| Genetic and Enzymatic Characteristics of CYP2A13 in Relation to Lung Damage. | Genetic and Enzymatic Characteristics of CYP2A13 in Relation to Lung Damage.
Vrzal R., Free PMC Article | 12/25/2021 |
| Molecular docking and oxidation kinetics of 3-phenyl coumarin derivatives by human CYP2A13. | Molecular docking and oxidation kinetics of 3-phenyl coumarin derivatives by human CYP2A13.
Juvonen RO, Jokinen EM, Huuskonen J, Kärkkäinen O, Raunio H, Pentikäinen OT. | 12/18/2021 |
| Association between CYP2A13 polymorphisms and lung cancer: A protocol for systematic review and meta-analysis. | Association between CYP2A13 polymorphisms and lung cancer: A protocol for systematic review and meta-analysis.
Ma L, Jin G, Yang Y, Pang Y, Wang W, Zhang H, Liu J, Wu P, Wang Z, Wang K, Chang R, Li J, Zhu Z., Free PMC Article | 01/9/2021 |
| Study provides evidence that CYP2A13 gene polymorphisms may be candidate biomarkers of lung cancer susceptibility in Chinese. | HapMap-based study: CYP2A13 may be a potential key metabolic enzyme gene in the carcinogenesis of lung cancer in non-smokers.
Hua F, Guo Y, Sun Q, Yang L, Gao F., Free PMC Article | 03/28/2020 |
| Functional analysis of variations in P450 2A13 allelic variants may help to understand the consequences of P450 2A13 polymorphism in bioactivation of many tobacco-derived carcinogens. | In vitro functional analysis of human cytochrome P450 2A13 genetic variants: P450 2A13*2, *3, *4, and *10.
Kim V, Yeom S, Lee Y, Park HG, Cho MA, Kim H, Kim D. | 08/31/2019 |
| Oxidation of 1-chloropyrene by human CYP1 family and CYP2A subfamily cytochrome P450 enzymes: catalytic roles of two CYP1B1 and five CYP2A13 allelic variants | Oxidation of 1-chloropyrene by human CYP1 family and CYP2A subfamily cytochrome P450 enzymes: catalytic roles of two CYP1B1 and five CYP2A13 allelic variants.
Shimada T, Murayama N, Kakimoto K, Takenaka S, Lim YR, Yeom S, Kim D, Yamazaki H, Guengerich FP, Komori M., Free PMC Article | 09/8/2018 |
| CYP2A13 is the most efficient enzyme to metabolize N'-Nitrosonornicotine in vitro. | In vitro metabolism of N'-Nitrosonornicotine catalyzed by cytochrome P450 2A13 and its inhibition by nicotine, N'-Nitrosoanatabine and N'-Nitrosoanabasine.
Liu X, Zhang J, Wang L, Yang B, Zhang C, Liu W, Zhou J. | 02/4/2017 |
| The results of this case-control study suggested that the CYP2A13*1/*2 genotype decreased the risk of susceptibility to bladder cancer in Japanese smokers | CYP2A13 Genetic Polymorphisms in Relation to the Risk of Bladder Cancer in Japanese Smokers.
Kumondai M, Hosono H, Orikasa K, Arai Y, Arai T, Sugimura H, Ozono S, Sugiyama T, Takayama T, Sasaki T, Hirasawa N, Hiratsuka M. | 01/28/2017 |
| CYP2A13 levels in human lungs can be suppressed by disease-associated inflammation in tissue donors. | Suppression of pulmonary CYP2A13 expression by carcinogen-induced lung tumorigenesis in a CYP2A13-humanized mouse model.
Liu Z, Megaraj V, Li L, Sell S, Hu J, Ding X., Free PMC Article | 12/19/2015 |
| an etiologically relevant interaction between CYP2A13 and ABCB1 associated with lung cancer was analysed | Pulmonary expression of CYP2A13 and ABCB1 is regulated by FOXA2, and their genetic interaction is associated with lung cancer.
Xiang C, Wang J, Kou X, Chen X, Qin Z, Jiang Y, Sun C, Xu J, Tan W, Jin L, Lin D, He F, Wang H. | 10/3/2015 |
| The transgenic CYP2A13 is active. | Generation and characterization of a novel CYP2A13--transgenic mouse model.
Jia K, Li L, Liu Z, Hartog M, Kluetzman K, Zhang QY, Ding X., Free PMC Article | 02/14/2015 |
| CYP2A13 played a critical role in AFB1-induced neoplastic transformation. | Cytochrome P450 2A13 mediates the neoplastic transformation of human bronchial epithelial cells at a low concentration of aflatoxin B1.
Zhang Z, Lu H, Huan F, Meghan C, Yang X, Wang Y, Wang X, Wang X, Wang SL. | 04/19/2014 |
| Data suggest important role of CYP2A13 in AFG1- (aflatoxin G1)-induced cytotoxicity, DNA damage, and activation of signal pathways in bronchial epithelium; data suggest similarities in CYP2A13-catalyzed bioactivation of AFG1 and AFB1 (aflatoxin B1). | Cytochrome P450 2A13 is an efficient enzyme in metabolic activation of aflatoxin G1 in human bronchial epithelial cells.
Zhang Z, Yang X, Wang Y, Wang X, Lu H, Zhang X, Xiao X, Li S, Wang X, Wang SL. | 04/12/2014 |
| CYP2A13 is efficient in 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone bioactivation in vivo and it can mediate 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis. | Role of CYP2A13 in the bioactivation and lung tumorigenicity of the tobacco-specific lung procarcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone: in vivo studies using a CYP2A13-humanized mouse model.
Megaraj V, Zhou X, Xie F, Liu Z, Yang W, Ding X., Free PMC Article | 04/5/2014 |
| Findings suggest the potential involvement of pulmonary CYP2A13 in the early occurrence of NSCLC as well as in the development of EGFR gene mutations. | Pulmonary CYP2A13 levels are associated with early occurrence of lung cancer-Its implication in mutagenesis of non-small cell lung carcinoma.
Chiang HC, Lee H, Chao HR, Chiou YH, Tsou TC. | 02/15/2014 |
| an efficient approach for expressing functionally characterized, highly active and homogeneous CYP2A13 proteins. | Optimization of heme precursors for the expression of human cytochrome P450 2A13 and its co-expression with oxidoreductase in baculovirus/sf9 system.
Lu HY, Qiu LL, Yang XJ, Zhang XM, Zhang Z, Wang SL. | 11/23/2013 |
| CYP2A13 plays an important role in low-concentration AFB1-induced DNA damage, possibly linking environmental airborne AFB1 to genetic injury in the human respiratory system. | Hypoxia inducible factor-1 (HIF-1)-flavin containing monooxygenase-2 (FMO-2) signaling acts in silver nanoparticles and silver ion toxicity in the nematode, Caenorhabditis elegans.
Eom HJ, Ahn JM, Kim Y, Choi J. | 10/19/2013 |
| Findings suggest that CYP2A13 plays an important role in low-concentration AFB1-induced DNA damage, possibly linking environmental airborne AFB1 to genetic injury in human respiratory system. | Cytochrome P450 2A13 enhances the sensitivity of human bronchial epithelial cells to aflatoxin B1-induced DNA damage.
Yang X, Zhang Z, Wang X, Wang Y, Zhang X, Lu H, Wang SL. | 10/19/2013 |
| The differential distribution pattern of CYP2A13 in the respiratory tract, which is of importance in considering the pulmonary susceptibility to carcinogens and the following lung cancer development, is detailed. | Differential distribution of CYP2A6 and CYP2A13 in the human respiratory tract.
Chiang HC, Wang CK, Tsou TC. | 03/16/2013 |
| Tissue distribution of transgenic mRNA expression agrees well with the known respiratory tract-selective expression of CYP2A13 and CYP2F1 and hepatic expression of CYP2B6 in humans. | Generation and characterization of a CYP2A13/2B6/2F1-transgenic mouse model.
Wei Y, Wu H, Li L, Liu Z, Zhou X, Zhang QY, Weng Y, D'Agostino J, Ling G, Zhang X, Kluetzman K, Yao Y, Ding X., Free PMC Article | 03/9/2013 |
| Report selective expression of CYP2A13 in human pancreatic alpha-islet cells. | Selective expression of CYP2A13 in human pancreatic α-islet cells.
Guo Y, Zhu LR, Lu G, Wang H, Hong JY., Free PMC Article | 02/16/2013 |
| Report CYP2A-selective inhibitors to accurately distinguish between CYP2A6 and CYP2A13 activity. | Evaluation of inhibition selectivity for human cytochrome P450 2A enzymes.
Stephens ES, Walsh AA, Scott EE., Free PMC Article | 01/26/2013 |
| Although both the hepatic CYP2A6 and respiratory CYP2A13 enzymes metabolize these compounds, CYP2A13 does so with much higher catalytic efficiency, but the structural basis for this has been unclear | Nicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone binding and access channel in human cytochrome P450 2A6 and 2A13 enzymes.
DeVore NM, Scott EE., Free PMC Article | 11/17/2012 |
| The distribution frequencies of all eight known CYP2A13 missense alleles were examined in a Chinese Han population. | An investigation of the catalytic activity of CYP2A13*4 with coumarin and polymorphisms of CYP2A13 in a Chinese Han population.
Liu T, Hong Y, Li Z, Hong J, Zeng S, Zheng M, Chen S. | 08/25/2012 |
| present results provide the first direct in vitro evidence demonstrating the predominant roles of CYP2A13 in 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced mutagenesis, possibly via metabolic activation of NNK alpha-hydroxylation | Metabolic effects of CYP2A6 and CYP2A13 on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced gene mutation--a mammalian cell-based mutagenesis approach.
Chiang HC, Wang CY, Lee HL, Tsou TC. | 09/3/2011 |