| Revealing the potential of solute carrier family 31 (copper transporters), member 1: Insights into its role in bladder cancer progression and therapeutic implications. | Revealing the potential of solute carrier family 31 (copper transporters), member 1: Insights into its role in bladder cancer progression and therapeutic implications.
Lin YZ, Liu WH, Wu YP, Cai H, Zheng QS, Wei Y, Xu N, Xue XY., Free PMC Article | 05/30/2024 |
| Identification of cuproptosis-related gene SLC31A1 and upstream LncRNA-miRNA regulatory axis in breast cancer. | Identification of cuproptosis-related gene SLC31A1 and upstream LncRNA-miRNA regulatory axis in breast cancer.
Wu JH, Cheng TC, Zhu B, Gao HY, Zheng L, Chen WX., Free PMC Article | 11/15/2023 |
| Cuproptosis-related gene SLC31A1: prognosis values and potential biological functions in cancer. | Cuproptosis-related gene SLC31A1: prognosis values and potential biological functions in cancer.
Qi Y, Yao Q, Li X, Li X, Zhang W, Qu P., Free PMC Article | 10/30/2023 |
| Cuproptosis-related gene SLC31A1 expression correlates with the prognosis and tumor immune microenvironment in glioma. | Cuproptosis-related gene SLC31A1 expression correlates with the prognosis and tumor immune microenvironment in glioma.
Wang J, Li S, Guo Y, Zhao C, Chen Y, Ning W, Yang J, Zhang H., Free PMC Article | 08/30/2023 |
| High expression of cuproptosis-related SLC31A1 gene in relation to unfavorable outcome and deregulated immune cell infiltration in breast cancer: an analysis based on public databases. | High expression of cuproptosis-related SLC31A1 gene in relation to unfavorable outcome and deregulated immune cell infiltration in breast cancer: an analysis based on public databases.
Li L, Li L, Sun Q., Free PMC Article | 08/27/2022 |
| Effects of SLC31A1 and ATP7B polymorphisms on platinum resistance in patients with esophageal squamous cell carcinoma receiving neoadjuvant chemoradiotherapy. | Effects of SLC31A1 and ATP7B polymorphisms on platinum resistance in patients with esophageal squamous cell carcinoma receiving neoadjuvant chemoradiotherapy.
Fujita K, Motoyama S, Sato Y, Wakita A, Nagaki Y, Minamiya Y, Miura M. | 09/18/2021 |
| Dual-mode imaging of copper transporter 1 in HepG2 cells by hyphenating confocal laser scanning microscopy with laser ablation ICPMS. | Dual-mode imaging of copper transporter 1 in HepG2 cells by hyphenating confocal laser scanning microscopy with laser ablation ICPMS.
Sun QX, Wei X, Zhang SQ, Chen ML, Yang T, Yu YL, Wang JH. | 07/3/2021 |
| Abnormalities in the copper transporter CTR1 in postmortem hippocampus in schizophrenia: A subregion and laminar analysis. | Abnormalities in the copper transporter CTR1 in postmortem hippocampus in schizophrenia: A subregion and laminar analysis.
Schoonover KE, Farmer CB, Morgan CJ, Sinha V, Odom L, Roberts RC., Free PMC Article | 06/19/2021 |
| Human marrow stromal cells secrete microRNA-375-containing exosomes to regulate glioma progression. | Human marrow stromal cells secrete microRNA-375-containing exosomes to regulate glioma progression.
Deng SZ, Lai MF, Li YP, Xu CH, Zhang HR, Kuang JG. | 05/15/2021 |
| PTBP1 modulates osteosarcoma chemoresistance to cisplatin by regulating the expression of the copper transporter SLC31A1. | PTBP1 modulates osteosarcoma chemoresistance to cisplatin by regulating the expression of the copper transporter SLC31A1.
Cheng C, Ding Q, Zhang Z, Wang S, Zhong B, Huang X, Shao Z., Free PMC Article | 05/1/2021 |
| Impaired copper transport in schizophrenia results in a copper-deficient brain state: A new side to the dysbindin story. | Impaired copper transport in schizophrenia results in a copper-deficient brain state: A new side to the dysbindin story.
Schoonover KE, Queern SL, Lapi SE, Roberts RC., Free PMC Article | 11/21/2020 |
| The loss of CTR1 resulted in a decrease in the level of COMMD1, XIAP, and NF-kappaB. Differently, the DMT1 deficiency induced increase of the COMMD1, HIF1alpha, and XIAP levels. | CRISP-R/Cas9 Mediated Deletion of Copper Transport Genes CTR1 and DMT1 in NSCLC Cell Line H1299. Biological and Pharmacological Consequences.
Ilyechova EY, Bonaldi E, Orlov IA, Skomorokhova EA, Puchkova LV, Broggini M., Free PMC Article | 11/30/2019 |
| SLC31A1-dependent copper levels are correlated with the malignant degree of pancreatic cancer. Copper deprivation increased mitochondrial Reactive Oxygen Species level and decreased ATP level, which rendered cancer cells in a dormant state. | Blockage of SLC31A1-dependent copper absorption increases pancreatic cancer cell autophagy to resist cell death.
Yu Z, Zhou R, Zhao Y, Pan Y, Liang H, Zhang JS, Tai S, Jin L, Teng CB., Free PMC Article | 04/20/2019 |
| combination of desferal with oxaliplatin can overcome cervical cancer oxaliplatin resistance through the regulation of hCtr1 and TfR1 | Desferal regulates hCtr1 and transferrin receptor expression through Sp1 and exhibits synergistic cytotoxicity with platinum drugs in oxaliplatin-resistant human cervical cancer cells in vitro and in vivo.
Chen SJ, Kuo CC, Pan HY, Tsou TC, Yeh SC, Chang JY., Free PMC Article | 02/24/2018 |
| Study showed that NEAT1 could function as a competing endogenous lncRNA in lung cancer, mediating CTR1 by sponging hsa-mir-98-5p. | NEAT1 upregulates EGCG-induced CTR1 to enhance cisplatin sensitivity in lung cancer cells.
Jiang P, Wu X, Wang X, Huang W, Feng Q., Free PMC Article | 12/30/2017 |
| This result indicates that the formation of copper-finger protein of Sp1 is the molecular basis of copper sensing for the transcriptional regulation of hCtr1 in mammalian cells. | Copper-finger protein of Sp1: the molecular basis of copper sensing.
Yuan S, Chen S, Xi Z, Liu Y. | 12/30/2017 |
| we assessed the role of miR-21 in mediating renal cell carcinoma chemoresistance and further showed that miR-21 silencing significantly (1) increased chemosensitivity of paclitaxel, 5-fluorouracil, oxaliplatin, and dovitinib; (2) decreased expression of multi-drug resistance genes; and (4) increased SLC22A1/OCT1, SLC22A2/OCT2, and SLC31A1/CTR1 platinum influx transporter expression | Targeting miR-21 decreases expression of multi-drug resistant genes and promotes chemosensitivity of renal carcinoma.
Gaudelot K, Gibier JB, Pottier N, Hémon B, Van Seuningen I, Glowacki F, Leroy X, Cauffiez C, Gnemmi V, Aubert S, Perrais M. | 07/29/2017 |
| Gene duplication and neo-functionalization in the evolutionary and functional divergence of the metazoan copper transporters Ctr1 and Ctr2 | Gene duplication and neo-functionalization in the evolutionary and functional divergence of the metazoan copper transporters Ctr1 and Ctr2.
Logeman BL, Wood LK, Lee J, Thiele DJ., Free PMC Article | 07/15/2017 |
| It has been demonstrated in ovarian cancer cells that cisplatin resistance and uptake correlates with reduced CTR1 and LRRC8A protein expression/activity and a concomitant upregulation in cisplatin exporting transporters (ATP7A, ATP7B), which implies that the resistant cells have a reduced ability to accumulate cisplatin and activate proapoptotic transporters for osmolytes. | Dual role of LRRC8A-containing transporters on cisplatin resistance in human ovarian cancer cells.
Sørensen BH, Dam CS, Stürup S, Lambert IH. | 07/1/2017 |
| CTR1 recycling via clathrin-mediated and Rab11 pathways enable cells to dynamically modulate copper entry | Dynamic internalization and recycling of a metal ion transporter: Cu homeostasis and CTR1, the human Cu⁺ uptake system.
Clifford RJ, Maryon EB, Kaplan JH., Free PMC Article | 01/14/2017 |
| C-Terminus of Human Copper Importer Ctr1 Acts as a Binding Site and Transfers Copper to Atox1 | The C-Terminus of Human Copper Importer Ctr1 Acts as a Binding Site and Transfers Copper to Atox1.
Kahra D, Kovermann M, Wittung-Stafshede P., Free PMC Article | 10/8/2016 |
| Studied the interaction of CTR1 and CTR2 in fully malignant HEK293T and OVCAR8 human ovarian cancer cells using a CRISPR-Cas9 knock out system. | The copper transporter 1 (CTR1) is required to maintain the stability of copper transporter 2 (CTR2).
Tsai CY, Liebig JK, Tsigelny IF, Howell SB., Free PMC Article | 08/27/2016 |
| High CTR1 Expression is associated with poor response to chemotherapy in Muscle-invasive Bladder Cancer. | Copper Transporter-CTR1 Expression and Pathological Outcomes in Platinum-treated Muscle-invasive Bladder Cancer Patients.
Kilari D, Iczkowski KA, Pandya C, Robin AJ, Messing EM, Guancial E, Kim ES. | 06/28/2016 |
| Gene silencing of either CTR1 or DMT1 did not affect copper accumulation in cells, but deficiency in both CTR1 and DMT1 resulted in a complete inhibition of copper uptake. | Copper uptake by DMT1: a compensatory mechanism for CTR1 deficiency in human umbilical vein endothelial cells.
Lin C, Zhang Z, Wang T, Chen C, James Kang Y. | 05/7/2016 |
| Two methionine residues in the MXXXM motif of of the CTR1 second transmembrane domain are important for binding to silver. | Self-Assembly of the Second Transmembrane Domain of hCtr1 in Micelles and Interaction with Silver Ion.
Dong Z, Wang Y, Wang C, Xu H, Guan L, Li Z, Li F. | 04/30/2016 |