| The kainate receptor GluK2 mediates cold sensing in mice. | The kainate receptor GluK2 mediates cold sensing in mice.
Cai W, Zhang W, Zheng Q, Hor CC, Pan T, Fatima M, Dong X, Duan B, Xu XZS. | 04/15/2024 |
| The atypical 'hippocampal' glutamate receptor coupled to phospholipase D that controls stretch-sensitivity in primary mechanosensory nerve endings is homomeric purely metabotropic GluK2. | The atypical 'hippocampal' glutamate receptor coupled to phospholipase D that controls stretch-sensitivity in primary mechanosensory nerve endings is homomeric purely metabotropic GluK2.
Thompson KJ, Watson S, Zanato C, Dall'Angelo S, De Nooij JC, Pace-Bonello B, Shenton FC, Sanger HE, Heinz BA, Broad LM, Grosjean N, McQuillian JR, Dubini M, Pyner S, Greig I, Zanda M, Bleakman D, Banks RW, Bewick GS., Free PMC Article | 01/15/2024 |
| Presenilin and APP Regulate Synaptic Kainate Receptors. | Presenilin and APP Regulate Synaptic Kainate Receptors.
Barthet G, Moreira-de-Sá A, Zhang P, Deforges S, Castanheira J, Gorlewicz A, Mulle C., Free PMC Article | 02/15/2023 |
| Kainate receptors regulate the functional properties of young adult-born dentate granule cells. | Kainate receptors regulate the functional properties of young adult-born dentate granule cells.
Zhu Y, Armstrong JN, Contractor A., Free PMC Article | 02/19/2022 |
| Structural insights into GIRK2 channel modulation by cholesterol and PIP2. | Structural insights into GIRK2 channel modulation by cholesterol and PIP(2).
Mathiharan YK, Glaaser IW, Zhao Y, Robertson MJ, Skiniotis G, Slesinger PA., Free PMC Article | 02/12/2022 |
| Connexin 36 Mediates Orofacial Pain Hypersensitivity Through GluK2 and TRPA1. | Connexin 36 Mediates Orofacial Pain Hypersensitivity Through GluK2 and TRPA1.
Li Q, Ma TL, Qiu YQ, Cui WQ, Chen T, Zhang WW, Wang J, Mao-Ying QL, Mi WL, Wang YQ, Chu YX., Free PMC Article | 07/31/2021 |
| Seizure protein 6 controls glycosylation and trafficking of kainate receptor subunits GluK2 and GluK3. | Seizure protein 6 controls glycosylation and trafficking of kainate receptor subunits GluK2 and GluK3.
Pigoni M, Hsia HE, Hartmann J, Rudan Njavro J, Shmueli MD, Müller SA, Güner G, Tüshaus J, Kuhn PH, Kumar R, Gao P, Tran ML, Ramazanov B, Blank B, Hipgrave Ederveen AL, Von Blume J, Mulle C, Gunnersen JM, Wuhrer M, Rammes G, Busche MA, Koeglsperger T, Lichtenthaler SF., Free PMC Article | 04/13/2021 |
| Hippocampal CA3 kainate receptors have been found to contribute to seizure activities. | Sevoflurane activates hippocampal CA3 kainate receptors (Gluk2) to induce hyperactivity during induction and recovery in a mouse model.
Liang P, Li F, Liu J, Liao D, Huang H, Zhou C. | 04/20/2019 |
| loss of FMRP leads to the abnormal function and localization of kainite receptors. | Reduced synaptic function of Kainate receptors in the insular cortex of Fmr1 Knock-out mice.
Qiu S, Wu Y, Lv X, Li X, Zhuo M, Koga K., Free PMC Article | 01/12/2019 |
| The cytoplasmic domain of the GluK2 low-affinity subunit stabilizes kainate receptors at synapses. In contrast, the extracellular domain of the GluK4/5 high-affinity subunit synergistically controls the synaptic specificity of kainate receptors through interaction with C1q-like proteins. | Distinct Subunit Domains Govern Synaptic Stability and Specificity of the Kainate Receptor.
Straub C, Noam Y, Nomura T, Yamasaki M, Yan D, Fernandes HB, Zhang P, Howe JR, Watanabe M, Contractor A, Tomita S., Free PMC Article | 12/2/2017 |
| GluK2-mediated increase in KCC2 recycling to the surface membrane translates to a hyperpolarization of the reversal potential for GABA (EGABA). | A kainate receptor subunit promotes the recycling of the neuron-specific K(+)-Cl(-) co-transporter KCC2 in hippocampal neurons.
Pressey JC, Mahadevan V, Khademullah CS, Dargaei Z, Chevrier J, Ye W, Huang M, Chauhan AK, Meas SJ, Uvarov P, Airaksinen MS, Woodin MA., Free PMC Article | 04/29/2017 |
| Loss of parkin function in primary cultured neurons causes GluK2 protein to accumulate in the plasma membrane. | Parkin regulates kainate receptors by interacting with the GluK2 subunit.
Maraschi A, Ciammola A, Folci A, Sassone F, Ronzitti G, Cappelletti G, Silani V, Sato S, Hattori N, Mazzanti M, Chieregatti E, Mulle C, Passafaro M, Sassone J., Free PMC Article | 11/28/2015 |
| Interictal and ictal discharges are minimized in mice lacking the GluK2 subunit. | Contribution of aberrant GluK2-containing kainate receptors to chronic seizures in temporal lobe epilepsy.
Peret A, Christie LA, Ouedraogo DW, Gorlewicz A, Epsztein J, Mulle C, Crépel V. | 08/22/2015 |
| 14-3-3 proteins are an important regulator of GluK2a-containing KARs and may contribute to the slow decay kinetics of native KAR-EPSCs. | Modulation of GluK2a subunit-containing kainate receptors by 14-3-3 proteins.
Sun C, Qiao H, Zhou Q, Wang Y, Wu Y, Zhou Y, Li Y., Free PMC Article | 11/16/2013 |
| This study demonistrated that grik2 gene expression in mouse dorsal raphe nucleus | Patterned expression of ion channel genes in mouse dorsal raphe nucleus determined with the Allen Mouse Brain Atlas.
Templin JS, Bang SJ, Soiza-Reilly M, Berde CB, Commons KG., Free PMC Article | 09/15/2012 |
| The results show that NETO2 is a kainate receptor subunit with significant effects on glutamate signaling mechanisms in brain. | A transmembrane accessory subunit that modulates kainate-type glutamate receptors.
Zhang W, St-Gelais F, Grabner CP, Trinidad JC, Sumioka A, Morimoto-Tomita M, Kim KS, Straub C, Burlingame AL, Howe JR, Tomita S., Free PMC Article | 05/20/2011 |
| To our knowledge, the present work is the first report of a GluK receptor as the target of chronic treatment with mood-stabilizing drugs. This effect was both drug-specific and receptor subtype-specific. | Down-regulation of GluK2 kainate receptor expression by chronic treatment with mood-stabilizing anti-convulsants or lithium in cultured astrocytes and brain, but not in neurons.
Li B, Zhang S, Li M, Zhang H, Hertz L, Peng L. | 01/21/2010 |
| Our results are indicative of either down-regulation of kainate receptors or modulation of their functional characteristics in weaver (Girk2-wv mutant) granule cells. | Expression of GluR6 kainate receptor subunit in granular layer of weaver mouse cerebellum.
Spiliopoulos K, Fragioudaki K, Giompres P, Kouvelas E, Mitsacos A. | 01/21/2010 |
| The involvement of the kainate receptor subunit GluR6 (GRIK2) in mediating behavioral displays related to behavioral symptoms of mania | Evidence for the involvement of the kainate receptor subunit GluR6 (GRIK2) in mediating behavioral displays related to behavioral symptoms of mania.
Shaltiel G, Maeng S, Malkesman O, Pearson B, Schloesser RJ, Tragon T, Rogawski M, Gasior M, Luckenbaugh D, Chen G, Manji HK., Free PMC Article | 01/21/2010 |
| Gbeta5-RGS complexes co-localize with mGluR6 in retinal ON-bipolar cells. | Gbeta5-RGS complexes co-localize with mGluR6 in retinal ON-bipolar cells.
Morgans CW, Weiwei Liu, Wensel TG, Brown RL, Perez-Leon JA, Bearnot B, Duvoisin RM., Free PMC Article | 01/21/2010 |
| The related kinases SGK2 and SGK3 similarly stimulate GluR6, but are less effective than SGK1. | Glucocorticoid adrenal steroids and glucocorticoid-inducible kinase isoforms in the regulation of GluR6 expression.
Strutz-Seebohm N, Seebohm G, Shumilina E, Mack AF, Wagner HJ, Lampert A, Grahammer F, Henke G, Just L, Skutella T, Hollmann M, Lang F., Free PMC Article | 01/21/2010 |
| In the present study, we used knock-out mice to explore the contribution of GluR5 and GluR6 receptors to sensory responses, fear memory, and learning-related synaptic potentiation in the amygdala. | Altered behavioral responses to noxious stimuli and fear in glutamate receptor 5 (GluR5)- or GluR6-deficient mice.
Ko S, Zhao MG, Toyoda H, Qiu CS, Zhuo M., Free PMC Article | 01/21/2010 |
| role for kainate receptors in the maturation of mossy fibre synapses. | Postnatal maturation of mossy fibre excitatory transmission in mouse CA3 pyramidal cells: a potential role for kainate receptors.
Marchal C, Mulle C., Free PMC Article | 01/21/2010 |
| GluR6 kainate receptors are critically involved in inhibiting transmission at both A delta and C fibre monosynaptic pathways. Presynaptic GluR5 kainate receptors play limited role in inhibiting C fibre-activated pathway. | Modulation of excitatory synaptic transmission in the spinal substantia gelatinosa of mice deficient in the kainate receptor GluR5 and/or GluR6 subunit.
Youn DH, Randic M., Free PMC Article | 01/21/2010 |
| The facilitatory effects of kainate on mossy fiber synaptic transmission and plasticity are mediated by GLU(K6)-containing kainate receptors. | Assessing the role of GLUK5 and GLUK6 at hippocampal mossy fiber synapses.
Breustedt J, Schmitz D., Free PMC Article | 01/21/2010 |