| High SPATA18 Expression and its Diagnostic and Prognostic Value in Clear Cell Renal Cell Carcinoma. | High SPATA18 Expression and its Diagnostic and Prognostic Value in Clear Cell Renal Cell Carcinoma.
Lingui X, Weifeng L, Yufei W, Yibin Z., Free PMC Article | 02/10/2023 |
| SPATA18 Expression Predicts Favorable Clinical Outcome in Colorectal Cancer. | SPATA18 Expression Predicts Favorable Clinical Outcome in Colorectal Cancer.
Sugimura-Nagata A, Koshino A, Nagao K, Nagano A, Komura M, Ueki A, Ebi M, Ogasawara N, Tsuzuki T, Kasai K, Takahashi S, Kasugai K, Inaguma S., Free PMC Article | 04/16/2022 |
| p53/Mieap-regulated mitochondrial quality control plays an important role as a tumor suppressor in gastric and esophageal cancers. | p53/Mieap-regulated mitochondrial quality control plays an important role as a tumor suppressor in gastric and esophageal cancers.
Sano H, Futamura M, Gaowa S, Kamino H, Nakamura Y, Yamaguchi K, Tanaka Y, Yasufuku I, Nakakami A, Arakawa H, Yoshida K. | 02/27/2021 |
| Causative role for defective expression of mitochondria-eating protein in accumulation of mitochondria in thyroid oncocytic cell tumors. | Causative role for defective expression of mitochondria-eating protein in accumulation of mitochondria in thyroid oncocytic cell tumors.
Mussazhanova Z, Shimamura M, Kurashige T, Ito M, Nakashima M, Nagayama Y., Free PMC Article | 12/12/2020 |
| Mieap-induced accumulation of lysosomes within mitochondria (MALM) regulates gastric cancer cell invasion under hypoxia by suppressing reactive oxygen species accumulation. | Mieap-induced accumulation of lysosomes within mitochondria (MALM) regulates gastric cancer cell invasion under hypoxia by suppressing reactive oxygen species accumulation.
Okuyama K, Kitajima Y, Egawa N, Kitagawa H, Ito K, Aishima S, Yanagihara K, Tanaka T, Noshiro H., Free PMC Article | 10/3/2020 |
| DNA damage invokes mitophagy through a pathway involving Spata18. | DNA damage invokes mitophagy through a pathway involving Spata18.
Dan X, Babbar M, Moore A, Wechter N, Tian J, Mohanty JG, Croteau DL, Bohr VA., Free PMC Article | 09/12/2020 |
| Results show that Mieap induced caspase-dependent mitochondrial apoptosis in breast cancer (BC) cells. Mieap protein was downregulated and its promoter methylated in BC with more aggressive and malignant phenotypes. | Possible role of p53/Mieap-regulated mitochondrial quality control as a tumor suppressor in human breast cancer.
Gaowa S, Futamura M, Tsuneki M, Kamino H, Tajima JY, Mori R, Arakawa H, Yoshida K., Free PMC Article | 01/5/2019 |
| The physical interaction of Mieap, BNIP3 and NIX at the mitochondrial outer membrane may play a critical role in the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. | BNIP3 and NIX mediate Mieap-induced accumulation of lysosomal proteins within mitochondria.
Nakamura Y, Kitamura N, Shinogi D, Yoshida M, Goda O, Murai R, Kamino H, Arakawa H., Free PMC Article | 06/9/2012 |
| Mieap induced vacuole-like structures (designated as MIV for Mieap-induced vacuole), which engulfed and degraded the unhealthy mitochondria by accumulating lysosomes | Mieap, a p53-inducible protein, controls mitochondrial quality by repairing or eliminating unhealthy mitochondria.
Kitamura N, Nakamura Y, Miyamoto Y, Miyamoto T, Kabu K, Yoshida M, Futamura M, Ichinose S, Arakawa H., Free PMC Article | 08/6/2011 |
| Mieap induces intramitochondrial lysosome-like organella that plays a critical role in mitochondrial quality control by eliminating oxidized mitochondrial proteins | Possible existence of lysosome-like organella within mitochondria and its role in mitochondrial quality control.
Miyamoto Y, Kitamura N, Nakamura Y, Futamura M, Miyamoto T, Yoshida M, Ono M, Ichinose S, Arakawa H., Free PMC Article | 08/6/2011 |
| show that SPATA18 transcription is induced by p53 in a variety of cell types of both human and mouse origin | SPATA18, a spermatogenesis-associated gene, is a novel transcriptional target of p53 and p63.
Bornstein C, Brosh R, Molchadsky A, Madar S, Kogan-Sakin I, Goldstein I, Chakravarti D, Flores ER, Goldfinger N, Sarig R, Rotter V., Free PMC Article | 06/4/2011 |
| beta-sarcoglycan and SPATA18 may have a role in limb-girdle muscular dystrophy type 2E | Homozygous microdeletion of chromosome 4q11-q12 causes severe limb-girdle muscular dystrophy type 2E with joint hyperlaxity and contractures.
Kaindl AM, Jakubiczka S, Lücke T, Bartsch O, Weis J, Stoltenburg-Didinger G, Aksu F, Oexle K, Koehler K, Huebner A. | 01/21/2010 |