| MUC17 mutations and methylation are associated with poor prognosis in adult-type diffuse glioma patients. | MUC17 mutations and methylation are associated with poor prognosis in adult-type diffuse glioma patients.
Machado GC, Ferrer VP. | 09/13/2023 |
| Acquired resistance to EGFR-TKIs in NSCLC mediates epigenetic downregulation of MUC17 by facilitating NF-kappaB activity via UHRF1/DNMT1 complex. | Acquired resistance to EGFR-TKIs in NSCLC mediates epigenetic downregulation of MUC17 by facilitating NF-κB activity via UHRF1/DNMT1 complex.
Lin S, Ruan H, Qin L, Zhao C, Gu M, Wang Z, Liu B, Wang H, Wang J., Free PMC Article | 02/15/2023 |
| Overexpression and increased presentation at the plasma membrane of wild-type MUC17 and its phosphodeficient variant MUC17 S-4492A protected Caco-2 cells against adhesion of enteropathogenic Escherichia coli, indicating that C-terminal phosphorylation of MUC17 may play a functional role in epithelial cell protection. | The human transmembrane mucin MUC17 responds to TNFα by increased presentation at the plasma membrane.
Schneider H, Berger E, Dolan B, Martinez-Abad B, Arike L, Pelaseyed T, Hansson GC., Free PMC Article | 03/21/2020 |
| MUC17 inactivated NFkappaB to inhibit gastric cancer cell proliferation in response to pro-inflammatory cytokines. The MUC17 function was dependent on its conserved epidermal growth factor domain and on downstream sequences to enable its interaction with myosin-9, resulting in a regulatory feedback loop between myosin-9, p53, and RhoA, and then activation of p38 to negatively regulate the NFkappaB pathway in gastric ca... | Mucin 17 inhibits the progression of human gastric cancer by limiting inflammatory responses through a MYH9-p53-RhoA regulatory feedback loop.
Yang B, Wu A, Hu Y, Tao C, Wang JM, Lu Y, Xing R., Free PMC Article | 12/14/2019 |
| MUC17 polymorphisms are involved in endometriosis development and the associated infertility in the Taiwanese population. | Genetic variations of MUC17 are associated with endometriosis development and related infertility.
Yang CW, Chang CY, Lai MT, Chang HW, Lu CC, Chen Y, Chen CM, Lee SC, Tsai PW, Yang SH, Lin CH, Sheu JJ, Tsai FJ., Free PMC Article | 10/24/2015 |
| Carbachol stimulated enterocyte MUC17 endocytosis is concomitant with NHE3 internalization and CFTR membrane recruitment. | Carbachol-induced MUC17 endocytosis is concomitant with NHE3 internalization and CFTR membrane recruitment in enterocytes.
Pelaseyed T, Gustafsson JK, Gustafsson IJ, Ermund A, Hansson GC., Free PMC Article | 10/26/2013 |
| The HIF1alpha-mediated hypoxic signal pathway contributes to MUC17 expression, and DNA methylation of hypoxia responsive element could be a determinant of the hypoxic inducibility of MUC17 in pancreatic cancer cells. | Expression of MUC17 is regulated by HIF1α-mediated hypoxic responses and requires a methylation-free hypoxia responsible element in pancreatic cancer.
Kitamoto S, Yokoyama S, Higashi M, Yamada N, Matsubara S, Takao S, Batra SK, Yonezawa S., Free PMC Article | 05/4/2013 |
| Both native and exogenous MUC17 play a role in attachment and invasion of enteroinvasive E. coli in colonic cell lines and in maintaining epithelial barrier function. | Muc17 protects intestinal epithelial cells from enteroinvasive E. coli infection by promoting epithelial barrier integrity.
Resta-Lenert S, Das S, Batra SK, Ho SB., Free PMC Article | 08/20/2011 |
| Hypomethylation status in the MUC17 promoter could be a novel epigenetic marker for the diagnosis of Pancreatic ductal adenocarcinomas. | DNA methylation and histone H3-K9 modifications contribute to MUC17 expression.
Kitamoto S, Yamada N, Yokoyama S, Houjou I, Higashi M, Goto M, Batra SK, Yonezawa S., Free PMC Article | 06/4/2011 |
| Results indicate that the potential protective effects of this membrane-bound mucin are primarily or secondarily diminished in inflammatory and neoplastic conditions. | Expression of intestinal MUC17 membrane-bound mucin in inflammatory and neoplastic diseases of the colon.
Senapati S, Ho SB, Sharma P, Das S, Chakraborty S, Kaur S, Niehans G, Batra SK., Free PMC Article | 02/26/2011 |
| augments intestinal cell restitution and enhances healing of experimental colitis in mice | Human intestinal MUC17 mucin augments intestinal cell restitution and enhances healing of experimental colitis.
Luu Y, Junker W, Rachagani S, Das S, Batra SK, Heinrikson RL, Shekels LL, Ho SB., Free PMC Article | 09/20/2010 |
| The authors demonstrate that apically atypical enteropathogenic Escherichia coli infection is followed by increased production of secreted MUC2 and MUC5AC mucins and membrane-bound MUC3 and MUC4 mucins. | Two atypical enteropathogenic Escherichia coli strains induce the production of secreted and membrane-bound mucins to benefit their own growth at the apical surface of human mucin-secreting intestinal HT29-MTX cells.
Vieira MA, Gomes TA, Ferreira AJ, Knöbl T, Servin AL, Liévin-Le Moal V., Free PMC Article | 03/29/2010 |
| Reflux laryngitis is associated with down-regulation of mucin gene expression. | Mucin gene expression in human laryngeal epithelia: effect of laryngopharyngeal reflux.
Samuels TL, Handler E, Syring ML, Pajewski NM, Blumin JH, Kerschner JE, Johnston N. | 01/21/2010 |
| Pdzk1 plays a specific role in stabilizing Muc17 in the apical membrane of small intestinal enterocytes. | The C-terminus of the transmembrane mucin MUC17 binds to the scaffold protein PDZK1 that stably localizes it to the enterocyte apical membrane in the small intestine.
Malmberg EK, Pelaseyed T, Petersson AC, Seidler UE, De Jonge H, Riordan JR, Hansson GC. | 01/21/2010 |
| surface localization of the smaller subunit of MUC17 is dependent on its N-glycosylation status | N-glycosylation is required for the surface localization of MUC17 mucin.
Ho JJ, Jaituni RS, Crawley SC, Yang SC, Gum JR, Kim YS. | 01/21/2010 |
| The MUC17 sequence has been extended toward its 5'-extremity to complete the sequence and localize the promoter and regulatory elements. | Characterization of human mucin MUC17. Complete coding sequence and organization.
Moniaux N, Junker WM, Singh AP, Jones AM, Batra SK. | 01/21/2010 |
| sequence homology & chromosome mapping | MUC17, a novel membrane-tethered mucin.
Gum JR Jr, Crawley SC, Hicks JW, Szymkowski DE, Kim YS. | 01/21/2010 |