferation and Invasion in Breast Carcinoma Cells.
Hu G, Xu Y, Chen W, Wang J, Zhao C, Wang M., Free PMC Article | 03/25/2017 |
| IQGAP1, IQGAP2, and IQGAP3 have diverse roles in vertebrate physiology, operating in the kidney, nervous system, cardiovascular system, pancreas, and lung. (Review) | The biology of IQGAP proteins: beyond the cytoskeleton.
Hedman AC, Smith JM, Sacks DB., Free PMC Article | 12/26/2015 |
| Mammalian IQGAP proteins may play a role in cytokinesis by regulating the localization of key cytokinesis regulatory proteins to the contractile apparatus during mitosis. | Involvement of IQGAP family proteins in the regulation of mammalian cell cytokinesis.
Adachi M, Kawasaki A, Nojima H, Nishida E, Tsukita S. | 05/16/2015 |
| IQGAP3 may contribute to the pathogenesis of lung cancer by modulating EGFR-ERK signaling | IQGAP3 promotes EGFR-ERK signaling and the growth and metastasis of lung cancer cells.
Yang Y, Zhao W, Xu QW, Wang XS, Zhang Y, Zhang J., Free PMC Article | 01/17/2015 |
| The first IQ-motifs from IQGAP2 and IQGAP3 form transient interactions with calmodulin in the absence of calcium. | IQ-motif selectivity in human IQGAP2 and IQGAP3: binding of calmodulin and myosin essential light chain.
Atcheson E, Hamilton E, Pathmanathan S, Greer B, Harriott P, Timson DJ., Free PMC Article | 01/17/2015 |
| Observational study of gene-disease association. (HuGE Navigator) | Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.
Flachsbart F, Franke A, Kleindorp R, Caliebe A, Blanché H, Schreiber S, Nebel A. | 12/5/2010 |