| Impaired cathepsin D in retinal pigment epithelium cells mediates Stargardt disease pathogenesis. | Impaired cathepsin D in retinal pigment epithelium cells mediates Stargardt disease pathogenesis.
Ng ESY, Hu J, Jiang Z, Radu RA., | 10/21/2024 |
| Cathepsin D is essential for the degradomic shift of macrophages required to resolve liver fibrosis. | Cathepsin D is essential for the degradomic shift of macrophages required to resolve liver fibrosis.
Ruiz-Blázquez P, Fernández-Fernández M, Pistorio V, Martinez-Sanchez C, Costanzo M, Iruzubieta P, Zhuravleva E, Cacho-Pujol J, Ariño S, Del Castillo-Cruz A, Núñez S, Andersen JB, Ruoppolo M, Crespo J, García-Ruiz C, Pavone LM, Reinheckel T, Sancho-Bru P, Coll M, Fernández-Checa JC, Moles A., Free PMC Article | 09/12/2024 |
| CTSD upregulation as a key driver of spinal ligament abnormalities in spinal stenosis. | CTSD upregulation as a key driver of spinal ligament abnormalities in spinal stenosis.
Li L, Zheng ZZ, Jiang JJ, Chen JL, Jiang B, Li YW, Dai YL, Wang B. | 07/18/2024 |
| Downregulation of Protease Cathepsin D and Upregulation of Pathologic alpha-Synuclein Mediate Paucity of DNAJC6-Induced Degeneration of Dopaminergic Neurons. | Downregulation of Protease Cathepsin D and Upregulation of Pathologic α-Synuclein Mediate Paucity of DNAJC6-Induced Degeneration of Dopaminergic Neurons.
Chiu CC, Chen YL, Weng YH, Liu SY, Li HL, Yeh TH, Wang HL., Free PMC Article | 07/17/2024 |
| Monocytes Release Pro-Cathepsin D to Drive Blood-to-Brain Transcytosis in Diabetes. | Monocytes Release Pro-Cathepsin D to Drive Blood-to-Brain Transcytosis in Diabetes.
Zhao D, Huang ZK, Liang Y, Li ZJ, Zhang XW, Li KH, Wu H, Zhang XD, Li CS, An D, Sun X, An MX, Shi JX, Bao YJ, Tian L, Wang DF, Wu AH, Chen YH, Zhao WD. | 04/4/2024 |
| Extracellular alpha-synuclein impairs sphingosine 1-phosphate receptor type 3 (S1PR3)-regulated lysosomal delivery of cathepsin D in HeLa cells. | Extracellular α-synuclein impairs sphingosine 1-phosphate receptor type 3 (S1PR3)-regulated lysosomal delivery of cathepsin D in HeLa cells.
Nishida S, Matovelo SA, Kajimoto T, Nakamura SI, Okada T. | 03/6/2024 |
| A novel function by cathepsin D in degradation of nucleic acids. | A novel function by cathepsin D in degradation of nucleic acids.
Zhang Y, Yu Y, Zhou H, Zhao M, Pan X. | 11/18/2023 |
| Expression and significance of cathepsin C and cathepsin D during pregnancy and Preeclampsia. | Expression and significance of cathepsin C and cathepsin D during pregnancy and Preeclampsia.
Song J, Zhu N, Pan X, Guo L, Kong X., Free PMC Article | 10/10/2023 |
| CircRNA-406918 enhances the degradation of advanced glycation end products in photoaged human dermal fibroblasts via targeting cathepsin D. | CircRNA-406918 enhances the degradation of advanced glycation end products in photoaged human dermal fibroblasts via targeting cathepsin D.
Qu Y, Wang M, Lan J, Huang X, Huang J, Li H, Zheng Y, Xu Q. | 09/20/2023 |
| Maintenance of cathepsin D-dependent autophagy-lysosomal function protects against cardiac ischemia/reperfusion injury. | Maintenance of cathepsin D-dependent autophagy-lysosomal function protects against cardiac ischemia/reperfusion injury.
Zhuang Q, Zhang Y, Zhu Y, He L, Kang C, Ke P, Lin H, Xiong Y, Huang X. | 06/7/2023 |
| Targeted Proteins Reveal Cathepsin D as a Novel Biomarker in Differentiating Hepatocellular Carcinoma from Cirrhosis and Other Liver Cancers. | Targeted Proteins Reveal Cathepsin D as a Novel Biomarker in Differentiating Hepatocellular Carcinoma from Cirrhosis and Other Liver Cancers.
Chuaypen N, Sriphoosanaphan S, Vorasittha A, Pinjaroen N, Chaiyarit S, Thongboonkerd V, Tangkijvanich P, Sirichindakul P., Free PMC Article | 07/9/2022 |
| High Expression of the Lysosomal Protease Cathepsin D Confers Better Prognosis in Neuroblastoma Patients by Contrasting EGF-Induced Neuroblastoma Cell Growth. | High Expression of the Lysosomal Protease Cathepsin D Confers Better Prognosis in Neuroblastoma Patients by Contrasting EGF-Induced Neuroblastoma Cell Growth.
Secomandi E, Salwa A, Vidoni C, Ferraresi A, Follo C, Isidoro C., Free PMC Article | 05/21/2022 |
| The c.863A>G (p.Glu288Gly) variant of the CTSD gene is not associated with CLN10 disease. | The c.863A>G (p.Glu288Gly) variant of the CTSD gene is not associated with CLN10 disease.
Yang J, Ding X, Meng S, Cai J, Zhou W., Free PMC Article | 03/26/2022 |
| Elevated mRNA expression and defective processing of cathepsin D in HeLa cells lacking the mannose 6-phosphate pathway. | Elevated mRNA expression and defective processing of cathepsin D in HeLa cells lacking the mannose 6-phosphate pathway.
Liu L, Doray B., Free PMC Article | 02/19/2022 |
| Expression of cathepsins B and D by cancer stem cells in head and neck metastatic malignant melanoma. | Expression of cathepsins B and D by cancer stem cells in head and neck metastatic malignant melanoma.
Sangster AB, Chang-McDonald B, Patel J, Bockett N, Paterson E, Davis PF, Tan ST. | 01/29/2022 |
| Myosteatosis in NAFLD patients correlates with plasma Cathepsin D. | Myosteatosis in NAFLD patients correlates with plasma Cathepsin D.
Ding L, De Munck TJI, Oligschlaeger Y, Dos Reis IM, Verbeek J, Koek GH, Houben T, Shiri-Sverdlov R. | 01/8/2022 |
| Impact of cathepsin D activity and C224T polymorphism (rs17571) on chronic obstructive pulmonary disease: correlations with oxidative and inflammatory markers. | Impact of cathepsin D activity and C224T polymorphism (rs17571) on chronic obstructive pulmonary disease: correlations with oxidative and inflammatory markers.
Bchir S, Boumiza S, Ben Nasr H, Garrouch A, Kallel I, Tabka Z, Chahed K. | 01/1/2022 |
| Significances of viable synergistic autophagy-associated cathepsin B and cathepsin D (CTSB/CTSD) as potential biomarkers for sudden cardiac death. | Significances of viable synergistic autophagy-associated cathepsin B and cathepsin D (CTSB/CTSD) as potential biomarkers for sudden cardiac death.
Dai J, Zhang Q, Wan C, Liu J, Zhang Q, Yu Y, Wang J., Free PMC Article | 12/25/2021 |
| Identification of BAG2 and Cathepsin D as Plasma Biomarkers for Parkinson's Disease. | Identification of BAG2 and Cathepsin D as Plasma Biomarkers for Parkinson's Disease.
Kang J, Kim JW, Heo H, Lee J, Park KY, Yoon JH, Chang J., Free PMC Article | 12/11/2021 |
| PICALM regulates cathepsin D processing and lysosomal function. | PICALM regulates cathepsin D processing and lysosomal function.
Hattersley KJ, Carosi JM, Hein LK, Bensalem J, Sargeant TJ. | 11/22/2021 |
| Expression profiling of precuneus layer III cathepsin D-immunopositive pyramidal neurons in mild cognitive impairment and Alzheimer's disease: Evidence for neuronal signaling vulnerability. | Expression profiling of precuneus layer III cathepsin D-immunopositive pyramidal neurons in mild cognitive impairment and Alzheimer's disease: Evidence for neuronal signaling vulnerability.
He B, Perez SE, Lee SH, Ginsberg SD, Malek-Ahmadi M, Mufson EJ., Free PMC Article | 11/22/2021 |
| Neuroprotective Properties of Kempferol Derivatives from Maesa membranacea against Oxidative Stress-Induced Cell Damage: An Association with Cathepsin D Inhibition and PI3K/Akt Activation. | Neuroprotective Properties of Kempferol Derivatives from Maesa membranacea against Oxidative Stress-Induced Cell Damage: An Association with Cathepsin D Inhibition and PI3K/Akt Activation.
Jantas D, Malarz J, Le TN, Stojakowska A., Free PMC Article | 10/30/2021 |
| The lysosomal endopeptidases Cathepsin D and L are selective and effective proteases for the middle-down characterization of antibodies. | The lysosomal endopeptidases Cathepsin D and L are selective and effective proteases for the middle-down characterization of antibodies.
Čaval T, Hecht ES, Tang W, Uy-Gomez M, Nichols A, Kil YJ, Sandoval W, Bern M, Heck AJR., Free PMC Article | 10/2/2021 |
| Identification of Cathepsin D as a Plasma Biomarker for Alzheimer's Disease. | Identification of Cathepsin D as a Plasma Biomarker for Alzheimer's Disease.
Kim JW, Jung SY, Kim Y, Heo H, Hong CH, Seo SW, Choi SH, Son SJ, Lee S, Chang J., Free PMC Article | 08/28/2021 |
| Tandem mass tag-based proteomic analysis reveals cathepsin-mediated anti-autophagic and pro-apoptotic effects under proliferative diabetic retinopathy. | Tandem mass tag-based proteomic analysis reveals cathepsin-mediated anti-autophagic and pro-apoptotic effects under proliferative diabetic retinopathy.
Niu R, Wang J, Geng C, Li Y, Dong L, Liu L, Chang Y, Shen J, Nie Z, Zhang Y, Hu B., Free PMC Article | 05/8/2021 |