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    CYP3A7 cytochrome P450 family 3 subfamily A member 7 [ Homo sapiens (human) ]

    Gene ID: 1551, updated on 17-Jun-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Allele and genotype frequencies of CYP3A4, CYP3A5, CYP3A7, and GSTP1 gene polymorphisms among mainland Tibetan, Mongolian, Uyghur, and Han Chinese populations.

    Allele and genotype frequencies of CYP3A4, CYP3A5, CYP3A7, and GSTP1 gene polymorphisms among mainland Tibetan, Mongolian, Uyghur, and Han Chinese populations.
    Qi G, Han C, Zhou Y, Wang X.

    04/9/2022
    CYP3A7, CYP3A4, and CYP3A5 genetic polymorphisms in recipients rather than donors influence tacrolimus concentrations in the early stages after liver transplantation.

    CYP3A7, CYP3A4, and CYP3A5 genetic polymorphisms in recipients rather than donors influence tacrolimus concentrations in the early stages after liver transplantation.
    Dong Y, Xu Q, Li R, Tao Y, Zhang Q, Li J, Ma Z, Shen C, Zhong M, Wang Z, Qiu X.

    12/11/2021
    Development of template systems for ligand interactions of CYP3A5 and CYP3A7 and their distinctions from CYP3A4 template.

    Development of template systems for ligand interactions of CYP3A5 and CYP3A7 and their distinctions from CYP3A4 template.
    Yamazoe Y, Tohkin M.

    11/22/2021
    Human Fetal Liver Metabolism of Oxycodone Is Mediated by CYP3A7.

    Human Fetal Liver Metabolism of Oxycodone Is Mediated by CYP3A7.
    Shum S, Isoherranen N., Free PMC Article

    10/9/2021
    Urinary Bile Acid Profile of Newborns Born by Cesarean Section Is Characterized by Oxidative Metabolism of Primary Bile Acids: Limited Roles of Fetal-Specific CYP3A7 in Cholate Oxidations.

    Urinary Bile Acid Profile of Newborns Born by Cesarean Section Is Characterized by Oxidative Metabolism of Primary Bile Acids: Limited Roles of Fetal-Specific CYP3A7 in Cholate Oxidations.
    Wang WX, Chen L, Wang GY, Zhang JL, Tan XW, Lin QH, Chen YJ, Zhang J, Zhu PP, Miao J, Su MM, Liu CX, Jia W, Lan K.

    09/18/2021
    CYP3A7*1C allele: linking premenopausal oestrone and progesterone levels with risk of hormone receptor-positive breast cancers.

    CYP3A7*1C allele: linking premenopausal oestrone and progesterone levels with risk of hormone receptor-positive breast cancers.
    Johnson N, Maguire S, Morra A, Kapoor PM, Tomczyk K, Jones ME, Schoemaker MJ, Gilham C, Bolla MK, Wang Q, Dennis J, Ahearn TU, Andrulis IL, Anton-Culver H, Antonenkova NN, Arndt V, Aronson KJ, Augustinsson A, Baynes C, Freeman LEB, Beckmann MW, Benitez J, Bermisheva M, Blomqvist C, Boeckx B, Bogdanova NV, Bojesen SE, Brauch H, Brenner H, Burwinkel B, Campa D, Canzian F, Castelao JE, Chanock SJ, Chenevix-Trench G, Clarke CL, NBCS Collaborators, Conroy DM, Couch FJ, Cox A, Cross SS, Czene K, Dörk T, Eliassen AH, Engel C, Evans DG, Fasching PA, Figueroa J, Floris G, Flyger H, Gago-Dominguez M, Gapstur SM, García-Closas M, Gaudet MM, Giles GG, Goldberg MS, González-Neira A, AOCS Group, Guénel P, Hahnen E, Haiman CA, Håkansson N, Hall P, Hamann U, Harrington PA, Hart SN, Hooning MJ, Hopper JL, Howell A, Hunter DJ, ABCTB Investigators, kConFab Investigators, Jager A, Jakubowska A, John EM, Kaaks R, Keeman R, Khusnutdinova E, Kitahara CM, Kosma VM, Koutros S, Kraft P, Kristensen VN, Kurian AW, Lambrechts D, Le Marchand L, Linet M, Lubiński J, Mannermaa A, Manoukian S, Margolin S, Martens JWM, Mavroudis D, Mayes R, Meindl A, Milne RL, Neuhausen SL, Nevanlinna H, Newman WG, Nielsen SF, Nordestgaard BG, Obi N, Olshan AF, Olson JE, Olsson H, Orban E, Park-Simon TW, Peterlongo P, Plaseska-Karanfilska D, Pylkäs K, Rennert G, Rennert HS, Ruddy KJ, Saloustros E, Sandler DP, Sawyer EJ, Schmutzler RK, Scott C, Shu XO, Simard J, Smichkoska S, Sohn C, Southey MC, Spinelli JJ, Stone J, Tamimi RM, Taylor JA, Tollenaar RAEM, Tomlinson I, Troester MA, Truong T, Vachon CM, van Veen EM, Wang SS, Weinberg CR, Wendt C, Wildiers H, Winqvist R, Wolk A, Zheng W, Ziogas A, Dunning AM, Pharoah PDP, Easton DF, Howie AF, Peto J, Dos-Santos-Silva I, Swerdlow AJ, Chang-Claude J, Schmidt MK, Orr N, Fletcher O., Free PMC Article

    07/17/2021
    Associations Between Cytochrome P450 (CYP) Gene Single-Nucleotide Polymorphisms and Second-to-Fourth Digit Ratio in Chinese University Students.

    Associations Between Cytochrome P450 (CYP) Gene Single-Nucleotide Polymorphisms and Second-to-Fourth Digit Ratio in Chinese University Students.
    Zhang J, Yang M, Luan P, Jia W, Liu Q, Ma Z, Dang J, Lu H, Ma Q, Wang Y, Mu C, Huo Z., Free PMC Article

    05/29/2021
    CYP3A Polymorphism and Chronic Mercury Intoxication.

    CYP3A Polymorphism and Chronic Mercury Intoxication.
    Chernyak YI, Merinova AP.

    02/6/2021
    Scaling in vitro activity of CYP3A7 suggests human fetal livers do not clear retinoic acid entering from maternal circulation.

    Scaling in vitro activity of CYP3A7 suggests human fetal livers do not clear retinoic acid entering from maternal circulation.
    Topletz AR, Zhong G, Isoherranen N., Free PMC Article

    10/3/2020
    kcat values, rather than Km values, for 6beta-hydroxylation of three steroid hormones by CYP3A7 are different from those of CYP3A4 and CYP3A5

    Comparison of steroid hormone hydroxylation mediated by cytochrome P450 3A subfamilies.
    Niwa T, Okamoto A, Narita K, Toyota M, Kato K, Kobayashi K, Sasaki S.

    07/18/2020
    role of CYP3A7 in development, disease, and xenobiotic metaboolism

    Neonatal cytochrome P450 CYP3A7: A comprehensive review of its role in development, disease, and xenobiotic metabolism.
    Li H, Lampe JN., Free PMC Article

    03/28/2020
    CYP3A7 showed abnormally elevated activities at 500 and 750 muM.

    Stereoselective Oxidation Kinetics of Deoxycholate in Recombinant and Microsomal CYP3A Enzymes: Deoxycholate 19-Hydroxylation Is an In Vitro Marker of CYP3A7 Activity.
    Chen YJ, Zhang J, Zhu PP, Tan XW, Lin QH, Wang WX, Yin SS, Gao LZ, Su MM, Liu CX, Xu L, Jia W, Sevrioukova IF, Lan K., Free PMC Article

    02/22/2020
    CYP3A7 rs2257401 is associated with tacrolimus pharmacokinetics in kidney transplantation.

    Whole exome sequencing for the identification of CYP3A7 variants associated with tacrolimus concentrations in kidney transplant patients.
    Sohn M, Kim MG, Han N, Kim IW, Gim J, Min SI, Song EY, Kim YS, Jung HS, Shin YK, Ha J, Oh JM., Free PMC Article

    10/19/2019
    our data indicate an alternative binding mode for testosterone in CYP3A7 that favors the 2alpha-hydroxylation, suggesting significant structural differences in its active site compared with CYP3A4/5

    Digging Deeper into CYP3A Testosterone Metabolism: Kinetic, Regioselectivity, and Stereoselectivity Differences between CYP3A4/5 and CYP3A7.
    Kandel SE, Han LW, Mao Q, Lampe JN., Free PMC Article

    06/30/2018
    polymorphisms may modify the response to dietary methylmercury exposure during early life development

    CYP3A genes and the association between prenatal methylmercury exposure and neurodevelopment.
    Llop S, Tran V, Ballester F, Barbone F, Sofianou-Katsoulis A, Sunyer J, Engström K, Alhamdow A, Love TM, Watson GE, Bustamante M, Murcia M, Iñiguez C, Shamlaye CF, Rosolen V, Mariuz M, Horvat M, Tratnik JS, Mazej D, van Wijngaarden E, Davidson PW, Myers GJ, Rand MD, Broberg K., Free PMC Article

    02/17/2018
    Methylation status of cytosine in the CYP3A7 proximal promoter correlated with changes in developmental expression of mRNA.

    Dynamics of Cytosine Methylation in the Proximal Promoters of CYP3A4 and CYP3A7 in Pediatric and Prenatal Livers.
    Vyhlidal CA, Bi C, Ye SQ, Leeder JS.

    01/27/2018
    Occupancy by modified histones was consistent with chromatin structural changes contributing to the mechanisms regulating CYP3A7 ontogeny.

    Role of Chromatin Structural Changes in Regulating Human CYP3A Ontogeny.
    Giebel NL, Shadley JD, McCarver DG, Dorko K, Gramignoli R, Strom SC, Yan K, Simpson PM, Hines RN., Free PMC Article

    01/27/2018
    All three neonicotinoid pesticides induced the expression of CYP3A7 in H295R cells; induction was reversed by co-treatment of H295R cells with exogenous estriol. CYP3A7 is normally expressed in fetal liver and is a key enzyme involved in estriol synthesis.

    The use of a unique co-culture model of fetoplacental steroidogenesis as a screening tool for endocrine disruptors: The effects of neonicotinoids on aromatase activity and hormone production.
    Caron-Beaudoin E, Viau R, Hudon-Thibeault AA, Vaillancourt C, Sanderson JT.

    09/30/2017
    The CYP3A7*1C allele is associated with a lower urinary estrone levels, a more pronounced reduction in 2-hydroxylation pathway estrone metabolites (EMs) and a lower ratio of 2-hydroxylation:16alpha-hydroxylation EMs in premenopausal women.

    CYP3A7*1C allele is associated with reduced levels of 2-hydroxylation pathway oestrogen metabolites.
    Sood D, Johnson N, Jain P, Siskos AP, Bennett M, Gilham C, Busana MC, Peto J, Dos-Santos-Silva I, Keun HC, Fletcher O., Free PMC Article

    06/10/2017
    data suggested that hepatocyte nuclear factor 4 alpha and glucocorticoid receptor, and epigenetic changes of H3K4me2 and H3K27me3 are associated with the ontogenic expressions of CYP3A4/3A7 in the livers of the Chinese Han population.

    Developmental regulation of CYP3A4 and CYP3A7 in Chinese Han population.
    He H, Nie YL, Li JF, Meng XG, Yang WH, Chen YL, Wang SJ, Ma X, Kan QC, Zhang LR.

    03/18/2017
    These results suggest the existence of a marked inter-individual variability regarding the presence of the isoforms of CYP3A. In addition, since sorafenib is metabolized by CYP3A4, but not by CYP3A7, an overexpression of CYP3A4 may lead to an increase in the degradation of the drug and then to clinical ineffectiveness.

    Immunohistochemical markers of CYP3A4 and CYP3A7: a new tool towards personalized pharmacotherapy of hepatocellular carcinoma.
    Fanni D, Manchia M, Lai F, Gerosa C, Ambu R, Faa G., Free PMC Article

    02/18/2017
    CYP3A7*1C influences outcome are required.

    Cytochrome P450 Allele CYP3A7*1C Associates with Adverse Outcomes in Chronic Lymphocytic Leukemia, Breast, and Lung Cancer.
    Johnson N, De Ieso P, Migliorini G, Orr N, Broderick P, Catovsky D, Matakidou A, Eisen T, Goldsmith C, Dudbridge F, Peto J, Dos-Santos-Silva I, Ashworth A, Ross G, Houlston RS, Fletcher O., Free PMC Article

    07/30/2016
    CYP3A4, CYP3A7, UGT2B11 and UGT2B15 genes are significantly downregulated in melanosis coli.

    Histopathology of melanosis coli and determination of its associated genes by comparative analysis of expression microarrays.
    Li XΑ, Zhou Y, Zhou SΧ, Liu HR, Xu JM, Gao L, Yu XJ, Li XH., Free PMC Article

    06/28/2016
    Differences in the expression of nuclear receptors might determine the variability in CYP3A4 and CYP3A7 expression observed in foetal liver.

    Expression of CYP3A4 and CYP3A7 in Human Foetal Tissues and its Correlation with Nuclear Receptors.
    Betts S, Björkhem-Bergman L, Rane A, Ekström L.

    06/28/2016
    Only CYP1A1, CYP1B1, CYP3A4, CYP3A5 and CYP3A7 expressed in lymphocytes and monocytes.

    Cytochrome P450 isoforms are differently up-regulated in aflatoxin B₁-exposed human lymphocytes and monocytes.
    Bahari A, Mehrzad J, Mahmoudi M, Bassami MR, Dehghani H.

    09/20/2014
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