| Oligodendrocyte-selective deletion of the eIF2alpha kinase Perk/Eif2ak3 limits functional recovery after spinal cord injury. | Oligodendrocyte-selective deletion of the eIF2α kinase Perk/Eif2ak3 limits functional recovery after spinal cord injury.
Saraswat Ohri S, Forston MD, Myers SA, Brown BL, Andres KR, Howard RM, Gao Y, Liu Y, Cavener DR, Hetman M, Whittemore SR. | 05/13/2024 |
| Loss of TRIM29 mitigates viral myocarditis by attenuating PERK-driven ER stress response in male mice. | Loss of TRIM29 mitigates viral myocarditis by attenuating PERK-driven ER stress response in male mice.
Wang J, Lu W, Zhang J, Du Y, Fang M, Zhang A, Sungcad G, Chon S, Xing J., Free PMC Article | 04/29/2024 |
| DNAJC10 maintains survival and self-renewal of leukemia stem cells through PERK branch of the unfolded protein response. | DNAJC10 maintains survival and self-renewal of leukemia stem cells through PERK branch of the unfolded protein response.
Li M, Wu X, Chen M, Hao S, Yu Y, Li X, Zhao E, Xu M, Yu Z, Wang Z, Xu N, Jin C, Yin Y., Free PMC Article | 03/12/2024 |
| Partial Deletion of Perk Improved High-Fat Diet-Induced Glucose Intolerance in Mice. | Partial Deletion of Perk Improved High-Fat Diet-Induced Glucose Intolerance in Mice.
Lee J, Kim MJ, Moon S, Lim JY, Park KS, Jung HS., Free PMC Article | 01/9/2024 |
| ALKBH5 protects against stroke by reducing endoplasmic reticulum stress-dependent inflammation injury via the STAT5/PERK/EIF2alpha/CHOP signaling pathway in an m[6]A-YTHDF1-dependent manner. | ALKBH5 protects against stroke by reducing endoplasmic reticulum stress-dependent inflammation injury via the STAT5/PERK/EIF2α/CHOP signaling pathway in an m(6)A-YTHDF1-dependent manner.
Liu C, Chen H, Tao X, Li C, Li A, Wu W. | 01/4/2024 |
| Pericentrin deficiency in smooth muscle cells augments atherosclerosis through HSF1-driven cholesterol biosynthesis and PERK activation. | Pericentrin deficiency in smooth muscle cells augments atherosclerosis through HSF1-driven cholesterol biosynthesis and PERK activation.
Majumder S, Chattopadhyay A, Wright JM, Guan P, Buja LM, Kwartler CS, Milewicz DM., Free PMC Article | 11/14/2023 |
| SEL1L preserves CD8[+] T-cell survival and homeostasis by fine-tuning PERK signaling and the IL-15 receptor-mediated mTORC1 axis. | SEL1L preserves CD8(+) T-cell survival and homeostasis by fine-tuning PERK signaling and the IL-15 receptor-mediated mTORC1 axis.
Gao Y, Li W, Wang Z, Zhang C, He Y, Liu X, Tang K, Zhang W, Long Q, Liu Y, Zhang J, Zhang B, Zhang L., | 10/10/2023 |
| Role of PERK-mediated pathway in the effect of mild hypothermia after cerebral ischaemia/reperfusion. | Role of PERK-mediated pathway in the effect of mild hypothermia after cerebral ischaemia/reperfusion.
Zhao J, Xia C, Tang Y, Wan H. | 09/15/2023 |
| Astrocytic deletion of protein kinase R-like ER kinase (PERK) does not affect learning and memory in aged mice but worsens outcome from experimental stroke. | Astrocytic deletion of protein kinase R-like ER kinase (PERK) does not affect learning and memory in aged mice but worsens outcome from experimental stroke.
Lahiri A, Walton JC, Zhang N, Billington N, DeVries AC, Meares GP., | 08/16/2023 |
| PERK Inhibition Suppresses Neovascularization and Protects Neurons During Ischemia-Induced Retinopathy. | PERK Inhibition Suppresses Neovascularization and Protects Neurons During Ischemia-Induced Retinopathy.
Shi S, Ding C, Zhu S, Xia F, Buscho SE, Li S, Motamedi M, Liu H, Zhang W., Free PMC Article | 08/14/2023 |
| Oxidized phospholipids facilitate calcific aortic valve disease by elevating ATF4 through the PERK/eIF2alpha axis. | Oxidized phospholipids facilitate calcific aortic valve disease by elevating ATF4 through the PERK/eIF2α axis.
Zhu X, Yang L, Han X, Huang C, Huang G, Wei T, Shu L, Xu J., Free PMC Article | 08/7/2023 |
| The GRP78-PERK axis contributes to memory and synaptic impairments in Huntington's disease R6/1 mice. | The GRP78-PERK axis contributes to memory and synaptic impairments in Huntington's disease R6/1 mice.
Espina M, Di Franco N, Brañas-Navarro M, Navarro IR, Brito V, Lopez-Molina L, Costas-Insua C, Guzmán M, Ginés S. | 08/7/2023 |
| Connexin 37 sequestering of activated-ERK in the cytoplasm promotes p27-mediated endothelial cell cycle arrest. | Connexin 37 sequestering of activated-ERK in the cytoplasm promotes p27-mediated endothelial cell cycle arrest.
Acharya BR, Fang JS, Jeffery ED, Chavkin NW, Genet G, Vasavada H, Nelson EA, Sheynkman GM, Humphries MJ, Hirschi KK., Free PMC Article | 06/7/2023 |
| The inhibition of ORMDL3 prevents Alzheimer's disease through ferroptosis by PERK/ATF4/HSPA5 pathway. | The inhibition of ORMDL3 prevents Alzheimer's disease through ferroptosis by PERK/ATF4/HSPA5 pathway.
Shao Y, Xu Y, Di H, Shi X, Wang Y, Liu H, Song L., Free PMC Article | 05/19/2023 |
| PERK/ATF4-dependent expression of the stress response protein REDD1 promotes proinflammatory cytokine expression in the heart of obese mice. | PERK/ATF4-dependent expression of the stress response protein REDD1 promotes proinflammatory cytokine expression in the heart of obese mice.
Stevens SA, Gonzalez Aguiar MK, Toro AL, Yerlikaya EI, Sunilkumar S, VanCleave AM, Pfleger J, Bradley EA, Kimball SR, Dennis MD., Free PMC Article | 01/28/2023 |
| Scleral PERK and ATF6 as targets of myopic axial elongation of mouse eyes. | Scleral PERK and ATF6 as targets of myopic axial elongation of mouse eyes.
Ikeda SI, Kurihara T, Jiang X, Miwa Y, Lee D, Serizawa N, Jeong H, Mori K, Katada Y, Kunimi H, Ozawa N, Shoda C, Ibuki M, Negishi K, Torii H, Tsubota K., Free PMC Article | 10/22/2022 |
| Preventing Cholesterol-Induced Perk (Protein Kinase RNA-Like Endoplasmic Reticulum Kinase) Signaling in Smooth Muscle Cells Blocks Atherosclerotic Plaque Formation. | Preventing Cholesterol-Induced Perk (Protein Kinase RNA-Like Endoplasmic Reticulum Kinase) Signaling in Smooth Muscle Cells Blocks Atherosclerotic Plaque Formation.
Chattopadhyay A, Guan P, Majumder S, Kaw K, Zhou Z, Zhang C, Prakash SK, Kaw A, Buja LM, Kwartler CS, Milewicz DM., Free PMC Article | 08/6/2022 |
| PERK reprograms hematopoietic progenitor cells to direct tumor-promoting myelopoiesis in the spleen. | PERK reprograms hematopoietic progenitor cells to direct tumor-promoting myelopoiesis in the spleen.
Liu M, Wu C, Luo S, Hua Q, Chen HT, Weng Y, Xu J, Lin H, Wang L, Li J, Zhu L, Guo Z, Zhuang SM, Kang T, Zheng L., Free PMC Article | 05/7/2022 |
| PERK in POMC neurons connects celastrol with metabolism. | PERK in POMC neurons connects celastrol with metabolism.
He Z, Lieu L, Dong Y, Afrin S, Chau D, Kabahizi A, Wallace B, Cao J, Hwang ES, Yao T, Huang Y, Okolo J, Cheng B, Gao Y, Hu L, Williams KW., Free PMC Article | 03/19/2022 |
| Cell-type-specific disruption of PERK-eIF2alpha signaling in dopaminergic neurons alters motor and cognitive function. | Cell-type-specific disruption of PERK-eIF2α signaling in dopaminergic neurons alters motor and cognitive function.
Longo F, Mancini M, Ibraheem PL, Aryal S, Mesini C, Patel JC, Penhos E, Rahman N, Mamcarz M, Santini E, Rice ME, Klann E., Free PMC Article | 03/19/2022 |
| ER stress protein PERK promotes inappropriate innate immune responses and pathogenesis during RSV infection. | ER stress protein PERK promotes inappropriate innate immune responses and pathogenesis during RSV infection.
Narayanan S, Elesela S, Rasky AJ, Morris SH, Kumar S, Lombard D, Lukacs NW. | 02/12/2022 |
| A cold-stress-inducible PERK/OGT axis controls TOM70-assisted mitochondrial protein import and cristae formation. | A cold-stress-inducible PERK/OGT axis controls TOM70-assisted mitochondrial protein import and cristae formation.
Latorre-Muro P, O'Malley KE, Bennett CF, Perry EA, Balsa E, Tavares CDJ, Jedrychowski M, Gygi SP, Puigserver P., Free PMC Article | 01/29/2022 |
| Bisphenol A Induces Accelerated Cell Aging in Murine Endothelium. | Bisphenol A Induces Accelerated Cell Aging in Murine Endothelium.
Moreno-Gómez-Toledano R, Sánchez-Esteban S, Cook A, Mínguez-Moratinos M, Ramírez-Carracedo R, Reventún P, Delgado-Marín M, Bosch RJ, Saura M., Free PMC Article | 01/22/2022 |
| The PERK/PKR-eIF2alpha Pathway Negatively Regulates Porcine Hemagglutinating Encephalomyelitis Virus Replication by Attenuating Global Protein Translation and Facilitating Stress Granule Formation. | The PERK/PKR-eIF2α Pathway Negatively Regulates Porcine Hemagglutinating Encephalomyelitis Virus Replication by Attenuating Global Protein Translation and Facilitating Stress Granule Formation.
Shi J, Li Z, Xu R, Zhang J, Zhou Q, Gao R, Lu H, Lan Y, Zhao K, He H, Gao F, He W., Free PMC Article | 01/22/2022 |
| ER stress and its PERK branch enhance TCR-induced activation in regulatory T cells. | ER stress and its PERK branch enhance TCR-induced activation in regulatory T cells.
Feng ZZ, Luo N, Liu Y, Hu JN, Ma T, Yao YM. | 11/13/2021 |