| Blood DNA methylation profiling identifies cathepsin Z dysregulation in pulmonary arterial hypertension. | Blood DNA methylation profiling identifies cathepsin Z dysregulation in pulmonary arterial hypertension.
Ulrich A, Wu Y, Draisma H, Wharton J, Swietlik EM, Cebola I, Vasilaki E, Balkhiyarova Z, Jarvelin MR, Auvinen J, Herzig KH, Coghlan JG, Lordan J, Church C, Howard LS, Pepke-Zaba J, Toshner M, Wort SJ, Kiely DG, Condliffe R, Lawrie A, Gräf S, Morrell NW, Wilkins MR, Prokopenko I, Rhodes CJ., Free PMC Article | 01/10/2024 |
| Defective cathepsin Z affects EGFR expression and causes autosomal dominant palmoplantar keratoderma. | Defective cathepsin Z affects EGFR expression and causes autosomal dominant palmoplantar keratoderma.
Malovitski K, Sarig O, Feller Y, Bergson S, Assaf S, Mohamad J, Pavlovsky M, Giladi M, Sprecher E. | 09/6/2023 |
| Granulomatous rosacea in Chinese patients: Clinical-histopathological analysis and pathogenesis exploration. | Granulomatous rosacea in Chinese patients: Clinical-histopathological analysis and pathogenesis exploration.
Jiang Y, Huang Y, Ma G, Liu T, Li Q, Wu H, Li J. | 07/12/2023 |
| Upregulation of Cathepsin X in Glioblastoma: Interplay with gamma-Enolase and the Effects of Selective Cathepsin X Inhibitors. | Upregulation of Cathepsin X in Glioblastoma: Interplay with γ-Enolase and the Effects of Selective Cathepsin X Inhibitors.
Majc B, Habič A, Novak M, Rotter A, Porčnik A, Mlakar J, Župunski V, Pečar Fonović U, Knez D, Zidar N, Gobec S, Kos J, Lah Turnšek T, Pišlar A, Breznik B., Free PMC Article | 03/19/2022 |
| Decreased levels of cathepsin Z mRNA expressed by immune blood cells: diagnostic and prognostic implications in prostate cancer. | Decreased levels of cathepsin Z mRNA expressed by immune blood cells: diagnostic and prognostic implications in prostate cancer.
Batista AAS, Franco BM, Perez MM, Pereira EG, Rodrigues T, Wroclawski ML, Fonseca FLA, Suarez ER., Free PMC Article | 08/14/2021 |
| our present study revealed that KMT2A epigenetically promotes cancer progression by targeting CTSZ, which has specific functions in cancer invasion and metastasis. | KMT2A histone methyltransferase contributes to colorectal cancer development by promoting cathepsin Z transcriptional activation.
Fang Y, Zhang D, Hu T, Zhao H, Zhao X, Lou Z, He Y, Qin W, Xia J, Zhang X, Ye LC., Free PMC Article | 08/1/2020 |
| CTSZ polymorphisms are associated with jaundice-stage progression in primary biliary cholangitis. | NELFCD and CTSZ loci are associated with jaundice-stage progression in primary biliary cholangitis in the Japanese population.
Nishida N, Aiba Y, Hitomi Y, Kawashima M, Kojima K, Kawai Y, Ueno K, Nakamura H, Yamashiki N, Tanaka T, Tamura S, Mori A, Yagi S, Soejima Y, Yoshizumi T, Takatsuki M, Tanaka A, Harada K, Shimoda S, Komori A, Eguchi S, Maehara Y, Uemoto S, Kokudo N, Nagasaki M, Tokunaga K, Nakamura M., Free PMC Article | 11/30/2019 |
| results indicate that altered expression and localization of cathepsin Z in hepatocytes are characteristic features of primary biliary cholangitis (PBC) and other cholestatic liver diseases, and are implicated in the progression of PBC. | Increased expression and altered localization of cathepsin Z are associated with progression to jaundice stage in primary biliary cholangitis.
Aiba Y, Harada K, Ito M, Suematsu T, Aishima S, Hitomi Y, Nishida N, Kawashima M, Takatsuki M, Eguchi S, Shimoda S, Nakamura H, Komori A, Abiru S, Nagaoka S, Migita K, Yatsuhashi H, Tokunaga K, Nakamura M., Free PMC Article | 10/26/2019 |
| Deguelin inhibits the activation of CtsZ downstream FAK/Src/Paxillin signaling. | Deguelin attenuates non-small cell lung cancer cell metastasis through inhibiting the CtsZ/FAK signaling pathway.
Li W, Yu X, Ma X, Xie L, Xia Z, Liu L, Yu X, Wang J, Zhou H, Zhou X, Yang Y, Liu H. | 09/21/2019 |
| expression of cathepsin B and X was detected in stromal cells and cancer cells throughout the glioblastoma (GBM) sections, whereas cathepsin K expression was more restricted to arteriole-rich regions in the GBM sections. Metabolic mapping showed that cathepsin B, but not cathepsin K is active in GSC niches. | Cysteine cathepsins B, X and K expression in peri-arteriolar glioblastoma stem cell niches.
Breznik B, Limbaeck Stokin C, Kos J, Khurshed M, Hira VVV, Bošnjak R, Lah TT, Van Noorden CJF., Free PMC Article | 11/24/2018 |
| we evaluated the involvement of cathepsin B and X in the TGF-b1 signaling pathway, one of the key signaling mechanisms triggering epithelial-mesenchymal transition in cancer. In MCF-7 cells the expression of cathepsin B was shown to depend on their activation with TGF-b1 while, for cathepsin X, a TGF-b1 independent mechanism of induction during EMT is indicated. | Cysteine cathepsins B and X promote epithelial-mesenchymal transition of tumor cells.
Mitrović A, Pečar Fonović U, Kos J. | 06/9/2018 |
| Down-regulation of RPLP0 resulted in G1 arrest of gastric cancer cells, whereas knockdown of Cathepsin X led to G1 arrest and apoptosis | Dysregulation of apoptotic signaling pathways by interaction of RPLP0 and cathepsin X/Z in gastric cancer.
Teller A, Jechorek D, Hartig R, Adolf D, Reißig K, Roessner A, Franke S. | 10/17/2015 |
| Cathepsin X (CTSX) is involved in early tumorigenesis and in the stabilization of tumor cell formation in colorectal cancer. | Characterization of cathepsin X in colorectal cancer development and progression.
Jechorek D, Votapek J, Meyer F, Kandulski A, Roessner A, Franke S. | 08/21/2015 |
| The significant association of cathepsin X with survival in a group of patients who received no chemotherapy and the absence of this association in the group who received chemotherapy, suggest the possible predictive value for response to chemotherapy. | Prognostic and predictive value of cathepsin X in serum from colorectal cancer patients.
Vižin T, Christensen IJ, Wilhelmsen M, Nielsen HJ, Kos J., Free PMC Article | 12/20/2014 |
| Suggest CTSZ rs34069356 polymorphism is not associated with pulmonary tuberculosis in a sample Iranian population. | Association of CTSZ rs34069356 and MC3R rs6127698 gene polymorphisms with pulmonary tuberculosis.
Hashemi M, Eskandari-Nasab E, Moazeni-Roodi A, Naderi M, Sharifi-Mood B, Taheri M. | 03/1/2014 |
| We show that sequential cleavage of C-terminal amino acids from the beta(2) cytoplasmic tail of LFA-1, by CatX, enhances binding of the adaptor protein talin to LFA-1 and triggers formation of the latter's high-affinity form | Cathepsin X cleavage of the beta2 integrin regulates talin-binding and LFA-1 affinity in T cells.
Jevnikar Z, Obermajer N, Doljak B, Turk S, Gobec S, Svajger U, Hailfinger S, Thome M, Kos J. | 09/13/2012 |
| Cathepsins L and Z are critical in degrading polyglutamine-containing proteins within lysosomes. | Cathepsins L and Z are critical in degrading polyglutamine-containing proteins within lysosomes.
Bhutani N, Piccirillo R, Hourez R, Venkatraman P, Goldberg AL., Free PMC Article | 07/28/2012 |
| cathepsin Z contributes to tumor metastasis by inducing epithelial-mesenchymal transition in hepatocellular carcinoma | Overexpression of cathepsin Z contributes to tumor metastasis by inducing epithelial-mesenchymal transition in hepatocellular carcinoma.
Wang J, Chen L, Li Y, Guan XY., Free PMC Article | 06/9/2012 |
| cathepsin X deficiency leads to accelerated cellular senescence and consequently to diminished cellular proliferation and migration/invasion implying a potential role of cathepsin X in bypassing cellular senescence. | Cellular senescence induced by cathepsin X downregulation.
Kraus S, Bunsen T, Schuster S, Cichoń MA, Tacke M, Reinheckel T, Sommerhoff CP, Jochum M, Nägler DK. | 11/26/2011 |
| Polymorphisms in MC3R promoter and CTSZ 3'UTR are associated with tuberculosis susceptibility. | Polymorphisms in MC3R promoter and CTSZ 3'UTR are associated with tuberculosis susceptibility.
Adams LA, Möller M, Nebel A, Schreiber S, van der Merwe L, van Helden PD, Hoal EG., Free PMC Article | 09/17/2011 |
| associated with tuberculosis in a Ugandan household contact study | Genetic susceptibility to tuberculosis associated with cathepsin Z haplotype in a Ugandan household contact study.
Baker AR, Zalwango S, Malone LL, Igo RP Jr, Qiu F, Nsereko M, Adams MD, Supelak P, Mayanja-Kizza H, Boom WH, Stein CM., Free PMC Article | 08/20/2011 |
| Cysteine proteases bleomycin hydrolase and cathepsin Z mediate N-terminal proteolysis and toxicity of mutant huntingtin. | Cysteine proteases bleomycin hydrolase and cathepsin Z mediate N-terminal proteolysis and toxicity of mutant huntingtin.
Ratovitski T, Chighladze E, Waldron E, Hirschhorn RR, Ross CA., Free PMC Article | 07/23/2011 |
| unlikely that CTSZ gene plays a major role in tuberculosis susceptibility in African populations | Mapping of a novel susceptibility locus suggests a role for MC3R and CTSZ in human tuberculosis.
Cooke GS, Campbell SJ, Bennett S, Lienhardt C, McAdam KP, Sirugo G, Sow O, Gustafson P, Mwangulu F, van Helden P, Fine P, Hoal EG, Hill AV, Cooke GS, Campbell SJ, Bennett S, Lienhardt C, McAdam KP, Sirugo G, Sow O, Gustafson P, Mwangulu F, van Helden P, Fine P, Hoal EG, Hill AV., Free PMC Articles: PMC2643210, PMC2643210 | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (3) articlesOxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey.
Starr JM, Shiels PG, Harris SE, Pattie A, Pearce MS, Relton CL, Deary IJ. Mapping of a novel susceptibility locus suggests a role for MC3R and CTSZ in human tuberculosis.
Cooke GS, Campbell SJ, Bennett S, Lienhardt C, McAdam KP, Sirugo G, Sow O, Gustafson P, Mwangulu F, van Helden P, Fine P, Hoal EG, Hill AV, Cooke GS, Campbell SJ, Bennett S, Lienhardt C, McAdam KP, Sirugo G, Sow O, Gustafson P, Mwangulu F, van Helden P, Fine P, Hoal EG, Hill AV. A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition.
Harris SE, Fox H, Wright AF, Hayward C, Starr JM, Whalley LJ, Deary IJ. | 05/11/2008 |
| the extracellular function of cathepsin X may include binding to integrins thereby modulating the attachment of migrating cells to ECM components [Cathepsin X] | RGD-dependent binding of procathepsin X to integrin alphavbeta3 mediates cell-adhesive properties.
Lechner AM, Assfalg-Machleidt I, Zahler S, Stoeckelhuber M, Machleidt W, Jochum M, Nägler DK. | 01/21/2010 |