| Fcgr2b and Fcgr3 are the major genetic factors for cartilage antibody-induced arthritis, overriding the effect of Hc encoding complement C5. | Fcgr2b and Fcgr3 are the major genetic factors for cartilage antibody-induced arthritis, overriding the effect of Hc encoding complement C5.
Xu Z, Moreno-Giró À, Zhao D, Krämer A, Pandey RK, Xu B, Lundström SL, Holmdahl R. | 04/18/2024 |
| Impact of surface receptors TLR2, CR3, and FcgammaRIII on Rhodococcus equi phagocytosis and intracellular survival in macrophages. | Impact of surface receptors TLR2, CR3, and FcγRIII on Rhodococcus equi phagocytosis and intracellular survival in macrophages.
da Silveira BP, Barhoumi R, Bray JM, Cole-Pfeiffer HM, Mabry CJ, Burghardt RC, Cohen ND, Bordin AI., Free PMC Article | 01/29/2024 |
| Role of FcgammaRIII in the nasal cavity of BALB/c mice in the primary amebic meningoencephalitis protection model. | Role of FcγRIII in the nasal cavity of BALB/c mice in the primary amebic meningoencephalitis protection model.
Rojas-Ortega DA, Rojas-Hernández S, Sánchez-Mendoza ME, Gómez-López M, Sánchez-Camacho JV, Rosales-Cruz E, Yépez MMC., Free PMC Article | 04/19/2023 |
| The CD3zeta adaptor structure determines functional differences between human and mouse CD16 Fc receptor signaling. | The CD3ζ adaptor structure determines functional differences between human and mouse CD16 Fc receptor signaling.
Aguilar OA, Fong LK, Ishiyama K, DeGrado WF, Lanier LL., Free PMC Article | 05/7/2022 |
| FcgRIII Deficiency and FcgRIIb Defeciency Promote Renal Injury in Diabetic Mice. | FcgRIII Deficiency and FcgRIIb Defeciency Promote Renal Injury in Diabetic Mice.
Zhang R, Wang T, Yin Q, Zhang J, Li L, Guo R, Han Q, Li H, Wang Y, Wang J, Gurung P, Lu Y, Cheng J, Bai L, Zhang J, Liu F., Free PMC Article | 02/8/2020 |
| Although enhanced humoral immune responses were observed in the absence of FcgammaRIIIA in the mouse asthma model, no overall regulation by FcgammaRIIIA, especially in terms of those parameters measuring lung tissue inflammation, was recorded. In the absence of FcgammaRIIB, augmented immune responses measured as serum antibody levels as well as those in various regulatory pathways in this mouse asthma model were observed. | FcγRIIIA Negatively Impacts Humoral Immune Responses but Not Overall Lung Inflammation in an Ovalbumin-Induced Allergic Asthma Mouse Model.
Zhou P, Wu T, Jin X, Li J, Yan H, Zhou L, Huang Y, Wang J, Zhou H, Zhu X, Zou X, Fang Y. | 05/26/2018 |
| FcgammaRIIb and FcgammaRIII are involved in the CRP-induced expression of MMPs and TIMP-1 and the CRP-induced phosphorylation of p38, whereas the FcgammaR-independent pathway may regulate the CRP-induced MMP-11 expression and the CRP-induced ERK1/2 phosphorylation. | Effects of C-reactive protein on the expression of matrix metalloproteinases and their inhibitors via Fcγ receptors on 3T3-L1 adipocytes.
Nakai K, Tanaka H, Yamanaka K, Takahashi Y, Murakami F, Matsuike R, Sekino J, Tanabe N, Morita T, Yamazaki Y, Kawato T, Maeno M., Free PMC Article | 03/3/2018 |
| PLCd1 negatively regulates lipopolysaccharide-induced production of IL-1b and Fc gamma receptor-mediated phagocytosis in macrophages. | Phospholipase C δ1 in macrophages negatively regulates TLR4-induced proinflammatory cytokine production and Fcγ receptor-mediated phagocytosis.
Kudo K, Uchida T, Sawada M, Nakamura Y, Yoneda A, Fukami K. | 11/18/2017 |
| Meanwhile, the observed reduction in the phagocytic activity of the MafB-shRNA-expressing cells was attenuated by ectopic expression of Fcgr3. Together, the results presented here indicate that MafB influences the phagocytic activity of macrophages by promoting Fcgr3, but not Fcgr2b, expression. | MafB enhances the phagocytic activity of RAW264.7 macrophages by promoting Fcgr3 expression.
Nemoto T, Shibata Y, Inoue S, Igarashi A, Tokairin Y, Yamauchi K, Kimura T, Sato M, Sato K, Nakano H, Abe S, Nishiwaki M, Kubota I. | 05/27/2017 |
| Fcgr3 resided in Kupffer cells, and it contributed to the inhibition of the growth of liver tumor cells. | Effect of CD16a, the surface receptor of Kupffer cells, on the growth of hepatocellular carcinoma cells.
Li XY, Wu L, Li SW, Zhou WB, Wang MY, Zuo GQ, Liu CA, Ding X., Free PMC Article | 03/4/2017 |
| FcgammaRIII knockout mice displayed significantly less cellular infiltration in the lungs after hRSV infection, compared with wild-type mice, suggesting a potentially harmful, IgG-independent role for this receptor in hRSV disease. | Contribution of Fcγ receptors to human respiratory syncytial virus pathogenesis and the impairment of T-cell activation by dendritic cells.
Gómez RS, Ramirez BA, Céspedes PF, Cautivo KM, Riquelme SA, Prado CE, González PA, Kalergis AM., Free PMC Article | 06/4/2016 |
| Nlrp3-inflammasome and FcgammaRIII have roles in Dengue virus and antiplatelet autoantibody-induced hemorrhage | Dengue virus and antiplatelet autoantibodies synergistically induce haemorrhage through Nlrp3-inflammasome and FcγRIII.
Lien TS, Sun DS, Chang CM, Wu CY, Dai MS, Chan H, Wu WS, Su SH, Lin YY, Chang HH. | 04/9/2016 |
| FcgammaRIII inhibits osteoclastogenesis by depriving other osteoclastogenic Ig-like receptors of FcRgamma. | Immune complexes regulate bone metabolism through FcRγ signalling.
Negishi-Koga T, Gober HJ, Sumiya E, Komatsu N, Okamoto K, Sawa S, Suematsu A, Suda T, Sato K, Takai T, Takayanagi H. | 03/26/2016 |
| Data show that mast cells (MC) FcgammaRIII-induced degranulation promotes antibody-enhanced vascular leakage. | Dengue vascular leakage is augmented by mast cell degranulation mediated by immunoglobulin Fcγ receptors.
Syenina A, Jagaraj CJ, Aman SA, Sridharan A, St John AL., Free PMC Article | 02/6/2016 |
| Fcgamma-RII and Fcgamma-RIII might participate in the uptake and/or transport of IgG through the intestinal epithelia of adult mice. | Intraperitoneal Immunization with Cry1Ac Protoxin from Bacillus thuringiensis Provokes Upregulation of Fc-Gamma-II/and Fc-Gamma-III Receptors Associated with IgG in the Intestinal Epithelium of Mice.
Moreno-Fierros L, Verdín-Terán SL, García-Hernández AL. | 09/26/2015 |
| Scavenger receptor function of mouse Fcgamma receptor III contributes to progression of atherosclerosis in apolipoprotein E hyperlipidemic mice. | Scavenger receptor function of mouse Fcγ receptor III contributes to progression of atherosclerosis in apolipoprotein E hyperlipidemic mice.
Zhu X, Ng HP, Lai YC, Craigo JK, Nagilla PS, Raghani P, Nagarajan S., Free PMC Article | 12/20/2014 |
| These results suggest that respiratory syncytial virus persistence in macrophages induce intracellular effects that have an impact on Fcgamma receptor gene expression at both mRNA and protein levels. | Respiratory syncytial virus persistence in macrophages upregulates Fcgamma receptors expression.
Gaona J, Santiago-Olivares C, Ortega E, Gómez B., Free PMC Article | 09/20/2014 |
| Antitumor activities of agonistic anti-TNFR antibodies require differential FcgammaRIIB coengagement in vivo. | Antitumor activities of agonistic anti-TNFR antibodies require differential FcγRIIB coengagement in vivo.
Li F, Ravetch JV., Free PMC Article | 02/1/2014 |
| These data demonstrate the initiation of endothelial barrier dysfunction in vitro and in vivo by direct binding of anti-HNA-3a on endothelial cells. | Anti-human neutrophil antigen-3a induced transfusion-related acute lung injury in mice by direct disturbance of lung endothelial cells.
Bayat B, Tjahjono Y, Sydykov A, Werth S, Hippenstiel S, Weissmann N, Sachs UJ, Santoso S. | 12/14/2013 |
| Absence of FcgammaRIII in heart transplantation is associated with enhanced inflammation, alloantibody production, and complement activation leading to accelerated cardiac allograft rejection. | Absence of FcγRIII results in increased proinflammatory response in FcγRIII-KO cardiac recipients.
Erdinc Sunay MM, Fox-Talbot K, Velidedeoglu E, Baldwin WM 3rd, Wasowska BA., Free PMC Article | 12/7/2013 |
| allergen-specific IgG can enhance secondary responses by ligating FcgammaRIII on antigen-presenting cells to augment development of Th2-mediated responses in the lungs via an IL-33-dependent mechanism | IL-33-dependent induction of allergic lung inflammation by FcγRIII signaling.
Tjota MY, Williams JW, Lu T, Clay BS, Byrd T, Hrusch CL, Decker DC, de Araujo CA, Bryce PJ, Sperling AI., Free PMC Article | 07/6/2013 |
| FcgammaRIII contributes to a therapy model of B16 lung metastases; activating IgG receptors are necessary for the protective effect of monoclonal antibody. | Cutting edge: FcγRIII (CD16) and FcγRI (CD64) are responsible for anti-glycoprotein 75 monoclonal antibody TA99 therapy for experimental metastatic B16 melanoma.
Albanesi M, Mancardi DA, Macdonald LE, Iannascoli B, Zitvogel L, Murphy AJ, Daëron M, Leusen JH, Bruhns P. | 02/23/2013 |
| NKG2D-mediated, but not Fc receptor-mediated, recognition increases natural killer (NK) cell degranulation; only NKG2D engagement substantially enhances degranulation. | Cutting edge: tumor-targeting antibodies enhance NKG2D-mediated NK cell cytotoxicity by stabilizing NK cell-tumor cell interactions.
Deguine J, Breart B, Lemaître F, Bousso P. | 02/23/2013 |
| The mechanism(s) of phagocytosis in the second phase of blood incompatibility reaction required neither C3 nor FcgammaRs | Biphasic clearance of incompatible red blood cells through a novel mechanism requiring neither complement nor Fcγ receptors in a murine model.
Liepkalns JS, Hod EA, Stowell SR, Cadwell CM, Spitalnik SL, Zimring JC. | 02/16/2013 |
| Our findings reveal a fine-tuning system for regulating mast cell apoptosis through aggregating FcgammaRIIB and Fcgamma RIIIA receptors by IgG immune complexes. | Apoptosis of mouse mast cells is reciprocally regulated by the IgG receptors FcγRIIB and FcγRIIIA.
Fang Y, Larsson L, Bruhns P, Xiang Z. | 02/2/2013 |