| The IRAK1/IRF5 axis initiates IL-12 response by dendritic cells and control of Toxoplasma gondii infection. | The IRAK1/IRF5 axis initiates IL-12 response by dendritic cells and control of Toxoplasma gondii infection.
Pereira M, Ramalho T, Andrade WA, Durso DF, Souza MC, Fitzgerald KA, Golenbock DT, Silverman N, Gazzinelli RT. | 03/5/2024 |
| Phosphorylation of USP20 on Ser334 by IRAK1 promotes IL-1beta-evoked signaling in vascular smooth muscle cells and vascular inflammation. | Phosphorylation of USP20 on Ser334 by IRAK1 promotes IL-1β-evoked signaling in vascular smooth muscle cells and vascular inflammation.
Zhang L, Wu JH, Jean-Charles PY, Murali P, Zhang W, Jazic A, Kaur S, Nepliouev I, Stiber JA, Snow K, Freedman NJ, Shenoy SK., Free PMC Article | 08/7/2023 |
| IRAK-M suppresses the activation of microglial NLRP3 inflammasome and GSDMD-mediated pyroptosis through inhibiting IRAK1 phosphorylation during experimental autoimmune encephalomyelitis. | IRAK-M suppresses the activation of microglial NLRP3 inflammasome and GSDMD-mediated pyroptosis through inhibiting IRAK1 phosphorylation during experimental autoimmune encephalomyelitis.
Wang Y, Pei S, Liu Z, Ding Y, Qian T, Wen H, Hsu SW, Zhou Z, Zhang J, Wang H., Free PMC Article | 02/25/2023 |
| Viperin impairs the innate immune response through the IRAK1-TRAF6-TAK1 axis to promote Mtb infection. | Viperin impairs the innate immune response through the IRAK1-TRAF6-TAK1 axis to promote Mtb infection.
Zhou X, Zhang Z, Xu H, Zhu B, Zhang L, Lie L, Huang Y, Du X, Liu H, Li Y, Huang Y, Hu S, Zhou C, Wen Q, Pepplenbosch MP, Ma L. | 10/8/2022 |
| Nonhematopoietic IRAK1 drives arthritis via neutrophil chemoattractants. | Nonhematopoietic IRAK1 drives arthritis via neutrophil chemoattractants.
Hoyler T, Bannert B, André C, Beck D, Boulay T, Buffet D, Caesar N, Calzascia T, Dawson J, Kyburz D, Hennze R, Huppertz C, Littlewood-Evans A, Loetscher P, Mertz KD, Niwa S, Robert G, Rush JS, Ruzzante G, Sarret S, Stein T, Touil I, Wieczorek G, Zipfel G, Hawtin S, Junt T., Free PMC Article | 07/16/2022 |
| Eliminating chronic myeloid leukemia stem cells by IRAK1/4 inhibitors. | Eliminating chronic myeloid leukemia stem cells by IRAK1/4 inhibitors.
Tanaka Y, Takeda R, Fukushima T, Mikami K, Tsuchiya S, Tamura M, Adachi K, Umemoto T, Asada S, Watanabe N, Morishita S, Imai M, Nagata M, Araki M, Takizawa H, Fukuyama T, Lamagna C, Masuda ES, Ito R, Goyama S, Komatsu N, Takaku T, Kitamura T., Free PMC Article | 02/19/2022 |
| IRAK1-dependent Regnase-1-14-3-3 complex formation controls Regnase-1-mediated mRNA decay. | IRAK1-dependent Regnase-1-14-3-3 complex formation controls Regnase-1-mediated mRNA decay.
Akaki K, Ogata K, Yamauchi Y, Iwai N, Tse KM, Hia F, Mochizuki A, Ishihama Y, Mino T, Takeuchi O., Free PMC Article | 11/27/2021 |
| MyD88 oligomer size functions as a physical threshold to trigger IL1R Myddosome signaling. | MyD88 oligomer size functions as a physical threshold to trigger IL1R Myddosome signaling.
Deliz-Aguirre R, Cao F, Gerpott FHU, Auevechanichkul N, Chupanova M, Mun Y, Ziska E, Taylor MJ., Free PMC Article | 10/9/2021 |
| Pharmacological inhibition of IRAK1 attenuates colitis-induced tumorigenesis in mice by inhibiting the inflammatory response and epithelial-mesenchymal transition. | Pharmacological inhibition of IRAK1 attenuates colitis-induced tumorigenesis in mice by inhibiting the inflammatory response and epithelial-mesenchymal transition.
Feng Z, Duan Z, Shi G, Wang Q, Zhou J, Chen Y. | 10/2/2021 |
| Altered Inflammatory Pathway but Unaffected Liver Fibrosis in Mouse Models of Nonalcoholic Steatohepatitis Involving Interleukin-1 Receptor-Associated Kinase 1 Knockout. | Altered Inflammatory Pathway but Unaffected Liver Fibrosis in Mouse Models of Nonalcoholic Steatohepatitis Involving Interleukin-1 Receptor-Associated Kinase 1 Knockout.
Lei Y, Yang T, Shan A, Di W, Dai M, Nan J, Liu D, Cao Y, Jiang X., Free PMC Article | 05/22/2021 |
| These findings indicate that BAP31 may modulate inflammatory cytokines and cognitive impairment induced by neuroinflammation through IRAK1 | BAP31 regulates IRAK1-dependent neuroinflammation in microglia.
Liu X, Jiao K, Jia CC, Li GX, Yuan Q, Xu JK, Hou Y, Wang B., Free PMC Article | 07/18/2020 |
| Pharmacological inhibition or siRNA mediated knockdown of IRAK1/4 attenuated Nod1-mediated activation of NF-kappaB, JNK, and the expression of proinflammatory cytokines. These results reveal that Nod1-mediated lipolysis promoted accumulation of DAG, which engaged PKCdelta and IRAK1/4 to augment inflammation in 3T3-L1 adipocytes. | Nod1-mediated lipolysis promotes diacylglycerol accumulation and successive inflammation via PKCδ-IRAK axis in adipocytes.
Sharma A, Maurya CK, Arha D, Rai AK, Singh S, Varshney S, Schertzer JD, Tamrakar AK. | 08/17/2019 |
| IRAK1 is one of the critical components involved in podocyte apoptosis in Diabetic nephropathy. | Down-regulation of IRAK1 attenuates podocyte apoptosis in diabetic nephropathy through PI3K/Akt signaling pathway.
Zhang Y, Chen X, Yuan L, Zhang Y, Wu J, Guo N, Chen X, Liu J. | 05/25/2019 |
| Findings demonstrate that the pro- and anti-inflammatory responses to gAd in innate immune cells are time-dependent, and mediated by the activation of the IkappaB/NF-kappaB pathway, and IRAK-1 downregulation, respectively. | Globular Adiponectin Exerts a Pro-Inflammatory Effect via IκB/NF-κB Pathway Activation and Anti-Inflammatory Effect by IRAK-1 Downregulation.
Lee KH, Jeong J, Woo J, Lee CH, Yoo CG., Free PMC Article | 12/22/2018 |
| suppression of inflammatory responses and T cells apoptosis were observed with elevated expression of IRAK-M and PDL-1, and interference and neutralization of these 2 molecules led to partly reversed suppression of inflammation. | Endotoxin Tolerant Dendritic Cells Suppress Inflammatory Responses in Splenocytes via Interleukin-1 Receptor Associated Kinase (IRAK)-M and Programmed Death-Ligand 1 (PDL-1).
Zhou Y, Xia Q, Wang X, Fu S., Free PMC Article | 10/27/2018 |
| The expression of IL-1 receptor-associated kinase 1 (IRAK1) that regulates NF-kappaB, p38, and the JNK signaling pathways, was also increased by MPQP. | Anti-inflammatory effects of a novel compound, MPQP, through the inhibition of IRAK1 signaling pathways in LPS-stimulated RAW 264.7 macrophages.
Kim BR, Cho YC, Cho S., Free PMC Article | 10/20/2018 |
| role of microRNA-146a in regulating the expression of IRAK1 in cerebral ischemia-reperfusion injury | The role of microRNA-146a in regulating the expression of IRAK1 in cerebral ischemia-reperfusion injury.
Chu B, Zhou Y, Zhai H, Li L, Sun L, Li Y. | 10/6/2018 |
| These findings demonstrate that Dectin-1, Irak1, and Rip2 are involved in response to Aspergillus fumigatus infection. Dectin-1 modulates the expression of Irak1 and Rip2. | The Expression of Dectin-1, Irak1 and Rip2 During the Host Response to Aspergillus fumigatus.
Liu J, Yu L, Chen C, Zhou J, Gong X, Li D, Hou D, Song Y, Shao C. | 08/25/2018 |
| MiR-146a/ MiR-146b could down-regulate the TRAF6 and IRAK1 expression and promote proliferation, migration and angiogenesis ability of endothelial progenitor cells, which could be important for recovery of patients with hyperacute ischemic stroke. | Regulatory effects of miR-146a/b on the function of endothelial progenitor cells in acute ischemic stroke in mice.
Su ZF, Sun ZW, Zhang Y, Wang S, Yu QG, Wu ZB. | 05/19/2018 |
| miR-146a inhibits inflammatory cytokine production in B cells through directly targeting IRAK1, suggesting a regulatory role of miR-146a in B cell-mediated periodontal inflammation. | miR-146a regulates inflammatory cytokine production in Porphyromonas gingivalis lipopolysaccharide-stimulated B cells by targeting IRAK1 but not TRAF6.
Jiang S, Hu Y, Deng S, Deng J, Yu X, Huang G, Kawai T, Han X., Free PMC Article | 04/28/2018 |
| NLRC3 promoted K48-linked polyubiquitination and degradation of interleukin-1 receptor-associated kinase 1 (IRAK1). | NLRC3 promotes host resistance against Pseudomonas aeruginosa-induced keratitis by promoting the degradation of IRAK1.
Guo L, Kong Q, Dong Z, Dong W, Fu X, Su L, Tan X. | 04/21/2018 |
| these findings identify a transcription-independent, rapid, and nongenomic glucocorticoid suppression of TLR9 ligand-mediated IRAK1 ubiquitination as a novel mechanism for restraining acute inflammatory reactions | Inhibition of IRAK1 Ubiquitination Determines Glucocorticoid Sensitivity for TLR9-Induced Inflammation in Macrophages.
Kong F, Liu Z, Jain VG, Shima K, Suzuki T, Muglia LJ, Starczynowski DT, Pasare C, Bhattacharyya S., Free PMC Article | 11/26/2017 |
| These results suggest that the IRAK1-binding protein OPTN negatively regulates IL-1beta/LPS-induced NF-kappaB activation by preventing polyubiquitination of TRAF6. | Identification of optineurin as an interleukin-1 receptor-associated kinase 1-binding protein and its role in regulation of MyD88-dependent signaling.
Tanishima M, Takashima S, Honda A, Yasuda D, Tanikawa T, Ishii S, MaruYama T., Free PMC Article | 10/28/2017 |
| Data, including data from studies in knockout mice, suggest that Irak1 is involved in regulating glucose metabolism and insulin sensitivity in skeletal muscle (but not in liver and not in obesity due to high-fat diet); insulin sensitivity is 30% higher in Irak1 knockout mice on chow diet, but Irak1 deletion does not affect development of glucose intolerance due to high-fat diet. | Deletion of interleukin 1 receptor-associated kinase 1 (Irak1) improves glucose tolerance primarily by increasing insulin sensitivity in skeletal muscle.
Sun XJ, Kim SP, Zhang D, Sun H, Cao Q, Lu X, Ying Z, Li L, Henry RR, Ciaraldi TP, Taylor SI, Quon MJ., Free PMC Article | 08/12/2017 |
| Suppression of IRAK1 or IRAK4 Catalytic Activity, but Not Type 1 IFN Signaling, Prevents Lupus Nephritis in Mice Expressing a Ubiquitin Binding-Defective Mutant of ABIN1 | Suppression of IRAK1 or IRAK4 Catalytic Activity, but Not Type 1 IFN Signaling, Prevents Lupus Nephritis in Mice Expressing a Ubiquitin Binding-Defective Mutant of ABIN1.
Nanda SK, Lopez-Pelaez M, Arthur JS, Marchesi F, Cohen P., Free PMC Article | 07/29/2017 |