| CRKL Enhances YAP Signaling through Binding and JNK/JUN Pathway Activation in Liver Cancer. | CRKL Enhances YAP Signaling through Binding and JNK/JUN Pathway Activation in Liver Cancer.
Wesener MC, Weiler SME, Bissinger M, Klessinger TF, Rose F, Merker S, Luzarowski M, Ruppert T, Helm B, Klingmüller U, Schirmacher P, Breuhahn K., Free PMC Article | 09/19/2024 |
| CRKL dictates anti-PD-1 resistance by mediating tumor-associated neutrophil infiltration in hepatocellular carcinoma. | CRKL dictates anti-PD-1 resistance by mediating tumor-associated neutrophil infiltration in hepatocellular carcinoma.
Xie P, Yu M, Zhang B, Yu Q, Zhao Y, Wu M, Jin L, Yan J, Zhou B, Liu S, Li X, Zhou C, Zhu X, Huang C, Xu Y, Xiao Y, Zhou J, Fan J, Hung MC, Ye Q, Guo L, Li H. | 07/10/2024 |
| CRKL but not CRKII contributes to hemin-induced erythroid differentiation of CML. | CRKL but not CRKII contributes to hemin-induced erythroid differentiation of CML.
Guo C, Lv X, Zhang Q, Yi L, Ren Y, Li Z, Yan J, Zheng S, Sun MZ, Liu S., Free PMC Article | 05/9/2024 |
| Exploring the short linear motif-mediated protein-protein interactions of CrkL through ProP-PD. | Exploring the short linear motif-mediated protein-protein interactions of CrkL through ProP-PD.
Pagano L, Simonetti L, Pennacchietti V, Toto A, Malagrinò F, Ivarsson Y, Gianni S. | 03/15/2024 |
| Cancer-associated fibroblast exosome LINC00355 promotes epithelial-mesenchymal transition and chemoresistance in colorectal cancer through the miR-34b-5p/CRKL axis. | Cancer-associated fibroblast exosome LINC00355 promotes epithelial-mesenchymal transition and chemoresistance in colorectal cancer through the miR-34b-5p/CRKL axis.
Hu JH, Tang HN, Wang YH. | 02/22/2024 |
| Identification of CRKL as an oncogenic biomarker for prognosis and immunotherapy in melanoma, and its potential molecular mechanism. | Identification of CRKL as an oncogenic biomarker for prognosis and immunotherapy in melanoma, and its potential molecular mechanism.
Li Z, Wu X, Chen S, Zhong J, Qiu X, Kpegah JKSK, Shi K, Can L, Zhang X, Yin M, Xie H, Su J, Zhou J. | 05/28/2023 |
| Experimental Characterization of the Interaction between the N-Terminal SH3 Domain of Crkl and C3G. | Experimental Characterization of the Interaction between the N-Terminal SH3 Domain of Crkl and C3G.
Pagano L, Malagrinò F, Nardella C, Gianni S, Toto A., Free PMC Article | 02/5/2022 |
| Central 22q11.2 deletion (LCR22 B-D) in a fetus with severe fetal growth restriction and a mother with severe systemic lupus erythematosus: Further evidence of CRKL haploinsufficiency in the pathogenesis of 22q11.2 deletion syndrome. | Central 22q11.2 deletion (LCR22 B-D) in a fetus with severe fetal growth restriction and a mother with severe systemic lupus erythematosus: Further evidence of CRKL haploinsufficiency in the pathogenesis of 22q11.2 deletion syndrome.
Lin I, Afshar Y, Goldstein J, Grossman J, Grody WW, Quintero-Rivera F. | 01/22/2022 |
| Silencing of the CrkL gene reverses the doxorubicin resistance of K562/ADR cells through regulating PI3K/Akt/MRP1 signaling. | Silencing of the CrkL gene reverses the doxorubicin resistance of K562/ADR cells through regulating PI3K/Akt/MRP1 signaling.
Yu J, Chen WX, Xie WJ, Chen RW, Lin DQ, You WW, Ye WL, Zhang HQ, Lin DH, Xu JP., Free PMC Article | 01/15/2022 |
| Phosphorylation of CrkL S114 induced by common gamma chain cytokines and T-cell receptor signal transduction. | Phosphorylation of CrkL S114 induced by common gamma chain cytokines and T-cell receptor signal transduction.
Estrada A 3rd, Rodriguez AC, Rodriguez G, Grant AH, Ayala-Marin YM, Arrieta AJ, Kirken RA., Free PMC Article | 11/13/2021 |
| CRKL, AIFM3, AIF, BCL2, and UBASH3A during Human Kidney Development. | CRKL, AIFM3, AIF, BCL2, and UBASH3A during Human Kidney Development.
Lozic M, Minarik L, Racetin A, Filipovic N, Saraga Babic M, Vukojevic K., Free PMC Article | 10/16/2021 |
| CRKL promotes hepatocarcinoma through enhancing glucose metabolism of cancer cells via activating PI3K/Akt. | CRKL promotes hepatocarcinoma through enhancing glucose metabolism of cancer cells via activating PI3K/Akt.
Guo C, Gao C, Lv X, Zhao D, Greenaway FT, Hao L, Tian Y, Liu S, Sun MZ., Free PMC Article | 09/25/2021 |
| Quantitative assessment of glioblastoma phenotypes in vitro establishes cell migration as a robust readout of Crk and CrkL activity. | Quantitative assessment of glioblastoma phenotypes in vitro establishes cell migration as a robust readout of Crk and CrkL activity.
Park T, Large N, Curran T., Free PMC Article | 09/11/2021 |
| Bifunctional Role of CrkL during Bone Remodeling. | Bifunctional Role of CrkL during Bone Remodeling.
Kim JH, Kim K, Kim I, Seong S, Kook H, Kim KK, Koh JT, Kim N., Free PMC Article | 08/7/2021 |
| Novel role for CRK adaptor proteins as essential components of SRC/FAK signaling for epithelial-mesenchymal transition and colorectal cancer aggressiveness. | Novel role for CRK adaptor proteins as essential components of SRC/FAK signaling for epithelial-mesenchymal transition and colorectal cancer aggressiveness.
Franke FC, Slusarenko BO, Engleitner T, Johannes W, Laschinger M, Rad R, Nitsche U, Janssen KP. | 04/17/2021 |
| CRKL promotes proliferation, migration, invasion of laryngeal squamous cell carcinoma. | CRKL promotes proliferation, migration, invasion of laryngeal squamous cell carcinoma.
Yu M, Gong ZP, Ma ZL, Yao ZF, Liu C, Wang J, Li YS, Zhang ZX. | 04/3/2021 |
| Downregulated miR29a promotes B cell overactivation by upregulating Crklike protein in systemic lupus erythematosus. | Downregulated miR‑29a promotes B cell overactivation by upregulating Crk‑like protein in systemic lupus erythematosus.
Shi X, Ye L, Xu S, Guo G, Zuo Z, Ye M, Zhu L, Li B, Xue X, Lin Q, Ding X., Free PMC Article | 03/20/2021 |
| miR-429-CRKL axis regulates clear cell renal cell carcinoma malignant progression through SOS1/MEK/ERK/MMP2/MMP9 pathway. | miR-429-CRKL axis regulates clear cell renal cell carcinoma malignant progression through SOS1/MEK/ERK/MMP2/MMP9 pathway.
Wang J, Wang C, Li Q, Guo C, Sun W, Zhao D, Jiang S, Hao L, Tian Y, Liu S, Sun MZ. | 02/13/2021 |
| Crk1/2 and CrkL play critical roles in maintaining podocyte morphology and function. | Crk1/2 and CrkL play critical roles in maintaining podocyte morphology and function.
Du J, Meng L, Pang L, Jin B, Duan N, Huang C, Huang H, Li H. | 02/2/2021 |
| A novel ETV6-miR-429-CRKL regulatory circuitry contributes to aggressiveness of hepatocellular carcinoma. | A novel ETV6-miR-429-CRKL regulatory circuitry contributes to aggressiveness of hepatocellular carcinoma.
Guo C, Gao C, Zhao D, Li J, Wang J, Sun X, Liu Q, Hao L, Greenaway FT, Tian Y, Liu S, Sun MZ., Free PMC Article | 01/23/2021 |
| Copy number gains of the putative CRKL oncogene in laryngeal squamous cell carcinoma result in strong nuclear expression of the protein and influence cell proliferation and migration. | Copy number gains of the putative CRKL oncogene in laryngeal squamous cell carcinoma result in strong nuclear expression of the protein and influence cell proliferation and migration.
Kostrzewska-Poczekaj M, Bednarek K, Jarmuz-Szymczak M, Bodnar M, Filas V, Marszalek A, Bartochowska A, Grenman R, Kiwerska K, Szyfter K, Giefing M., Free PMC Article | 11/21/2020 |
| LncRNA FAL1 promotes the development of oral squamous cell carcinoma through regulating the microRNA-761/CRKL pathway. | LncRNA FAL1 promotes the development of oral squamous cell carcinoma through regulating the microRNA-761/CRKL pathway.
Ye J, Jiao Y. | 10/3/2020 |
| MiR-335 suppresses cell proliferation and migration by upregulating CRKL in bladder cancer. | MiR-335 suppresses cell proliferation and migration by upregulating CRKL in bladder cancer.
Liu XK, Chen D, Li X. | 08/13/2020 |
| High CRKL expression is associated with gastric cancer. | Overexpression of CrkL as a novel biomarker for poor prognosis in gastric cancer.
Feng R, Li J, Sah BK, Yuan F, Jin X, Yan M, Liu B, Li C, Zhu Z. | 03/21/2020 |
| This is the first report of CRKL-regulation of the alternative splicing of a number of genes critical in tumorigenesis and cancer progression, which is consistent with CRKL reported role as a signaling adaptor and a kinase. | CRKL regulates alternative splicing of cancer-related genes in cervical cancer samples and HeLa cell.
Song Q, Yi F, Zhang Y, Jun Li DK, Wei Y, Yu H, Zhang Y., Free PMC Article | 12/14/2019 |