| Inhibiting IL11RA to mitigate hepatic metastasis in skin cutaneous melanoma: Comprehensive insights from in vitro and in vivo investigations. | Inhibiting IL11RA to mitigate hepatic metastasis in skin cutaneous melanoma: Comprehensive insights from in vitro and in vivo investigations.
Zhang ZG, Zhu HM, Hua HK., Free PMC Article | 03/14/2024 |
| Interleukin-11 receptor expression on monocytes is dispensable for their recruitment and pathogen uptake during Leishmania major infection. | Interleukin-11 receptor expression on monocytes is dispensable for their recruitment and pathogen uptake during Leishmania major infection.
Baars I, Lokau J, Sauerland I, Müller AJ, Garbers C., Free PMC Article | 02/19/2022 |
| Similarities and differences between IL11 and IL11RA1 knockout mice for lung fibro-inflammation, fertility and craniosynostosis. | Similarities and differences between IL11 and IL11RA1 knockout mice for lung fibro-inflammation, fertility and craniosynostosis.
Ng B, Widjaja AA, Viswanathan S, Dong J, Chothani SP, Lim S, Shekeran SG, Tan J, McGregor NE, Walker EC, Sims NA, Schafer S, Cook SA., Free PMC Article | 11/6/2021 |
| Colitis-induced IL11 promotes colon carcinogenesis. | Colitis-induced IL11 promotes colon carcinogenesis.
Wang H, Wang DH, Yang X, Sun Y, Yang CS., Free PMC Article | 10/2/2021 |
| Fibroblast-specific IL11 signaling drives chronic inflammation in murine fibrotic lung disease. | Fibroblast-specific IL11 signaling drives chronic inflammation in murine fibrotic lung disease.
Ng B, Dong J, Viswanathan S, Widjaja AA, Paleja BS, Adami E, Ko NSJ, Wang M, Lim S, Tan J, Chothani SP, Albani S, Schafer S, Cook SA. | 03/27/2021 |
| Cleavage of the Interleukin-11 receptor induces processing of its C-terminal fragments by the gamma-secretase and the proteasome. | Cleavage of the Interleukin-11 receptor induces processing of its C-terminal fragments by the gamma-secretase and the proteasome.
Lokau J, Flynn CM, Garbers C. | 08/26/2017 |
| In spite of clear changes in the temporal expression of both IL-11 and its receptor, no significant differences in motor function are found after spinal cord injury. | Evaluating the role of IL-11, a novel cytokine in the IL-6 family, in a mouse model of spinal cord injury.
Cho N, Nguyen DH, Satkunendrarajah K, Branch DR, Fehlings MG., Free PMC Article | 06/15/2013 |
| Signaling through the IL-35 receptor required the transcription factors STAT1 and STAT4. | The composition and signaling of the IL-35 receptor are unconventional.
Collison LW, Delgoffe GM, Guy CS, Vignali KM, Chaturvedi V, Fairweather D, Satoskar AR, Garcia KC, Hunter CA, Drake CG, Murray PJ, Vignali DA., Free PMC Article | 06/12/2012 |
| Demyelination and oligodendrocyte death are exacerbated in IL-11 receptor alpha-deficient mice, suggesting avenues to enhance oligodendrocyte viability and restrict central nervous system inflammation in multiple sclerosis. | Proapoptotic and antiapoptotic actions of Stat1 versus Stat3 underlie neuroprotective and immunoregulatory functions of IL-11.
Zhang J, Zhang Y, Dutta DJ, Argaw AT, Bonnamain V, Seto J, Braun DA, Zameer A, Hayot F, Lòpez CB, Raine CS, John GR., Free PMC Article | 10/29/2011 |
| These results provide, at least in part, an explanation for the defective small decidua of mice lacking the Il11ra gene, and reveal for the first time that cyclin D3, CDKN1A (p21), and BIRC5 (Survivin) are targets of IL11 in the decidua. | Involvement of cyclin D3, CDKN1A (p21), and BIRC5 (Survivin) in interleukin 11 stimulation of decidualization in mice.
Li F, Devi YS, Bao L, Mao J, Gibori G. | 01/21/2010 |
| IL-13-induced lung inflammation, remodeling, respiratory failure and death are all diminished in mice deficient in the IL-11 receptor alpha-gp130 complex. | IL-11 receptor alpha in the pathogenesis of IL-13-induced inflammation and remodeling.
Chen Q, Rabach L, Noble P, Zheng T, Lee CG, Homer RJ, Elias JA. | 01/21/2010 |
| This study underlines the importance of gp130 cytokines in proliferation and establishes its role in auto-paracrine pituitary growth regulation. | Involvement of the gp130 cytokine transducer in MtT/S pituitary somatotroph tumour development in an autocrine-paracrine model.
Graciarena M, Carbia-Nagashima A, Onofri C, Perez-Castro C, Giacomini D, Renner U, Stalla GK, Arzt E. | 01/21/2010 |
| IL-11 signaling is clearly required for normal bone turnover and normal trabecular bone mass, yet not for the effects of estradiol or estrogen deficiency on the skeleton. | Interleukin-11 receptor signaling is required for normal bone remodeling.
Sims NA, Jenkins BJ, Nakamura A, Quinn JM, Li R, Gillespie MT, Ernst M, Robb L, Martin TJ. | 01/21/2010 |