| Molecular basis of human trace amine-associated receptor 1 activation. | Molecular basis of human trace amine-associated receptor 1 activation.
Zilberg G, Parpounas AK, Warren AL, Yang S, Wacker D., Free PMC Article | 01/9/2024 |
| Ligand recognition and G-protein coupling of trace amine receptor TAAR1. | Ligand recognition and G-protein coupling of trace amine receptor TAAR1.
Xu Z, Guo L, Yu J, Shen S, Wu C, Zhang W, Zhao C, Deng Y, Tian X, Feng Y, Hou H, Su L, Wang H, Guo S, Wang H, Wang K, Chen P, Zhao J, Zhang X, Yong X, Cheng L, Liu L, Yang S, Yang F, Wang X, Yu X, Xu Y, Sun JP, Yan W, Shao Z. | 01/4/2024 |
| Structural and signaling mechanisms of TAAR1 enabled preferential agonist design. | Structural and signaling mechanisms of TAAR1 enabled preferential agonist design.
Shang P, Rong N, Jiang JJ, Cheng J, Zhang MH, Kang D, Qi L, Guo L, Yang GM, Liu Q, Zhou Z, Li XB, Zhu KK, Meng QB, Han X, Yan W, Kong Y, Yang L, Wang X, Lei D, Feng X, Liu X, Yu X, Wang Y, Li Q, Shao ZH, Yang F, Sun JP. | 11/27/2023 |
| T1AM/TAAR1 System Reduces Inflammatory Response and beta-Amyloid Toxicity in Human Microglial HMC3 Cell Line. | T1AM/TAAR1 System Reduces Inflammatory Response and β-Amyloid Toxicity in Human Microglial HMC3 Cell Line.
Polini B, Ricardi C, Bertolini A, Carnicelli V, Rutigliano G, Saponaro F, Zucchi R, Chiellini G., Free PMC Article | 08/19/2023 |
| Thymosin alpha1 interacts with Galectin-1 modulating the beta-galactosides affinity and inducing alteration in the biological activity. | Thymosin α1 interacts with Galectin-1 modulating the β-galactosides affinity and inducing alteration in the biological activity.
Matteucci C, Nepravishta R, Argaw-Denboba A, Mandaliti W, Giovinazzo A, Petrone V, Balestrieri E, Sinibaldi-Vallebona P, Pica F, Paci M, Garaci E. | 04/26/2023 |
| Trace amine-associated receptor 1 (TAAR1): Potential application in mood disorders: A systematic review. | Trace amine-associated receptor 1 (TAAR1): Potential application in mood disorders: A systematic review.
Alnefeesi Y, Tamura JK, Lui LMW, Jawad MY, Ceban F, Ling S, Nasri F, Rosenblat JD, McIntyre RS. | 03/5/2022 |
| Search for Structural Basis of Interactions of Biogenic Amines with Human TAAR1 and TAAR6 Receptors. | Search for Structural Basis of Interactions of Biogenic Amines with Human TAAR1 and TAAR6 Receptors.
Glyakina AV, Pavlov CD, Sopova JV, Gainetdinov RR, Leonova EI, Galzitskaya OV., Free PMC Article | 02/5/2022 |
| TAAR1 Expression in Human Macrophages and Brain Tissue: A Potential Novel Facet of MS Neuroinflammation. | TAAR1 Expression in Human Macrophages and Brain Tissue: A Potential Novel Facet of MS Neuroinflammation.
Barnes DA, Galloway DA, Hoener MC, Berry MD, Moore CS., Free PMC Article | 01/1/2022 |
| Cadaverine and Spermine Elicit Ca(2+) Uptake in Human CP Cells via a Trace Amine-Associated Receptor 1 Dependent Pathway. | Cadaverine and Spermine Elicit Ca(2+) Uptake in Human CP Cells via a Trace Amine-Associated Receptor 1 Dependent Pathway.
Almeida-Santos D, Duarte AC, Gonçalves I, Ferreira CL, Ferrer I, Ishikawa H, Schwerk C, Schroten H, Santos CRA. | 10/9/2021 |
| Trace Amine-Associated Receptor 1 (TAAR1) Is a Positive Prognosticator for Epithelial Ovarian Cancer. | Trace Amine-Associated Receptor 1 (TAAR1) Is a Positive Prognosticator for Epithelial Ovarian Cancer.
Vogelsang TLR, Vattai A, Schmoeckel E, Kaltofen T, Chelariu-Raicu A, Zheng M, Mahner S, Mayr D, Jeschke U, Trillsch F., Free PMC Article | 09/25/2021 |
| Neuroadaptation to chronic Methamphetamine use may be altered by TAAR1 genotype and result in increased dopamine signaling and craving in individuals with the V288V genotype. | Trace amine-associated receptor gene polymorphism increases drug craving in individuals with methamphetamine dependence.
Loftis JM, Lasarev M, Shi X, Lapidus J, Janowsky A, Hoffman WF, Huckans M., Free PMC Article | 03/14/2020 |
| Findings suggest that TAAR1 activation protects against methamphetamine-induced cell apoptosis and TAAR1 may play a role in cell death in neurodegenerative diseases. | Activation of Trace Amine-Associated Receptor 1 Stimulates an Antiapoptotic Signal Cascade via Extracellular Signal-Regulated Kinase 1/2.
Shi X, Swanson TL, Miner NB, Eshleman AJ, Janowsky A., Free PMC Article | 12/21/2019 |
| It clearly demonstrate variable expression and sub-cellular localization of TAAR1 across BC cell lines, we find no evidence for association with BC subtype. | TAAR1 levels and sub-cellular distribution are cell line but not breast cancer subtype specific.
Pitts MS, McShane JN, Hoener MC, Christian SL, Berry MD. | 09/7/2019 |
| This study identified a rare heterozygous variant (c.545G>T; p.Cys182Phe) in Trace amine associated receptor 1 gene (TAAR1 6q23.2) in three affected members in a small SZ family. | Possible role of rare variants in Trace amine associated receptor 1 in schizophrenia.
John J, Kukshal P, Bhatia T, Chowdari KV, Nimgaonkar VL, Deshpande SN, Thelma BK., Free PMC Article | 07/28/2018 |
| TAAR1 seems to be an independent predictor for breast cancer survival. | Increased trace amine-associated receptor 1 (TAAR1) expression is associated with a positive survival rate in patients with breast cancer.
Vattai A, Akyol E, Kuhn C, Hofmann S, Heidegger H, von Koch F, Hermelink K, Wuerstlein R, Harbeck N, Mayr D, Spitzweg C, Toth B, Mahner S, Jeschke U, Ditsch N. | 03/24/2018 |
| SNPs in human TAAR1 alter its function, resulting in expressed, but functional, sub-functional and non-functional receptors | Genetic Polymorphisms Affect Mouse and Human Trace Amine-Associated Receptor 1 Function.
Shi X, Walter NA, Harkness JH, Neve KA, Williams RW, Lu L, Belknap JK, Eshleman AJ, Phillips TJ, Janowsky A., Free PMC Article | 10/1/2016 |
| an increase in TAAR1 receptor expression is concomitant with lymphocyte immune activation, suggesting a possible role for TAAR1 in the generation or regulation of an immune response | Trace amine associated receptor 1 signaling in activated lymphocytes.
Panas MW, Xie Z, Panas HN, Hoener MC, Vallender EJ, Miller GM., Free PMC Article | 05/25/2013 |
| biogenic amines potently regulate blood cell functions via TAAR1 and TAAR2 and open the perspective of their specific pharmacological modulation. | Biogenic amines activate blood leukocytes via trace amine-associated receptors TAAR1 and TAAR2.
Babusyte A, Kotthoff M, Fiedler J, Krautwurst D. | 04/20/2013 |
| Methamphetamine-but not morphine-induced conditioned place preference was augmented in TAAR1 transgenic mice. | Augmentation of methamphetamine-induced behaviors in transgenic mice lacking the trace amine-associated receptor 1.
Achat-Mendes C, Lynch LJ, Sullivan KA, Vallender EJ, Miller GM., Free PMC Article | 09/29/2012 |
| Trace amine 1 receptors (TA1R) exert an inhibitory influence on both dopaminergic and serotonergic transmission, and MDMA (ecstasy) auto-inhibits its neurochemical and functional actions by recruitment of TA1R. | Genetic deletion of trace amine 1 receptors reveals their role in auto-inhibiting the actions of ecstasy (MDMA).
Di Cara B, Maggio R, Aloisi G, Rivet JM, Lundius EG, Yoshitake T, Svenningsson P, Brocco M, Gobert A, De Groote L, Cistarelli L, Veiga S, De Montrion C, Rodriguez M, Galizzi JP, Lockhart BP, Cogé F, Boutin JA, Vayer P, Verdouw PM, Groenink L, Millan MJ., Free PMC Article | 01/21/2012 |
| data suggest that TAAR1 and D2R have functional and physical interactions that could be critical for the modulation of the dopaminergic system by TAAR1 in vivo | Functional interaction between trace amine-associated receptor 1 and dopamine D2 receptor.
Espinoza S, Salahpour A, Masri B, Sotnikova TD, Messa M, Barak LS, Caron MG, Gainetdinov RR., Free PMC Article | 10/22/2011 |
| Overview focuses on recent studies which reveal a role for TAAR1 in the functional regulation of monoamine transporters and the neuronal regulatory mechanisms that modulate dopaminergic activity. [review] | The emerging role of trace amine-associated receptor 1 in the functional regulation of monoamine transporters and dopaminergic activity.
Miller GM., Free PMC Article | 01/22/2011 |
| Data support that TAAR1 tonically activates inwardly rectifying K(+) channels, which reduces the basal firing frequency of dopamine neurons in the ventral tegmental area. | The selective antagonist EPPTB reveals TAAR1-mediated regulatory mechanisms in dopaminergic neurons of the mesolimbic system.
Bradaia A, Trube G, Stalder H, Norcross RD, Ozmen L, Wettstein JG, Pinard A, Buchy D, Gassmann M, Hoener MC, Bettler B., Free PMC Article | 01/21/2010 |
| A systematic evaluation of a series of beta-phenethylamines as ligands to TAAR1 is reported. | Structure-activity correlations for beta-phenethylamines at human trace amine receptor 1.
Lewin AH, Navarro HA, Mascarella SW., Free PMC Article | 01/21/2010 |
| Expression of neuronal trace amine-associated receptor (Taar) mRNAs in leukocytes. | Expression of neuronal trace amine-associated receptor (Taar) mRNAs in leukocytes.
Nelson DA, Tolbert MD, Singh SJ, Bost KL., Free PMC Article | 01/21/2010 |