| Podocyte SIRPalpha reduction aggravates lupus nephritis via promoting T cell inflammatory responses. | Podocyte SIRPα reduction aggravates lupus nephritis via promoting T cell inflammatory responses.
Qian B, Lu R, Mao S, Chen Y, Yang M, Zhang W, Zhang M, Zhu D, Liu Z, Zen K, Li L. | 09/25/2024 |
| Surfactant protein D prevents mucin overproduction in airway goblet cells via SIRPalpha. | Surfactant protein D prevents mucin overproduction in airway goblet cells via SIRPα.
Hata K, Tsubouchi K, Suzuki K, Eto D, Ando H, Yanagihara T, Kan-O K, Okamoto I., Free PMC Article | 02/1/2024 |
| Anti-tumor effect of PTEN and its effect on inhibition of the bone tumor through the CD47-SIRPalpha signaling pathway. | Anti-tumor effect of PTEN and its effect on inhibition of the bone tumor through the CD47-SIRPα signaling pathway.
Zhang Y, Hao J. | 02/1/2024 |
| A mAb to SIRPalpha downregulates the priming of naive CD4 + T cell in Primary immune thrombocytopenia. | A mAb to SIRPα downregulates the priming of naive CD4 + T cell in Primary immune thrombocytopenia.
Xie D, Feng Z, Yang W, Wang Y, Li R, Zhang S, Zhou Z. | 11/6/2023 |
| SIRP-alpha-IL-6 axis induces immunosuppressive macrophages in non-small-cell lung cancer. | SIRP-alpha-IL-6 axis induces immunosuppressive macrophages in non-small-cell lung cancer.
Wang B, Pan L, Chen M, Ma Y, Gao J, Tang D, Jiang Z. | 11/3/2023 |
| Clinical Significance of Signal Regulatory Protein Alpha (SIRPalpha) Expression in Hepatocellular Carcinoma. | Clinical Significance of Signal Regulatory Protein Alpha (SIRPα) Expression in Hepatocellular Carcinoma.
Tomiyama T, Itoh S, Iseda N, Toshida K, Kosai-Fujimoto Y, Tomino T, Kurihara T, Nagao Y, Morita K, Harada N, Liu YC, Ozaki D, Kohashi K, Oda Y, Mori M, Yoshizumi T. | 05/18/2023 |
| Clinical significance of signal regulatory protein alpha and T cell immunoreceptor with immunoglobulin and immunoreceptor tyrosine-based inhibition motif domain expression in undifferentiated pleomorphic sarcoma. | Clinical significance of signal regulatory protein alpha and T cell immunoreceptor with immunoglobulin and immunoreceptor tyrosine-based inhibition motif domain expression in undifferentiated pleomorphic sarcoma.
Ishihara S, Iwasaki T, Kohashi K, Kawaguchi K, Toda Y, Fujiwara T, Setsu N, Endo M, Matsumoto Y, Nakashima Y, Oda Y. | 04/27/2023 |
| Thrombospondin-1, CD47, and SIRPalpha display cell-specific molecular signatures in human islets and pancreata. | Thrombospondin-1, CD47, and SIRPα display cell-specific molecular signatures in human islets and pancreata.
Erdem N, Chen KT, Qi M, Zhao Y, Wu X, Garcia I, Ku HT, Montero E, Al-Abdullah IH, Kandeel F, Roep BO, Isenberg JS. | 03/30/2023 |
| Loss of myeloid cell-specific SIRPalpha, but not CD47, attenuates inflammation and suppresses atherosclerosis. | Loss of myeloid cell-specific SIRPα, but not CD47, attenuates inflammation and suppresses atherosclerosis.
Singla B, Lin HP, Ahn W, Xu J, Ma Q, Sghayyer M, Dong K, Cherian-Shaw M, Zhou J, Huo Y, White J, Csányi G., Free PMC Article | 01/7/2023 |
| SIRPalpha maintains macrophage homeostasis by interacting with PTK2B kinase in Mycobacterium tuberculosis infection and through autophagy and necroptosis. | SIRPα maintains macrophage homeostasis by interacting with PTK2B kinase in Mycobacterium tuberculosis infection and through autophagy and necroptosis.
Wang D, Lin Y, Xu F, Zhang H, Zhu X, Liu Z, Hu Y, Dong G, Sun B, Yu Y, Ma G, Tang Z, Legarda D, Ting A, Liu Y, Hou J, Dong L, Xiong H., Free PMC Article | 11/29/2022 |
| CD47-SIRPalpha Controls ADCC Killing of Primary T Cells by PMN Through a Combination of Trogocytosis and NADPH Oxidase Activation. | CD47-SIRPα Controls ADCC Killing of Primary T Cells by PMN Through a Combination of Trogocytosis and NADPH Oxidase Activation.
Gondois-Rey F, Miller T, Laletin V, Morelli X, Collette Y, Nunès J, Olive D., Free PMC Article | 07/23/2022 |
| XBP1 regulates the protumoral function of tumor-associated macrophages in human colorectal cancer. | XBP1 regulates the protumoral function of tumor-associated macrophages in human colorectal cancer.
Zhao Y, Zhang W, Huo M, Wang P, Liu X, Wang Y, Li Y, Zhou Z, Xu N, Zhu H., Free PMC Article | 03/5/2022 |
| CD47/SIRPalpha pathway mediates cancer immune escape and immunotherapy. | CD47/SIRPα pathway mediates cancer immune escape and immunotherapy.
Jia X, Yan B, Tian X, Liu Q, Jin J, Shi J, Hou Y., Free PMC Article | 02/26/2022 |
| Imaging of Glioblastoma Tumor-Associated Myeloid Cells Using Nanobodies Targeting Signal Regulatory Protein Alpha. | Imaging of Glioblastoma Tumor-Associated Myeloid Cells Using Nanobodies Targeting Signal Regulatory Protein Alpha.
De Vlaminck K, Romão E, Puttemans J, Pombo Antunes AR, Kancheva D, Scheyltjens I, Van Ginderachter JA, Muyldermans S, Devoogdt N, Movahedi K, Raes G., Free PMC Article | 02/12/2022 |
| Impact of SIRPalpha polymorphism on transplant outcomes in HLA-identical living donor kidney transplantation. | Impact of SIRPα polymorphism on transplant outcomes in HLA-identical living donor kidney transplantation.
Garcia-Sanchez C, Casillas-Abundis MA, Pinelli DF, Tambur AR, Hod-Dvorai R. | 12/4/2021 |
| Clinical significance of signal regulatory protein alpha (SIRPalpha) expression in esophageal squamous cell carcinoma. | Clinical significance of signal regulatory protein alpha (SIRPα) expression in esophageal squamous cell carcinoma.
Koga N, Hu Q, Sakai A, Takada K, Nakanishi R, Hisamatsu Y, Ando K, Kimura Y, Oki E, Oda Y, Mori M., Free PMC Article | 08/21/2021 |
| TSP1-CD47-SIRPalpha signaling facilitates the development of endometriosis by mediating the survival of ectopic endometrium. | TSP1-CD47-SIRPα signaling facilitates the development of endometriosis by mediating the survival of ectopic endometrium.
Liu Y, Li M, Wei C, Tang L, Sheng Y, Liu Y, Li D, Ding D, Qiu J, Zhu X. | 07/10/2021 |
| Expression and Prognostic Significance of CD47-SIRPA Macrophage Checkpoint Molecules in Colorectal Cancer. | Expression and Prognostic Significance of CD47-SIRPA Macrophage Checkpoint Molecules in Colorectal Cancer.
Sugimura-Nagata A, Koshino A, Inoue S, Matsuo-Nagano A, Komura M, Riku M, Ito H, Inoko A, Murakami H, Ebi M, Ogasawara N, Tsuzuki T, Takahashi S, Kasugai K, Kasai K, Inaguma S., Free PMC Article | 05/22/2021 |
| The CD47-SIRPalpha Immune Checkpoint. | The CD47-SIRPα Immune Checkpoint.
Logtenberg MEW, Scheeren FA, Schumacher TN., Free PMC Article | 11/21/2020 |
| Signal regulatory protein alpha protects podocytes through promoting autophagic activity. | Signal regulatory protein α protects podocytes through promoting autophagic activity.
Li L, Liu Y, Li S, Yang R, Zeng C, Rong W, Liang H, Zhang M, Zhu X, Kidder K, Liu Y, Liu Z, Zen K., Free PMC Article | 09/26/2020 |
| The enzymatic activity of isoQC is required for the sufficient binding of SIRPalpha to CD47. | Identification of Glutaminyl Cyclase isoenzyme isoQC as a regulator of SIRPα-CD47 axis.
Wu Z, Weng L, Zhang T, Tian H, Fang L, Teng H, Zhang W, Gao J, Hao Y, Li Y, Zhou H, Wang P., Free PMC Article | 09/12/2020 |
| Results show that SIRPalpha plays an important role as an anti-insulin mediator regulating pathways to cachexia. In muscle-specific SIRPalpha KO, changes in SIRPalpha serum levels seem to improve insulin signalling in muscle and white adipose tissue, suggesting crosstalk between muscle and adipose tissue. | Signal regulatory protein alpha initiates cachexia through muscle to adipose tissue crosstalk.
Wu J, Dong J, Verzola D, Hruska K, Garibotto G, Hu Z, Mitch WE, Thomas SS., Free PMC Article | 08/1/2020 |
| We also demonstrate the utility of the assay to characterize the activity of the first reported small molecule antagonists of the SIRPa-CD47 interaction. | A homogeneous SIRPα-CD47 cell-based, ligand-binding assay: Utility for small molecule drug development in immuno-oncology.
Burgess TL, Amason JD, Rubin JS, Duveau DY, Lamy L, Roberts DD, Farrell CL, Inglese J, Thomas CJ, Miller TW., Free PMC Article | 07/11/2020 |
| Increased numbers of high SIRPalpha expressing CD14(+) monocyte /macrophages were associated with an inferior survival in Follicular Lymphoma. | SIRPα expression delineates subsets of intratumoral monocyte/macrophages with different functional and prognostic impact in follicular lymphoma.
Chen YP, Kim HJ, Wu H, Price-Troska T, Villasboas JC, Jalali S, Feldman AL, Novak AJ, Yang ZZ, Ansell SM., Free PMC Article | 06/13/2020 |
| these results identify SIRPalpha as a counter-receptor for Mac-1 and suggest that the Mac-1-SIRPalpha interaction may be involved in macrophage fusion. | Interaction between the integrin Mac-1 and signal regulatory protein α (SIRPα) mediates fusion in heterologous cells.
Podolnikova NP, Hlavackova M, Wu Y, Yakubenko VP, Faust J, Balabiyev A, Wang X, Ugarova TP., Free PMC Article | 12/14/2019 |