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    CRHR1 corticotropin releasing hormone receptor 1 [ Homo sapiens (human) ]

    Gene ID: 1394, updated on 2-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Genetic Contributions to Attachment Stability Over Time: the Roles of CRHR1 Polymorphisms.

    Genetic Contributions to Attachment Stability Over Time: the Roles of CRHR1 Polymorphisms.
    Zhao W, Lan Q, Zhou M, Liang W, Yang Y, Gong P.

    01/7/2024
    CRHR1 polymorphism at rs242941, rs242940, and rs72834580: association of symptoms improvement with intranasal corticosteroids in allergic rhinitis Jordanian patients.

    CRHR1 polymorphism at rs242941, rs242940, and rs72834580: association of symptoms improvement with intranasal corticosteroids in allergic rhinitis Jordanian patients.
    Zihlif M, Abusara OH, Al-Qerem W, Al-Ibadah M, Mahafza TM, Al-Akhras FM, Mahafza NT.

    01/4/2024
    Novel corticotropin-releasing hormone receptor genes (CRHR1 and CRHR2) linkage to and association with polycystic ovary syndrome.

    Novel corticotropin-releasing hormone receptor genes (CRHR1 and CRHR2) linkage to and association with polycystic ovary syndrome.
    Amin M, Horst N, Wu R, Gragnoli C., Free PMC Article

    08/7/2023
    Genetic Variation, Stress, and Physiological Stress Response in Adults With Food Allergy or Celiac Disease.

    Genetic Variation, Stress, and Physiological Stress Response in Adults With Food Allergy or Celiac Disease.
    Ersig AL, Young EE, Brown RL, Malecki K.

    03/23/2023
    Relations among CRFR1 and FKBP5 genotype, cortisol, and cognitive function in aging humans: A Project FRONTIER study.

    Relations among CRFR1 and FKBP5 genotype, cortisol, and cognitive function in aging humans: A Project FRONTIER study.
    Harris BN, Cooke JT, Littlefield AK, Tucker CA, Campbell CM, King KS, Garrison Institute on Aging.

    08/6/2022
    The role of rs242941, rs1876828, rs242939 and rs110402 polymorphisms of CRHR1 gene and the depression: systematic review and meta-analysis.

    The role of rs242941, rs1876828, rs242939 and rs110402 polymorphisms of CRHR1 gene and the depression: systematic review and meta-analysis.
    Hernández-Díaz Y, González-Castro TB, Juárez-Rojop IE, Tovilla-Zárate CA, López-Narváez ML, Genis-Mendoza AD, Fresan A, Nicolini H.

    03/12/2022
    Spinal pain in employees exposed to abusive supervision: Evidence of a sex and CRHR1 CTC haplotype interaction.

    Spinal pain in employees exposed to abusive supervision: Evidence of a sex and CRHR1 CTC haplotype interaction.
    Sannes AC, Risøy A, Christensen JO, Nielsen MB, Gjerstad J., Free PMC Article

    01/22/2022
    Different effects of chronic social defeat on social behavior and the brain CRF system in adult male C57 mice with different susceptibilities.

    Different effects of chronic social defeat on social behavior and the brain CRF system in adult male C57 mice with different susceptibilities.
    Guo Q, Wang L, Yuan W, Li L, Zhang J, Hou W, Yang Y, Zhang X, Cai W, Ma H, Xun Y, Jia R, He Z, Tai F.

    05/22/2021
    Salivary cortisol response to psychosocial stress in the late evening depends on CRHR1 genotype.

    Salivary cortisol response to psychosocial stress in the late evening depends on CRHR1 genotype.
    Weeger J, Ising M, Müller-Myhsok B, Uhr M, Schmidt U, Steiger A.

    04/24/2021
    Prenatal and postnatal exposure to Tangshan earthquake and CRHR1 gene polymorphism influence risk of sleep disturbance in adulthood.

    Prenatal and postnatal exposure to Tangshan earthquake and CRHR1 gene polymorphism influence risk of sleep disturbance in adulthood.
    Chen YN, An CX, Wang R, Wang L, Song M, Yu LL, Sun FF, Wang XY., Free PMC Article

    03/27/2021
    Genetic variants in the glucocorticoid pathway genes and birth weight.

    Genetic variants in the glucocorticoid pathway genes and birth weight.
    Schneider MO, Hübner T, Pretscher J, Goecke TW, Schwitulla J, Häberle L, Kornhuber J, Ekici AB, Beckmann MW, Fasching PA, Schwenke E.

    03/20/2021
    Unveiling the genetic etiology of primary ciliary dyskinesia: When standard genetic approach is not enough.

    Unveiling the genetic etiology of primary ciliary dyskinesia: When standard genetic approach is not enough.
    Pereira R, Barbosa T, Alves Â, Santos R, Oliveira J, Sousa M.

    02/6/2021
    Association of Corticotropin-Releasing Hormone Receptor-1 Gene Polymorphisms and Personality Traits with Violent Aggression in Male Adolescents.

    Association of Corticotropin-Releasing Hormone Receptor-1 Gene Polymorphisms and Personality Traits with Violent Aggression in Male Adolescents.
    Liu L, Qiao Y, Shao Y, Yu SY, Zhang C, Zhang R, Wang DX, Zhao M, Xie B.

    11/21/2020
    Dysregulation of bladder corticotropin-releasing hormone receptor in the pathogenesis of human interstitial cystitis/bladder pain syndrome.

    Dysregulation of bladder corticotropin-releasing hormone receptor in the pathogenesis of human interstitial cystitis/bladder pain syndrome.
    Jhang JF, Birder LA, Jiang YH, Hsu YH, Ho HC, Kuo HC., Free PMC Article

    11/21/2020
    Aneurysmal subarachnoid haemorrhage: effect of CRHR1 genotype on fatigue and depression.

    Aneurysmal subarachnoid haemorrhage: effect of CRHR1 genotype on fatigue and depression.
    Vetkas A, Prans E, Kõks S, Rätsep T, Asser T., Free PMC Article

    09/12/2020
    Structural determinants governing beta-arrestin2 interaction with PDZ proteins and recruitment to CRFR1.

    Structural determinants governing β-arrestin2 interaction with PDZ proteins and recruitment to CRFR1.
    Gupta S, Abd-Elrahman KS, Albaker A, Dunn HA, Ferguson SSG.

    09/12/2020
    Genome-wide Association Study of Maximum Habitual Alcohol Intake in >140,000 U.S. European and African American Veterans Yields Novel Risk Loci.

    Genome-wide Association Study of Maximum Habitual Alcohol Intake in >140,000 U.S. European and African American Veterans Yields Novel Risk Loci.
    Gelernter J, Sun N, Polimanti R, Pietrzak RH, Levey DF, Lu Q, Hu Y, Li B, Radhakrishnan K, Aslan M, Cheung KH, Li Y, Rajeevan N, Sayward F, Harrington K, Chen Q, Cho K, Honerlaw J, Pyarajan S, Lencz T, Quaden R, Shi Y, Hunter-Zinck H, Gaziano JM, Kranzler HR, Concato J, Zhao H, Stein MB, Department of Veterans Affairs Cooperative Studies Program (No. 575B), Million Veteran Program., Free PMC Article

    08/15/2020
    DNA methylation levels within CpG sites in NR3C1, CRH, CRHR1, and CRHR2 were associated with risk for major depressive disorder across adolescence and young adulthood.

    DNA methylation of HPA-axis genes and the onset of major depressive disorder in adolescent girls: a prospective analysis.
    Humphreys KL, Moore SR, Davis EG, MacIsaac JL, Lin DTS, Kobor MS, Gotlib IH., Free PMC Article

    07/18/2020
    The activation of CRHR1 and CRHR2 remarkably reduced the conversion of microtubules-associated protein 1 light chain 3-B (LC3B) protein, LC3BI to LC3BII and hence repressed macroautophagy/autophagy, resulting in migration inhibition.

    Activated CRH receptors inhibit autophagy by repressing conversion of LC3BI to LC3BII.
    Jin L, Qian Y, Zhou J, Dai L, Cao C, Zhu C, Li S.

    07/18/2020
    Our results suggested that genetic variants of CRHR1 and CRHR2 genes in addition to physical negligence, and emotional and sexual abuse, contribute to increase risk of presented at least one suicide attempt

    Effect of CRHR1 and CRHR2 gene polymorphisms and childhood trauma in suicide attempt.
    Sanabrais-Jiménez MA, Sotelo-Ramirez CE, Ordoñez-Martinez B, Jiménez-Pavón J, Ahumada-Curiel G, Piana-Diaz S, Flores-Flores G, Flores-Ramos M, Jiménez-Anguiano A, Camarena B.

    07/4/2020
    Study has demonstrated that infant or fetus exposure to earthquake impairs visual spatial memory during adulthood and CRHR1 polymorphisms (rs242924 and rs7209436) and earthquake exposure may interact with each other to accentuate this impairment.

    Effects of early trauma and corticotropin-releasing factor receptor 1 gene polymorphism on adult visual spatial memory.
    Sun FF, Wang R, Li N, Zhao XC, Wang L, Song M, Yu LL, Chen YN, An CX, Wang XY., Free PMC Article

    06/20/2020
    CRHR1 SNP rs110402 genotype plays a role in psychosocial neural processing and cortisol response in healthy adults. The activity in dACC may mediate effect of rs110402 on psychosocial stress processing in the healthy population. Moreover, level of dACC activation may be associated with stress vulnerability.

    Effect of corticotropin-releasing hormone receptor1 gene variation on psychosocial stress reaction via the dorsal anterior cingulate cortex in healthy adults.
    Li C, Sun X, Dong D, Zhong X, Wang X, Yao S.

    06/13/2020
    rs7225082 in the intron of CRHR1 is significantly associated with the magnitude of decrease in respiratory severity score 7 days after starting treatment with systemic corticosteroid

    Genetic variation in CRHR1 is associated with short-term respiratory response to corticosteroids in preterm infants at risk for bronchopulmonary dysplasia.
    Lewis T, Truog W, Norberg M, Ballard PL, Torgerson D, TOLSURF Study Group., Free PMC Article

    05/16/2020
    Review: role of CRHR1 and CRHR2 in basic CV physiology and in the pathophysiology of CV diseases.[review]

    Corticotropin-Releasing Hormone Family and Their Receptors in the Cardiovascular System.
    Takefuji M, Murohara T.

    02/29/2020
    SNPs located in the corticotropin releasing factor receptor 1 (CRFR1) locus can impair the expression of several genes in several tissues, including terminal ileum and colon. This implies its association with Irritable bowel syndrome and would be in line with the brain-gut axis hypothesis.

    Mucosal RNA and protein expression as the next frontier in IBS: abnormal function despite morphologically intact small intestinal mucosa.
    Rodiño-Janeiro BK, Pardo-Camacho C, Santos J, Martínez C.

    02/15/2020
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