| The NKG2D ligand ULBP4 is not expressed by human monocytes. | The NKG2D ligand ULBP4 is not expressed by human monocytes.
Lazarova M, Kim Y, Steinle A., Free PMC Article | 08/7/2021 |
| Transcriptomic analysis of micropapillary high grade T1 urothelial bladder cancer. | Transcriptomic analysis of micropapillary high grade T1 urothelial bladder cancer.
Bowden M, Nadal R, Zhou CW, Werner L, Barletta J, Juanpere N, Lloreta J, Hernandez-Llodrà S, Morote J, de Torres I, Orsola A, Cejas P, Long H, Bellmunt J., Free PMC Article | 04/24/2021 |
| An association of the raet1e polymorphisms with an increased risk of developing premature CAD and with cardiometabolic parameters has been shown for the first time. | Raet1e Polymorphisms Are Associated with Increased Risk of Developing Premature Coronary Artery Disease and with Some Cardiometabolic Parameters: The GEA Mexican Study.
Posadas-Sánchez R, Roque-Ramírez B, Rodríguez-Pérez JM, Pérez-Hernández N, Fragoso JM, Villarreal-Molina T, Coral-Vázquez R, Tejero-Barrera ME, Posadas-Romero C, Vargas-Alarcón G., Free PMC Article | 05/11/2019 |
| decreased expression levels of ULBP4 in NPC tissues as compared to that in normal NP epithelial tissues. In addition, low ULBP4 expression correlated with poor OS, DFS, DMFS, and may prove to be a novel prognostic factor. | Decreased expression of the NKG2D ligand ULBP4 may be an indicator of poor prognosis in patients with nasopharyngeal carcinoma.
Xu Y, Zhou L, Zong J, Ye Y, Chen G, Chen Y, Liao X, Guo Q, Qiu S, Lin S, Chen H, Pan J., Free PMC Article | 04/7/2018 |
| Blocking the interaction of NKG2D with its ligands deleted the sensitizing effects of HCQ. In addition, we showed that HCQ did not affect the synthesis or degradation of ULBP4, but induced the translocation of ULBP4 from the cytoplasm to the cell membrane | Hydroxychloroquine sensitizes chronic myeloid leukemia cells to Vγ9Vδ2 T cell-mediated lysis independent of autophagy.
Han B, Zhao Y, Lin Y, Fu S, Wang L, Zhang M, Tie R, Wang B, Luo Y, Liu L, Yu J, Huang H. | 07/22/2017 |
| 5 of the 7 promoter polymorphisms of the RAET1E gene may disrupt transcription factor binding | Characterization of 5' promoter and exon 1-3 polymorphism of the RAET1E gene.
Cox ST, Pearson H, Laza-Briviesca R, Pesoa S, Vullo C, Madrigal JA, Saudemont A. | 12/31/2016 |
| RAET1E promoter polymorphism has increased to nine types, and there are now 12 alleles determined by the coding exons, including one null. | Increasing polymorphism of the RAET1E/ULBP4 gene in humans.
Pearson H, Madrigal JA, Saudemont A, Cox ST. | 10/22/2016 |
| genetic polymorphism among the ethnic groups | Single nucleotide polymorphism analysis of the NKG2D ligand cluster on the long arm of chromosome 6: Extensive polymorphisms and evidence of diversity between human populations.
Antoun A, Jobson S, Cook M, O'Callaghan CA, Moss P, Briggs DC, Antoun A, Jobson S, Cook M, O'Callaghan CA, Moss P, Briggs DC. | 10/4/2010 |
| Patients whose tumors had high expression of RAET1E, ULBP1 and ULBP3 surviving a median of 11, 14 and 11 months, respectively, compared with disease-specific survival of 29, 30 and 25 months in patients whose tumors showed no expression of these ligands | ULBP2 and RAET1E NKG2D ligands are independent predictors of poor prognosis in ovarian cancer patients.
McGilvray RW, Eagle RA, Rolland P, Jafferji I, Trowsdale J, Durrant LG. | 08/30/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | New genetic associations detected in a host response study to hepatitis B vaccine.
Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, Hibberd ML, Seielstad M. | 04/7/2010 |
| Observational study of genotype prevalence. (HuGE Navigator) | See all PubMed (2) articlesSingle nucleotide polymorphism analysis of the NKG2D ligand cluster on the long arm of chromosome 6: Extensive polymorphisms and evidence of diversity between human populations.
Antoun A, Jobson S, Cook M, O'Callaghan CA, Moss P, Briggs DC, Antoun A, Jobson S, Cook M, O'Callaghan CA, Moss P, Briggs DC. Polymorphisms of NKG2D ligands: diverse RAET1/ULBP genes in northeastern Thais.
Romphruk AV, Romphruk A, Naruse TK, Raroengjai S, Puapairoj C, Inoko H, Leelayuwat C. | 09/16/2009 |
| data suggest that ULBP4 functions as a ligand for both TCRgammadelta and NKG2D and may play a key role in immune surveillance of tumor development and clearance of viral infection | The NKG2D ligand ULBP4 binds to TCRgamma9/delta2 and induces cytotoxicity to tumor cells through both TCRgammadelta and NKG2D.
Kong Y, Cao W, Xi X, Ma C, Cui L, He W. | 01/21/2010 |
| All ULBP4 splice variants (ULBP4-I, ULBP4-II and ULBP4-III) were type 1 membrane-spanning molecules and had the ability to bind with human NKG2D receptor in vitro | Four novel ULBP splice variants are ligands for human NKG2D.
Cao W, Xi X, Wang Z, Dong L, Hao Z, Cui L, Ma C, He W. | 01/21/2010 |
| immune escape mechanism of tumors via alternative splicing of ULBP RNA to generate a free soluble ULBP protein, RAET1E2, that may impair NKG2D-mediated NK cell cytotoxicity to tumors | RAET1E2, a soluble isoform of the UL16-binding protein RAET1E produced by tumor cells, inhibits NKG2D-mediated NK cytotoxicity.
Cao W, Xi X, Hao Z, Li W, Kong Y, Cui L, Ma C, Ba D, He W. | 01/21/2010 |
| Binds the activating receptor NKG2D. | Two human ULBP/RAET1 molecules with transmembrane regions are ligands for NKG2D.
Bacon L, Eagle RA, Meyer M, Easom N, Young NT, Trowsdale J. | 01/21/2010 |