| Heterozygous Dab1 Null Mutation Disrupts Neocortical and Hippocampal Development. | Heterozygous Dab1 Null Mutation Disrupts Neocortical and Hippocampal Development.
Honda T, Hirota Y, Nakajima K., Free PMC Article | 04/14/2023 |
| Immunoexpression Pattern of Autophagy Markers in Developing and Postnatal Kidneys of Dab1[-/-](yotari) Mice. | Immunoexpression Pattern of Autophagy Markers in Developing and Postnatal Kidneys of Dab1(-/-)(yotari) Mice.
Maglica M, Kelam N, Haque E, Perutina I, Racetin A, Filipović N, Katsuyama Y, Vukojević K., Free PMC Article | 04/1/2023 |
| Immunohistochemical Expression Pattern of FGFR1, FGFR2, RIP5, and HIP2 in Developing and Postnatal Kidneys of Dab1(-/-) (yotari) Mice. | Immunohistochemical Expression Pattern of FGFR1, FGFR2, RIP5, and HIP2 in Developing and Postnatal Kidneys of Dab1(-/-) (yotari) Mice.
Kelam N, Racetin A, Katsuyama Y, Vukojević K, Kostić S., Free PMC Article | 03/19/2022 |
| Defective Reelin/Dab1 signaling pathways associated with disturbed hippocampus development of homozygous yotari mice. | Defective Reelin/Dab1 signaling pathways associated with disturbed hippocampus development of homozygous yotari mice.
Arimitsu N, Mizukami Y, Shimizu J, Takai K, Suzuki T, Suzuki N. | 11/27/2021 |
| Connexin Expression Is Altered in Liver Development of Yotari (dab1 -/-) Mice. | Connexin Expression Is Altered in Liver Development of Yotari (dab1 -/-) Mice.
Paštar V, Lozić M, Kelam N, Filipović N, Bernard B, Katsuyama Y, Vukojević K., Free PMC Article | 10/30/2021 |
| A Homozygous Dab1(-/-) Is a Potential Novel Cause of Autosomal Recessive Congenital Anomalies of the Mice Kidney and Urinary Tract. | A Homozygous Dab1(-/-) Is a Potential Novel Cause of Autosomal Recessive Congenital Anomalies of the Mice Kidney and Urinary Tract.
Racetin A, Filipović N, Lozić M, Ogata M, Gudelj Ensor L, Kelam N, Kovačević P, Watanabe K, Katsuyama Y, Saraga-Babić M, Glavina Durdov M, Vukojević K., Free PMC Article | 09/25/2021 |
| Disabled 1 Is Part of a Signaling Pathway Activated by Epidermal Growth Factor Receptor. | Disabled 1 Is Part of a Signaling Pathway Activated by Epidermal Growth Factor Receptor.
Dlugosz P, Teufl M, Schwab M, Kohl KE, Nimpf J., Free PMC Article | 09/11/2021 |
| Reelin dorsal horn neurons co-express Lmx1b and are mispositioned in disabled-1 mutant mice. | Reelin dorsal horn neurons co-express Lmx1b and are mispositioned in disabled-1 mutant mice.
Yvone GM, Chavez-Martinez CL, Nguyen AR, Wang DJ, Phelps PE., Free PMC Article | 09/4/2021 |
| Apolipoprotein E promotes white matter remodeling via the Dab1-dependent pathway after traumatic brain injury. | Apolipoprotein E promotes white matter remodeling via the Dab1-dependent pathway after traumatic brain injury.
Huang ZJ, Cao F, Wu Y, Peng JH, Zhong JJ, Jiang Y, Yin C, Guo ZD, Sun XC, Jiang L, Cheng CJ., Free PMC Article | 08/28/2021 |
| Mutations in the Reelin pathway are associated with abnormal expression of microglial IgG FC receptors in the cerebellar cortex. | Mutations in the Reelin pathway are associated with abnormal expression of microglial IgG FC receptors in the cerebellar cortex.
Rahimi-Balaei M, Jiao X, Dalvand A, Shabanipour S, Chung SH, Amiri S, Kong J, Marzban H. | 05/1/2021 |
| Reelin and its downstream molecules, including Dab1, play crucial roles in the neural regeneration and subsequent recovery of motor function in our hemiplegic mouse model | Roles of Reelin/Disabled1 pathway on functional recovery of hemiplegic mice after neural cell transplantation; Reelin promotes migration toward motor cortex and maturation to motoneurons of neural grafts.
Arimitsu N, Takai K, Fujiwara N, Shimizu J, Ueda Y, Wakisaka S, Hirotsu C, Murayama MA, Suzuki T, Suzuki N. | 02/29/2020 |
| Findings illustrate a DCC-Dab1 interaction that ensures proper neuronal migration during neocortical development. | DCC-Mediated Dab1 Phosphorylation Participates in the Multipolar-to-Bipolar Transition of Migrating Neurons.
Zhang JH, Zhao YF, He XX, Zhao Y, He ZX, Zhang L, Huang Y, Wang YB, Hu L, Liu L, Yu HL, Xu JH, Lai MM, Zhao DD, Cui L, Guo WX, Xiong WC, Ding YQ, Zhu XJ. | 11/9/2019 |
| alternative splicing of Dab1 modulates the tyrosine motif switch and mediates Multipolar-to-bipolar transition of cortical neurons | Alternative Splicing of Disabled-1 Controls Multipolar-to-Bipolar Transition of Migrating Neurons in the Neocortex.
Zhang B, Wang W, Zhang Z, Hu Y, Meng F, Wang F, Lou H, Zhu L, Godbout R, Duan S, Gao Z. | 11/9/2019 |
| Deletion of Dab1 in endothelial cells leads to a reduced secretion of laminin-alpha4 and decreased activation of integrin-beta1 in glial cells, which in turn control neuronal migration and barrier properties of the neurovascular unit. | Endothelial Dab1 signaling orchestrates neuro-glia-vessel communication in the central nervous system.
Segarra M, Aburto MR, Cop F, Llaó-Cid C, Härtl R, Damm M, Bethani I, Parrilla M, Husainie D, Schänzer A, Schlierbach H, Acker T, Mohr L, Torres-Masjoan L, Ritter M, Acker-Palmer A. | 10/27/2018 |
| In intestine a truncated Dab1 variant transmits the reelin signal and may play a role in clathrin-mediated apical endocytosis and in the control of cell-to-cell junction assembly. Dab1 variant may be a nucleocytoplasmic shuttling protein, inferred from its sequence and nuclear location. | Small and large intestine express a truncated Dab1 isoform that assembles in cell-cell junctions and co-localizes with proteins involved in endocytosis.
Vázquez-Carretero MD, García-Miranda P, Balda MS, Matter K, Peral MJ, Ilundain AA. | 09/8/2018 |
| These observations suggest that the morphogenesis in these hippocampal formation subdivisions employs different developmental mechanisms involving Dab1 function. | Dab1 contributes differently to the morphogenesis of the hippocampal subdivisions.
Blume M, Inoguchi F, Sugiyama T, Owada Y, Osumi N, Aimi Y, Taki K, Katsuyama Y. | 06/2/2018 |
| These results suggest that deficiency of Reelin-Dab1 signal in the dorsal forebrain is involved in the pathogenesis of some symptoms of human psychiatric disorders. | Dorsal Forebrain-Specific Deficiency of Reelin-Dab1 Signal Causes Behavioral Abnormalities Related to Psychiatric Disorders.
Imai H, Shoji H, Ogata M, Kagawa Y, Owada Y, Miyakawa T, Sakimura K, Terashima T, Katsuyama Y. | 05/26/2018 |
| RBX2, a core component of the E3 ubiquitin ligase CRL5, is essential for retinal layering and function. RBX2 regulates the final cell position of rod bipolar cells, cone photoreceptors and Muller glia. Our data indicate that sustained RELN/DAB1 signaling, triggered by depletion of RBX2 or SOCS7 - a CRL5 substrate adaptor known to recruit DAB1 - causes rod bipolar cell misposition. | RBX2 maintains final retinal cell position in a DAB1-dependent and -independent fashion.
Fairchild CL, Hino K, Han JS, Miltner AM, Peinado Allina G, Brown CE, Burns ME, La Torre A, Simó S., Free PMC Article | 04/14/2018 |
| Mice with low or no Dab1 expression exhibited reduced calling rates, altered call-type usage, and differential vocal development trajectories. | Mice with Dab1 or Vldlr insufficiency exhibit abnormal neonatal vocalization patterns.
Fraley ER, Burkett ZD, Day NF, Schwartz BA, Phelps PE, White SA., Free PMC Article | 03/31/2018 |
| Results showed that the Dab1 nuclear localization signal mutant can translocate into the nucleus via an unconventional temperature-dependent/ATP-dependent and cytoplasmic soluble factor-independent/RanGTP gradient-independent manner, suggesting that Dab1 has 2 different nuclear translocation pathways; and that the regulation of subcellular localization of Dab1 is important for the proper migration of excitatory neurons. | Proper Level of Cytosolic Disabled-1, Which Is Regulated by Dual Nuclear Translocation Pathways, Is Important for Cortical Neuronal Migration.
Honda T, Nakajima K. | 01/20/2018 |
| This study showed that spontaneous Dab1 mutations causing cerebellar pathology are impaired in motor functions during the neonatal period. | Behavioral effects of neonatal lesions on the cerebellar system.
Lalonde R, Strazielle C. | 02/20/2016 |
| an aberrant fragment of Dab1 protein (p64/60) is present in the brain of yotari mouse | Aberrant fragment of Dab1 protein is present in yotari mouse.
Onoue A, Takeuchi M, Kohno T, Hattori M. | 09/26/2015 |
| When pregnant mice are exposed to EMF, Dab1 expression increases in the EMF-treated fetal cerebral cortex extracts as compared to controls and SHAM group. | Effects of electromagnetic fields on reelin and Dab1 expression in the developing cerebral cortex.
Hemmati M, Mashayekhi F, Firouzi F, Ashori M, Mashayekhi H. | 04/4/2015 |
| It findings link reelin with Dab1 and suggest that Dab1 functions downstream of reelin action on the homeostasis of the crypt-villus unit. | Dab1 and reelin participate in a common signal pathway that controls intestinal crypt/villus unit dynamics.
Vázquez-Carretero MD, García-Miranda P, Calonge ML, Peral MJ, Ilundain AA. | 10/18/2014 |
| The results of this study indicate a causal relation between the downregulation of Dab1 protein levels during development and the structural and behavioral deficits associated with psychiatric diseases in the adult. | Transient downregulation of Dab1 protein levels during development leads to behavioral and structural deficits: relevance for psychiatric disorders.
Teixeira CM, Masachs N, Muhaisen A, Bosch C, Pérez-Martínez J, Howell B, Soriano E., Free PMC Article | 09/13/2014 |