| Goosecoid promotes pancreatic adenocarcinoma metastasis through TGF-beta signaling. | Goosecoid promotes pancreatic adenocarcinoma metastasis through TGF-β signaling.
Meng Y, Li R, Jiang W, Chen W, Li Z, Xu Z, Geng S. | 08/6/2024 |
| USP21 modulates Goosecoid function through deubiquitination. | USP21 modulates Goosecoid function through deubiquitination.
Liu F, Fu Q, Li Y, Zhang K, Tang M, Jiang W, Bo B, Cui Y, Kong L., Free PMC Article | 09/12/2020 |
| Performed mutational analysis of TCOF1, GSC, and HOXA2 to determine the mutational features of the 3 genes in Chinese patients with Treacher Collins syndrome. | Mutational Analysis of TCOF1, GSC, and HOXA2 in Patients With Treacher Collins Syndrome.
Hao S, Jin L, Wang H, Li C, Zheng F, Ma D, Zhang T., Free PMC Article | 02/24/2018 |
| We find that DIGIT is divergent to Goosecoid (GSC) and expressed during endoderm differentiation. Deletion of the SMAD3-occupied enhancer proximal to DIGIT inhibits DIGIT and GSC expression and definitive endoderm differentiation. | DIGIT Is a Conserved Long Noncoding RNA that Regulates GSC Expression to Control Definitive Endoderm Differentiation of Embryonic Stem Cells.
Daneshvar K, Pondick JV, Kim BM, Zhou C, York SR, Macklin JA, Abualteen A, Tan B, Sigova AA, Marcho C, Tremblay KD, Mager J, Choi MY, Mullen AC., Free PMC Article | 12/2/2017 |
| 5 genomic variants in GSC, HOXA2 and PRKRA were identified through mutational analysis in Chinese patients with microtia. | Mutational analysis of GSC, HOXA2 and PRKRA in 106 Chinese patients with microtia.
Hao S, Jin L, Li C, Wang H, Zheng F, Ma D, Zhang T. | 03/18/2017 |
| GSC is also a prognostic factor for poor survival and metastasis of HCC, which suggests its potential as a therapeutic target for metastatic HCC. | Goosecoid promotes the metastasis of hepatocellular carcinoma by modulating the epithelial-mesenchymal transition.
Xue TC, Ge NL, Zhang L, Cui JF, Chen RX, You Y, Ye SL, Ren ZG., Free PMC Article | 07/4/2015 |
| Results suggest that GSC is the most potential biomarker of drug response and poor prognosis in ovarian serous carcinomas. | Overexpression of goosecoid homeobox is associated with chemoresistance and poor prognosis in ovarian carcinoma.
Kang KW, Lee MJ, Song JA, Jeong JY, Kim YK, Lee C, Kim TH, Kwak KB, Kim OJ, An HJ. | 01/17/2015 |
| EtOH exposure increased the expression of an organizer specific gene, goosecoid, in human embryonic carcinoma cells. | Chronic ethanol exposure increases goosecoid (GSC) expression in human embryonic carcinoma cell differentiation.
Halder D, Park JH, Choi MR, Chai JC, Lee YS, Mandal C, Jung KH, Chai YG. | 11/8/2014 |
| SAMS, a syndrome of short stature, auditory-canal atresia, mandibular hypoplasia, and skeletal abnormalities is a unique neurocristopathy caused by mutations in Goosecoid. | SAMS, a syndrome of short stature, auditory-canal atresia, mandibular hypoplasia, and skeletal abnormalities is a unique neurocristopathy caused by mutations in Goosecoid.
Parry DA, Logan CV, Stegmann AP, Abdelhamed ZA, Calder A, Khan S, Bonthron DT, Clowes V, Sheridan E, Ghali N, Chudley AE, Dobbie A, Stumpel CT, Johnson CA., Free PMC Article | 02/15/2014 |
| GSC represses EVX1 expression and is required for development of anterior primitive-streak-like cell progeny in response to activin. | EVEN-SKIPPED HOMEOBOX 1 controls human ES cell differentiation by directly repressing GOOSECOID expression.
Kalisz M, Winzi M, Bisgaard HC, Serup P. | 03/3/2012 |
| the 4 recently reported SNPs,located near BNC2, SORCS1, GSC and WDR72 loci, affecting glycemic control in type 1 diabetes had no apparent effect on HbA1c in type 2 diabetes; but, for SORCS1 SNP, findings do not rule out possible relationship with HbA1c | Evaluation of four novel genetic variants affecting hemoglobin A1c levels in a population-based type 2 diabetes cohort (the HUNT2 study).
Hertel JK, Johansson S, Ræder H, Platou CG, Midthjell K, Hveem K, Molven A, Njølstad PR., Free PMC Article | 04/16/2011 |
| The goosecoid gene mutation in exon 3 may be involved in the malformation events (microtia) in this family. | Pedigree and genetic study of a bilateral congenital microtia family.
Zhang Q, Zhang J, Yin W. | 04/19/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | Environmental and genetic factors associated with congenital microtia: a case-control study in Jiangsu, China, 2004 to 2007.
Zhang QG, Zhang J, Yu P, Shen H. | 01/20/2010 |
| Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) | A genome-wide association study identifies a novel major locus for glycemic control in type 1 diabetes, as measured by both A1C and glucose.
Paterson AD, Waggott D, Boright AP, Hosseini SM, Shen E, Sylvestre MP, Wong I, Bharaj B, Cleary PA, Lachin JM, MAGIC (Meta-Analyses of Glucose and Insulin-related traits Consortium), Below JE, Nicolae D, Cox NJ, Canty AJ, Sun L, Bull SB, Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research Group., Free PMC Article | 12/2/2009 |
| GSC protein might contribute to the observed phenotype. | A child with deletion (14)(q24.3q32.13) and auditory neuropathy.
Schlade-Bartusiak K, Macintyre G, Zunich J, Cox DW. | 01/21/2010 |
| Goosecoid promotes tumor cell malignancy and suggest that other conserved organizer genes may function similarly in human cancer | The Spemann organizer gene, Goosecoid, promotes tumor metastasis.
Hartwell KA, Muir B, Reinhardt F, Carpenter AE, Sgroi DC, Weinberg RA., Free PMC Article | 01/21/2010 |