| Spitz melanoma with MAP3K8::ABLIM1 rearrangement: a case report with review of the literature. | Spitz melanoma with MAP3K8::ABLIM1 rearrangement: a case report with review of the literature.
Sibira R, Vu A, Giubellino A, Murugan P., Free PMC Article | 10/10/2024 |
| The TRIM4 E3 ubiquitin ligase degrades TPL2 and is modulated by oncogenic KRAS. | The TRIM4 E3 ubiquitin ligase degrades TPL2 and is modulated by oncogenic KRAS.
Bansod S, Dodhiawala PB, Geng Y, Bulle A, Liu P, Li L, Townsend R, Grierson PM, Held JM, Adhikari H, Lim KH., Free PMC Article | 10/2/2024 |
| Clinical, Morphologic, and Molecular Features of MAP3K8 Rearranged Spitz Neoplasms: A Retrospective Study Documenting That Bonafide Spitz Melanomas Are Rare. | Clinical, Morphologic, and Molecular Features of MAP3K8 Rearranged Spitz Neoplasms: A Retrospective Study Documenting That Bonafide Spitz Melanomas Are Rare.
Patel P, Hagstrom M, Sharma N, Chen A, Dhillon S, Fumero-Velázquez M, Olivares S, Gerami P. | 03/15/2024 |
| Overexpression of TPL2 may be a predictor of good prognosis in patients with breast invasive ductal carcinoma. | Overexpression of TPL2 may be a predictor of good prognosis in patients with breast invasive ductal carcinoma.
Yu Q, Wan D, Fu R, Li F, Zhang Y., Free PMC Article | 10/24/2023 |
| Tumor progression locus 2 (TPL2): A Cot-plicated progression from inflammation to chronic liver disease. | Tumor progression locus 2 (TPL2): A Cot-plicated progression from inflammation to chronic liver disease.
Gutierrez AH, Mazariegos MS, Alemany S, Nevzorova YA, Cubero FJ, Sanz-García C. | 03/7/2023 |
| Epigenetic Regulation of MAP3K8 in EBV-Associated Gastric Carcinoma. | Epigenetic Regulation of MAP3K8 in EBV-Associated Gastric Carcinoma.
Roy G, Yang T, Liu S, Luo YL, Liu Y, Zhong Q., Free PMC Article | 03/1/2023 |
| ALKBH5/MAP3K8 axis regulates PD-L1+ macrophage infiltration and promotes hepatocellular carcinoma progression. | ALKBH5/MAP3K8 axis regulates PD-L1+ macrophage infiltration and promotes hepatocellular carcinoma progression.
You Y, Wen D, Zeng L, Lu J, Xiao X, Chen Y, Song H, Liu Z., Free PMC Article | 08/27/2022 |
| Loss of Tpl2 activates compensatory signaling and resistance to EGFR/MET dual inhibition in v-RAS transduced keratinocytes. | Loss of Tpl2 activates compensatory signaling and resistance to EGFR/MET dual inhibition in v-RAS transduced keratinocytes.
Kelley MB, Geddes TJ, Ochiai M, Lampl NM, Kothmann WW, Fierstein SR, Kent V, DeCicco-Skinner K., Free PMC Article | 05/7/2022 |
| Cell adhesion tunes inflammatory TPL2 kinase signal transduction. | Cell adhesion tunes inflammatory TPL2 kinase signal transduction.
Vougioukalaki M, Georgila K, Athanasiadis EI, Eliopoulos AG., Free PMC Article | 03/12/2022 |
| Unravelling the Impact of the Genetic Variant rs1042058 within the TPL2 Risk Gene Locus on Molecular and Clinical Disease Course Patients with Inflammatory Bowel Disease. | Unravelling the Impact of the Genetic Variant rs1042058 within the TPL2 Risk Gene Locus on Molecular and Clinical Disease Course Patients with Inflammatory Bowel Disease.
Morsy Y, Brillant N, Franc Y, Scharl M, Wawrzyniak M, On Behalf Of The Swiss Ibd Cohort Study Group., Free PMC Article | 01/8/2022 |
| MAP3K8 Regulates Cox-2-Mediated Prostaglandin E2 Production in the Lung and Suppresses Pulmonary Inflammation and Fibrosis. | MAP3K8 Regulates Cox-2-Mediated Prostaglandin E(2) Production in the Lung and Suppresses Pulmonary Inflammation and Fibrosis.
Zannikou M, Barbayianni I, Fanidis D, Grigorakaki T, Vlachopoulou E, Konstantopoulos D, Fousteri M, Nikitopoulou I, Kotanidou A, Kaffe E, Aidinis V. | 08/7/2021 |
| Melanocytic tumors with MAP3K8 fusions: report of 33 cases with morphological-genetic correlations. | Melanocytic tumors with MAP3K8 fusions: report of 33 cases with morphological-genetic correlations.
Houlier A, Pissaloux D, Masse I, Tirode F, Karanian M, Pincus LB, McCalmont TH, LeBoit PE, Bastian BC, Yeh I, de la Fouchardière A. | 04/13/2021 |
| TPL2 enforces RAS-induced inflammatory signaling and is activated by point mutations. | TPL2 enforces RAS-induced inflammatory signaling and is activated by point mutations.
Dodhiawala PB, Khurana N, Zhang D, Cheng Y, Li L, Wei Q, Seehra K, Jiang H, Grierson PM, Wang-Gillam A, Lim KH., Free PMC Article | 02/13/2021 |
| ATF-2 and Tpl2 regulation of endothelial cell cycle progression and apoptosis. | ATF-2 and Tpl2 regulation of endothelial cell cycle progression and apoptosis.
Fearnley GW, Latham AM, Hollstein M, Odell AF, Ponnambalam S. | 02/6/2021 |
| Her2 promotes early dissemination of breast cancer by suppressing the p38 pathway through Skp2-mediated proteasomal degradation of Tpl2. | Her2 promotes early dissemination of breast cancer by suppressing the p38 pathway through Skp2-mediated proteasomal degradation of Tpl2.
Wang G, Wang J, Chang A, Cheng D, Huang S, Wu D, Sirkisoon S, Yang S, Lin HK, Lo HW, Xiang R, Sun P., Free PMC Article | 12/12/2020 |
| The increased inflammation of Map3k8(-/-) mice in allergic airway inflammation and colitis results from reduced ABIN-2 signaling, rather than blocked TPL-2 signaling. | ABIN-2, of the TPL-2 Signaling Complex, Modulates Mammalian Inflammation.
Webb LV, Ventura S, Ley SC. | 09/19/2020 |
| Study offers the characterization of oncogenic MAP3K8 alterations occurring exclusively in driver mutation-negative melanoma. It identifies six carboxy-terminal truncating MAP3K8 rearrangements in both primary and metastatic melanomas that were associated with decreased overall survival. Rearrangement and amplification of the MAP3K8 locus result in increased levels of a truncated but active MAP3K8 protein. | Identification of Targetable Recurrent MAP3K8 Rearrangements in Melanomas Lacking Known Driver Mutations.
Lehmann BD, Shaver TM, Johnson DB, Li Z, Gonzalez-Ericsson PI, Sánchez V, Shyr Y, Sanders ME, Pietenpol JA., Free PMC Article | 06/20/2020 |
| protein expression significantly increased in fatty liver | Tumor Progression Locus 2 in Hepatocytes Potentiates Both Liver and Systemic Metabolic Disorders in Mice.
Gong J, Fang C, Zhang P, Wang PX, Qiu Y, Shen LJ, Zhang L, Zhu XY, Tian S, Li F, Wang Z, Huang Z, Wang A, Zhang XD, She ZG. | 05/23/2020 |
| The IKK2-TPL2-JNK axis mediates essential LMP1 survival signals in Epstein-Barr virus-transformed human B cells and post-transplant lymphoma. | A central role of IKK2 and TPL2 in JNK activation and viral B-cell transformation.
Voigt S, Sterz KR, Giehler F, Mohr AW, Wilson JB, Moosmann A, Kieser A., Free PMC Article | 05/23/2020 |
| MAP3K8-altered Spitz melanoma show the presence of cohesive cellular nodules in the dermis and an epithelioid-cell phenotype. | Pathologic Characteristics of Spitz Melanoma With MAP3K8 Fusion or Truncation in a Pediatric Cohort.
Newman S, Pappo A, Raimondi S, Zhang J, Barnhill R, Bahrami A. | 04/18/2020 |
| The combination of TPL2 knockdown and TNFalpha gives rise to a synthetic lethality phenotype via receptor-interacting serine/threonine-protein kinase 1 (RIPK1)-dependent and -independent mechanisms. Whereas wild-type TPL2 rescues the phenotype, its kinase-dead mutant does not. | The combination of TPL2 knockdown and TNFα causes synthetic lethality via caspase-8 activation in human carcinoma cell lines.
Serebrennikova OB, Paraskevopoulou MD, Aguado-Fraile E, Taraslia V, Ren W, Thapa G, Roper J, Du K, Croce CM, Tsichlis PN., Free PMC Article | 04/4/2020 |
| our data reveal a novel role of the secretory S100A11 in PDAC disseminative progression through activation of surrounding fibroblasts triggered by the S100A11-RAGE-TPL2-COX2 pathway. The findings of this study will contribute to the establishment of a novel therapeutic antidote to PDACs that are difficult to treat by regulating cancer-associated fibroblasts (CAFs) through targeting the identified pathway | Upregulation of Mobility in Pancreatic Cancer Cells by Secreted S100A11 Through Activation of Surrounding Fibroblasts.
Mitsui Y, Tomonobu N, Watanabe M, Kinoshita R, Sumardika IW, Youyi C, Murata H, Yamamoto KI, Sadahira T, Rodrigo AGH, Takamatsu H, Araki K, Yamauchi A, Yamamura M, Fujiwara H, Inoue Y, Futami J, Saito K, Iioka H, Kondo E, Nishibori M, Toyooka S, Yamamoto Y, Nasu Y, Sakaguchi M., Free PMC Article | 01/11/2020 |
| Hypoxia increased expression of MAP3K8 concomitant with the potentiation of TNF-alpha secretion. | Hypoxia potentiates monocyte-derived dendritic cells for release of tumor necrosis factor α via MAP3K8.
Paardekooper LM, Bendix MB, Ottria A, de Haer LW, Ter Beest M, Radstake TRDJ, Marut W, van den Bogaart G., Free PMC Article | 08/3/2019 |
| High TPL2 expression was significantly correlated with distant metastasis and low immunoscore in colorectal cancer. | TPL2 expression is correlated with distant metastasis and poor prognosis in colorectal cancer.
Pyo JS, Park MJ, Kim CN. | 05/11/2019 |
| elevated Tpl2 protein and transcript levels are associated with resistance to imatinib mesylate. | Overexpression of Tpl2 is linked to imatinib resistance and activation of MEK-ERK and NF-κB pathways in a model of chronic myeloid leukemia.
Chorzalska A, Ahsan N, Rao RSP, Roder K, Yu X, Morgan J, Tepper A, Hines S, Zhang P, Treaba DO, Zhao TC, Olszewski AJ, Reagan JL, Liang O, Gruppuso PA, Dubielecka PM., Free PMC Article | 03/30/2019 |