| Galphai1/3 mediate Netrin-1-CD146-activated signaling and angiogenesis. | Gαi1/3 mediate Netrin-1-CD146-activated signaling and angiogenesis.
Li Y, Chai JL, Shi X, Feng Y, Li JJ, Zhou LN, Cao C, Li KR., Free PMC Article | 05/12/2023 |
| In Vivo Metabolic Roles of G Proteins of the Gi Family Studied With Novel Mouse Models. | In Vivo Metabolic Roles of G Proteins of the Gi Family Studied With Novel Mouse Models.
Wess J., Free PMC Article | 01/22/2022 |
| Allosteric Inhibition of Adenylyl Cyclase Type 5 by G-Protein: A Molecular Dynamics Study. | Allosteric Inhibition of Adenylyl Cyclase Type 5 by G-Protein: A Molecular Dynamics Study.
Frezza E, Amans TM, Martin J., Free PMC Article | 09/18/2021 |
| Requirement of Galphai1 and Galphai3 in interleukin-4-induced signaling, macrophage M2 polarization and allergic asthma response. | Requirement of Gαi1 and Gαi3 in interleukin-4-induced signaling, macrophage M2 polarization and allergic asthma response.
Bai JY, Li Y, Xue GH, Li KR, Zheng YF, Zhang ZQ, Jiang Q, Liu YY, Zhou XZ, Cao C., Free PMC Article | 08/21/2021 |
| Adipocyte Gi signaling is essential for maintaining whole-body glucose homeostasis and insulin sensitivity. | Adipocyte G(i) signaling is essential for maintaining whole-body glucose homeostasis and insulin sensitivity.
Wang L, Pydi SP, Zhu L, Barella LF, Cui Y, Gavrilova O, Bence KK, Vernochet C, Wess J., Free PMC Article | 08/29/2020 |
| AC6 is tightly regulated by intrinsic receptor-independent Gi activity. | Constitutive inhibitory G protein activity upon adenylyl cyclase-dependent cardiac contractility is limited to adenylyl cyclase type 6.
Bull Melsom C, Cosson MV, Ørstavik Ø, Lai NC, Hammond HK, Osnes JB, Skomedal T, Nikolaev V, Levy FO, Krobert KA., Free PMC Article | 02/15/2020 |
| This study presents an unexpected proinflammatory switch from Galphas to GalphaI glp1r signaling in burn monocytes which promotes ERK1/2 and NF-kappaB activation | Proinflammatory switch from Gαs to Gαi signaling by Glucagon-like peptide-1 receptor in murine splenic monocyte following burn injury.
Zhang QH, Hao JW, Li GL, Ji XJ, Yao XD, Dong N, Yao YM. | 08/25/2018 |
| Gnai1 function is impaired in the spinal cord of Ews/Ewsr1 KO mice | Integrated analysis of omics data using microRNA-target mRNA network and PPI network reveals regulation of Gnai1 function in the spinal cord of Ews/Ewsr1 KO mice.
Lee CJ, Ahn H, Lee SB, Shin JY, Park WY, Kim JI, Lee J, Ryu H, Kim S., Free PMC Article | 10/28/2017 |
| LGN and Galphai participate in a long-inferred signal that originates outside the bundle to model its staircase-like architecture, a property that is essential for direction sensitivity to mechanical deflection and hearing. | A link between planar polarity and staircase-like bundle architecture in hair cells.
Tarchini B, Tadenev AL, Devanney N, Cayouette M., Free PMC Article | 09/16/2017 |
| stimulation of GPR17 by the small molecule agonist MDL29,951 (2-carboxy-4,6-dichloro-1H-indole-3-propionic acid) decreases myelin basic protein expression levels mainly by triggering the Galphai/o signaling pathway. | The Orphan G Protein-coupled Receptor GPR17 Negatively Regulates Oligodendrocyte Differentiation via Gαi/o and Its Downstream Effector Molecules.
Simon K, Hennen S, Merten N, Blättermann S, Gillard M, Kostenis E, Gomeza J., Free PMC Article | 05/21/2016 |
| Gnai1 missense mutation is responsible of hyperpigmentation in mouse model. | Gnaq(M1J): An ENU-Induced Mutant Allele Affecting Pigmentation in the Mouse.
Pratt CH, Dionne LA, Fairfield H, Dadras SS, Potter CS, Sundberg JP., Free PMC Article | 05/21/2016 |
| acidosis in inflamed tissues may be a decisive factor to regulate switching of PKA and PKCepsilon dependence via proton-sensing G-protein-coupled receptors. | Acidosis Mediates the Switching of Gs-PKA and Gi-PKCε Dependence in Prolonged Hyperalgesia Induced by Inflammation.
Huang WY, Dai SP, Chang YC, Sun WH., Free PMC Article | 02/6/2016 |
| Data show that guanine nucleotide-binding protein G(i) subunit alpha-1 and alpha-3 (Galphai1/3) can interact with CD14 antigen/Grb2-associated binding protein Gab1, which modulates macrophage polarization in vitro and in vivo. | Gαi1 and Gαi3 regulate macrophage polarization by forming a complex containing CD14 and Gab1.
Li X, Wang D, Chen Z, Lu E, Wang Z, Duan J, Tian W, Wang Y, You L, Zou Y, Cheng Y, Zhu Q, Wan X, Xi T, Jiang M, Han Y, Cao C, Birnbaumer L, Chu WM, Yang Y., Free PMC Article | 07/25/2015 |
| By using mice deficient in individual Galphai/o G-protein subunits, authors demonstrate that Galphai1 and Galphai3 are the critical in vivo targets of ADP-ribosylation underlying vasoactive amine sensitization elicited by pertussis toxin exposure. | G proteins Gαi1/3 are critical targets for Bordetella pertussis toxin-induced vasoactive amine sensitization.
Diehl SA, McElvany B, Noubade R, Seeberger N, Harding B, Spach K, Teuscher C., Free PMC Article | 04/12/2014 |
| leucine can directly facilitate insulin signaling through a Galphai protein-dependent intracellular signaling pathway | Leucine facilitates insulin signaling through a Gαi protein-dependent signaling pathway in hepatocytes.
Yang X, Mei S, Wang X, Li X, Liu R, Ma Y, Hao L, Yao P, Liu L, Sun X, Gu H, Liu Z, Cao W., Free PMC Article | 06/1/2013 |
| Inactive Galpha(i1)-GDP enhances the affinity of RGS14 for H-Ras-GTP in live cells, resulting in a ternary signaling complex that is further regulated by G protein-coupled receptors. | Assembly and function of the regulator of G protein signaling 14 (RGS14)·H-Ras signaling complex in live cells are regulated by Gαi1 and Gαi-linked G protein-coupled receptors.
Vellano CP, Brown NE, Blumer JB, Hepler JR., Free PMC Article | 03/30/2013 |
| Mice with mutations of Gnai1 or Gnai2 have neither fusions of ribs nor lumbar vertebrae, but loss of both Gnai3 and one of the other two genes increases the number and severity of rib fusions without affecting the lumbar fusions. | Development of the mammalian axial skeleton requires signaling through the Gα(i) subfamily of heterotrimeric G proteins.
Plummer NW, Spicher K, Malphurs J, Akiyama H, Abramowitz J, Nürnberg B, Birnbaumer L., Free PMC Article | 02/23/2013 |
| Results suggest a model in which the Gbetagamma dimer that is released as a result of the dissociation from Galpha(o) upon activation of mGluR6 closes the TRPM1 channel, perhaps via a direct interaction. | G-protein-mediated inhibition of the Trp channel TRPM1 requires the Gβγ dimer.
Shen Y, Rampino MA, Carroll RC, Nawy S., Free PMC Article | 08/25/2012 |
| RGS14 can form complexes with GPCRs in cells that are dependent on Galpha(i/o) and these RGS14.Galpha(i1).GPCR complexes may be substrates for other signaling partners such as Ric-8A | G protein-coupled receptors and resistance to inhibitors of cholinesterase-8A (Ric-8A) both regulate the regulator of g protein signaling 14 RGS14·Gαi1 complex in live cells.
Vellano CP, Maher EM, Hepler JR, Blumer JB., Free PMC Article | 01/14/2012 |
| The decrease in beta(2)-AR may account for additional relaxation impairment, given that there is no enhancement over nontransgenic after pertussis toxin, despite AC5 overexpression. | Paradoxical attenuation of β2-AR function in airway smooth muscle by Gi-mediated counterregulation in transgenic mice overexpressing type 5 adenylyl cyclase.
Wang WC, Schillinger RM, Malone MM, Liggett SB., Free PMC Article | 05/7/2011 |
| in osteoblasts CB2 targets a Gi protein-cyclin D1 mitogenic axis | CB2 cannabinoid receptor targets mitogenic Gi protein-cyclin D1 axis in osteoblasts.
Ofek O, Attar-Namdar M, Kram V, Dvir-Ginzberg M, Mechoulam R, Zimmer A, Frenkel B, Shohami E, Bab I., Free PMC Article | 04/30/2011 |
| Data show that mice lacking G(o2)alpha, but not those lacking alpha subunits of either G(o1) or any G(i) proteins, handle glucose loads more efficiently than wild-type (WT) mice. | Augmented glucose-induced insulin release in mice lacking G(o2), but not G(o1) or G(i) proteins.
Wang Y, Park S, Bajpayee NS, Nagaoka Y, Boulay G, Birnbaumer L, Jiang M., Free PMC Article | 04/30/2011 |
| Activation of the Rsg14-Galphai1-GDP signaling complex is regulated by Ric8. | Activation of the regulator of G protein signaling 14-Gαi1-GDP signaling complex is regulated by resistance to inhibitors of cholinesterase-8A.
Vellano CP, Shu FJ, Ramineni S, Yates CK, Tall GG, Hepler JR., Free PMC Article | 04/16/2011 |
| analysis of a novel Gi, P2Y-independent signaling pathway mediating Akt phosphorylation in response to thrombin receptors | A G(i) -independent mechanism mediating Akt phosphorylation in platelets.
Xiang B, Zhang G, Liu J, Morris AJ, Smyth SS, Gartner TK, Li Z., Free PMC Article | 02/26/2011 |
| CKbeta8- and CKbeta8-1-induced activation of ERK1/2 is mediated by the G(i)/G(o) protein, PLC, and PKCdelta. | CKbeta8/CCL23 and its isoform CKbeta8-1 induce up-regulation of cyclins via the G(i)/G(o) protein/PLC/PKCdelta/ERK leading to cell-cycle progression.
Kim J, Kim YS, Ko J. | 05/31/2010 |