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    Mapre1 microtubule-associated protein, RP/EB family, member 1 [ Mus musculus (house mouse) ]

    Gene ID: 13589, updated on 18-Sep-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Photo-Excited Toluidine Blue Disaggregates the Repeat Tau and Modulates End-Binding Protein EB1, Cytoskeletal Structure in Neuronal Cells.

    Photo-Excited Toluidine Blue Disaggregates the Repeat Tau and Modulates End-Binding Protein EB1, Cytoskeletal Structure in Neuronal Cells.
    Chinnathambi S, Dubey T, Chandrashekar M.

    04/21/2023
    Targeting the Microtubule EB1-CLASP2 Complex Modulates NaV1.5 at Intercalated Discs.

    Targeting the Microtubule EB1-CLASP2 Complex Modulates Na(V)1.5 at Intercalated Discs.
    Marchal GA, Jouni M, Chiang DY, Pérez-Hernández M, Podliesna S, Yu N, Casini S, Potet F, Veerman CC, Klerk M, Lodder EM, Mengarelli I, Guan K, Vanoye CG, Rothenberg E, Charpentier F, Redon R, George AL Jr, Verkerk AO, Bezzina CR, MacRae CA, Burridge PW, Delmar M, Galjart N, Portero V, Remme CA., Free PMC Article

    01/15/2022
    MACF1 promotes preosteoblast migration by mediating focal adhesion turnover through EB1.

    MACF1 promotes preosteoblast migration by mediating focal adhesion turnover through EB1.
    Su P, Yin C, Li D, Yang C, Wang X, Pei J, Tian Y, Qian A., Free PMC Article

    08/28/2021
    Arl4D-EB1 interaction promotes centrosomal recruitment of EB1 and microtubule growth.

    Arl4D-EB1 interaction promotes centrosomal recruitment of EB1 and microtubule growth.
    Lin SJ, Huang CF, Wu TS, Li CC, Lee FS., Free PMC Article

    06/12/2021
    Crosstalk between EB1 protein and Ankyrin-G is decisive for axon initial segment assembly.

    Cooperative Interactions between 480 kDa Ankyrin-G and EB Proteins Assemble the Axon Initial Segment.
    Fréal A, Fassier C, Le Bras B, Bullier E, De Gois S, Hazan J, Hoogenraad CC, Couraud F., Free PMC Article

    09/17/2016
    We describe here a novel function for tau as a direct regulator of eb1 and eb2 proteins in differentiating neuronal cells

    Tau regulates the localization and function of End-binding proteins 1 and 3 in developing neuronal cells.
    Sayas CL, Tortosa E, Bollati F, Ramírez-Ríos S, Arnal I, Avila J.

    06/27/2015
    Data indicate that cortactin as an Src-dependent interacting partner of EB1.

    Microtubule dynamic instability controls podosome patterning in osteoclasts through EB1, cortactin, and Src.
    Biosse Duplan M, Zalli D, Stephens S, Zenger S, Neff L, Oelkers JM, Lai FP, Horne W, Rottner K, Baron R., Free PMC Article

    02/15/2014
    Data indicate that EB1(MAPRE1) is up-regulated in osteoblasts and is required for bone cell differentiation.

    EB1 levels are elevated in ascorbic Acid (AA)-stimulated osteoblasts and mediate cell-cell adhesion-induced osteoblast differentiation.
    Pustylnik S, Fiorino C, Nabavi N, Zappitelli T, da Silva R, Aubin JE, Harrison RE., Free PMC Article

    11/16/2013
    MAP1B interacts directly with EB1 and EB3 (EBs), two core 'microtubule plus-end tracking proteins' ( TIPs), and sequesters them in the cytosol of developing neuronal cells.

    MAP1B regulates microtubule dynamics by sequestering EB1/3 in the cytosol of developing neuronal cells.
    Tortosa E, Galjart N, Avila J, Sayas CL., Free PMC Article

    06/29/2013
    the Amer2-EB1-APC complex regulates cell migration by altering microtubule stability.

    Amer2 protein interacts with EB1 protein and adenomatous polyposis coli (APC) and controls microtubule stability and cell migration.
    Pfister AS, Hadjihannas MV, Röhrig W, Schambony A, Behrens J., Free PMC Article

    01/5/2013
    Detyrosination regulates CAP-Gly proteins interaction with alpha-tubulin, but not with EB1.

    Cap-Gly proteins at microtubule plus ends: is EB1 detyrosination involved?
    Bosson A, Soleilhac JM, Valiron O, Job D, Andrieux A, Moutin MJ., Free PMC Article

    07/14/2012
    End binding protein 1 is required for single-cell polarization and directional cell motility.

    SMRT analysis of MTOC and nuclear positioning reveals the role of EB1 and LIC1 in single-cell polarization.
    Hale CM, Chen WC, Khatau SB, Daniels BR, Lee JS, Wirtz D., Free PMC Article

    07/7/2012
    These findings support a model where EB1 protein links microtubules to actin protrusion and cell polarity through signaling pathways involving PKC.

    The microtubule-associated protein EB1 maintains cell polarity through activation of protein kinase C.
    Schober JM, Kwon G, Jayne D, Cain JM., Free PMC Article

    03/24/2012
    EB1 coordinates melanoma cell migration through regulating the balance between lamellipodial and filopodial protrusion.

    Migration and actin protrusion in melanoma cells are regulated by EB1 protein.
    Schober JM, Cain JM, Komarova YA, Borisy GG.

    01/21/2010
    Results suggest that EB1 is necessary for the early stages of muscle differentiation.

    Microtubule plus-end binding protein EB1 is necessary for muscle cell differentiation, elongation and fusion.
    Zhang T, Zaal KJ, Sheridan J, Mehta A, Gundersen GG, Ralston E., Free PMC Article

    01/21/2010
    Results suggest that EB1 favours the lateral association of free tubulin at microtubule-sheet edges, thereby stimulating nucleation, sheet growth and closure.

    EB1 regulates microtubule dynamics and tubulin sheet closure in vitro.
    Vitre B, Coquelle FM, Heichette C, Garnier C, Chrétien D, Arnal I.

    01/21/2010
    EB1 was highly expressed in Sertoli cells and located along microtubule bundles in Sertoli cell processes,indicating a requirement of proper microtubule arrays for Sertoli cell plasticity and function.

    The microtubule plus end-binding protein EB1 is involved in Sertoli cell plasticity in testicular seminiferous tubules.
    Wang F, Zhang Q, Cao J, Huang Q, Zhu X.

    01/21/2010
    Localization of EB1 at the centriole/basal body is required for primary cilia assembly in fibroblasts.

    EB1 is required for primary cilia assembly in fibroblasts.
    Schrøder JM, Schneider L, Christensen ST, Pedersen LB.

    01/21/2010
    An EB1 mutant lacking the C-terminal tail could also fully rescue CLIP dissociation kinetics, but could only partially restore CLIP accumulation at the tips, suggesting that the interaction of CLIPs with the EB tails contributes to CLIP localization.

    EB1 and EB3 control CLIP dissociation from the ends of growing microtubules.
    Komarova Y, Lansbergen G, Galjart N, Grosveld F, Borisy GG, Akhmanova A., Free PMC Article

    01/21/2010
    results show an evolutionarily conserved pathway for microtubule capture, and suggest that mDia functions as a scaffold protein for EB1 and APC to stabilize microtubules and promote cell migration.

    EB1 and APC bind to mDia to stabilize microtubules downstream of Rho and promote cell migration.
    Wen Y, Eng CH, Schmoranzer J, Cabrera-Poch N, Morris EJ, Chen M, Wallar BJ, Alberts AS, Gundersen GG.

    01/21/2010
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