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    CYP2E1 cytochrome P450 family 2 subfamily E member 1 [ Homo sapiens (human) ]

    Gene ID: 1571, updated on 25-Apr-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    ERRgamma-inducible FGF23 promotes alcoholic liver injury through enhancing CYP2E1 mediated hepatic oxidative stress.

    ERRγ-inducible FGF23 promotes alcoholic liver injury through enhancing CYP2E1 mediated hepatic oxidative stress.
    Jung YS, Radhakrishnan K, Hammad S, Müller S, Müller J, Noh JR, Kim J, Lee IK, Cho SJ, Kim DK, Kim YH, Lee CH, Dooley S, Choi HS., Free PMC Article

    04/3/2024
    USP14 governs CYP2E1 to promote nonalcoholic fatty liver disease through deubiquitination and stabilization of HSP90AA1.

    USP14 governs CYP2E1 to promote nonalcoholic fatty liver disease through deubiquitination and stabilization of HSP90AA1.
    Wei D, Tian X, Zhu L, Wang H, Sun C., Free PMC Article

    08/30/2023
    CYP2E1 triggered GRP78/ATF6/CHOP signaling axis inhibit apoptosis and promotes progression of hepatocellular carcinoma.

    CYP2E1 triggered GRP78/ATF6/CHOP signaling axis inhibit apoptosis and promotes progression of hepatocellular carcinoma.
    Ishteyaque S, Yadav KS, Verma S, Washimkar KR, Mugale MN.

    08/30/2023
    ADH1B, ADH1B/C and CYP2E1 Gene Polymorphism and the Risk of Fetal Alcohol Spectrum Disorder.

    ADH1B, ADH1B/C and CYP2E1 Gene Polymorphism and the Risk of Fetal Alcohol Spectrum Disorder.
    Kukowka A, Brzuchalski B, Kurzawski M, Malinowski D, Białecka MA., Free PMC Article

    08/9/2023
    Influence of alcohol consumption and alcohol metabolism variants on breast cancer risk among Black women: results from the AMBER consortium.

    Influence of alcohol consumption and alcohol metabolism variants on breast cancer risk among Black women: results from the AMBER consortium.
    Young KL, Olshan AF, Lunetta K, Graff M, Williams LA, Yao S, Zirpoli GR, Troester M, Palmer JR., Free PMC Article

    06/14/2023
    Generation and Characterization of CYP2E1-Overexpressing HepG2 Cells to Study the Role of CYP2E1 in Hepatic Hypoxia-Reoxygenation Injury.

    Generation and Characterization of CYP2E1-Overexpressing HepG2 Cells to Study the Role of CYP2E1 in Hepatic Hypoxia-Reoxygenation Injury.
    Alwadei N, Rashid M, Chandrashekar DV, Rahighi S, Totonchy J, Sharma A, Mehvar R., Free PMC Article

    06/7/2023
    CYP2E1 C-1054T and 96-bp I/D genetic variations and risk of gestational diabetes mellitus in chinese women: a case-control study.

    CYP2E1 C-1054T and 96-bp I/D genetic variations and risk of gestational diabetes mellitus in chinese women: a case-control study.
    Pu Y, Liu Q, Hu K, Liu X, Bai H, Wu Y, Zhou M, Fan P., Free PMC Article

    06/5/2023
    Association between CYP2E1 C-1054T and 96-bp I/D genetic variations and the risk of polycystic ovary syndrome in Chinese women.

    Association between CYP2E1 C-1054T and 96-bp I/D genetic variations and the risk of polycystic ovary syndrome in Chinese women.
    Pu Y, Liu Q, Liu H, Bai H, Huang W, Xi M, Fan P.

    01/14/2023
    CYP2E1-dependent upregulation of SIRT7 is response to alcohol mediated metastasis in hepatocellular carcinoma.

    CYP2E1-dependent upregulation of SIRT7 is response to alcohol mediated metastasis in hepatocellular carcinoma.
    Zhang C, Zhao J, Zhao J, Liu B, Tang W, Liu Y, Huang W, Weinman SA, Li Z., Free PMC Article

    12/24/2022
    Association between CYP2E1 polymorphisms and colorectal cancer risk: a systematic review and meta-analysis.

    Association between CYP2E1 polymorphisms and colorectal cancer risk: a systematic review and meta-analysis.
    Sharzehan MAK, Sito H, Abdullah N, Alexiou A, Papadakis M, Jamal R, Tan SC., Free PMC Article

    12/3/2022
    Vulvar angiomyofibroblastoma is molecularly defined by recurrent MTG1-CYP2E1 fusions.

    Vulvar angiomyofibroblastoma is molecularly defined by recurrent MTG1-CYP2E1 fusions.
    Boyraz B, Tajiri R, Alwaqfi RR, Paula ADC, Ye Q, Nielsen GP, Hung YP, Oliva E, Weigelt B, Hisaoka M, Watkins JC., Free PMC Article

    11/19/2022
    CYP2D6 and CYP2E1 Gene Polymorphisms and their Association with Cervical Cancer Susceptibility: A Hospital Based Case-Control Study from South-Western Maharashtra.

    CYP2D6 and CYP2E1 Gene Polymorphisms and their Association with Cervical Cancer Susceptibility: A Hospital Based Case-Control Study from South-Western Maharashtra.
    Datkhile KD, Durgawale PP, Gudur RA, Gudur AK, Patil SR., Free PMC Article

    09/3/2022
    NAT2 and CYP2E1 polymorphisms and antituberculosis drug-induced hepatotoxicity in Peruvian patients.

    NAT2 and CYP2E1 polymorphisms and antituberculosis drug-induced hepatotoxicity in Peruvian patients.
    Jaramillo-Valverde L, Levano KS, Tarazona DD, Capristano S, Zegarra-Chapoñan R, Sanchez C, Yufra-Picardo VM, Tarazona-Santos E, Ugarte-Gil C, Guio H., Free PMC Article

    08/20/2022
    CYP2E1 plays a suppressive role in hepatocellular carcinoma by regulating Wnt/Dvl2/beta-catenin signaling.

    CYP2E1 plays a suppressive role in hepatocellular carcinoma by regulating Wnt/Dvl2/β-catenin signaling.
    Zhu L, Yang X, Feng J, Mao J, Zhang Q, He M, Mi Y, Mei Y, Jin G, Zhang H., Free PMC Article

    05/14/2022
    Potential pathogenetic link between angiomyofibroblastoma and superficial myofibroblastoma in the female lower genital tract based on a novel MTG1-CYP2E1 fusion.

    Potential pathogenetic link between angiomyofibroblastoma and superficial myofibroblastoma in the female lower genital tract based on a novel MTG1-CYP2E1 fusion.
    Tajiri R, Shiba E, Iwamura R, Kubo C, Nawata A, Harada H, Yoshino K, Hisaoka M.

    03/26/2022
    Allelic and genotypic frequencies of NAT2, CYP2E1, and AADAC genes in a cohort of Peruvian tuberculosis patients.

    Allelic and genotypic frequencies of NAT2, CYP2E1, and AADAC genes in a cohort of Peruvian tuberculosis patients.
    Levano KS, Jaramillo-Valverde L, Tarazona DD, Sanchez C, Capristano S, Vásquez-Loarte T, Solari L, Mendoza-Ticona A, Soto A, Rojas C, Zegarra-Chapoñan R, Guio H., Free PMC Article

    03/26/2022
    CYP2C8 and CYP2E1 genetic variants increase risk of tuberculosis in northwest Chinese Han population.

    CYP2C8 and CYP2E1 genetic variants increase risk of tuberculosis in northwest Chinese Han population.
    Xing S, Wang Y, He X, Yang W, Hu Q, He Y, Yuan D, Jin T.

    03/19/2022
    TA allele of rs2070673 in the CYP2E1 gene is associated with lobular inflammation and nonalcoholic steatohepatitis in patients with biopsy-proven nonalcoholic fatty liver disease.

    TA allele of rs2070673 in the CYP2E1 gene is associated with lobular inflammation and nonalcoholic steatohepatitis in patients with biopsy-proven nonalcoholic fatty liver disease.
    Ma HL, Chen SD, Zheng KI, Yu Y, Wang XX, Tang LJ, Li G, Rios RS, Huang OY, Zheng XY, Xu RA, Targher G, Byrne CD, Wang XD, Chen YP, Zheng MH.

    03/19/2022
    Genetic variation of pharmacogenomic VIP variants in Zhuang nationality of southern China.

    Genetic variation of pharmacogenomic VIP variants in Zhuang nationality of southern China.
    Liu Y, Li H, Cao K, Liu J, Sun Y, Wu J, Xiong Z, Niu F, Li J, Jin T.

    11/27/2021
    Inhibition of androgen/AR signaling inhibits diethylnitrosamine (DEN) induced tumour initiation and remodels liver immune cell networks.

    Inhibition of androgen/AR signaling inhibits diethylnitrosamine (DEN) induced tumour initiation and remodels liver immune cell networks.
    Helms TH, Mullins RD, Thomas-Ahner JM, Kulp SK, Campbell MJ, Lucas F, Schmidt N, LeMoine DM, Getaneh S, Xie Z, Phelps MA, Clinton SK, Coss CC., Free PMC Article

    11/13/2021
    [Liver Tissue-specific Genes IGFALS,CYP3A4,SLC22A1 and CYP2E1 May be Associated with Poor Prognosis of Liver Cancer].

    [Liver Tissue-specific Genes IGFALS,CYP3A4,SLC22A1 and CYP2E1 May be Associated with Poor Prognosis of Liver Cancer].
    Zhang YY, Cao J, Chen XT, Chen JH, Zheng YB.

    09/4/2021
    New insight and potential therapy for NAFLD: CYP2E1 and flavonoids.

    New insight and potential therapy for NAFLD: CYP2E1 and flavonoids.
    Wang K, Tan W, Liu X, Deng L, Huang L, Wang X, Gao X.

    07/24/2021
    Plasma cholinesterase activity is influenced by interactive effect between omethoate exposure and CYP2E1 polymorphisms.

    Plasma cholinesterase activity is influenced by interactive effect between omethoate exposure and CYP2E1 polymorphisms.
    Wang T, Zhang H, Li L, Zhang W, Wang Q, Wang W.

    06/19/2021
    Synonymous mutation rs2515641 affects CYP2E1 mRNA and protein expression and susceptibility to drug-induced liver injury.

    Synonymous mutation rs2515641 affects CYP2E1 mRNA and protein expression and susceptibility to drug-induced liver injury.
    Chen K, Guo R, Wei C.

    04/24/2021
    Association between genetic variants in CYP2E1 and CTRC genes and susceptibility to alcoholic pancreatitis: A systematic review and meta-analysis.

    Association between genetic variants in CYP2E1 and CTRC genes and susceptibility to alcoholic pancreatitis: A systematic review and meta-analysis.
    Usategui-Martín R, Carbonell C, Novo-Veleiro I, Hernández-Pinchete S, Mirón-Canelo JA, Chamorro AJ, Marcos M.

    03/27/2021
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