Changes in the Bile Acid Pool and Timing of Female Puberty: Potential Novel Role of Hypothalamic TGR5.
Vanden Brink H, Vandeputte D, Brito IL, Ronnekleiv OK, Roberson MS, Lomniczi A., Free PMC Article

Gpbar-1/cAMP/PKA signaling mitigates macrophage-mediated acute cholestatic liver injury via antagonizing NLRP3-ASC inflammasome.
Zhuang L, Jia N, Zhang L, Zhang Q, Antwi SO, Sartorius K, Wu K, Sun D, Xi D, Lu Y.

TGR5 deficiency in excitatory neurons ameliorates Alzheimer's pathology by regulating APP processing.
Li C, Wang L, Xie W, Chen E, Chen Y, Li H, Can D, Lei A, Wang Y, Zhang J., Free PMC Article

The function of the gut microbiota-bile acid-TGR5 axis in diarrhea-predominant irritable bowel syndrome.
Zhan K, Wu H, Xu Y, Rao K, Zheng H, Qin S, Yang Y, Jia R, Chen W, Huang S., Free PMC Article

Gut microbiota-mediated ursodeoxycholic acids regulate the inflammation of microglia through TGR5 signaling after MCAO.
Zhang F, Deng Y, Wang H, Fu J, Wu G, Duan Z, Zhang X, Cai Y, Zhou H, Yin J, He Y.

Activation of GPBAR1 attenuates vascular inflammation and atherosclerosis in a mouse model of NAFLD-related cardiovascular disease.
Biagioli M, Marchianò S, Di Giorgio C, Bordoni M, Urbani G, Bellini R, Massa C, Sami Ullah Khan R, Roselli R, Chiara Monti M, Morretta E, Giordano A, Vellecco V, Bucci M, Jilani Iqbal A, Saviano A, Ab Mansour A, Ricci P, Distrutti E, Zampella A, Cieri E, Cirino G, Fiorucci S.

GPBAR1 preserves neurite and synapse of dopaminergic neurons via RAD21-OPCML signaling: Role in preventing Parkinson's disease in mouse model and human patients.
Zhang Y, Sun X, Zhang Y, Kang Z, Cai L, Ding J, Lu M, Hu G.

Lithocholic acid inhibits dendritic cell activation by reducing intracellular glutathione via TGR5 signaling.
Hu J, Zhang Y, Yi S, Wang C, Huang X, Pan S, Yang J, Yuan G, Tan S, Li H., Free PMC Article

Structural basis and molecular mechanism of biased GPBAR signaling in regulating NSCLC cell growth via YAP activity.
Ma L, Yang F, Wu X, Mao C, Guo L, Miao T, Zang SK, Jiang X, Shen DD, Wei T, Zhou H, Wei Q, Li S, Shu Q, Feng S, Jiang C, Chu B, Du L, Sun JP, Yu X, Zhang Y, Zhang P., Free PMC Article

GPBAR1 promotes proliferation and is related to poor prognosis of high-grade glioma via inducing MAFB expression.
Sun S, Guo H, Liang N, Wu T, Zhang C, Li H.

GPCR19 Regulates P2X7R-Mediated NLRP3 Inflammasomal Activation of Microglia by Amyloid β in a Mouse Model of Alzheimer's Disease.
Islam J, Cho JA, Kim JY, Park KS, Koh YJ, Chung CY, Lee EJ, Nam SJ, Lee K, Kim SH, Park SH, Lee DY, Kim BC, Lee KH, Seong SY., Free PMC Article

GLP-1 Mediates Regulation of Colonic ACE2 Expression by the Bile Acid Receptor GPBAR1 in Inflammation.
Biagioli M, Marchianò S, Roselli R, Di Giorgio C, Bellini R, Bordoni M, Distrutti E, Catalanotti B, Zampella A, Graziosi L, Donini A, Fiorucci S., Free PMC Article

Faecal bile acids and colonic bile acid membrane receptor correlate with symptom severity of diarrhoea-predominant irritable bowel syndrome: A pilot study.
Wei W, Wang H, Zhang Y, Zhang Y, Niu B, Chen S, Zhang W, Yao S.

Circulating Bile Acids in Liver Failure Activate TGR5 and Induce Monocyte Dysfunction.
Leonhardt J, Haider RS, Sponholz C, Leonhardt S, Drube J, Spengler K, Mihaylov D, Neugebauer S, Kiehntopf M, Lambert NA, Kortgen A, Bruns T, Tacke F, Hoffmann C, Bauer M, Heller R., Free PMC Article

GPBAR1 Promotes Proliferation of Serous Ovarian Cancer by Inducing Smad4 Ubiquitination.
Li H, Zhao J, Shi X.

FGF19 and FGFR4 promotes the progression of gallbladder carcinoma in an autocrine pathway dependent on GPBAR1-cAMP-EGR1 axis.
Chen T, Liu H, Liu Z, Li K, Qin R, Wang Y, Liu J, Li Z, Gao Q, Pan C, Yang F, Zhao W, Zhang Z, Xu Y.

Cryo-EM structure of activated bile acids receptor TGR5 in complex with stimulatory G protein.
Chen G, Wang X, Ge Y, Ma L, Chen Q, Liu H, Du Y, Ye RD, Hu H, Ren R., Free PMC Article

Progress in research on the roles of TGR5 receptor in liver diseases.
Ma K, Tang D, Yu C, Zhao L.

TGR5/Cathepsin E signaling regulates macrophage innate immune activation in liver ischemia and reperfusion injury.
Zhou H, Zhou S, Shi Y, Wang Q, Wei S, Wang P, Cheng F, Auwerx J, Schoonjans K, Lu L.

TGR5 Regulates Macrophage Inflammation in Nonalcoholic Steatohepatitis by Modulating NLRP3 Inflammasome Activation.
Shi Y, Su W, Zhang L, Shi C, Zhou J, Wang P, Wang H, Shi X, Wei S, Wang Q, Auwerx J, Schoonjans K, Yu Y, Pan R, Zhou H, Lu L., Free PMC Article

Bile Acids and GPBAR-1: Dynamic Interaction Involving Genes, Environment and Gut Microbiome.
Portincasa P, Di Ciaula A, Garruti G, Vacca M, De Angelis M, Wang DQ., Free PMC Article

Overexpression of TGR5 alleviates myocardial ischemia/reperfusion injury via AKT/GSK-3β mediated inflammation and mitochondrial pathway.
Li J, Cheng R, Wan H., Free PMC Article

Structural basis of GPBAR activation and bile acid recognition.
Yang F, Mao C, Guo L, Lin J, Ming Q, Xiao P, Wu X, Shen Q, Guo S, Shen DD, Lu R, Zhang L, Huang S, Ping Y, Zhang C, Ma C, Zhang K, Liang X, Shen Y, Nan F, Yi F, Luca VC, Zhou J, Jiang C, Sun JP, Xie X, Yu X, Zhang Y.

Bariatric surgery reveals a gut-restricted TGR5 agonist with anti-diabetic effects.
Chaudhari SN, Harris DA, Aliakbarian H, Luo JN, Henke MT, Subramaniam R, Vernon AH, Tavakkoli A, Sheu EG, Devlin AS., Free PMC Article

Decreased Expression of TGR5 in Vogt-Koyanagi-Harada (VKH) Disease.
Yang J, Hu J, Feng L, Yi S, Ye Z, Lin M, Liu X, Pu Y, Kijlstra A, Yang P, Li H.