| SH3-domain mutations selectively disrupt Csk homodimerization or PTPN22 binding. | SH3-domain mutations selectively disrupt Csk homodimerization or PTPN22 binding.
Brian BF 4th, Sjaastad FV, Freedman TS., Free PMC Article | 04/23/2022 |
| Molecular mapping of platelet hyperreactivity in diabetes: the stress proteins complex HSPA8/Hsp90/CSK2alpha and platelet aggregation in diabetic and normal platelets. | Molecular mapping of platelet hyperreactivity in diabetes: the stress proteins complex HSPA8/Hsp90/CSK2α and platelet aggregation in diabetic and normal platelets.
Chiva-Blanch G, Peña E, Cubedo J, García-Arguinzonis M, Pané A, Gil PA, Perez A, Ortega E, Padró T, Badimon L. | 08/14/2021 |
| Depletion of Csk preferentially reduces the protein level of LynA in a Cbl-dependent manner in cancer cells. | Depletion of Csk preferentially reduces the protein level of LynA in a Cbl-dependent manner in cancer cells.
Kuga T, Yamane Y, Hayashi S, Taniguchi M, Yamaguchi N, Yamagishi N., Free PMC Article | 12/5/2020 |
| CSK promotes innate immune response to DNA virus by phosphorylating MITA. | CSK promotes innate immune response to DNA virus by phosphorylating MITA.
Gao P, Hu MM, Shu HB. | 11/28/2020 |
| CD28 functions as a novel adaptor protein for CSK, and CSK regulates signaling downstream of CD28 | Carboxyl-Terminal Src Kinase Binds CD28 upon Activation and Mutes Downstream Signaling.
Skånland SS, Taskén K. | 04/11/2020 |
| Here we report that Csk is covalently modified by SUMO1 at lysine 53 (K53) both in vitro and in vivo. Treatment with hydrogen peroxide inhibited this modification to a certain extent, but PIAS3, identified as the main specific SUMO E3 ligase for Csk, could significantly enhance SUMO1-Csk level | SUMOylation of Csk Negatively Modulates its Tumor Suppressor Function.
Cui N, Liu T, Guo Y, Dou J, Yang Q, Zhang H, Chen R, Wang Y, Zhao X, Yu J, Huang J., Free PMC Article | 12/21/2019 |
| results demonstrate that c-Src directly phosphorylates the Notch intracellular domain at specific tyrosine residues and that mutation of these phosphorylation sites increases Notch responsive transcriptional activity. | Src kinase phosphorylates Notch1 to inhibit MAML binding.
LaFoya B, Munroe JA, Pu X, Albig AR., Free PMC Article | 12/14/2019 |
| This study demonstrate that in FcepsilonRI-activated mast cells CSK is a negative regulator of degranulation and chemotaxis, but a positive regulator of adhesion to fibronectin and production of proinflammatory cytokines. | Positive and Negative Regulatory Roles of C-Terminal Src Kinase (CSK) in FcεRI-Mediated Mast Cell Activation, Independent of the Transmembrane Adaptor PAG/CSK-Binding Protein.
Potuckova L, Draberova L, Halova I, Paulenda T, Draber P., Free PMC Article | 10/12/2019 |
| identified a novel and critical role of c-Src in guiding human neural stem cells differentiation to an oligodendrocyte lineage | Oligodendrocyte differentiation from human neural stem cells: A novel role for c-Src.
Wang L, Schlagal CR, Gao J, Hao Y, Dunn TJ, McGrath EL, Labastida JA, Yu Y, Feng SQ, Liu SY, Wu P. | 09/21/2019 |
| CSK is down-regulated in patients with rheumatoid arthritis. | Protein tyrosine phosphatase non-receptor 22 and C-Src tyrosine kinase genes are down-regulated in patients with rheumatoid arthritis.
Remuzgo-Martínez S, Genre F, Castañeda S, Corrales A, Moreno-Fresneda P, Ubilla B, Mijares V, Portilla V, González-Vela J, Pina T, Ocejo-Vinyals G, Irure-Ventura J, Blanco R, Martín J, Llorca J, López-Mejías R, González-Gay MA., Free PMC Article | 05/4/2019 |
| Meta-analysis shows that C-allele of CSK (rs1378942) associates with higher systolic and diastolic blood pressure in East Asian populations. | C-src tyrosine kinase gene rs1378942 polymorphism and hypertension in Asians: Review and meta-analysis.
Qian X, Li Y, Liu X, Tu R, Tian Z, Zhang H, Zhang X, Zhou W, Jiang J, Wang Y, Bie R, Wang C. | 04/27/2019 |
| It was discovered that pseudo-kinase pragmin uses the tyrosine kinase CSK to induce protein tyrosine phosphorylation in human cells. | Dimerization of the Pragmin Pseudo-Kinase Regulates Protein Tyrosine Phosphorylation.
Lecointre C, Simon V, Kerneur C, Allemand F, Fournet A, Montarras I, Pons JL, Gelin M, Brignatz C, Urbach S, Labesse G, Roche S. | 01/12/2019 |
| Study indicated that MTHFR rs1801133, FGF5 rs16998073 and CSK rs1378942 were associated with increased the risk of obesity in the Chinese children. | Gene-gene interactions and associations of six hypertension related single nucleotide polymorphisms with obesity risk in a Chinese children population.
Fu L, Zhang M, Hu YQ, Zhao X, Cheng H, Hou D, Mi J. | 10/27/2018 |
| These results identified a novel role for Csk as a host tyrosine kinase involved in dengue virus replication. | Identification and characterization of the role of c-terminal Src kinase in dengue virus replication.
Kumar R, Agrawal T, Khan NA, Nakayama Y, Medigeshi GR., Free PMC Article | 04/28/2018 |
| Domain interactions of C-terminal Src Kinase determined through NMR spectroscopy with segmental isotope labeling | Domain interactions of C-terminal Src Kinase determined through NMR spectroscopy with segmental isotope labeling.
Liu D, Yuan Y, Xu R, Cowburn D., Free PMC Article | 01/13/2018 |
| Data suggest that myristoylation of Src kinase is essential to facilitate Src-induced and high-fat diet-accelerated prostatic tumor progression; targeting Src kinase myristoylation, which is required for Src kinase association at cellular membrane, blocks dietary fat-accelerated tumorigenesis. | Myristoylation of Src kinase mediates Src-induced and high-fat diet-accelerated prostate tumor progression in mice.
Kim S, Yang X, Li Q, Wu M, Costyn L, Beharry Z, Bartlett MG, Cai H., Free PMC Article | 12/23/2017 |
| Linear mixed-effect regressions showed significant association between rs1378942 in CSK and systolic blood pressure (beta = 0.98+/-0.46, P = 3.4x10-2). The child genotype scores for diastolic and systolic blood pressure were not associated in children. | Parental and offspring contribution of genetic markers of adult blood pressure in early life: The FAMILY study.
Robiou-du-Pont S, Anand SS, Morrison KM, McDonald SD, Atkinson SA, Teo KK, Meyre D., Free PMC Article | 10/28/2017 |
| H2O2-induced Csk translocation to the plasma membrane leads to phosphorylation of Src at the tyrosine 530 residue resulting in a reduction of ERK1/2 phosphorylation. | Csk-Induced Phosphorylation of Src at Tyrosine 530 is Essential for H2O2-Mediated Suppression of ERK1/2 in Human Umbilical Vein Endothelial Cells.
Jeon BK, Kwon K, Kang JL, Choi YH., Free PMC Article | 09/2/2017 |
| Data suggest that as a natural inhibitor of c-Src kinase, naringin could be an effective candidate for the treatment of melanoma. | Naringin suppresses the metabolism of A375 cells by inhibiting the phosphorylation of c-Src.
Guo B, Zhang Y, Hui Q, Wang H, Tao K. | 02/18/2017 |
| deregulation of the Pragmin-Csk axis may induce aberrant cell migration that contributes to tumor invasion and metastasis | C-terminal Src kinase-mediated EPIYA phosphorylation of Pragmin creates a feed-forward C-terminal Src kinase activation loop that promotes cell motility.
Senda Y, Murata-Kamiya N, Hatakeyama M., Free PMC Article | 02/18/2017 |
| Our results do not support association between PTPN22/CSK and Henoch-Schonlein purpura | Role of PTPN22 and CSK gene polymorphisms as predictors of susceptibility and clinical heterogeneity in patients with Henoch-Schönlein purpura (IgA vasculitis).
López-Mejías R, Genre F, Remuzgo-Martínez S, Pérez BS, Castañeda S, Llorca J, Ortego-Centeno N, Ubilla B, Mijares V, Pina T, Calvo-Río V, Palmou N, Miranda-Filloy JA, Parejo AN, Argila D, Sánchez-Pérez J, Rubio E, Luque ML, Blanco-Madrigal JM, Galíndez-Aguirregoikoa E, Ocejo-Vinyals JG, Martín J, Blanco R, González-Gay MA., Free PMC Article | 08/20/2016 |
| Results identify CSK downregulation as a principal driver of SRC activation and castration resistance. | Downregulation of c-SRC kinase CSK promotes castration resistant prostate cancer and pinpoints a novel disease subclass.
Yang CC, Fazli L, Loguercio S, Zharkikh I, Aza-Blanc P, Gleave ME, Wolf DA., Free PMC Article | 08/6/2016 |
| Variant rs1378942 near CSK was nominally associated with systolic blood pressure in a Chinese population. | Variant Near FGF5 Has Stronger Effects on Blood Pressure in Chinese With a Higher Body Mass Index.
Li J, Shi J, Huang W, Sun J, Wu Y, Duan Q, Luo J, Lange LA, Gordon-Larsen P, Zheng SL, Yuan W, Wang Y, Popkin BM, Mo Z, Xu J, Du S, Mohlke KL, Lange EM., Free PMC Article | 04/9/2016 |
| CSK is the kinase responsible for C-terminal phosphorylation of SRC, but not BRK. | Protein-tyrosine Phosphatase and Kinase Specificity in Regulation of SRC and Breast Tumor Kinase.
Fan G, Aleem S, Yang M, Miller WT, Tonks NK., Free PMC Article | 10/3/2015 |
| Data indicate that the potent c-Src inhibitors pyrazolo[3,4-d]pyrimidines showed in vivo activity in neuroblastoma xenograft model. | Combining X-ray crystallography and molecular modeling toward the optimization of pyrazolo[3,4-d]pyrimidines as potent c-Src inhibitors active in vivo against neuroblastoma.
Tintori C, Fallacara AL, Radi M, Zamperini C, Dreassi E, Crespan E, Maga G, Schenone S, Musumeci F, Brullo C, Richters A, Gasparrini F, Angelucci A, Festuccia C, Delle Monache S, Rauh D, Botta M. | 05/2/2015 |