| Genetic biomarkers of life-threatening pheochromocytoma-induced cardiomyopathy. | Genetic biomarkers of life-threatening pheochromocytoma-induced cardiomyopathy.
Amar J, Brunel J, Cardot Bauters C, Jacques V, Delmas C, Odou MF, Savagner F. | 05/7/2022 |
| alpha2A- and alpha2C-adrenoceptor expression and functionality in postmortem prefrontal cortex of schizophrenia subjects. | α(2A)- and α(2C)-adrenoceptor expression and functionality in postmortem prefrontal cortex of schizophrenia subjects.
Brocos-Mosquera I, Gabilondo AM, Diez-Alarcia R, Muguruza C, Erdozain AM, Meana JJ, Callado LF. | 04/23/2022 |
| Prognostic significance of alpha- and beta2-adrenoceptor gene expression in breast cancer patients. | Prognostic significance of α- and β2-adrenoceptor gene expression in breast cancer patients.
Rivero EM, Martinez LM, Bruque CD, Gargiulo L, Bruzzone A, Lüthy IA., Free PMC Article | 09/26/2020 |
| High alpha2-Adrenergic Receptor expression is associated with Pathogenesis of Preeclampsia and Fetal Growth Restriction. | Human Placenta Expresses α(2)-Adrenergic Receptors and May Be Implicated in Pathogenesis of Preeclampsia and Fetal Growth Restriction.
Motawea HKB, Chotani MA, Ali M, Ackerman W, Zhao G, Ahmed AAE, Buhimschi CS, Buhimschi IA., Free PMC Article | 08/24/2019 |
| alpha2A- and alpha2C-adrenoceptors are functional receptors for norepinephrine, dopamine, and other previously assumed selective D2-like receptor ligands. | α(2A)- and α(2C)-Adrenoceptors as Potential Targets for Dopamine and Dopamine Receptor Ligands.
Sánchez-Soto M, Casadó-Anguera V, Yano H, Bender BJ, Cai NS, Moreno E, Canela EI, Cortés A, Meiler J, Casadó V, Ferré S., Free PMC Article | 12/22/2018 |
| The frequency of alpha2CDel322-325-AR in suicide and non-suicide victims was similar. Genotype frequencies for the alpha2CDel322-325-AR polymorphism in depressed and schizophrenic subjects were higher than in controls, but these differences did not reach statistical significance. The results indicate that alpha2CDel322-325-AR may play a role in the pathophysiology of opiate abuse and dependence. | Alpha2C-adrenoceptor Del322-325 polymorphism and risk of psychiatric disorders: significant association with opiate abuse and dependence.
Rivero G, Martín-Guerrero I, de Prado E, Gabilondo AM, Callado LF, García-Sevilla JA, García-Orad Á, Meana JJ. | 05/27/2017 |
| Immunoreactivity for ADRA2C was densely distributed in vascular smooth muscle of nasal turbinates. | Immunohistochemical localization of alpha and beta adrenergic receptors in the human nasal turbinate.
Shirasaki H, Kanaizumi E, Himi T. | 01/14/2017 |
| ADRA2c is associated with heart rate recovery after exercise. | Genetic variation in alpha2-adrenoreceptors and heart rate recovery after exercise.
Kohli U, Diedrich A, Kannankeril PJ, Muszkat M, Sofowora GG, Hahn MK, English BA, Blakely RD, Stein CM, Kurnik D., Free PMC Article | 06/4/2016 |
| Common polymorphisms in the ADRA2C gene are not associated with orthostatic hypotension risk in Chinese. | Association between Common Genetic Variants of α2A-, α2B-, and α2C-Adrenergic Receptors and Orthostatic Hypotension.
Lu N, Yuan Y, Piao J, Pei F, Sun K, Zheng Y, Hui RT. | 10/31/2015 |
| Adrenergic receptor genotype influences heart failure severity and beta-blocker response in children with dilated cardiomyopathy. | Adrenergic receptor genotype influences heart failure severity and β-blocker response in children with dilated cardiomyopathy.
Reddy S, Fung A, Manlhiot C, Tierney ES, Chung WK, Blume E, Kaufman BD, Goldmuntz E, Colan S, Mital S., Free PMC Article | 09/26/2015 |
| alpha2C-adrenoreceptor interaction with filamin-2 | In silico modeling of human α2C-adrenoreceptor interaction with filamin-2.
Pawlowski M, Saraswathi S, Motawea HK, Chotani MA, Kloczkowski A., Free PMC Article | 04/18/2015 |
| Genetic variants of ADRA2C do not alter intracellular localization or plasma membrane trafficking. | Common α2A and α2C adrenergic receptor polymorphisms do not affect plasma membrane trafficking.
Hurt CM, Sorensen MW, Angelotti T., Free PMC Article | 01/31/2015 |
| the ADRA2C 322-325I/D genotype is a novel genetic risk marker for SBI among individuals with hyperhomocysteinemia. | Association between common genetic variants of α2A-, α2B- and α2C-adrenoceptors and the risk of silent brain infarction.
Kim JO, Jeon YJ, Kim OJ, Oh SH, Kim HS, Shin BS, Oh D, Kim EJ, Cho YK, Kim NK. | 01/10/2015 |
| the region comprising the N-terminal half of The receptors contributed to the alpha2C-selectivity of drug binding. | The C-terminal half of the α2C-adrenoceptor determines the receptor's membrane expression level and drug selectivity.
Jahnsen JA, Uhlén S. | 07/19/2014 |
| The ADRA2A and ADRA2C polymorphisms did not contribute to an increased risk of ischemic stroke or any pathophysiological subtype | Association between common genetic variants of α2A-, α2B-, and α2C-adrenergic receptors and ischemic stroke.
Oh SH, Min KT, Jeon YJ, Kim MH, Kim OJ, Shin BS, Oh D, Kim NK. | 06/15/2013 |
| Bucindolol prevents ventricular arrhythmias in subjects with heart failure and reduced left ventricular ejection fractions, and this effect is modulated by adrenergic alpha 2 receptor polymorphisms. | Adrenergic receptor polymorphisms and prevention of ventricular arrhythmias with bucindolol in patients with chronic heart failure.
Aleong RG, Sauer WH, Robertson AD, Liggett SB, Bristow MR. | 04/20/2013 |
| the predicted signal peptide in the N-terminal tail of the alpha(2C)-adrenoceptor does not act as a cleavable signal peptide | The predicted N-terminal signal sequence of the human α₂C-adrenoceptor does not act as a functional cleavable signal peptide.
Jahnsen JA, Uhlén S. | 09/15/2012 |
| there is little evidence for an association between alpha(2C)Del322-325 polymorphism and an increased prevalence of left ventricular hypertrophy in patients with systemic hypertension. | The α(2C)-Del322-325 adrenoceptor polymorphism and the occurrence of left ventricular hypertrophy in hypertensives.
Savva J, Alfakih K, Galloway SL, Hall AS, West RM, Ball SG, Balmforth AJ, Maqbool A. | 08/4/2012 |
| alpha1b and alpha2c AR is over-expressed in basal-like breast tumours of poor prognosis | Alpha- and beta-adrenergic receptor (AR) protein expression is associated with poor clinical outcome in breast cancer: an immunohistochemical study.
Powe DG, Voss MJ, Habashy HO, Zänker KS, Green AR, Ellis IO, Entschladen F. | 02/11/2012 |
| Genotype polymorphism frequencies for B1 receptor (amino acid positions 389 and 49) and alpha 2c receptor (deletion 322-325) are not significantly different in SC patients compared to female controls. | Adrenergic receptor polymorphisms in patients with stress (tako-tsubo) cardiomyopathy.
Sharkey SW, Maron BJ, Nelson P, Parpart M, Maron MS, Bristow MR. | 03/5/2011 |
| Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) | Family-based analysis of genetic variation underlying psychosis-inducing effects of cannabis: sibling analysis and proband follow-up.
van Winkel R, Genetic Risk and Outcome of Psychosis (GROUP) Investigators. | 12/5/2010 |
| The alpha(2C)-Del322-325 polymorphism does not exhibit reduced signalling to adenylyl cyclase and may not represent a clinically important phenotype. | Lack of effect of the alpha2C-adrenoceptor Del322-325 polymorphism on inhibition of cyclic AMP production in HEK293 cells.
Montgomery MD, Bylund DB., Free PMC Article | 07/12/2010 |
| The common ADRA2C variant affected pain perception before and after dexmedetomidine but did not affect other cognitive responses | Effects of variation in the human alpha2A- and alpha2C-adrenoceptor genes on cognitive tasks and pain perception.
Kohli U, Muszkat M, Sofowora GG, Harris PA, Friedman EA, Dupont WD, Scheinin M, Wood AJ, Stein CM, Kurnik D., Free PMC Article | 04/12/2010 |
| the norepinephrine lowering and clinical therapeutic responses to bucindolol were strongly influenced by alpha(2C) receptor genotype | An alpha2C-adrenergic receptor polymorphism alters the norepinephrine-lowering effects and therapeutic response of the beta-blocker bucindolol in chronic heart failure.
Bristow MR, Murphy GA, Krause-Steinrauf H, Anderson JL, Carlquist JF, Thaneemit-Chen S, Krishnan V, Abraham WT, Lowes BD, Port JD, Davis GW, Lazzeroni LC, Robertson AD, Lavori PW, Liggett SB. | 02/22/2010 |
| The ADRA2C del322-325 variant did not affect vascular sensitivity to local cold exposure. | The alpha2C-adrenoceptor deletion322-325 variant and cold-induced vasoconstriction.
Friedman EA, Harris PA, Wood AJ, Stein CM, Kurnik D., Free PMC Article | 01/21/2010 |