| Human Genetic Variation at rs10071329 Correlates With Adiposity-Related Traits, Modulates PPARGC1B Expression, and Alters Brown Adipocyte Function. | Human Genetic Variation at rs10071329 Correlates With Adiposity-Related Traits, Modulates PPARGC1B Expression, and Alters Brown Adipocyte Function.
Huang M, Prasad RB, Coral DE, Hjort L, Minja DTR, Mulder H, Franks PW, Kalamajski S., Free PMC Article | 03/25/2024 |
| HLA-DQA1*05 and upstream variants of PPARGC1B are associated with infliximab persistence in Japanese Crohn's disease patients. | HLA-DQA1*05 and upstream variants of PPARGC1B are associated with infliximab persistence in Japanese Crohn's disease patients.
Shimoda F, Naito T, Kakuta Y, Kawai Y, Tokunaga K, NCBN Controls WGS Consortium, Shimoyama Y, Moroi R, Shiga H, Nagasaki M, Kinouchi Y, Masamune A. | 11/22/2023 |
| Pulling rank with RNA: RANKL promotes the association of PGC-1beta/RNA complexes with NCoR/HDAC3 to activate gene expression in osteoclasts. | Pulling rank with RNA: RANKL promotes the association of PGC-1β/RNA complexes with NCoR/HDAC3 to activate gene expression in osteoclasts.
Torres HM, Yeo D, Westendorf JJ., Free PMC Article | 11/1/2023 |
| LMP1 mediates tumorigenesis through persistent epigenetic modifications and PGC1beta upregulation. | LMP1 mediates tumorigenesis through persistent epigenetic modifications and PGC1β upregulation.
Chen S, Zhang P, Feng J, Li R, Chen J, Zheng WV, Zhang H, Yao P., Free PMC Article | 02/11/2023 |
| Association between PPARgamma, PPARGC1A, and PPARGC1B genetic variants and susceptibility of gastric cancer in an Eastern Chinese population. | Association between PPARγ, PPARGC1A, and PPARGC1B genetic variants and susceptibility of gastric cancer in an Eastern Chinese population.
Chen B, Wang Y, Tang W, Chen Y, Liu C, Kang M, Xie J., Free PMC Article | 01/11/2023 |
| Analysis of Metabolic Regulators PGC1-alpha and PGC1-beta in Oral Squamous Cell Carcinoma with and without Hyperglycemia. | Analysis of Metabolic Regulators PGC1-α and PGC1-β in Oral Squamous Cell Carcinoma with and without Hyperglycemia.
Thamizhanambi TP, Rameshkumar A, Ramya R, Krishnan R, Dineshkumar T, Nandhini G., Free PMC Article | 09/3/2022 |
| Low expression of PGC-1beta and other mitochondrial biogenesis modulators in melanoma is associated with growth arrest and the induction of an immunosuppressive gene expression program dependent on MEK and IRF-1. | Low expression of PGC-1β and other mitochondrial biogenesis modulators in melanoma is associated with growth arrest and the induction of an immunosuppressive gene expression program dependent on MEK and IRF-1.
Laurin KM, Coutu-Beaudry K, Salazar A, Méribout N, Audet-Walsh É, Gravel SP. | 06/18/2022 |
| PGC1alpha/beta Expression Predicts Therapeutic Response to Oxidative Phosphorylation Inhibition in Ovarian Cancer. | PGC1α/β Expression Predicts Therapeutic Response to Oxidative Phosphorylation Inhibition in Ovarian Cancer.
Ghilardi C, Moreira-Barbosa C, Brunelli L, Ostano P, Panini N, Lupi M, Anastasia A, Fiordaliso F, Salio M, Formenti L, Russo M, Arrigoni E, Chiaradonna F, Chiorino G, Draetta G, Marszalek JR, Vellano CP, Pastorelli R, Bani M, Decio A, Giavazzi R., Free PMC Article | 04/9/2022 |
| UBQLN1 mediates sorafenib resistance through regulating mitochondrial biogenesis and ROS homeostasis by targeting PGC1beta in hepatocellular carcinoma. | UBQLN1 mediates sorafenib resistance through regulating mitochondrial biogenesis and ROS homeostasis by targeting PGC1β in hepatocellular carcinoma.
Xu J, Ji L, Ruan Y, Wan Z, Lin Z, Xia S, Tao L, Zheng J, Cai L, Wang Y, Liang X, Cai X., Free PMC Article | 03/12/2022 |
| Decreased PGC1beta expression results in disrupted human erythroid differentiation, impaired hemoglobinization and cell cycle exit. | Decreased PGC1β expression results in disrupted human erythroid differentiation, impaired hemoglobinization and cell cycle exit.
Sen T, Chen J, Singbrant S., Free PMC Article | 11/6/2021 |
| PI3K/AKT phosphorylation activates ERRalpha by upregulating PGC1alpha and PGC1beta in gallbladder cancer. | PI3K/AKT phosphorylation activates ERRα by upregulating PGC‑1α and PGC‑1β in gallbladder cancer.
Wang L, Yang M, Jin H., Free PMC Article | 10/30/2021 |
| The miR-378/PGC1beta/mTOR axis as an alternative mechanism to promote autophagy during adipogenesis. | The miR-378/PGC1β/mTOR axis as an alternative mechanism to promote autophagy during adipogenesis.
Lyu QR, Huang N, Dong K, Xie W, He J, Xu N, Zhang Y. | 09/18/2021 |
| Hepcidin-induced reduction in iron content and PGC-1beta expression negatively regulates osteoclast differentiation to play a protective role in postmenopausal osteoporosis. | Hepcidin-induced reduction in iron content and PGC-1β expression negatively regulates osteoclast differentiation to play a protective role in postmenopausal osteoporosis.
Zhang H, Wang A, Shen G, Wang X, Liu G, Yang F, Chen B, Wang M, Xu Y., Free PMC Article | 08/7/2021 |
| PPARGC1B Is Associated with Nontraumatic Osteonecrosis of the Femoral Head: A Genomewide Association Study on a Chart-Reviewed Cohort. | PPARGC1B Is Associated with Nontraumatic Osteonecrosis of the Femoral Head: A Genomewide Association Study on a Chart-Reviewed Cohort.
Zhang Y, Bowen TR, Lietman SA, Suk M, Williams MS, Lee MTM. | 04/3/2021 |
| Assessment of PPARGC1A, PPARGC1B, and PON1 Genetic Polymorphisms in Esophageal Squamous Cell Carcinoma Susceptibility in the Eastern Chinese Han Population: A Case-Control Study Involving 2351 Subjects. | Assessment of PPARGC1A, PPARGC1B, and PON1 Genetic Polymorphisms in Esophageal Squamous Cell Carcinoma Susceptibility in the Eastern Chinese Han Population: A Case-Control Study Involving 2351 Subjects.
Chen Z, Wang Y, Wang J, Kang M, Tang W, Chen S. | 10/3/2020 |
| Yin Yang 1 facilitates hepatocellular carcinoma cell lipid metabolism and tumor progression by inhibiting PGC-1beta-induced fatty acid oxidation. | Yin Yang 1 facilitates hepatocellular carcinoma cell lipid metabolism and tumor progression by inhibiting PGC-1β-induced fatty acid oxidation.
Li Y, Kasim V, Yan X, Li L, Meliala ITS, Huang C, Li Z, Lei K, Song G, Zheng X, Wu S., Free PMC Article | 09/12/2020 |
| Decreased maximum available Na(+) current with unchanged voltage dependences and unaltered K(+) current properties are associated in proarrhythmic reductions in action potential conduction velocity in Pgc-1beta(-/-) ventricles. | Reduced cardiomyocyte Na(+) current in the age-dependent murine Pgc-1β(-/-) model of ventricular arrhythmia.
Ahmad S, Valli H, Smyth R, Jiang AY, Jeevaratnam K, Matthews HR, Huang CL., Free PMC Article | 03/21/2020 |
| tis study shows that diffuse large B cell lymphoma-derived extracellular vesicles educate macrophages to promote tumor progression by increasing PGC-1beta | Diffuse large B cell lymphoma-derived extracellular vesicles educate macrophages to promote tumours progression by increasing PGC-1β.
Liu W, Zhu M, Wang H, Wang W, Lu Y. | 02/22/2020 |
| PGC1beta's organization of the osteoclast cytoskeleton is mediated by expression of GIT1, which also promotes mitochondrial biogenesis. | PGC1β Organizes the Osteoclast Cytoskeleton by Mitochondrial Biogenesis and Activation.
Zhang Y, Rohatgi N, Veis DJ, Schilling J, Teitelbaum SL, Zou W., Free PMC Article | 10/26/2019 |
| PGC1beta regulates multiple myeloma tumor growth through LDHA-mediated glycolytic metabolism. Targeting the PGC1beta/LDHA pathway may be a novel therapeutic strategy for multiple myeloma treatment. | PGC1β regulates multiple myeloma tumor growth through LDHA-mediated glycolytic metabolism.
Zhang H, Li L, Chen Q, Li M, Feng J, Sun Y, Zhao R, Zhu Y, Lv Y, Zhu Z, Huang X, Xie W, Xiang W, Yao P., Free PMC Article | 08/24/2019 |
| PPARGC1B and CNTN4 genotypes are associated with elevated thromboxane A2 formation and with an excess of cardiovascular events. Aspirin appears to blunt these associations. | Genetic variants in PPARGC1B and CNTN4 are associated with thromboxane A(2) formation and with cardiovascular event free survival in the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT).
McCarthy NS, Vangjeli C, Surendran P, Treumann A, Rooney C, Ho E, Sever P, Thom S, Hughes AD, Munroe PB, Howard P, Johnson T, Caulfield M, Shields DC, O'Brien E, Fitzgerald DJ, Stanton AV., Free PMC Article | 06/1/2019 |
| PGC1A and PGC1B methylation may serve as early biomarkers of cancer risk. | Promoter methylation of PGC1A and PGC1B predicts cancer incidence in a veteran cohort.
Kresovich JK, Joyce BT, Gao T, Zheng Y, Zhang Z, Achenbach CJ, Murphy RL, Just AC, Shen J, Yang H, Vokonas P, Schwartz J, Baccarelli AA, Hou L., Free PMC Article | 03/23/2019 |
| Peroxisome proliferator-activated receptor gamma coactivator 1-beta (PGC1beta) activates Hepatitis b virus (HBV) RNA and DNA synthesis poorly in human hepatoma (HepG2) and embryonic kidney (HEK293T) cells. PGC1beta inhibits Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1alpha)-mediated HBV biosynthesis. Competition between PGC1alpha and PGC1beta may regulate HBV transcription and replication. | Peroxisome proliferator-activated receptor γ coactivator family members competitively regulate hepatitis b virus biosynthesis.
Shalaby RE, Iram S, Oropeza CE, McLachlan A., Free PMC Article | 02/2/2019 |
| the KAT4 promoter was significantly activated by the transcriptional factors, NFE2related factor 2 and peroxisome proliferatoractivated receptor coactivator 1beta, which are targets of Syvn1induced degradation | The NRF2‑PGC‑1β pathway activates kynurenine aminotransferase 4 via attenuation of an E3 ubiquitin ligase, synoviolin, in a cecal ligation/perforation‑induced septic mouse model.
Ishida Y, Fujita H, Aratani S, Chijiiwa M, Taniguchi N, Yokota M, Ogihara Y, Uoshima N, Nagashima F, Uchino H, Nakajima T. | 11/3/2018 |
| Incrementally paced murine Pgc1beta(-/-) hearts show pro-arrhythmic atrial phenotypes that are age dependent. | Pro-arrhythmic atrial phenotypes in incrementally paced murine Pgc1β(-/-) hearts: effects of age.
Valli H, Ahmad S, Fraser JA, Jeevaratnam K, Huang CL., Free PMC Article | 07/21/2018 |