| Role of SLC5A8 as a Tumor Suppressor in Cervical Cancer. | Role of SLC5A8 as a Tumor Suppressor in Cervical Cancer.
Vargas-Sierra O, Hernández-Juárez J, Uc-Uc PY, Herrera LA, Domínguez-Gómez G, Gariglio P, Díaz-Chávez J. | 03/1/2024 |
| Role of hypermethylated SLC5A8 in follicular thyroid cancer diagnosis and prognosis prediction. | Role of hypermethylated SLC5A8 in follicular thyroid cancer diagnosis and prognosis prediction.
Yang Y, Liao C, Yang Q, Li Y, Tang Y, Xu B., Free PMC Article | 11/29/2023 |
| Structure and mechanism of the SGLT family of glucose transporters. | Structure and mechanism of the SGLT family of glucose transporters.
Han L, Qu Q, Aydin D, Panova O, Robertson MJ, Xu Y, Dror RO, Skiniotis G, Feng L., Free PMC Article | 05/7/2022 |
| Lactobacillus plantarum-derived metabolites sensitize the tumor-suppressive effects of butyrate by regulating the functional expression of SMCT1 in 5-FU-resistant colorectal cancer cells. | Lactobacillus plantarum-derived metabolites sensitize the tumor-suppressive effects of butyrate by regulating the functional expression of SMCT1 in 5-FU-resistant colorectal cancer cells.
Kim HJ, An J, Ha EM. | 01/22/2022 |
| miR-29a, b, and c regulate SLC5A8 expression in intestinal epithelial cells. | miR-29a, b, and c regulate SLC5A8 expression in intestinal epithelial cells.
Anbazhagan AN, Priyamvada S, Kumar A, Jayawardena D, Borthakur A, Saksena S, Gill RK, Alrefai WA, Dudeja PK., Free PMC Article | 09/25/2021 |
| SLC5A8 regulates the biological behaviors of cervical cancer cells through mediating the Wnt signaling pathway. | SLC5A8 regulates the biological behaviors of cervical cancer cells through mediating the Wnt signaling pathway.
Zhang XM, Meng QH, Kong FF, Wang K, Du LJ. | 04/24/2021 |
| Hypermethylated RASSF1 and SLC5A8 promoters alongside BRAF(V600E) mutation as biomarkers for papillary thyroid carcinoma. | Hypermethylated RASSF1 and SLC5A8 promoters alongside BRAF(V600E) mutation as biomarkers for papillary thyroid carcinoma.
Khatami F, Larijani B, Heshmat R, Nasiri S, Haddadi-Aghdam M, Teimoori-Toolabi L, Tavangar SM. | 03/13/2021 |
| PDZRN3 may regulate SMCT1 function by interfering with the interaction between SMCT1 and PDZK1. | Sodium-coupled monocarboxylate transporter 1 interacts with the RING finger- and PDZ domain-containing protein PDZRN3.
Otsuka Y, Furihata T, Nakagawa K, Ohno Y, Reien Y, Ouchi M, Wakashin H, Tsuruoka S, Anzai N., Free PMC Article | 12/21/2019 |
| SLC5A8 expression is repressed in human cervical cancer (CC) tumors and cell lines through epigenetic silencing. | Sodium-coupled monocarboxylate transporter is a target of epigenetic repression in cervical cancer.
Hernández-Juárez J, Vargas-Sierra O, Herrera LA, Cantú De León D, Fernández-Retana J, Pérez-Plasencia C, López-Camarillo C, Gariglio P, Díaz-Chávez J., Free PMC Article | 08/17/2019 |
| Results indicate that the SMCT1-PDZK1 interaction thus plays an important role in both lactate handling as well as urate reabsorption in the human kidney. | Identification of the multivalent PDZ protein PDZK1 as a binding partner of sodium-coupled monocarboxylate transporter SMCT1 (SLC5A8) and SMCT2 (SLC5A12).
Srivastava S, Nakagawa K, He X, Kimura T, Fukutomi T, Miyauchi S, Sakurai H, Anzai N., Free PMC Article | 06/1/2019 |
| Pendrin residues which are mutated in Pendred's syndrome are identical to those in the aligned position of sodium/iodide symporter (NIS) and apical iodide transporter (AIT). | Homology of pendrin, sodium-iodide symporter and apical iodide transporter.
Benvenga S, Guarneri F. | 01/26/2019 |
| The present work reveals much lower iodide affinity in the pocket of human SMCT1 analogous to the putative iodide-binding pocket of human NIS. | Iodide Binding in Sodium-Coupled Cotransporters.
Vergara-Jaque A, Fong P, Comer J., Free PMC Article | 10/20/2018 |
| Human SMCT1 is regulated by insulin and SGK1. | Insulin and SGK1 reduce the function of Na+/monocarboxylate transporter 1 (SMCT1/SLC5A8).
López-Barradas A, González-Cid T, Vázquez N, Gavi-Maza M, Reyes-Camacho A, Velázquez-Villegas LA, Ramírez V, Zandi-Nejad K, Mount DB, Torres N, Tovar AR, Romero MF, Gamba G, Plata C., Free PMC Article | 06/10/2017 |
| Data suggest positive correlation between BMI (body mass index)/waist circumference in morbidly obese or obese subjects and jejunal mucosa mRNA abundance of SMCT1; BMI was not significantly correlated with mRNA abundance for glucose transporters SGLT1 and GLUT2 or the low-affinity short-chain fatty acid/monocarboxylate transporter SMCT2. | Nutrient Transporter Expression in the Jejunum in Relation to Body Mass Index in Patients Undergoing Bariatric Surgery.
Irving BA, Wood GC, Bennotti PN, Babu E, Deshpande A, Lent MR, Petrick A, Gabrielsen J, Strodel W, Gerhard GS, Still CD, Ganapathy V, Rolston DD., Free PMC Article | 04/15/2017 |
| Underexpression of SLC5A8 is associated with hepatocellular carcinoma. | Downregulation of SLC5A8 inhibits hepatocellular carcinoma progression through regulation of Wnt/β-catenin signaling.
Hu BS, Xiong SM, Li G, Li JP. | 02/18/2017 |
| Data suggest that SLC5A8, SLC5A5 (sodium-iodide symporter), and SLC26A4 (pendrin), the 3 known iodide transporters, are important in breast tissue metabolism in lactation and in breast neoplasms. [REVIEW] | Iodide transport and breast cancer.
Poole VL, McCabe CJ. | 12/5/2015 |
| Gene silencing of SLC5A8 by hypermethylation was associated with poor prognosis in cases of node-negative stage I and II lung adenocarcinoma. | Prognostic Significance of Aberrant Methylation of Solute Carrier Gene Family 5A8 in Lung Adenocarcinoma.
Ikeda K, Shiraishi K, Koga T, Motooka Y, Fujino K, Shibata H, Mori T, Suzuki M. | 08/8/2015 |
| Data indicate oncogenic HRAS (HRAS(G12V)) as a potent mediator of SLC5A8 silencing in human nontransformed normal mammary epithelial cell lines and in mouse mammary tumors through DNMT1. | Molecular mechanism of SLC5A8 inactivation in breast cancer.
Elangovan S, Pathania R, Ramachandran S, Ananth S, Padia RN, Srinivas SR, Babu E, Hawthorn L, Schoenlein PV, Boettger T, Smith SB, Prasad PD, Ganapathy V, Thangaraju M., Free PMC Article | 11/30/2013 |
| These results suggest that DNA methylation in the SLC5A8 promoter region may suppress the expression of SLC5A8 in lung tumor. | Gene silencing of SLC5A8 identified by genome-wide methylation profiling in lung cancer.
Park JY, Kim D, Yang M, Park HY, Lee SH, Rincon M, Kreahling J, Plass C, Smiraglia DJ, Tockman MS, Kim SJ., Free PMC Article | 07/20/2013 |
| SLC5A8 suppresses tumour progression through depletion of survivin without involving its transport function | The plasma membrane transporter SLC5A8 suppresses tumour progression through depletion of survivin without involving its transport function.
Coothankandaswamy V, Elangovan S, Singh N, Prasad PD, Thangaraju M, Ganapathy V., Free PMC Article | 03/30/2013 |
| SLC5A8 nuclear translocation and loss of expression are associated with poor outcome in pancreatic ductal adenocarcinoma. | SLC5A8 nuclear translocation and loss of expression are associated with poor outcome in pancreatic ductal adenocarcinoma.
Helm J, Coppola D, Ganapathy V, Lloyd M, Centeno BA, Chen DT, Malafa MP, Park JY., Free PMC Article | 11/24/2012 |
| SLC5A8 has a role in prostate cancer risk and aggressiveness | Protein expressions and genetic variations of SLC5A8 in prostate cancer risk and aggressiveness.
Lin HY, Park HY, Radlein S, Mahajan NP, Sellers TA, Zachariah B, Pow-Sang J, Coppola D, Ganapathy V, Park JY., Free PMC Article | 12/17/2011 |
| SLC5A8 is highly methylated in African American colon adenomas | SLC5A8 gene, a transporter of butyrate: a gut flora metabolite, is frequently methylated in African American colon adenomas.
Brim H, Kumar K, Nazarian J, Hathout Y, Jafarian A, Lee E, Green W, Smoot D, Park J, Nouraie M, Ashktorab H., Free PMC Article | 10/15/2011 |
| Efficacy of LP or their secreted soluble factors to stimulate SMCT1 expression and function and to counteract the inhibitory effects of TNF-alpha on butyrate absorption could have potential therapeutic value. | The probiotic Lactobacillus plantarum counteracts TNF-{alpha}-induced downregulation of SMCT1 expression and function.
Borthakur A, Anbazhagan AN, Kumar A, Raheja G, Singh V, Ramaswamy K, Dudeja PK., Free PMC Article | 10/30/2010 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Genetic variation in 3-hydroxy-3-methylglutaryl CoA reductase modifies the chemopreventive activity of statins for colorectal cancer.
Lipkin SM, Chao EC, Moreno V, Rozek LS, Rennert H, Pinchev M, Dizon D, Rennert G, Kopelovich L, Gruber SB. | 06/30/2010 |