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    DBH dopamine beta-hydroxylase [ Homo sapiens (human) ]

    Gene ID: 1621, updated on 2-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Right thalamic volume mediates impact of the dopamine beta-hydroxylase gene on the endowment effect.

    Right thalamic volume mediates impact of the dopamine beta-hydroxylase gene on the endowment effect.
    Wang T, Zeng J, Huang W, Xiong X, Su L.

    06/17/2024
    Association of dopamine beta-hydroxylase polymorphism rs1611115 and serum levels with psychiatric disorders in Pakistani population.

    Association of dopamine β-hydroxylase polymorphism rs1611115 and serum levels with psychiatric disorders in Pakistani population.
    Hashmi AN, Ahmed Dharejo R, Zubair UB, Khan N, Kashif I, Ajmal M, Taj R, Qamar R, Azam M.

    06/5/2024
    Effect of rs1108580 of DBH and rs1006737 of CACNA1C on Cognition and Tardive Dyskinesia in a North Indian Schizophrenia Cohort.

    Effect of rs1108580 of DBH and rs1006737 of CACNA1C on Cognition and Tardive Dyskinesia in a North Indian Schizophrenia Cohort.
    Punchaichira TJ, Kukshal P, Bhatia T, Deshpande SN, Thelma BK.

    11/22/2023
    Multifactor Dimensionality Reduction Analysis to Evaluate the Association of Dopamine Beta-Hydroxylase (DBetaH) Polymorphisms with Susceptibility to Dementia (SADEM Study).

    Multifactor Dimensionality Reduction Analysis to Evaluate the Association of Dopamine Beta-Hydroxylase (DΒH) Polymorphisms with Susceptibility to Dementia (SADEM Study).
    Juárez-Cedillo T, Martínez-Rodríguez N, Fragoso JM, Islas-Pérez V, López-Martínez A, Valle-Medina A.

    06/28/2023
    Association between 19-bp Insertion/Deletion Polymorphism of Dopamine beta-Hydroxylase and Autism Spectrum Disorder in Thai Patients.

    Association between 19-bp Insertion/Deletion Polymorphism of Dopamine β-Hydroxylase and Autism Spectrum Disorder in Thai Patients.
    Wongpaiboonwattana W, Hnoonual A, Limprasert P., Free PMC Article

    10/1/2022
    Immunohistochemical Expression of Choline Acetyltransferase and Catecholamine-Synthesizing Enzymes in Head-and-Neck and Thoracoabdominal Paragangliomas and Pheochromocytomas.

    Immunohistochemical Expression of Choline Acetyltransferase and Catecholamine-Synthesizing Enzymes in Head-and-Neck and Thoracoabdominal Paragangliomas and Pheochromocytomas.
    Kimura N, Shiga K, Kaneko KI, Oki Y, Sugisawa C, Saito J, Tawara S, Akahori H, Sogabe S, Yamashita T, Takekoshi K, Naruse M, Katabami T.

    03/26/2022
    Association between dopamine beta-hydroxylase polymorphism and attention function in suicide attempters with chronic schizophrenia.

    Association between dopamine beta-hydroxylase polymorphism and attention function in suicide attempters with chronic schizophrenia.
    Hui L, Hu WM, Zhu ZH, Gao ST, Han M, Fan Y, Tian Q, Yin XY, Yuan Y, Jiang CX, Yin GZ, Jia QF, Zhang XY.

    09/18/2021
    Relationships of Cerebrospinal Fluid Alzheimer's Disease Biomarkers and COMT, DBH, and MAOB Single Nucleotide Polymorphisms.

    Relationships of Cerebrospinal Fluid Alzheimer's Disease Biomarkers and COMT, DBH, and MAOB Single Nucleotide Polymorphisms.
    Babić Leko M, Nikolac Perković M, Klepac N, Švob Štrac D, Borovečki F, Pivac N, Hof PR, Šimić G., Free PMC Article

    04/24/2021
    Association of regulatory variants of dopamine beta-hydroxylase with cognition and tardive dyskinesia in schizophrenia subjects.

    Association of regulatory variants of dopamine β-hydroxylase with cognition and tardive dyskinesia in schizophrenia subjects.
    Punchaichira TJ, Mukhopadhyay A, Kukshal P, Bhatia T, Deshpande SN, Thelma BK., Free PMC Article

    02/6/2021
    The Epistasis Project: A Multi-Cohort Study of the Effects of BDNF, DBH, and SORT1 Epistasis on Alzheimer's Disease Risk.

    The Epistasis Project: A Multi-Cohort Study of the Effects of BDNF, DBH, and SORT1 Epistasis on Alzheimer's Disease Risk.
    Belbin O, Morgan K, Medway C, Warden D, Cortina-Borja M, van Duijn CM, Adams HHH, Frank-Garcia A, Brookes K, Sánchez-Juan P, Alvarez V, Heun R, Kölsch H, Coto E, Kehoe PG, Rodriguez-Rodriguez E, Bullido MJ, Ikram MA, Smith AD, Lehmann DJ.

    08/22/2020
    The data obtained in the present study suggest that the selected DBH variants are unlikely to have any significant contribution towards modifying the clinical symptoms of Indian WD patients.

    Dopamine β hydroxylase (DBH) polymorphisms do not contribute towards the clinical course of Wilson's disease in Indian patients.
    Roy S, Ghosh S, Bhattacharya S, Saha A, Das SK, Gangopadhyay PK, Bavdekar A, Ray K, Sengupta M, Ray J.

    07/18/2020
    The results show that DBH polymorphism appears play an important role in CUD patients' response to doxazosin treatment.

    Pharmacogenetics of Dopamine β-Hydroxylase in cocaine dependence therapy with doxazosin.
    Zhang X, Nielsen DA, Domingo CB, Shorter DI, Nielsen EM, Kosten TR., Free PMC Article

    05/23/2020
    We found a significant effect of DBH genotype status on the capacity to maintain attention over time (sustained attention) as measured by the continuous performance task.

    Dissociable Catecholaminergic Modulation of Visual Attention: Differential Effects of Catechol-O-Methyltransferase and Dopamine Beta-Hydroxylase Genes on Visual Attention.
    Shalev N, Vangkilde S, Neville MJ, Tunbridge EM, Nobre AC, Chechlacz M., Free PMC Article

    03/7/2020
    These data suggest that DBH might influence the susceptibility of Parkinson disease.

    Dopamine β Hydroxylase (DBH) is a potential modifier gene associated with Parkinson's disease in Eastern India.
    Ghosh A, Sadhukhan T, Giri S, Biswas A, Das SK, Ray K, Ray J.

    12/28/2019
    This is the first report of a noradrenergic genetic polymorphism (rs6271; Arg549Cys) associated with Inflammatory bowel diseases. This polymorphism is associated with significantly lower levels of circulating DbetaH.

    A single nucleotide polymorphism in dopamine beta hydroxylase (rs6271(C>T)) is over-represented in inflammatory bowel disease patients and reduces circulating enzyme.
    Gonzalez-Lopez E, Kawasawa-Imamura Y, Zhang L, Huang X, Koltun WA, Coates MD, Vrana KE., Free PMC Article

    11/2/2019
    This meta-analysis suggests that the DBH rs1611115 genetic polymorphism might not be associated with Parkinson's disease.

    Association of the rs1611115 polymorphism in DBH gene with Parkinson's disease: a meta-analysis.
    Kang S, Bi M, Du X, Jiao Q, Jiang H.

    01/5/2019
    Most DBH polymorphisms from the currently available loci showed no linkage to Alzheimer's disease, Parkinson's disease, and schizophrenia, indicating the lower possibility of these loci serving as genetic markers of the risks of diseases with neurodegenerative characteristics. On the other hand, the DBH rs2283123 and rs2007153 polymorphisms could have opposite effects on schizophrenia development in Caucasians

    Association of Dopamine Beta-Hydroxylase Polymorphisms with Alzheimer's Disease, Parkinson's Disease and Schizophrenia: Evidence Based on Currently Available Loci.
    Tang S, Yao B, Li N, Lin S, Huang Z.

    12/22/2018
    The findings of this study confirmed a strong association between genotype at rs1611115 and pDbetaH activity in Chinese patients with schizophrenia. Our data also suggest the rs1108580 polymorphism may influence some aspects of cognitive function in schizophrenia.

    Associations between the DBH gene, plasma dopamine β-hydroxylase activity and cognitive measures in Han Chinese patients with schizophrenia.
    Sun Z, Ma Y, Li W, He J, Li J, Yang X, Mao P, Cubells JF, Tang YL.

    11/10/2018
    Its single-nucleotide polymorphisms involves in dopaminergic metabolism and motor and cognitive function in older adults

    Genetic markers of dopaminergic transmission predict performance for older males but not females.
    Hupfeld KE, Vaillancourt DE, Seidler RD., Free PMC Article

    10/6/2018
    This study demonstrate the genetic influence of a family history of alcohol use disorders and DAT and DBH gene polymorphisms on the risk of withdrawal seizures and delirium tremens.

    [Combination of DAT and DBH gene polymorphisms with a family history of alcohol use disorders increases the risk of withdrawal seizures and delirium tremens during alcohol withdrawal in alcohol-dependent men].
    Kibitov AO, Ivashchenko DV, Brodyansky VM, Chuprova NA, Shuvalov SA.

    05/19/2018
    Homospecific activity computed for the WT of DBH and variant proteins showed a marginal decrease in A318S, W544S and R549C variants

    Characterization of SNPs in the dopamine-β-hydroxylase gene providing new insights into its structure-function relationship.
    Punchaichira TJ, Dey SK, Mukhopadhyay A, Kundu S, Thelma BK.

    04/28/2018
    This study indicated that DBH5'-Ins/Del polymorphism may not play a role in the susceptibility to tardive dyskinesia and cognitive deficits in schizophrenia with tardive dyskinesia.

    Association between DBH 19bp insertion/deletion polymorphism and cognition in schizophrenia with and without tardive dyskinesia.
    Hui L, Han M, Yin GZ, Zhang Y, Huang XF, Qian ZK, Gu WG, Gu XC, Zhu XM, Soares JC, Ning Y, Zheng Y, Du XD, Zhang XY.

    01/6/2018
    DRD2 A2/A1, DRD3 Ser9Gly, DbetaH -1021C>T, OPRM1 A118G and GRIK1 rs2832407C>A are not associated with alcoholism alone or in interaction.

    Association study of DRD2 A2/A1, DRD3 Ser9Gly, DβH -1021C>T, OPRM1 A118G and GRIK1 rs2832407C>A polymorphisms with alcohol dependence.
    Ragia G, Veresies I, Veresie L, Veresies K, Manolopoulos VG.

    11/11/2017
    Results suggest that interference of cannabis and cocaine with cognitive impulse control and functional corticostriatal connectivity depends on DBH genotype.

    Cannabis and cocaine decrease cognitive impulse control and functional corticostriatal connectivity in drug users with low activity DBH genotypes.
    Ramaekers JG, van Wel JH, Spronk D, Franke B, Kenis G, Toennes SW, Kuypers KP, Theunissen EL, Stiers P, Verkes RJ., Free PMC Article

    10/21/2017
    Dopamine beta-Hydroxylase Deficiency is associated with Hyperinsulinemia and Insulin Resistance.

    Hyperinsulinemia and Insulin Resistance in Dopamine β-Hydroxylase Deficiency.
    Arnold AC, Garland EM, Celedonio JE, Raj SR, Abumrad NN, Biaggioni I, Robertson D, Luther JM, Shibao CA., Free PMC Article

    06/24/2017
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