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    AGR3 anterior gradient 3, protein disulphide isomerase family member [ Homo sapiens (human) ]

    Gene ID: 155465, updated on 2-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Prognostic Impact of AGR3 Protein Expression in Breast Cancer: A Systematic Review and Meta-analysis.

    Prognostic Impact of AGR3 Protein Expression in Breast Cancer: A Systematic Review and Meta-analysis.
    Moraes CL, Mendonça CR, Melo NCE, Tacon FSA, Junior JPM, Amaral WND., Free PMC Article

    11/15/2023
    Over-expression of Anterior Gradient 3 Is Associated With Tumor Progression and Poor Survival in Gastric Cancer.

    Over-expression of Anterior Gradient 3 Is Associated With Tumor Progression and Poor Survival in Gastric Cancer.
    Lee WS, Park SY, Park YL, Joo YE., Free PMC Article

    01/11/2023
    Integrative analysis of genomic and transcriptomic alterations of AGR2 and AGR3 in cancer.

    Integrative analysis of genomic and transcriptomic alterations of AGR2 and AGR3 in cancer.
    Fessart D, Villamor I, Chevet E, Delom F, Robert J., Free PMC Article

    07/30/2022
    Estrogen-regulated AGR3 activates the estrogen receptor signaling pathway to promote tamoxifen resistance in breast cancer.

    Estrogen-regulated AGR3 activates the estrogen receptor signaling pathway to promote tamoxifen resistance in breast cancer.
    Jiang R, Sun Y, Chen X, Shi P.

    11/6/2021
    Profile of anterior gradient 3 (AGR3) mRNA expression and serum levels in benign and malignant breast tumors.

    Profile of anterior gradient 3 (AGR3) mRNA expression and serum levels in benign and malignant breast tumors.
    Prihantono P, Rahardjo W, Syamsu SA, Smaradhania N.

    10/30/2021
    Anterior Gradient Protein 3 and S100 Calcium-Binding Protein P Levels in Different Endometrial Epithelial Compartments May Play an Important Role in Recurrent Pregnancy Failure.

    Anterior Gradient Protein 3 and S100 Calcium-Binding Protein P Levels in Different Endometrial Epithelial Compartments May Play an Important Role in Recurrent Pregnancy Failure.
    Tempest N, Batchelor E, Hill CJ, Al-Lamee H, Drury J, Drakeley AJ, Hapangama DK., Free PMC Article

    05/22/2021
    AGR3 promotes the stemness of colorectal cancer via modulating Wnt/beta-catenin signalling.

    AGR3 promotes the stemness of colorectal cancer via modulating Wnt/β-catenin signalling.
    Chi J, Zhang H, Hu J, Song Y, Li J, Wang L, Wang Z.

    02/6/2021
    The recombinant expression, purification, crystallization and structure of the human AGR3 are described.

    Crystal structure of human anterior gradient protein 3.
    Nguyen VD, Biterova E, Salin M, Wierenga RK, Ruddock LW., Free PMC Article

    01/26/2019
    Results show that AGR3 was highly upregulated in low-grade serous carcinoma (LGSC) compared to high-grade serous carcinoma (HGSC). It can be use along with p53 for differential diagnosis of HGSC and LGSC.

    Combination of TP53 and AGR3 to distinguish ovarian high-grade serous carcinoma from low-grade serous carcinoma.
    Qiu C, Wang Y, Wang X, Zhang Q, Li Y, Xu Y, Jin C, Bu H, Zheng W, Yang X, Lu N, Kong B.

    10/13/2018
    transcriptionally activated in hepatitis C virus-infected cells by HCV NS5A

    The NS5A protein of hepatitis C virus transcriptionally upregulates the AGR3 gene expression.
    Chen M, Gan X, Deng L, Hotta H.

    02/6/2016
    Data show the potential usability of anterior gradient homolog 3 (AGR3) and anterior gradient homolog 2 (AGR2) as biomarkers for blood-based early detection of breast cancer.

    AGR3 in breast cancer: prognostic impact and suitable serum-based biomarker for early cancer detection.
    Garczyk S, von Stillfried S, Antonopoulos W, Hartmann A, Schrauder MG, Fasching PA, Anzeneder T, Tannapfel A, Ergönenc Y, Knüchel R, Rose M, Dahl E., Free PMC Article

    01/16/2016
    AGR3 is a specialized member of the PDI family that plays an unexpected role in the regulation of CBF and mucociliary clearance in the airway.

    The Endoplasmic Reticulum Resident Protein AGR3. Required for Regulation of Ciliary Beat Frequency in the Airway.
    Bonser LR, Schroeder BW, Ostrin LA, Baumlin N, Olson JL, Salathe M, Erle DJ., Free PMC Article

    01/2/2016
    Relying on available data and in silico analyses, study shows that AGR2 and AGR3 proteins are co-expressed or uncoupled in context-dependent manners in diverse carcinomas and healthy tissues.

    The role of AGR2 and AGR3 in cancer: similar but not identical.
    Obacz J, Takacova M, Brychtova V, Dobes P, Pastorekova S, Vojtesek B, Hrstka R.

    09/26/2015
    AGR3 was is predominantly expressed in liver cholangiocytes but not present in liver hepatocytes, making this protain a good marker for differential diagnosis of intrahepatic cholangiocarcinoma

    Differential expression of anterior gradient protein 3 in intrahepatic cholangiocarcinoma and hepatocellular carcinoma.
    Brychtova V, Zampachova V, Hrstka R, Fabian P, Novak J, Hermanova M, Vojtesek B.

    08/9/2014
    AGR3 expression in ovarian cancer is independent of oestrogen-receptor expression.

    Anterior Gradient-3: a novel biomarker for ovarian cancer that mediates cisplatin resistance in xenograft models.
    Gray TA, MacLaine NJ, Michie CO, Bouchalova P, Murray E, Howie J, Hrstka R, Maslon MM, Nenutil R, Vojtesek B, Langdon S, Hayward L, Gourley C, Hupp TR.

    07/21/2012
    AGR3 could serve as a prognostic marker for survival in patients with low grade and high grade serous ovarian carcinomas.

    The anterior gradient homolog 3 (AGR3) gene is associated with differentiation and survival in ovarian cancer.
    King ER, Tung CS, Tsang YT, Zu Z, Lok GT, Deavers MT, Malpica A, Wolf JK, Lu KH, Birrer MJ, Mok SC, Gershenson DM, Wong KK., Free PMC Article

    07/16/2011
    specific induction of Hag2 and Hag3 during hormone-induced breast carcinomas further support developmental specificity for the PDI/ERp family members

    Diversity of the protein disulfide isomerase family: identification of breast tumor induced Hag2 and Hag3 as novel members of the protein family.
    Persson S, Rosenquist M, Knoblach B, Khosravi-Far R, Sommarin M, Michalak M.

    01/21/2010
    hAG-2 and hAG-3, human homologues of genes involved in differentiation, are associated with oestrogen receptor-positive breast tumours and interact with metastasis gene C4.4a and dystroglycan [hAG-3 protein]

    hAG-2 and hAG-3, human homologues of genes involved in differentiation, are associated with oestrogen receptor-positive breast tumours and interact with metastasis gene C4.4a and dystroglycan.
    Fletcher GC, Patel S, Tyson K, Adam PJ, Schenker M, Loader JA, Daviet L, Legrain P, Parekh R, Harris AL, Terrett JA., Free PMC Article

    01/21/2010
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