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    CYP2B6 cytochrome P450 family 2 subfamily B member 6 [ Homo sapiens (human) ]

    Gene ID: 1555, updated on 5-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Functional significance of CYP2B6 gene rare allelic variants identified in Japanese individuals.

    Functional significance of CYP2B6 gene rare allelic variants identified in Japanese individuals.
    Yamazaki S, Hishinuma E, Suzuki Y, Ueda A, Kijogi C, Nakayoshi T, Oda A, Saito S, Tadaka S, Kinoshita K, Maekawa M, Sato Y, Kumondai M, Mano N, Hirasawa N, Hiratsuka M.

    11/5/2024
    Prenatal efavirenz exposure is independently associated with maternal, but not fetal CYP2B6 genotype.

    Prenatal efavirenz exposure is independently associated with maternal, but not fetal CYP2B6 genotype.
    Eniayewu O, Akinloye A, Shenkoya B, Azuka U, Bolaji O, Adejuyigbe E, Owen A, Olagunju A., Free PMC Article

    10/25/2024
    The role of polymorphic cytochrome P450 gene (CYP2B6) in B-chronic lymphocytic leukemia (B-CLL) incidence and outcome among Egyptian patients.

    The role of polymorphic cytochrome P450 gene (CYP2B6) in B-chronic lymphocytic leukemia (B-CLL) incidence and outcome among Egyptian patients.
    Al-Adl M, Youssef MM, El-Sebaie A, Refaat S, El-Said A., Free PMC Article

    04/4/2024
    Genetic polymorphisms in CYP2B6 may be associated with lung cancer risk in the Chinese Han population.

    Genetic polymorphisms in CYP2B6 may be associated with lung cancer risk in the Chinese Han population.
    Ma X, Zang X, Yang L, Zhou W, Li Y, Wei J, Guo J, Han J, Liang J, Jin T.

    02/22/2024
    Cytochrome P450 2B6 and UDP-Glucuronosyltransferase Enzyme-Mediated Clearance of Ciprofol (HSK3486) in Humans: The Role of Hepatic and Extrahepatic Metabolism.

    Cytochrome P450 2B6 and UDP-Glucuronosyltransferase Enzyme-Mediated Clearance of Ciprofol (HSK3486) in Humans: The Role of Hepatic and Extrahepatic Metabolism.
    Zhou Y, Dong H, Fan J, Zhu M, Liu L, Wang Y, Tang P, Chen X.

    01/12/2024
    Genetic polymorphisms of CYP2B6 is a risk of metabolic associated fatty liver disease in Chinese population.

    Genetic polymorphisms of CYP2B6 is a risk of metabolic associated fatty liver disease in Chinese population.
    Zhang J, Ma S, Zhou W, Feng J, Kang Y, Yang W, Zhang H, Deng F.

    01/5/2024
    Expression of CYP2B6 Enzyme in Human Liver Tissue of HIV and HCV Patients.

    Expression of CYP2B6 Enzyme in Human Liver Tissue of HIV and HCV Patients.
    Obradovic B, Roberts O, Owen A, Milosevic I, Milic N, Ranin J, Dragovic G., Free PMC Article

    08/3/2023
    Physiologically Based Pharmacokinetic Modeling to Determine the Impact of CYP2B6 Genotype on Efavirenz Exposure in Children, Mothers and Breastfeeding Infants.

    Physiologically Based Pharmacokinetic Modeling to Determine the Impact of CYP2B6 Genotype on Efavirenz Exposure in Children, Mothers and Breastfeeding Infants.
    Pan X, Rowland Yeo K.

    06/26/2023
    Multidisciplinary Insights into the Structure-Function Relationship of the CYP2B6 Active Site.

    Multidisciplinary Insights into the Structure-Function Relationship of the CYP2B6 Active Site.
    Angle ED, Cox PM.

    03/3/2023
    Allelic and Genotype Frequencies of CYP2B6[ *]2 (64C > T) and CYP2B6[ *]3 (777C > A) in Three Dominant Ethnicities of the Iranian Population.

    Allelic and Genotype Frequencies of CYP2B6(∗)2 (64C > T) and CYP2B6(∗)3 (777C > A) in Three Dominant Ethnicities of the Iranian Population.
    Khavandegar A, Tavakoli-Far B, Ansari S, Veis-Karami P, Ghasemi F, Sheibaninia S, Jazayeri R, Houshmand M., Free PMC Article

    03/1/2023
    Human CYP2B6 produces oxylipins from polyunsaturated fatty acids and reduces diet-induced obesity.

    Human CYP2B6 produces oxylipins from polyunsaturated fatty acids and reduces diet-induced obesity.
    Heintz MM, Eccles JA, Olack EM, Maner-Smith KM, Ortlund EA, Baldwin WS., Free PMC Article

    12/24/2022
    CYP2B6 SINGLE NUCLEOTIDE POLYMORPHISMS IN AN AZERBAIJANI POPULATION.

    CYP2B6 SINGLE NUCLEOTIDE POLYMORPHISMS IN AN AZERBAIJANI POPULATION.
    Ildirim N.

    12/24/2022
    The Efficacy of Cyclophosphamide Combined with Prednisone in Membranous Nephropathy Patients with Different Cytochrome P450 2B6 Gene Polymorphisms and Analysis of Factors Influencing the Efficacy.

    The Efficacy of Cyclophosphamide Combined with Prednisone in Membranous Nephropathy Patients with Different Cytochrome P450 2B6 Gene Polymorphisms and Analysis of Factors Influencing the Efficacy.
    Zhang M, Lv Y, Liu H., Free PMC Article

    10/29/2022
    Adenosine N(6)-methylation upregulates the expression of human CYP2B6 by altering the chromatin status.

    Adenosine N(6)-methylation upregulates the expression of human CYP2B6 by altering the chromatin status.
    Isono M, Nakano M, Fukami T, Nakajima M.

    10/29/2022
    Lack of association of CYP2B6 pharmacogenetics with cyclophosphamide toxicity in patients with cancer.

    Lack of association of CYP2B6 pharmacogenetics with cyclophosphamide toxicity in patients with cancer.
    Hwang M, Medley S, Shakeel F, Vanderwerff B, Zawistowski M, Kidwell KM, Hertz DL.

    08/27/2022
    New Genetic Variants in CYP2B6 and SLC6A Support the Role of Oxidative Stress in Familial Meniere's Disease.

    New Genetic Variants in CYP2B6 and SLC6A Support the Role of Oxidative Stress in Familial Ménière's Disease.
    Skarp S, Korvala J, Kotimäki J, Sorri M, Männikkö M, Hietikko E., Free PMC Article

    07/2/2022
    Genetic variants in CYP2B6 and HSD17B12 associated with risk of squamous cell carcinoma of the head and neck.

    Genetic variants in CYP2B6 and HSD17B12 associated with risk of squamous cell carcinoma of the head and neck.
    Liu H, Li G, Sturgis EM, Shete S, Dahlstrom KR, Du M, Amos CI, Christiani DC, Lazarus P, Wei Q., Free PMC Article

    06/25/2022
    The Role of CYP2B6*6 Gene Polymorphisms in 3,5,6-Trichloro-2-pyridinol Levels as a Biomarker of Chlorpyrifos Toxicity Among Indonesian Farmers.

    The Role of CYP2B6*6 Gene Polymorphisms in 3,5,6-Trichloro-2-pyridinol Levels as a Biomarker of Chlorpyrifos Toxicity Among Indonesian Farmers.
    Liem JF, Suryandari DA, Malik SG, Mansyur M, Soemarko DS, Kekalih A, Subekti I, Suyatna FD, Pangaribuan B., Free PMC Article

    06/18/2022
    Trough plasma nevirapine levels, immunologic and virologic responses in composite CYP2B6*6/*18 HIV-infected adult Nigerian patients.

    Trough plasma nevirapine levels, immunologic and virologic responses in composite CYP2B6*6/*18 HIV-infected adult Nigerian patients.
    Abdullahi ST, Soyinka JO, Bolarinwa RA, Olarewaju OJ, Salami AK, Bakare-Odunola MT.

    06/11/2022
    The role of CYP2B6 516G>T polymorphism on efavirenz/nevirapine toxicity. Implications on treatment outcomes: Lessons from Botswana.

    The role of CYP2B6 516G>T polymorphism on efavirenz/nevirapine toxicity. Implications on treatment outcomes: Lessons from Botswana.
    Maseng MJ, Tawe L, Thami PK, Moyo S, Kasvosve I, Novitsky V, Essex M, Russo G, Gaseitsiwe S, Paganotti GM., Free PMC Article

    05/14/2022
    CYP2B6 allelic variants and non-genetic factors influence CYP2B6 enzyme function.

    CYP2B6 allelic variants and non-genetic factors influence CYP2B6 enzyme function.
    Mangó K, Kiss ÁF, Fekete F, Erdős R, Monostory K., Free PMC Article

    05/14/2022
    Association of CYP2B6 genetic polymorphisms with bupropion and hydroxybupropion exposure: A systematic review and meta-analysis.

    Association of CYP2B6 genetic polymorphisms with bupropion and hydroxybupropion exposure: A systematic review and meta-analysis.
    Eum S, Sayre F, Lee AM, Stingl JC, Bishop JR.

    03/19/2022
    Associations of CYP2B6 genetic polymorphisms with Hirschsprung's disease in a southern Chinese population.

    Associations of CYP2B6 genetic polymorphisms with Hirschsprung's disease in a southern Chinese population.
    Liu Y, Lan C, Li B, Wang N, Zuo X, Huang L, Wu Y, Zhu Y., Free PMC Article

    03/12/2022
    Novel associations between CYP2B6 polymorphisms, perioperative methadone metabolism and clinical outcomes in children.

    Novel associations between CYP2B6 polymorphisms, perioperative methadone metabolism and clinical outcomes in children.
    Packiasabapathy S, Aruldhas BW, Zhang P, Overholser BR, Quinney SK, Sadhasivam S., Free PMC Article

    02/12/2022
    DEC1 negatively regulates CYP2B6 expression by binding to the CYP2B6 promoter region ascribed to IL-6-induced downregulation of CYP2B6 expression in HeLa cells.

    DEC1 negatively regulates CYP2B6 expression by binding to the CYP2B6 promoter region ascribed to IL-6-induced downregulation of CYP2B6 expression in HeLa cells.
    Luan X, Zhao Y, Bu N, Chen Y, Chen N.

    02/5/2022
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