| Cortistatin deficiency reveals a dysfunctional brain endothelium with impaired gene pathways, exacerbated immune activation, and disrupted barrier integrity. | Cortistatin deficiency reveals a dysfunctional brain endothelium with impaired gene pathways, exacerbated immune activation, and disrupted barrier integrity.
Castillo-González J, Ruiz JL, Serrano-Martínez I, Forte-Lago I, Ubago-Rodriguez A, Caro M, Pérez-Gómez JM, Benítez-Troncoso A, Andrés-León E, Sánchez-Navarro M, Luque RM, González-Rey E., Free PMC Article | 11/1/2023 |
| Somatostatin, Cortistatin and Their Receptors Exert Antitumor Actions in Androgen-Independent Prostate Cancer Cells: Critical Role of Endogenous Cortistatin. | Somatostatin, Cortistatin and Their Receptors Exert Antitumor Actions in Androgen-Independent Prostate Cancer Cells: Critical Role of Endogenous Cortistatin.
Sáez-Martínez P, Porcel-Pastrana F, Pérez-Gómez JM, Pedraza-Arévalo S, Gómez-Gómez E, Jiménez-Vacas JM, Gahete MD, Luque RM., Free PMC Article | 11/19/2022 |
| Cytoskeleton Protein Filamin A Is Required for Efficient Somatostatin Receptor Type 2 Internalization and Recycling through Rab5 and Rab4 Sorting Endosomes in Tumor Somatotroph Cells. | Cytoskeleton Protein Filamin A Is Required for Efficient Somatostatin Receptor Type 2 Internalization and Recycling through Rab5 and Rab4 Sorting Endosomes in Tumor Somatotroph Cells.
Treppiedi D, Mangili F, Giardino E, Catalano R, Locatelli M, Lania AG, Spada A, Arosio M, Calebiro D, Mantovani G, Peverelli E. | 07/17/2021 |
| Cortistatin protects against intervertebral disc degeneration through targeting mitochondrial ROS-dependent NLRP3 inflammasome activation. | Cortistatin protects against intervertebral disc degeneration through targeting mitochondrial ROS-dependent NLRP3 inflammasome activation.
Zhao Y, Qiu C, Wang W, Peng J, Cheng X, Shangguan Y, Xu M, Li J, Qu R, Chen X, Jia S, Luo D, Liu L, Li P, Guo F, Vasilev K, Liu L, Hayball J, Dong S, Pan X, Li Y, Guo L, Cheng L, Li W., Free PMC Article | 05/22/2021 |
| Decreased maternal serum cortistatin levels in pregnancies with gestational diabetes mellitus. | Decreased maternal serum cortistatin levels in pregnancies with gestational diabetes mellitus.
Akbas M, Koltan SO, Koyuncu FM, Artunc Ulkumen B, Taneli F, Ozdemir H. | 01/2/2021 |
| Comparison of predictive value of NT-proBNP, sST2 and MMPs in heart failure patients with different ejection fractions. | Comparison of predictive value of NT-proBNP, sST2 and MMPs in heart failure patients with different ejection fractions.
Pan W, Yang D, Yu P, Yu H., Free PMC Article | 12/5/2020 |
| CST suppresses TNF-alphain-duction of cartilage degeneration through binding to TNFRs and main-tains homeostasis of chondrocytes in Osteoarthritis. | Cortistatin binds to TNF-α receptors and protects against osteoarthritis.
Zhao Y, Li Y, Qu R, Chen X, Wang W, Qiu C, Liu B, Pan X, Liu L, Vasilev K, Hayball J, Dong S, Li W., Free PMC Article | 07/13/2019 |
| Patients with newly diagnosed type 2 diabetes mellitus had lower plasma levels of vortistatin (CST) than healthy controls, and plasma CST was associated with glucose metabolism and insulin resistance. | Circulating levels of cortistatin are correlated with metabolic parameters in patients with newly diagnosed type 2 diabetes mellitus.
Chen W, Fu Y, Yin X, Liu Y. | 04/21/2018 |
| There is a relationship between plamsa CST and BCKDK in sepsis patients. | The plasma levels of CST and BCKDK in patients with sepsis.
Zhang B, Sun GZ, Zhu ML, Li Y, Sun DJ, Zhang B, Bai XP. | 12/23/2017 |
| Cortistatin emerges as a natural endogenous regulator of smooth muscle cells under pathological conditions and an attractive candidate for the pharmacological management of vascular diseases that course with neointimal lesion formation. | Cortistatin inhibits migration and proliferation of human vascular smooth muscle cells and decreases neointimal formation on carotid artery ligation.
Duran-Prado M, Morell M, Delgado-Maroto V, Castaño JP, Aneiros-Fernandez J, de Lecea L, Culler MD, Hernandez-Cortes P, O'Valle F, Delgado M. | 07/27/2013 |
| Identifies post-translational cleavage products of the homologous rat protein. | Processing of rat preprocortistatin in mouse AtT-20 cells.
Puebla L, Mouchantaf R, Sasi R, Khare S, Bennett HP, James S, Patel YC. | 11/10/2010 |
| The cortistatin expression in the temporal lobe of Alzheimer's disease patients is decressed. | Expression of Somatostatin, cortistatin, and their receptors, as well as dopamine receptors, but not of neprilysin, are reduced in the temporal lobe of Alzheimer's disease patients.
Gahete MD, Rubio A, Durán-Prado M, Avila J, Luque RM, Castaño JP. | 09/13/2010 |
| Human immune cells produce CST, whereas macrophage lineage and activated endothelium express sst2, and human lymphocytes express sst3. The human thymus expresses sst1, 2, 3, MrgX2 and almost all immune cells express GHS-R. [review] | The role of cortistatin in the human immune system.
van Hagen PM, Dalm VA, Staal F, Hofland LJ. | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesComprehensive copy number variant (CNV) analysis of neuronal pathways genes in psychiatric disorders identifies rare variants within patients.
Saus E, Brunet A, Armengol L, Alonso P, Crespo JM, Fernández-Aranda F, Guitart M, Martín-Santos R, Menchón JM, Navinés R, Soria V, Torrens M, Urretavizcaya M, Vallès V, Gratacòs M, Estivill X. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.
Gratacòs M, Costas J, de Cid R, Bayés M, González JR, Baca-García E, de Diego Y, Fernández-Aranda F, Fernández-Piqueras J, Guitart M, Martín-Santos R, Martorell L, Menchón JM, Roca M, Sáiz-Ruiz J, Sanjuán J, Torrens M, Urretavizcaya M, Valero J, Vilella E, Estivill X, Carracedo A, Psychiatric Genetics Network Group. | 01/11/2009 |
| A lower expression of CST exists in diabetic retinas and it is associated with retinal neurodegeneration. | Lowered cortistatin expression is an early event in the human diabetic retina and is associated with apoptosis and glial activation.
Carrasco E, Hernández C, de Torres I, Farrés J, Simó R., Free PMC Article | 01/21/2010 |
| first extensive study demonstrating that lymphoid tissues and immune cells express different levels of CST mRNA and that its expression can be regulated; hypothesize a role as an endogenous ligand of at least the sst2 receptor in the immune system | Cortistatin rather than somatostatin as a potential endogenous ligand for somatostatin receptors in the human immune system.
Dalm VA, van Hagen PM, van Koetsveld PM, Langerak AW, van der Lely AJ, Lamberts SW, Hofland LJ. | 01/21/2010 |
| Cortistatin plays a role in the auto/paracrine regulation of the endocrine pancreas | Presence of cortistatin in the human pancreas.
Papotti M, Tarabra E, Allia E, Bozzalla-Cassione F, Broglio F, Deghenghi R, Ghigo E, Muccioli G. | 01/21/2010 |
| Endocrine activities of cortistatin-14 and its interaction with GHRH and ghrelin in humans. | Endocrine activities of cortistatin-14 and its interaction with GHRH and ghrelin in humans.
Broglio F, Arvat E, Benso A, Gottero C, Prodam F, Grottoli S, Papotti M, Muccioli G, van der Lely AJ, Deghenghi R, Ghigo E. | 01/21/2010 |
| study demonstrates for the first time a selective and inducible expression of the recently discovered cortistatin, as well as somatostatin receptor 2, in human monocyte-derived cells | Expression of somatostatin, cortistatin, and somatostatin receptors in human monocytes, macrophages, and dendritic cells.
Dalm VA, van Hagen PM, van Koetsveld PM, Achilefu S, Houtsmuller AB, Pols DH, van der Lely AJ, Lamberts SW, Hofland LJ. | 01/21/2010 |
| Intravitreous somatostatin-like immunoreactivity deficit occurs in ptients with proliferative diabetic retinopathy. | Somatostatin molecular variants in the vitreous fluid: a comparative study between diabetic patients with proliferative diabetic retinopathy and nondiabetic control subjects.
Hernández C, Carrasco E, Casamitjana R, Deulofeu R, García-Arumí J, Simó R. | 01/21/2010 |
| cortistatin-14 shown to be a high affinity ligand for G protein coupled receptor MrgX2 which is expressed in dorsal root ganglion | MrgX2 is a high potency cortistatin receptor expressed in dorsal root ganglion.
Robas N, Mead E, Fidock M. | 01/21/2010 |