| [Monogenic variants in Laccase domain-containing 1 (LACC1) as the cause of juvenile arthritis]. | [Monogenic variants in Laccase domain-containing 1 (LACC1) as the cause of juvenile arthritis].
Knieper AM, von Stuckrad ASL, Minden K, Goetzke CC, Kallinich T. | 02/13/2024 |
| LACC1: A critical involvement in macrophage immunometabolism. | LACC1: A critical involvement in macrophage immunometabolism.
Li Y, Wu Z, Tan X, Tang L, Ouyang F. | 08/9/2023 |
| LACC1 bridges NOS2 and polyamine metabolism in inflammatory macrophages. | LACC1 bridges NOS2 and polyamine metabolism in inflammatory macrophages.
Wei Z, Oh J, Flavell RA, Crawford JM., Free PMC Article | 10/1/2022 |
| [Macrophage involvement in juvenile arthritis onset: LACC1 bridges the gap?]", trans "Role des macrophages dans le developpement de l'arthrite juvenile - LACC1 fait-il le lien ? | [Macrophage involvement in juvenile arthritis onset: LACC1 bridges the gap?].
Mathieu AL, Omarjee O, Walzer T, Belot A. | 04/16/2022 |
| A novel loss-of-function mutation in LACC1 underlies hereditary juvenile arthritis with extended intra-familial phenotypic heterogeneity. | A novel loss-of-function mutation in LACC1 underlies hereditary juvenile arthritis with extended intra-familial phenotypic heterogeneity.
Butbul Aviel Y, Ofir A, Ben-Izhak O, Vlodavsky E, Karbian N, Brik R, Mevorach D, Magen D. | 02/12/2022 |
| LACC1 deficiency links juvenile arthritis with autophagy and metabolism in macrophages. | LACC1 deficiency links juvenile arthritis with autophagy and metabolism in macrophages.
Omarjee O, Mathieu AL, Quiniou G, Moreews M, Ainouze M, Frachette C, Melki I, Dumaine C, Gerfaud-Valentin M, Duquesne A, Kallinich T, Tahir Turanli E, Malcus C, Viel S, Pescarmona R, Georgin-Lavialle S, Jamilloux Y, Larbre JP, Sarrabay G, Magnotti F, Rice GI, Bleicher F, Reboulet J, Merabet S, Henry T, Crow YJ, Faure M, Walzer T, Belot A., Free PMC Article | 09/18/2021 |
| LACC1 Required for NOD2-Induced, ER Stress-Mediated Innate Immune Outcomes in Human Macrophages and LACC1 Risk Variants Modulate These Outcomes. | LACC1 Required for NOD2-Induced, ER Stress-Mediated Innate Immune Outcomes in Human Macrophages and LACC1 Risk Variants Modulate These Outcomes.
Huang C, Hedl M, Ranjan K, Abraham C., Free PMC Article | 09/26/2020 |
| Our findings confirm that LACC1 variants can be responsible for the recessive form of juvenile arthritis. | LACC1 Gene Defects in Familial Form of Juvenile Arthritis.
Karacan I, Uğurlu S, Şahin S, Everest E, Kasapçopur Ö, Tolun A, Özdoğan H, Turanli ET. | 11/16/2019 |
| mRNA expression levels of both HIF1A and LACC1 were upregulated in the skin lesions of individuals with leprosy. | Missense Variants in HIF1A and LACC1 Contribute to Leprosy Risk in Han Chinese.
Wang D, Fan Y, Malhi M, Bi R, Wu Y, Xu M, Yu XF, Long H, Li YY, Zhang DF, Yao YG., Free PMC Article | 12/22/2018 |
| LACC1 is critical for amplifying PRR-induced outcomes, an effect that is attenuated by the LACC1 disease-risk variant. | Human LACC1 increases innate receptor-induced responses and a LACC1 disease-risk variant modulates these outcomes.
Lahiri A, Hedl M, Yan J, Abraham C., Free PMC Article | 11/24/2018 |
| FAMIN is a peroxisome-associated protein with primary role(s) in macrophages and other immune cells, where its metabolic functions may be modulated by PPAR signaling events | Functional Analyses of the Crohn's Disease Risk Gene LACC1.
Assadi G, Vesterlund L, Bonfiglio F, Mazzurana L, Cordeddu L, Schepis D, Mjösberg J, Ruhrmann S, Fabbri A, Vukojevic V, Percipalle P, Salomons FA, Laurencikiene J, Törkvist L, Halfvarson J, D'Amato M., Free PMC Article | 07/15/2017 |
| The results show that a frameshift mutation in LACC1 leads to a similar juvenile arthritis phenotype as previously described. This mutations strongly supports the significance of these gene variants in the development of juvenile arthritis | Juvenile arthritis caused by a novel FAMIN (LACC1) mutation in two children with systemic and extended oligoarticular course.
Kallinich T, Thorwarth A, von Stuckrad SL, Rösen-Wolff A, Luksch H, Hundsdoerfer P, Minden K, Krawitz P., Free PMC Article | 04/1/2017 |
| LACC1 common SNPs represent genetic risk factors also for JIA and ulcerative colitis. | LACC1 polymorphisms in inflammatory bowel disease and juvenile idiopathic arthritis.
Assadi G, Saleh R, Hadizadeh F, Vesterlund L, Bonfiglio F, Halfvarson J, Törkvist L, Eriksson AS, Harris HE, Sundberg E, D'Amato M. | 02/18/2017 |
| There is an association of a mutation in LACC1 with a monogenic form of systemic juvenile idiopathic arthritis. | Association of a mutation in LACC1 with a monogenic form of systemic juvenile idiopathic arthritis.
Wakil SM, Monies DM, Abouelhoda M, Al-Tassan N, Al-Dusery H, Naim EA, Al-Younes B, Shinwari J, Al-Mohanna FA, Meyer BF, Al-Mayouf S. | 04/4/2015 |
| Association between leprosy and tag SNPs at NOD2 (rs8057431) and CCDC122-LACC1 (rs4942254). | NOD2 and CCDC122-LACC1 genes are associated with leprosy susceptibility in Brazilians.
Sales-Marques C, Salomão H, Fava VM, Alvarado-Arnez LE, Amaral EP, Cardoso CC, Dias-Batista IM, da Silva WL, Medeiros P, da Cunha Lopes Virmond M, Lana FC, Pacheco AG, Moraes MO, Mira MT, Pereira Latini AC. | 02/14/2015 |
| Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) | Genomewide association study of leprosy.
Zhang FR, Huang W, Chen SM, Sun LD, Liu H, Li Y, Cui Y, Yan XX, Yang HT, Yang RD, Chu TS, Zhang C, Zhang L, Han JW, Yu GQ, Quan C, Yu YX, Zhang Z, Shi BQ, Zhang LH, Cheng H, Wang CY, Lin Y, Zheng HF, Fu XA, Zuo XB, Wang Q, Long H, Sun YP, Cheng YL, Tian HQ, Zhou FS, Liu HX, Lu WS, He SM, Du WL, Shen M, Jin QY, Wang Y, Low HQ, Erwin T, Yang NH, Li JY, Zhao X, Jiao YL, Mao LG, Yin G, Jiang ZX, Wang XD, Yu JP, Hu ZH, Gong CH, Liu YQ, Liu RY, Wang DM, Wei D, Liu JX, Cao WK, Cao HZ, Li YP, Yan WG, Wei SY, Wang KJ, Hibberd ML, Yang S, Zhang XJ, Liu JJ. | 01/20/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (4) articlesAssociation between genome-wide association studies reported SNPs and pediatric-onset Crohn's disease in Canadian children.
Amre DK, Mack DR, Morgan K, Israel D, Deslandres C, Seidman EG, Lambrette P, Costea I, Krupoves A, Fegury H, Dong J, Xhu Z, Grimard G, Levy E. Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging.
Wheeler HE, Metter EJ, Tanaka T, Absher D, Higgins J, Zahn JM, Wilhelmy J, Davis RW, Singleton A, Myers RM, Ferrucci L, Kim SK. Analysis of 39 Crohn's disease risk loci in Swedish inflammatory bowel disease patients.
Törkvist L, Halfvarson J, Ong RT, Lördal M, Sjöqvist U, Bresso F, Björk J, Befrits R, Löfberg R, Blom J, Carlson M, Padyukov L, D'Amato M, Seielstad M, Pettersson S. Investigation of Crohn's disease risk loci in ulcerative colitis further defines their molecular relationship.
Anderson CA, Massey DC, Barrett JC, Prescott NJ, Tremelling M, Fisher SA, Gwilliam R, Jacob J, Nimmo ER, Drummond H, Lees CW, Onnie CM, Hanson C, Blaszczyk K, Ravindrarajah R, Hunt S, Varma D, Hammond N, Lewis G, Attlesey H, Watkins N, Ouwehand W, Strachan D, McArdle W, Lewis CM, Wellcome Trust Case Control Consortium, Lobo A, Sanderson J, Jewell DP, Deloukas P, Mansfield JC, Mathew CG, Satsangi J, Parkes M. | 01/11/2009 |