| ApoER2-Dab1 disruption as the origin of pTau-associated neurodegeneration in sporadic Alzheimer's disease. | ApoER2-Dab1 disruption as the origin of pTau-associated neurodegeneration in sporadic Alzheimer's disease.
Ramsden CE, Zamora D, Horowitz MS, Jahanipour J, Calzada E, Li X, Keyes GS, Murray HC, Curtis MA, Faull RM, Sedlock A, Maric D., Free PMC Article | 12/20/2023 |
| the repeat region associated with SCA37 is highly polymorphic, mutable, and unstable, and the AluJb seems to have had a role in these features, as the (ATTTC)n insertion was probably originated by one or more T>C substitutions in the Alu element. | Mutational mechanism for DAB1 (ATTTC)(n) insertion in SCA37: ATTTT repeat lengthening and nucleotide substitution.
Loureiro JR, Oliveira CL, Mota C, Castro AF, Costa C, Loureiro JL, Coutinho P, Martins S, Sequeiros J, Silveira I. | 03/17/2023 |
| Whole genome analysis in APOE4 homozygotes identifies the DAB1-RELN pathway in Alzheimer's disease pathogenesis. | Whole genome analysis in APOE4 homozygotes identifies the DAB1-RELN pathway in Alzheimer's disease pathogenesis.
Bracher-Smith M, Leonenko G, Baker E, Crawford K, Graham AC, Salih DA, Howell BW, Hardy J, Escott-Price V., Free PMC Article | 10/8/2022 |
| Inhibition of microRNA-300 inhibits cell adhesion, migration, and invasion of prostate cancer cells by promoting the expression of DAB1. | Inhibition of microRNA-300 inhibits cell adhesion, migration, and invasion of prostate cancer cells by promoting the expression of DAB1.
Li L, Hao J, Yan CQ, Wang HF, Meng B, Cai SY., Free PMC Article | 12/11/2021 |
| Disabled 1 Is Part of a Signaling Pathway Activated by Epidermal Growth Factor Receptor. | Disabled 1 Is Part of a Signaling Pathway Activated by Epidermal Growth Factor Receptor.
Dlugosz P, Teufl M, Schwab M, Kohl KE, Nimpf J., Free PMC Article | 09/11/2021 |
| Our study strongly suggests that Dab1 may be a potential tumour suppressor gene in breast cancer. | Disabled-1 is down-regulated in clinical breast cancer and regulates cell apoptosis through NF-κB/Bcl-2/caspase-9.
Cao RJ, Li K, Xing WY, Du S, Li Q, Zhu XJ, Cui SS., Free PMC Article | 06/20/2020 |
| The appearance of DAB1 and Reelin during fetal kidney development confirms their potential significant role in the formation of kidney structure or function. High DAB1 expression in the DCT implies its regulatory role in tubular formation or function maintenance during development. | Expression and localization of DAB1 and Reelin during normal human kidney development.
Racetin A, Jurić M, Filipović N, Šolić I, Kosović I, Glavina Durdov M, Kunac N, Zekić Tomaš S, Saraga M, Šoljić V, Martinović V, Petričević J, Restović I, Lasić V, Kostić S, Kablar B, Watanabe K, Katsuyama Y, Saraga Babić M, Vukojević K., Free PMC Article | 04/4/2020 |
| our findings provide direct evidence for the impaired Reelin-DAB1 transduction cascade in a patient with deleterious variants in the RELN gene, suggest, for the first time, an abnormal interplay between Reelin-DAB1 and mTORC1 signaling pathways in a patient with nonsyndromic ASD | Rare RELN variants affect Reelin-DAB1 signal transduction in autism spectrum disorder.
Sánchez-Sánchez SM, Magdalon J, Griesi-Oliveira K, Yamamoto GL, Santacruz-Perez C, Fogo M, Passos-Bueno MR, Sertié AL. | 08/17/2019 |
| In intestine a truncated Dab1 variant transmits the reelin signal and may play a role in clathrin-mediated apical endocytosis and in the control of cell-to-cell junction assembly. Dab1 variant may be a nucleocytoplasmic shuttling protein, inferred from its sequence and nuclear location. | Small and large intestine express a truncated Dab1 isoform that assembles in cell-cell junctions and co-localizes with proteins involved in endocytosis.
Vázquez-Carretero MD, García-Miranda P, Balda MS, Matter K, Peral MJ, Ilundain AA. | 09/8/2018 |
| these results establish an unstable repeat insertion in DAB1 as a cause of cerebellar degeneration. | A Pentanucleotide ATTTC Repeat Insertion in the Non-coding Region of DAB1, Mapping to SCA37, Causes Spinocerebellar Ataxia.
Seixas AI, Loureiro JR, Costa C, Ordóñez-Ugalde A, Marcelino H, Oliveira CL, Loureiro JL, Dhingra A, Brandão E, Cruz VT, Timóteo A, Quintáns B, Rouleau GA, Rizzu P, Carracedo Á, Bessa J, Heutink P, Sequeiros J, Sobrido MJ, Coutinho P, Silveira I., Free PMC Article | 08/5/2017 |
| Study shows that early neural cells transiently express Reelin at the time they leave the presumptive olfactory/vomeronasal epithelium and that Dab 1 is present in the migratory cell mass and in the presumptive ensheathing cells in the absence of reelin. | Human Neural Cells Transiently Express Reelin during Olfactory Placode Development.
Antal MC, Samama B, Ghandour MS, Boehm N., Free PMC Article | 05/21/2016 |
| this study is the first to provide genetic evidence for DAB1 as a candidate AD liability/protection gene, although the strength of the contribution of DAB1 may differ among populations | Functional enrichment analysis of three Alzheimer's disease genome-wide association studies identities DAB1 as a novel candidate liability/protective gene.
Gao H, Tao Y, He Q, Song F, Saffen D. | 11/7/2015 |
| results of this study demonstrated the presence of reelin, its receptors VLDLR and ApoER2 as well as Dab1 in the ENS and might indicate a novel role of the reelin system in regulating neuronal plasticity and pre-synaptic functions in the ENS. | Expression and regulation of reelin and its receptors in the enteric nervous system.
Böttner M, Ghorbani P, Harde J, Barrenschee M, Hellwig I, Vogel I, Ebsen M, Förster E, Wedel T. | 04/18/2015 |
| The finding of this study suggested that variations in DAB1 involved in the Reelin signaling pathway might contribute to genetic susceptibility to autism with Chinese Han decent. | Association study between genes in Reelin signaling pathway and autism identifies DAB1 as a susceptibility gene in a Chinese Han population.
Li J, Liu J, Zhao L, Ma Y, Jia M, Lu T, Ruan Y, Li Q, Yue W, Zhang D, Wang L. | 12/21/2013 |
| Variation in genes encoding proteins at the gateway of Reelin signaling: ligands RELN and APOE, their common receptors APOER2 and VLDLR, and adaptor DAB1, was examined. | Impact of the Reelin signaling cascade (ligands-receptors-adaptor complex) on cognition in schizophrenia.
Verbrugghe P, Bouwer S, Wiltshire S, Carter K, Chandler D, Cooper M, Morar B, Razif MF, Henders A, Badcock JC, Dragovic M, Carr V, Almeida OP, Flicker L, Montgomery G, Jablensky A, Kalaydjieva L. | 09/8/2012 |
| show that Reelin-stimulated Notch-1 activation is dependent on Reelin signaling | Reelin regulates differentiation of neural stem cells by activation of notch signaling through Disabled-1 tyrosine phosphorylation.
Keilani S, Healey D, Sugaya K. | 07/28/2012 |
| alternative splicing of Dab1 is conserved in avian and mammalian species, with Dab1-L driving SFK phosphorylation in both species | Disabled-1 alternative splicing in human fetal retina and neural tumors.
Katyal S, Glubrecht DD, Li L, Gao Z, Godbout R., Free PMC Article | 07/21/2012 |
| we report for the first time, that DAB1 is significantly up-regulated in human frontal cortex brain samples of Alzheimer disease patients | The AICD interacting protein DAB1 is up-regulated in Alzheimer frontal cortex brain samples and causes deregulation of proteins involved in gene expression changes.
Müller T, Loosse C, Schrötter A, Schnabel A, Helling S, Egensperger R, Marcus K. | 12/10/2011 |
| Dab1, an essential component of the reelin pathway, is required for glia-independent somal translocation in the neocortex. | Reelin regulates cadherin function via Dab1/Rap1 to control neuronal migration and lamination in the neocortex.
Franco SJ, Martinez-Garay I, Gil-Sanz C, Harkins-Perry SR, Müller U., Free PMC Article | 04/16/2011 |
| Fe65 and Dab1 compete for binding to APP. Dab1 significantly decreased the amount of APP bound to LRP and the level of secreted APP and APP-CTF in LRP expressing cells | Dab1 binds to Fe65 and diminishes the effect of Fe65 or LRP1 on APP processing.
Kwon OY, Hwang K, Kim JA, Kim K, Kwon IC, Song HK, Jeon H. | 01/29/2011 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators., Free PMC Article | 09/15/2010 |
| Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) | Genome-wide association study of vitamin D concentrations in Hispanic Americans: the IRAS family study.
Engelman CD, Meyers KJ, Ziegler JT, Taylor KD, Palmer ND, Haffner SM, Fingerlin TE, Wagenknecht LE, Rotter JI, Bowden DW, Langefeld CD, Norris JM., Free PMC Article | 09/15/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium., Free PMC Article | 09/15/2010 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| Thus, the present observations suggest a correlation between Dab1 phosphorylation, Abeta deposition and PrP(sc) type in sCJD. | Involvement of Dab1 in APP processing and beta-amyloid deposition in sporadic Creutzfeldt-Jakob patients.
Gavín R, Ferrer I, del Río JA. | 06/28/2010 |