| Inhibition of DAPK3 Suppresses Radiation-Induced Cellular Senescence by Activation of a PGC1alpha-Dependent Metabolism Pathway in Brain Endothelial Cells. | Inhibition of DAPK3 Suppresses Radiation-Induced Cellular Senescence by Activation of a PGC1α-Dependent Metabolism Pathway in Brain Endothelial Cells.
Park JE, Park JW, Sim MK, Kim SR, Kim KS. | 05/21/2024 |
| YTHDF2 promotes gallbladder cancer progression and gemcitabine resistance via m6A-dependent DAPK3 degradation. | YTHDF2 promotes gallbladder cancer progression and gemcitabine resistance via m6A-dependent DAPK3 degradation.
Bai X, Chen J, Zhang W, Zhou S, Dong L, Huang J, He X., Free PMC Article | 11/16/2023 |
| Death-associated protein kinase 3 regulates the myogenic reactivity of cerebral arteries. | Death-associated protein kinase 3 regulates the myogenic reactivity of cerebral arteries.
Turner SR, Al-Ghabkari A, Carlson DA, Chappellaz M, Sutherland C, Haystead TAJ, Cole WC, MacDonald JA., Free PMC Article | 07/4/2023 |
| Molecular Network Analyses Implicate Death-Associated Protein Kinase 3 (DAPK3) as a Key Factor in Colitis-Associated Dysplasia Progression. | Molecular Network Analyses Implicate Death-Associated Protein Kinase 3 (DAPK3) as a Key Factor in Colitis-Associated Dysplasia Progression.
Chen HM, MacDonald JA., Free PMC Article | 10/8/2022 |
| Zipper interacting protein kinase (ZIPK) is a negative regulator of HIV-1 replication that is restricted by viral Nef protein through proteasomal degradation. | Zipper interacting protein kinase (ZIPK) is a negative regulator of HIV-1 replication that is restricted by viral Nef protein through proteasomal degradation.
Barman MK, Chand K, Mitra D. | 09/17/2022 |
| Sirt7 associates with ELK1 to participate in hyperglycemia memory and diabetic nephropathy via modulation of DAPK3 expression and endothelial inflammation. | Sirt7 associates with ELK1 to participate in hyperglycemia memory and diabetic nephropathy via modulation of DAPK3 expression and endothelial inflammation.
Li X, Liu J, Lu L, Huang T, Hou W, Wang F, Yu L, Wu F, Qi J, Chen X, Meng Z, Zhu M. | 07/23/2022 |
| ZIPK activates the IL-6/STAT3 signaling pathway and promotes cisplatin resistance in gastric cancer cells. | ZIPK activates the IL-6/STAT3 signaling pathway and promotes cisplatin resistance in gastric cancer cells.
Fan H, Ou Q, Su Q, Li G, Deng Z, Huang X, Bi J., Free PMC Article | 04/2/2022 |
| VIRMA contributes to non-small cell lung cancer progression via N(6)-methyladenosine-dependent DAPK3 post-transcriptional modification. | VIRMA contributes to non-small cell lung cancer progression via N(6)-methyladenosine-dependent DAPK3 post-transcriptional modification.
Xu Y, Chen Y, Yao Y, Xie H, Lu G, Du C, Cheng J, Zhou J. | 01/8/2022 |
| The tumor suppressor kinase DAPK3 drives tumor-intrinsic immunity through the STING-IFN-beta pathway. | The tumor suppressor kinase DAPK3 drives tumor-intrinsic immunity through the STING-IFN-β pathway.
Takahashi M, Lio CJ, Campeau A, Steger M, Ay F, Mann M, Gonzalez DJ, Jain M, Sharma S., Free PMC Article | 07/3/2021 |
| DAPK3 participates in the mRNA processing of immediate early genes in chronic lymphocytic leukaemia. | DAPK3 participates in the mRNA processing of immediate early genes in chronic lymphocytic leukaemia.
Thomas F, Holmes KB, Kreuz S, Hillmen P, Lefevre PF., Free PMC Article | 07/3/2021 |
| The phosphorylation of hCDC14A modulated by ZIPK regulates autophagy of murine pancreatic islet beta-TC3 cells upon glucose stimulation. | The phosphorylation of hCDC14A modulated by ZIPK regulates autophagy of murine pancreatic islet β-TC3 cells upon glucose stimulation.
Hu H, Yin JH, Shao DD, -L Wang L, He F, Huang XX, Guo HL, Xiang XN, Zhu SS, Zhang PH, Chen JS. | 05/15/2021 |
| Impairment of cytokinesis by cancer-associated DAPK3 mutations. | Impairment of cytokinesis by cancer-associated DAPK3 mutations.
Ono T, Terada F, Okumura M, Chihara T, Hamao K. | 03/28/2021 |
| Silencing DAPK3 blocks the autophagosome-lysosome fusion by mediating SNAP29 in trophoblast cells under high glucose treatment. | Silencing DAPK3 blocks the autophagosome-lysosome fusion by mediating SNAP29 in trophoblast cells under high glucose treatment.
Wang Y, Ji L, Peng Z, Lai R, Zhang X, Xu Y, Chen Z, Liu R, Zhong Y, Hu H, Wang L. | 11/21/2020 |
| Loss of ZIP facilitates JAK2-STAT3 activation in tamoxifen-resistant breast cancer. | Loss of ZIP facilitates JAK2-STAT3 activation in tamoxifen-resistant breast cancer.
Zhu N, Zhang J, Du Y, Qin X, Miao R, Nan J, Chen X, Sun J, Zhao R, Zhang X, Shi L, Li X, Lin Y, Wei W, Mao A, Zhang Z, Stark GR, Wang Y, Yang J., Free PMC Article | 10/3/2020 |
| The initial characterization of tumor-suppressing kinases- in particular members of the protein kinase C (PKC) family, MKK4 of the mitogen-activated protein kinase kinase family, and DAPK3 of the death-associated protein kinase family- laid the foundation for bioinformatic approaches that enable the identification of other tumor-suppressing kinases. | Orange is the new black: Kinases are the new master regulators of tumor suppression.
An E, Brognard J., Free PMC Article | 03/28/2020 |
| For the first time, the present study showed that anacardic acid induces cell apoptosis of prostatic cancer through autophagy by ER stress/DAPK3/Akt signaling pathway. | Anacardic acid induces cell apoptosis of prostatic cancer through autophagy by ER stress/DAPK3/Akt signaling pathway.
Tan J, Jiang X, Yin G, He L, Liu J, Long Z, Jiang Z, Yao K., Free PMC Article | 04/21/2018 |
| Activation of AKT negatively regulates the pro-apoptotic function of DAPK3 in prostate cancer. | Activation of AKT negatively regulates the pro-apoptotic function of death-associated protein kinase 3 (DAPK3) in prostate cancer.
Das TP, Suman S, Papu John AM, Pal D, Edwards A, Alatassi H, Ankem MK, Damodaran C., Free PMC Article | 07/29/2017 |
| Methylation of DAPK3 at CpG1 but not CpG2 was lower in men with type 2 diabetes compared with healthy control men. Moreover, a glucose challenge was associated with lower CpG1 and CpG2 methylation in DAPK3 in both men with type 2 diabetes and healthy men. | Insulin and Glucose Alter Death-Associated Protein Kinase 3 (DAPK3) DNA Methylation in Human Skeletal Muscle.
Mudry JM, Lassiter DG, Nylén C, García-Calzón S, Näslund E, Krook A, Zierath JR. | 06/10/2017 |
| DAPK3 controls proliferation, migration and tumor growth through activation of ERK/c-Myc signaling in lung adenocarcinoma cells. | Death-associated protein kinase 3 controls the tumor progression of A549 cells through ERK MAPK/c-Myc signaling.
Kake S, Usui T, Ohama T, Yamawaki H, Sato K. | 03/25/2017 |
| The results revealed mutations caused a significant structural variation in DAPK3, concentrated in flexible loops forming part of the ATP binding pocket which have been associated with very low kinase activity, and the cellular progression towards cancer | Biophysical changes of ATP binding pocket may explain loss of kinase activity in mutant DAPK3 in cancer: A molecular dynamic simulation analysis.
Agarwal T, Annamalai N, Maiti TK, Arsad H. | 07/2/2016 |
| Cellular and mouse modeling studies show that DAPK3 is a tumor suppressor gene and is important in early development. Also, its expression is downregulated in more aggressive breast cancer relative to less aggressive and normal patient samples. | DAPK3 suppresses acini morphogenesis and is required for mouse development.
Kocher BA, White LS, Piwnica-Worms D., Free PMC Article | 04/2/2016 |
| ROCK1 and ZIPK have diverse, but predominantly distinct regulatory functions in vascular SMC and that ROCK1-mediated activation of ZIPK is not involved in most of these functions. | The effects of knockdown of rho-associated kinase 1 and zipper-interacting protein kinase on gene expression and function in cultured human arterial smooth muscle cells.
Deng JT, Wang XL, Chen YX, O'Brien ER, Gui Y, Walsh MP., Free PMC Article | 11/28/2015 |
| DAPK3 plays a central role in preventing miR-17/miR-20a depletion-induced genome instability and in miR-17/miR-20a overexpression-triggered tumor formation. | Oncogenic miR-17/20a Forms a Positive Feed-forward Loop with the p53 Kinase DAPK3 to Promote Tumorigenesis.
Cai Z, Cao R, Zhang K, Xue Y, Zhang C, Zhou Y, Zhou J, Sun H, Fu XD., Free PMC Article | 11/7/2015 |
| These findings indicated that ZIPK may also be involved in the regulation of the cell cycle in human cells, by interacting with HsCdc14A. | Zipper-interacting protein kinase interacts with human cell division cycle 14A phosphatase.
Wu W, Hu H, Ye Z, Leong M, He M, Li Q, Hu R, Zhang S. | 09/26/2015 |
| findings suggest that ZIPK plays a role in the progression and completion of cytokinesis through MRLC phosphorylation | Phosphorylation of myosin II regulatory light chain by ZIP kinase is responsible for cleavage furrow ingression during cell division in mammalian cultured cells.
Hosoba K, Komatsu S, Ikebe M, Kotani M, Wenqin X, Tachibana T, Hosoya H, Hamao K., Free PMC Article | 06/6/2015 |