| Growth Hormone Action in Somatostatin Neurons Regulates Anxiety and Fear Memory. | Growth Hormone Action in Somatostatin Neurons Regulates Anxiety and Fear Memory.
Dos Santos WO, Juliano VAL, Chaves FM, Vieira HR, Frazao R, List EO, Kopchick JJ, Munhoz CD, Donato J Jr., Free PMC Article | 02/15/2024 |
| Tmem263 deletion disrupts the GH/IGF-1 axis and causes dwarfism and impairs skeletal acquisition. | Tmem263 deletion disrupts the GH/IGF-1 axis and causes dwarfism and impairs skeletal acquisition.
Sarver DC, Garcia-Diaz J, Saqib M, Riddle RC, Wong GW., Free PMC Article | 02/8/2024 |
| Promotion of Joint Degeneration and Chondrocyte Metabolic Dysfunction by Excessive Growth Hormone in Mice. | Promotion of Joint Degeneration and Chondrocyte Metabolic Dysfunction by Excessive Growth Hormone in Mice.
Zhu S, Liu H, Davis T, Willis CRG, Basu R, Witzigreuter L, Bell S, Szewczyk N, Lotz MK, Hill M, Fajardo RJ, O'Connor PM, Berryman DE, Kopchick JJ., Free PMC Article | 06/29/2023 |
| microRNA-449a reduces growth hormone-stimulated senescent cell burden through PI3K-mTOR signaling. | microRNA-449a reduces growth hormone-stimulated senescent cell burden through PI3K-mTOR signaling.
Noureddine S, Nie J, Schneider A, Menon V, Fliesen Z, Dhahbi J, Victoria B, Oyer J, Robles-Carrillo L, Nunes ADC, Ashiqueali S, Janusz A, Copik A, Robbins PD, Musi N, Masternak MM., Free PMC Article | 04/4/2023 |
| Ghrelin Gene Deletion Alters Pulsatile Growth Hormone Secretion in Adult Female Mice. | Ghrelin Gene Deletion Alters Pulsatile Growth Hormone Secretion in Adult Female Mice.
Hassouna R, Fernandez G, Lebrun N, Fiquet O, Roelfsema F, Labarthe A, Zizzari P, Tomasetto C, Epelbaum J, Viltart O, Chauveau C, Perello M, Tolle V., Free PMC Article | 02/19/2022 |
| Neurochemical phenotype of growth hormone-responsive cells in the mouse paraventricular nucleus of the hypothalamus. | Neurochemical phenotype of growth hormone-responsive cells in the mouse paraventricular nucleus of the hypothalamus.
Quaresma PGF, Dos Santos WO, Wasinski F, Metzger M, Donato J Jr. | 01/8/2022 |
| Growth Hormone Pulses and Liver Gene Expression Are Differentially Regulated by the Circadian Clock Gene Bmal1. | Growth Hormone Pulses and Liver Gene Expression Are Differentially Regulated by the Circadian Clock Gene Bmal1.
Schoeller EL, Tonsfeldt KJ, Sinkovich M, Shi R, Mellon PL., Free PMC Article | 10/23/2021 |
| Stimulation of endogenous pulsatile growth hormone secretion by activation of growth hormone secretagogue receptor reduces the fat accumulation and improves the insulin sensitivity in obese mice. | Stimulation of endogenous pulsatile growth hormone secretion by activation of growth hormone secretagogue receptor reduces the fat accumulation and improves the insulin sensitivity in obese mice.
Huang Z, Lu X, Huang L, Zhang C, Veldhuis JD, Cowley MA, Chen C. | 06/19/2021 |
| Insulin synthesized in the paraventricular nucleus of the hypothalamus regulates pituitary growth hormone production. | Insulin synthesized in the paraventricular nucleus of the hypothalamus regulates pituitary growth hormone production.
Lee J, Kim K, Cho JH, Bae JY, O'Leary TP, Johnson JD, Bae YC, Kim EK., Free PMC Article | 06/12/2021 |
| GH directly inhibits steatosis and liver injury in a sex-dependent and IGF1-independent manner. | GH directly inhibits steatosis and liver injury in a sex-dependent and IGF1-independent manner.
Sarmento-Cabral A, Del Rio-Moreno M, Vazquez-Borrego MC, Mahmood M, Gutierrez-Casado E, Pelke N, Guzman G, Subbaiah PV, Cordoba-Chacon J, Yakar S, Kineman RD., Free PMC Article | 05/1/2021 |
| RASSF10 regulates bone invasion of growth hormone-secreting adenomas via exosomes. | RASSF10 regulates bone invasion of growth hormone-secreting adenomas via exosomes.
Wang T, Liu H, Ji Z, Cheng Y, Du Y, Liu H, Liao J, Peng H. | 01/23/2021 |
| GH acts in concert with other "gestational hormones" to prepare the maternal organism for the metabolic demands of the offspring | Central growth hormone action regulates metabolism during pregnancy.
Teixeira PDS, Couto GC, Furigo IC, List EO, Kopchick JJ, Donato J Jr., Free PMC Article | 04/4/2020 |
| GH-/- mice have severely decreased IGF-1 levels, small body size, and altered body composition with increased adiposity. They are extremely insulin sensitive but glucose intolerant, with a dramatic reduction in pancreatic islet size. Subcutaneous WAT from GH-/- mice have significantly larger adipocytes and reduced fibrosis, neither of which occurred in perigonadal WAT, suggesting GH has a more pronounced effect on sc WAT. | GH Knockout Mice Have Increased Subcutaneous Adipose Tissue With Decreased Fibrosis and Enhanced Insulin Sensitivity.
List EO, Berryman DE, Buchman M, Jensen EA, Funk K, Duran-Ortiz S, Qian Y, Young JA, Slyby J, McKenna S, Kopchick JJ., Free PMC Article | 12/7/2019 |
| In this animal model, the somatotrope GHRH/GH/IGF1 axis plays a vital and unsuspected role in vaccine and immunological defense against S. pneumoniae. | Growth Hormone (GH) Deficient Mice With GHRH Gene Ablation Are Severely Deficient in Vaccine and Immune Responses Against Streptococcus pneumoniae.
Farhat K, Bodart G, Charlet-Renard C, Desmet CJ, Moutschen M, Beguin Y, Baron F, Melin P, Quatresooz P, Parent AS, Desmecht D, Sirard JC, Salvatori R, Martens H, Geenen VG., Free PMC Article | 09/28/2019 |
| Growth hormone-induced lipolysis is secondary to its reduction in the expression of FSP27. | Growth hormone controls lipolysis by regulation of FSP27 expression.
Sharma R, Luong Q, Sharma VM, Harberson M, Harper B, Colborn A, Berryman DE, Jessen N, Jørgensen JOL, Kopchick JJ, Puri V, Lee KY., Free PMC Article | 09/14/2019 |
| GH acts through its receptor in the liver to activate autophagy, preserve triglycerides, enhance gluconeogenesis, and prevent hypoglycemia in calorie-restricted mice, a model of famine. | Growth hormone acts on liver to stimulate autophagy, support glucose production, and preserve blood glucose in chronically starved mice.
Fang F, Shi X, Brown MS, Goldstein JL, Liang G., Free PMC Article | 05/25/2019 |
| The results indicate that increased circulating GH is associated with a reduced ovarian primordial follicle reserve and increased pFoxO3a content in oocytes. | Ovarian aging and the activation of the primordial follicle reserve in the long-lived Ames dwarf and the short-lived bGH transgenic mice.
Saccon TD, Moreira F, Cruz LA, Mondadori RG, Fang Y, Barros CC, Spinel L, Bartke A, Masternak MM, Schneider A., Free PMC Article | 05/19/2018 |
| These results indicate that up-regulation of GH in the lungs of DJ-1 KO mice may enhance the malignancy of B16F10 cells and nodule formation in pulmonary metastasis of melanoma. | Growth hormone is increased in the lungs and enhances experimental lung metastasis of melanoma in DJ-1 KO mice.
Chien CH, Lee MJ, Liou HC, Liou HH, Fu WM., Free PMC Article | 09/30/2017 |
| Confirmation of the impairment of GH-IGF-1 release in hyperphagic MC4R KO mice suggests a role for insulin in regulating both the release of GH, but also in mediating growth during periods of physiologically suppressed GH-IGF-1 levels | Hyperphagia in male melanocortin 4 receptor deficient mice promotes growth independently of growth hormone.
Tan HY, Steyn FJ, Huang L, Cowley M, Veldhuis JD, Chen C., Free PMC Article | 09/16/2017 |
| When charged with hypoxia-ischemia, mutant brains with deleted IGF-1 receptor were broadly protected from cell damage, neuroinflammation and cerebral edema. | Deleting IGF-1 receptor from forebrain neurons confers neuroprotection during stroke and upregulates endocrine somatotropin.
De Magalhaes Filho CD, Kappeler L, Dupont J, Solinc J, Villapol S, Denis C, Nosten-Bertrand M, Billard JM, Blaise A, Tronche F, Giros B, Charriaut-Marlangue C, Aïd S, Le Bouc Y, Holzenberger M., Free PMC Article | 04/29/2017 |
| Thiol-disulfide exchange reactions in hGH and related model peptides were influenced by higher order structure, by the size of the thiol reactant and by an Arg residue adjacent to Cys in the thiol reactant. | Thiol-Disulfide Exchange in Human Growth Hormone.
Chandrasekhar S, Moorthy BS, Xie R, Topp EM., Free PMC Article | 03/11/2017 |
| Growth hormone deficient mice exhibited renal hypertrophy in tubular epithelial cells. | Growth hormone (GH)-transgenic insulin-like growth factor 1 (IGF1)-deficient mice allow dissociation of excess GH and IGF1 effects on glomerular and tubular growth.
Blutke A, Schneider MR, Wolf E, Wanke R., Free PMC Article | 09/24/2016 |
| observations demonstrate that germline loss of ghrelin-O-acyltransferase alters Growth Hormone release and patterning | Effect of Deletion of Ghrelin-O-Acyltransferase on the Pulsatile Release of Growth Hormone in Mice.
Xie TY, Ngo ST, Veldhuis JD, Jeffery PL, Chopin LK, Tschöp M, Waters MJ, Tolle V, Epelbaum J, Chen C, Steyn FJ. | 09/10/2016 |
| alter miR-19b concentrations in hematopoietic stem cells (HSCs) and affect HSC migration | Sleep disruption impairs haematopoietic stem cell transplantation in mice.
Rolls A, Pang WW, Ibarra I, Colas D, Bonnavion P, Korin B, Heller HC, Weissman IL, de Lecea L., Free PMC Article | 05/21/2016 |
| Moderate elevations in circulating GH and IGF-I can directly increase basal insulin secretion without impacting beta-cell mass, independent of changes in whole body insulin sensitivity and hyperlipidemia. | Islet insulin content and release are increased in male mice with elevated endogenous GH and IGF-I, without evidence of systemic insulin resistance or alterations in β-cell mass.
Cordoba-Chacon J, Majumdar N, Pokala NK, Gahete MD, Kineman RD. | 04/9/2016 |