| KLF14 directly downregulates the expression of GPX4 to exert antitumor effects by promoting ferroptosis in cervical cancer. | KLF14 directly downregulates the expression of GPX4 to exert antitumor effects by promoting ferroptosis in cervical cancer.
Ye H, Ding X, Lv X, Du Y, Guo R, Qiu J, Li R, Cao L., Free PMC Article | 10/18/2024 |
| Potential Association of The Pathogenic Kruppel-like Factor 14 (KLF14) and Adiponectin (ADIPOQ) SNVs with Susceptibility to T2DM. | Potential Association of The Pathogenic Kruppel-like Factor 14 (KLF14) and Adiponectin (ADIPOQ) SNVs with Susceptibility to T2DM.
Elfaki I, Mir R, Tayeb F, Alalawy AI, Barnawi J, Dabla PK, Moawadh MS. | 06/28/2024 |
| KLF14 activates the JNK-signaling pathway to induce S-phase arrest in cervical cancer cells. | KLF14 activates the JNK-signaling pathway to induce S-phase arrest in cervical cancer cells.
Du Y, Ye H, Lin M, Cao L., Free PMC Article | 01/3/2024 |
| Biochemical association of regulatory variant of KLF14 genotype in the pathogenesis of cardiodiabetic patients. | Biochemical association of regulatory variant of KLF14 genotype in the pathogenesis of cardiodiabetic patients.
Alanazi AS, Rasheed S, Rehman K, Mallhi TH, Akash MSH, Alotaibi NH, Alzarea AI, Tanveer N, Khan YH., Free PMC Article | 06/28/2023 |
| KLF14/miR-1283/TFAP2C axis inhibits HER2-positive breast cancer progression via declining tumor cell proliferation. | KLF14/miR-1283/TFAP2C axis inhibits HER2-positive breast cancer progression via declining tumor cell proliferation.
Chen XZ, He WX, Luo RG, Xia GJ, Zhong JX, Chen QJ, Huang YY, Guan YX. | 03/21/2023 |
| KLF14 regulates the growth of hepatocellular carcinoma cells via its modulation of iron homeostasis through the repression of iron-responsive element-binding protein 2. | KLF14 regulates the growth of hepatocellular carcinoma cells via its modulation of iron homeostasis through the repression of iron-responsive element-binding protein 2.
Zhou H, Chen J, Fan M, Cai H, Dong Y, Qiu Y, Zhuang Q, Lei Z, Li M, Ding X, Yan P, Lin A, Zheng S, Yan Q., Free PMC Article | 01/28/2023 |
| Upregulation of KLF14 expression attenuates kidney fibrosis by inducing PPARalpha-mediated fatty acid oxidation. | Upregulation of KLF14 expression attenuates kidney fibrosis by inducing PPARα-mediated fatty acid oxidation.
Chen L, Sha ML, Chen FT, Jiang CY, Li D, Xu CL, Pan DS, Xu ZJ, Tang QL, Xia SJ, Sun LH, Fan GJ, Shao Y. | 01/21/2023 |
| Determining KLF14 tertiary structure and diagnostic significance in brain cancer progression. | Determining KLF14 tertiary structure and diagnostic significance in brain cancer progression.
Zahra K, Shabbir M, Badshah Y, Trembley JH, Badar Z, Khan K, Afsar T, Almajwal A, Alruwaili NW, Razak S., Free PMC Article | 05/28/2022 |
| Differential Genetic and Epigenetic Effects of the KLF14 Gene on Body Shape Indices and Metabolic Traits. | Differential Genetic and Epigenetic Effects of the KLF14 Gene on Body Shape Indices and Metabolic Traits.
Wu S, Hsu LA, Teng MS, Chou HH, Ko YL., Free PMC Article | 04/30/2022 |
| Kruppel-like factor 14 deletion in myeloid cells accelerates atherosclerotic lesion development. | Krüppel-like factor 14 deletion in myeloid cells accelerates atherosclerotic lesion development.
Wang H, Guo Y, Lu H, Luo Y, Hu W, Liang W, Garcia-Barrio MT, Chang L, Schwendeman A, Zhang J, Chen YE., Free PMC Article | 03/5/2022 |
| EZH2-mediated inhibition of KLF14 expression promotes HSCs activation and liver fibrosis by downregulating PPARgamma. | EZH2-mediated inhibition of KLF14 expression promotes HSCs activation and liver fibrosis by downregulating PPARγ.
Du Z, Liu M, Wang Z, Lin Z, Feng Y, Tian D, Xia L., Free PMC Article | 07/17/2021 |
| The KLF14 Variant is Associated with Type 2 Diabetes and HbA1C Level. | The KLF14 Variant is Associated with Type 2 Diabetes and HbA(1C) Level.
Shahvazian E, Mahmoudi MB, Farashahi Yazd E, Gharibi S, Moghimi B, HosseinNia P, Mirzaei M. | 07/10/2021 |
| T2D risk alleles are cis-eQTLs for KLF14, conferring reduced expression in human adipose tissue. | Regulatory variants at KLF14 influence type 2 diabetes risk via a female-specific effect on adipocyte size and body composition.
Small KS, Todorčević M, Civelek M, El-Sayed Moustafa JS, Wang X, Simon MM, Fernandez-Tajes J, Mahajan A, Horikoshi M, Hugill A, Glastonbury CA, Quaye L, Neville MJ, Sethi S, Yon M, Pan C, Che N, Viñuela A, Tsai PC, Nag A, Buil A, Thorleifsson G, Raghavan A, Ding Q, Morris AP, Bell JT, Thorsteinsdottir U, Stefansson K, Laakso M, Dahlman I, Arner P, Gloyn AL, Musunuru K, Lusis AJ, Cox RD, Karpe F, McCarthy MI, Small KS, Todorčević M, Civelek M, El-Sayed Moustafa JS, Wang X, Simon MM, Fernandez-Tajes J, Mahajan A, Horikoshi M, Hugill A, Glastonbury CA, Quaye L, Neville MJ, Sethi S, Yon M, Pan C, Che N, Viñuela A, Tsai PC, Nag A, Buil A, Thorleifsson G, Raghavan A, Ding Q, Morris AP, Bell JT, Thorsteinsdottir U, Stefansson K, Laakso M, Dahlman I, Arner P, Gloyn AL, Musunuru K, Lusis AJ, Cox RD, Karpe F, McCarthy MI., Free PMC Articles: PMC5935235, PMC5935235 | 06/14/2021 |
| Epstein-Barr Virus Facilitates Expression of KLF14 by Regulating the Cooperative Binding of the E2F-Rb-HDAC Complex in Latent Infection. | Epstein-Barr Virus Facilitates Expression of KLF14 by Regulating the Cooperative Binding of the E2F-Rb-HDAC Complex in Latent Infection.
Pei Y, Wong JH, Jha HC, Tian T, Wei Z, Robertson ES., Free PMC Article | 01/9/2021 |
| These results provide comprehensive insight into the KLF14-dependent regulation of antioxidant response and subsequent pathogenesis of castration resistance and indicate that interventions targeting the KLF14/HO-1 adaptive mechanism should be further explored for castration-resistant prostate cancer treatment. | KLF14 potentiates oxidative adaptation via modulating HO-1 signaling in castrate-resistant prostate cancer.
Luo XH, Liu JZ, Wang B, Men QL, Ju YQ, Yin FY, Zheng C, Li W. | 03/7/2020 |
| KLF14 inhibits the inflammatory response in endothelial cells; its protective effects are mediated by transcriptional inhibition of NF-kappaB p65 | Krüppel-like factor 14, a coronary artery disease associated transcription factor, inhibits endothelial inflammation via NF-κB signaling pathway.
Hu W, Lu H, Zhang J, Fan Y, Chang Z, Liang W, Wang H, Zhu T, Garcia-Barrio MT, Peng D, Chen YE, Guo Y., Free PMC Article | 11/23/2019 |
| we proved that DGCR5 can rescue the inhibited levels of KLF14 repressed by miR-346 mimics in MHCC-97H and Hep3B cells. Taken together, it was indicated in our study that DGCR5 can restrain the progression of HCC through sponging miR-346 and modulating KLF14 in vitro. | LncRNA DGCR5 represses the development of hepatocellular carcinoma by targeting the miR-346/KLF14 axis.
Wang YG, Liu J, Shi M, Chen FX. | 10/5/2019 |
| The modified methylation of TRIM59 and KLF14 in top athletes may be accounted for by the biological roles played by these genes. Their known anti-tumour and anti-inflammatory activities suggests that intense physical training has a complex influence on aging and potentially launches signalling networks that contribute to the observed lower risk of elite athletes to develop cardiovascular disease and cancer. | Modified aging of elite athletes revealed by analysis of epigenetic age markers.
Spólnicka M, Pośpiech E, Adamczyk JG, Freire-Aradas A, Pepłońska B, Zbieć-Piekarska R, Makowska Ż, Pięta A, Lareu MV, Phillips C, Płoski R, Żekanowski C, Branicki W., Free PMC Article | 09/14/2019 |
| downregulated in chronic liver diseases | Overexpression of KLF14 protects against immune-mediated hepatic injury in mice.
Chen X, Tan Q, Wang Y, Lv H, Wang Z, Lin Z, Du Z, Xiong S, Han J, Tian D, Wang B. | 07/20/2019 |
| Carriers of the KLF14 type 2 diabetes (T2D) risk allele shift body fat from gynoid stores to abdominal stores and display a marked increase in adipocyte cell size, and these effects on fat distribution, and the T2D association, are female specific. | Regulatory variants at KLF14 influence type 2 diabetes risk via a female-specific effect on adipocyte size and body composition.
Small KS, Todorčević M, Civelek M, El-Sayed Moustafa JS, Wang X, Simon MM, Fernandez-Tajes J, Mahajan A, Horikoshi M, Hugill A, Glastonbury CA, Quaye L, Neville MJ, Sethi S, Yon M, Pan C, Che N, Viñuela A, Tsai PC, Nag A, Buil A, Thorleifsson G, Raghavan A, Ding Q, Morris AP, Bell JT, Thorsteinsdottir U, Stefansson K, Laakso M, Dahlman I, Arner P, Gloyn AL, Musunuru K, Lusis AJ, Cox RD, Karpe F, McCarthy MI, Small KS, Todorčević M, Civelek M, El-Sayed Moustafa JS, Wang X, Simon MM, Fernandez-Tajes J, Mahajan A, Horikoshi M, Hugill A, Glastonbury CA, Quaye L, Neville MJ, Sethi S, Yon M, Pan C, Che N, Viñuela A, Tsai PC, Nag A, Buil A, Thorleifsson G, Raghavan A, Ding Q, Morris AP, Bell JT, Thorsteinsdottir U, Stefansson K, Laakso M, Dahlman I, Arner P, Gloyn AL, Musunuru K, Lusis AJ, Cox RD, Karpe F, McCarthy MI., Free PMC Articles: PMC5935235, PMC5935235 | 05/11/2019 |
| The study demonstrated that HAND2-AS1 exerts a suppressive role in colorectal cancer by sponging miR-1275 and modulating KLF14 expression. | LncRNA HAND2-AS1 sponging miR-1275 suppresses colorectal cancer progression by upregulating KLF14.
Zhou J, Lin J, Zhang H, Zhu F, Xie R. | 03/16/2019 |
| KIF14 was upregulated in colorectal cancer (CRC) tissues and promoted tumor cell proliferation. Study is the first to comprehensively demonstrate the expression profile and functional roles of KIF14 in CRC and reveal that downregulated miR-200c expression may contribute to increased KIF14 expression. | KIF14 promotes cell proliferation via activation of Akt and is directly targeted by miR-200c in colorectal cancer.
Wang ZZ, Yang J, Jiang BH, Di JB, Gao P, Peng L, Su XQ., Free PMC Article | 02/2/2019 |
| SNPs at the CETP, HNF4A and KLF14 locus are associated with HDL-C levels and type 2 diabetes (in female participants). | Assessment of established HDL-C loci for association with HDL-C levels and type 2 diabetes in Pima Indians.
Nair AK, Piaggi P, McLean NA, Kaur M, Kobes S, Knowler WC, Bogardus C, Hanson RL, Baier LJ., Free PMC Article | 12/17/2016 |
| KLF14 plays an important role in increasing glucose uptake and insulin sensitivity by the activation of PI3-kinase/Akt signaling pathway in vitro. | Krüppel-like factor 14 increases insulin sensitivity through activation of PI3K/Akt signal pathway.
Yang M, Ren Y, Lin Z, Tang C, Jia Y, Lai Y, Zhou T, Wu S, Liu H, Yang G, Li L. | 07/2/2016 |
| KLF14 transcription is significantly downregulated, whereas Plk4 transcription is upregulated in multiple types of cancers, and there exists an inverse correlation between KLF14 and Plk4 protein expression in human breast and colon cancers. | Loss of KLF14 triggers centrosome amplification and tumorigenesis.
Fan G, Sun L, Shan P, Zhang X, Huan J, Zhang X, Li D, Wang T, Wei T, Zhang X, Gu X, Yao L, Xuan Y, Hou Z, Cui Y, Cao L, Li X, Zhang S, Wang C., Free PMC Article | 05/7/2016 |