| Direct inhibition of human APOBEC3 deaminases by HIV-1 Vif independent of the proteolysis pathway. | Direct inhibition of human APOBEC3 deaminases by HIV-1 Vif independent of the proteolysis pathway.
Kamba K, Wan L, Unzai S, Morishita R, Takaori-Kondo A, Nagata T, Katahira M., | 02/12/2024 |
| The structural basis for HIV-1 Vif antagonism of human APOBEC3G. | The structural basis for HIV-1 Vif antagonism of human APOBEC3G.
Li YL, Langley CA, Azumaya CM, Echeverria I, Chesarino NM, Emerman M, Cheng Y, Gross JD., Free PMC Article | 03/24/2023 |
| Identification of Clinically Relevant HIV Vif Protein Motif Mutations through Machine Learning and Undersampling. | Identification of Clinically Relevant HIV Vif Protein Motif Mutations through Machine Learning and Undersampling.
Altamirano-Flores JS, Alvarado-Hernández LÁ, Cuevas-Tello JC, Tino P, Guerra-Palomares SE, Garcia-Sepulveda CA., Free PMC Article | 03/14/2023 |
| Dominant Negative Mutants of Human Immunodeficiency Virus Type 1 Viral Infectivity Factor (Vif) Disrupt Core-Binding Factor Beta-Vif Interaction. | Dominant Negative Mutants of Human Immunodeficiency Virus Type 1 Viral Infectivity Factor (Vif) Disrupt Core-Binding Factor Beta-Vif Interaction.
Duan S, Yu X, Wang C, Meng L, Gai Y, Zhou Y, Gu T, Yu B, Wu J, Yu X., Free PMC Article | 09/24/2022 |
| HIV-1 VIF and human APOBEC3G interaction directly observed through molecular specific labeling using a new dual promotor vector. | HIV-1 VIF and human APOBEC3G interaction directly observed through molecular specific labeling using a new dual promotor vector.
Myint W, Schiffer CA, Matsuo H., Free PMC Article | 07/9/2022 |
| Host AKT-mediated phosphorylation of HIV-1 accessory protein Vif potentiates infectivity via enhanced degradation of the restriction factor APOBEC3G. | Host AKT-mediated phosphorylation of HIV-1 accessory protein Vif potentiates infectivity via enhanced degradation of the restriction factor APOBEC3G.
Raja R, Wang C, Mishra R, Das A, Ali A, Banerjea AC., Free PMC Article | 05/14/2022 |
| STUB1/CHIP promotes ubiquitination and degradation of HIV-1 Vif to restore the cellular level of APOBEC3G protein. | STUB1/CHIP promotes ubiquitination and degradation of HIV-1 Vif to restore the cellular level of APOBEC3G protein.
Ali A, Kumar V, Banerjea AC. | 11/22/2021 |
| Multifaceted HIV-1 Vif interactions with human E3 ubiquitin ligase and APOBEC3s. | Multifaceted HIV-1 Vif interactions with human E3 ubiquitin ligase and APOBEC3s.
Hu Y, Knecht KM, Shen Q, Xiong Y., Free PMC Article | 07/24/2021 |
| Antagonism of PP2A is an independent and conserved function of HIV-1 Vif and causes cell cycle arrest. | Antagonism of PP2A is an independent and conserved function of HIV-1 Vif and causes cell cycle arrest.
Marelli S, Williamson JC, Protasio AV, Naamati A, Greenwood EJ, Deane JE, Lehner PJ, Matheson NJ., Free PMC Article | 04/13/2021 |
| High-speed atomic force microscopy directly visualizes conformational dynamics of the HIV Vif protein in complex with three host proteins. | High-speed atomic force microscopy directly visualizes conformational dynamics of the HIV Vif protein in complex with three host proteins.
Pan Y, Shlyakhtenko LS, Lyubchenko YL., Free PMC Article | 01/23/2021 |
| Functional and Structural Insights into a Vif/PPP2R5 Complex Elucidated Using Patient HIV-1 Isolates and Computational Modeling. | Functional and Structural Insights into a Vif/PPP2R5 Complex Elucidated Using Patient HIV-1 Isolates and Computational Modeling.
Salamango DJ, McCann JL, Demir Ö, Becker JT, Wang J, Lingappa JR, Temiz NA, Brown WL, Amaro RE, Harris RS., Free PMC Article | 01/2/2021 |
| HIV-1 Vif Triggers Cell Cycle Arrest by Degrading Cellular PPP2R5 Phospho-regulators. | HIV-1 Vif Triggers Cell Cycle Arrest by Degrading Cellular PPP2R5 Phospho-regulators.
Salamango DJ, Ikeda T, Moghadasi SA, Wang J, McCann JL, Serebrenik AA, Ebrahimi D, Jarvis MC, Brown WL, Harris RS., Free PMC Article | 09/26/2020 |
| Inhibition of Vif-Mediated Degradation of APOBEC3G through Competitive Binding of Core-Binding Factor Beta. | Inhibition of Vif-Mediated Degradation of APOBEC3G through Competitive Binding of Core-Binding Factor Beta.
Miyagi E, Welbourn S, Sukegawa S, Fabryova H, Kao S, Strebel K., Free PMC Article | 09/19/2020 |
| The analysis found HLA-associated HIV-1 CRF02_AG non-synonymous polymorphisms at 19 sites; 13 in gag and six in vif, including those that were newly determined. | Human Leukocyte Antigen-Associated HIV-1 CRF02_AG gag and vif Polymorphisms in Ghana.
Adusei-Poku MA, Matsuoka S, Bonney EY, Abana CZ, Duker EO, Nii-Trebi NI, Ofori SB, Mizutani T, Ishizaka A, Shiino T, Kawana-Tachikawa A, Ishikawa K, Ampofo WK, Matano T. | 04/18/2020 |
| The cryo-EM structure of the Vif-targeted C-terminal domain of human A3F in complex with HIV-1 Vif and the cellular cofactor core-binding factor beta (CBFbeta) at 3.9-A resolution shows that Vif and CBFbeta form a platform to recruit A3F, revealing a direct A3F-recruiting role of CBFbeta beyond Vif stabilization, and it captures multiple independent A3F-Vif interfaces. | Structural basis of antagonism of human APOBEC3F by HIV-1 Vif.
Hu Y, Desimmie BA, Nguyen HC, Ziegler SJ, Cheng TC, Chen J, Wang J, Wang H, Zhang K, Pathak VK, Xiong Y., Free PMC Article | 02/15/2020 |
| CBFB is essential for HIV-1 Vif to arrest host cells at G2/M phase. Vif-CBFB interaction is required for Vif-triggered cell cycle regulation. | Vif-CBFβ interaction is essential for Vif-induced cell cycle arrest.
Du J, Rui Y, Zheng W, Li P, Kang J, Zhao K, Sun T, Yu XF. | 01/18/2020 |
| Here, using a quantitative proteomics approach, the authors identify the E3 ligase ARIH2 as a regulator of the HIV-1 Vif protein-dependent CRL5-mediated APOBEC3 degradation. The CUL5(Vif/CBFss) complex recruits ARIH2 where it acts to transfer ubiquitin directly to the APOBEC3 targets. | ARIH2 Is a Vif-Dependent Regulator of CUL5-Mediated APOBEC3G Degradation in HIV Infection.
Hüttenhain R, Xu J, Burton LA, Gordon DE, Hultquist JF, Johnson JR, Satkamp L, Hiatt J, Rhee DY, Baek K, Crosby DC, Frankel AD, Marson A, Harper JW, Alpi AF, Schulman BA, Gross JD, Krogan NJ., Free PMC Article | 11/23/2019 |
| two stem-loop structures within the 5'-untranslated region of A3G mRNA are crucial for translation inhibition by Vif in HIV-infected cells, and most Vif alleles neutralize A3G translation efficiently | Translational regulation of APOBEC3G mRNA by Vif requires its 5'UTR and contributes to restoring HIV-1 infectivity.
Guerrero S, Libre C, Batisse J, Mercenne G, Richer D, Laumond G, Decoville T, Moog C, Marquet R, Paillart JC., Free PMC Article | 07/14/2018 |
| Vif was also unable to induce G2/M cell cycle arrest in other nonhuman cell types, including cells derived from nonhuman primates, leading to propose that one or more human-specific cofactors underpin Vif's ability to modulate the cell cycle. | HIV-1 Vif's Capacity To Manipulate the Cell Cycle Is Species Specific.
Evans EL 3rd, Becker JT, Fricke SL, Patel K, Sherer NM., Free PMC Article | 04/21/2018 |
| structural model suggests that the diverse FIV and HIV-1 Vifs use conserved residues for Cullin 5 binding, FIV Vif binds Cullin 5 independently of zinc, in contrast to HIV-1 Vif. | Identification of a Conserved Interface of Human Immunodeficiency Virus Type 1 and Feline Immunodeficiency Virus Vifs with Cullin 5.
Gu Q, Zhang Z, Gertzen CGW, Häussinger D, Gohlke H, Münk C., Free PMC Article | 04/14/2018 |
| Moreover, using a CBF-beta loss-of-function mutant, the authors demonstrated that the interaction between CBF-beta and Vif was not sufficient for Vif assistance; a region including F68 in CBF-beta was also required for the stability and function of Vif. | Clues for two-step virion infectivity factor regulation by core binding factor beta.
Ai Y, Ma J, Wang X., Free PMC Article | 07/15/2017 |
| Here, the authors show that APOBEC3G polyubiquitination is essential for its HIV-1 vif-induced degradation. | Differential Contributions of Ubiquitin-Modified APOBEC3G Lysine Residues to HIV-1 Vif-Induced Degradation.
Turner T, Shao Q, Wang W, Wang Y, Wang C, Kinlock B, Liu B., Free PMC Article | 06/24/2017 |
| cyclin F functions as an intrinsic cellular regulator of HIV-1 Vif and has a negative regulatory effect on the maintenance of viral infectivity by restoring APOBEC3G expression. | Cyclin F/FBXO1 Interacts with HIV-1 Viral Infectivity Factor (Vif) and Restricts Progeny Virion Infectivity by Ubiquitination and Proteasomal Degradation of Vif Protein through SCF(cyclin F) E3 Ligase Machinery.
Augustine T, Chaudhary P, Gupta K, Islam S, Ghosh P, Santra MK, Mitra D., Free PMC Article | 06/24/2017 |
| The overall conclusion from this study is that it may not be possible to select Vif-null viruses capable of replicating in relevant HIV target cells in vivo thus highlighting the critical role of Vif for HIV-1 replication. | Long-term passage of Vif-null HIV-1 in CD4(+) T cells expressing sub-lethal levels of APOBEC proteins fails to develop APOBEC resistance.
Miyagi E, Kao S, Fumitaka M, Buckler-White A, Plishka R, Strebel K., Free PMC Article | 05/27/2017 |
| Vif stabilization by CBFbeta is mainly caused by impairing MDM2-mediated degradation. | Core Binding Factor β Protects HIV, Type 1 Accessory Protein Viral Infectivity Factor from MDM2-mediated Degradation.
Matsui Y, Shindo K, Nagata K, Yoshinaga N, Shirakawa K, Kobayashi M, Takaori-Kondo A., Free PMC Article | 05/27/2017 |