| Interferon lambda receptor-1 isoforms differentially influence gene expression and HBV replication in stem cell-derived hepatocytes. | Interferon lambda receptor-1 isoforms differentially influence gene expression and HBV replication in stem cell-derived hepatocytes.
Novotny LA, Evans JG, Guo H, Kappler CS, Meissner EG., | 01/16/2024 |
| Influence of Canonical and Non-Canonical IFNLR1 Isoform Expression on Interferon Lambda Signaling. | Influence of Canonical and Non-Canonical IFNLR1 Isoform Expression on Interferon Lambda Signaling.
Evans JG, Novotny LA, Meissner EG., Free PMC Article | 04/6/2023 |
| Downregulated expression of IL28RA is involved in the pathogenesis of pancreatic ductal adenocarcinoma. | Downregulated expression of IL‑28RA is involved in the pathogenesis of pancreatic ductal adenocarcinoma.
Liu L, Qi Y, Huang D, Xu Y, Li M, Hong Z, Gu Y, Jia B, Luo X, Zhang S, Zhang S. | 12/11/2021 |
| Interferon III-related IL28RA variant is associated with rheumatoid arthritis and systemic lupus erythematosus and specific disease sub-phenotypes. | Interferon III-related IL28RA variant is associated with rheumatoid arthritis and systemic lupus erythematosus and specific disease sub-phenotypes.
Drehmer MN, Castro GV, Pereira IA, de Souza IR, Löfgren SE. | 10/16/2021 |
| Association of TNFRSF1A and IFNLR1 Gene Polymorphisms with the Risk of Developing Breast Cancer and Clinical Pathologic Features. | Association of TNFRSF1A and IFNLR1 Gene Polymorphisms with the Risk of Developing Breast Cancer and Clinical Pathologic Features.
Hausmann LD, de Almeida BS, de Souza IR, Drehmer MN, Fernandes BL, Wilkens RS, Vieira DSC, Lofgren SE, Lindenau JD, de Toledo E Silva G, Muniz YCN. | 10/2/2021 |
| Genetic Polymorphisms of the IFNLR1 Gene Correlate with HCV Infection and Biochemical Features of Chronic HCV Patients in Yunnan, China. | Genetic Polymorphisms of the IFNLR1 Gene Correlate with HCV Infection and Biochemical Features of Chronic HCV Patients in Yunnan, China.
Zhang AM, Wang Y, Xia X, Song Y. | 12/5/2020 |
| Significance of IL28RA in diagnosis of early pancreatic cancer and its regulation to pancreatic cancer cells by JAK/STAT signaling pathway - effects of IL28RA on pancreatic cancer. | Significance of IL28RA in diagnosis of early pancreatic cancer and its regulation to pancreatic cancer cells by JAK/STAT signaling pathway - effects of IL28RA on pancreatic cancer.
Yang L, Wei WC, Meng XN, Gao J, Guo N, Wu FT, Zeng WW. | 10/24/2020 |
| Differential expression of interferon-lambda receptor 1 splice variants determines the magnitude of the antiviral response induced by interferon-lambda 3 in human immune cells. | Differential expression of interferon-lambda receptor 1 splice variants determines the magnitude of the antiviral response induced by interferon-lambda 3 in human immune cells.
Santer DM, Minty GES, Golec DP, Lu J, May J, Namdar A, Shah J, Elahi S, Proud D, Joyce M, Tyrrell DL, Houghton M., Free PMC Article | 08/13/2020 |
| This study was designed to explore the genetic etiology of deafness in a large Chinese family with autosomal dominant, nonsyndromic, progressive sensorineural hearing loss (ADNSHL). Inner ear expression of Ifnlr1 was investigated by immunostaining in mice. ifnlr1 Morpholino knockdown Zebrafish were constructed to explore the deafness mechanism.. IFNLR1 mutations are associated with ADNSHL | Mutation of IFNLR1, an interferon lambda receptor 1, is associated with autosomal-dominant non-syndromic hearing loss.
Gao X, Yuan YY, Lin QF, Xu JC, Wang WQ, Qiao YH, Kang DY, Bai D, Xin F, Huang SS, Qiu SW, Guan LP, Su Y, Wang GJ, Han MY, Jiang Y, Liu HK, Dai P., Free PMC Article | 09/28/2019 |
| Interferon lambda receptor 1 (IFNLR1) mRNA is increased in human rhinovirus (HRV) bronchiolitis infants. Increased IFNLR1 transcript levels characterized HRV-infected infants with more severe bronchiolitis and blood eosinophilia. IFNLR1 transcript is increased in infants infected with HRVC species. | Interferon lambda receptor 1 (IFNL1R) transcript is highly expressed in rhinovirus bronchiolitis and correlates with disease severity.
Pierangeli A, Statzu M, Nenna R, Santinelli L, Petrarca L, Frassanito A, Gentile M, Antonelli G, Midulla F, Scagnolari C. | 07/6/2019 |
| IFN-lambda4 suppressed HIV infection of macrophages. This IFN-lambda4-mediated HIV inhibition was compromised by the antibodies against IFN-lambda receptor complex, IFN-lambdaR1/IL-10R2. | IFN-λ4 inhibits HIV infection of macrophages through signalling of IFN-λR1/IL-10R2 receptor complex.
Su QJ, Wang X, Zhou RH, Guo L, Liu H, Li JL, Ho WZ., Free PMC Article | 11/3/2018 |
| Significant associations were observed for 4 variants in IFNAR2, IFNLR1 with hepatitis B virus infection, and IFNLR1-rs4649203 was associated with hepatitis B recovery. Moreover, the authors demonstrated the clear relevance of 5 polymorphisms in IFNA1, IFNA2, IFNL4 with hepatocellular carcinoma. | Role of Functional IFNL4, IFNLR1, IFNA, IFNAR2 Polymorphisms in Hepatitis B virus-related liver disease in Han Chinese population.
Ma N, Zhang X, Yang L, Zhou J, Liu W, Gao X, Yu F, Zheng W, Ding S, Gao P, Yuan M, Liu D. | 10/20/2018 |
| In this structure, the receptor peptide forms an 85-A-long extended chain, in which both the previously identified box1 and box2 regions bind simultaneously to the FERM and SH2-like domains of JAK1. | Crystal Structure of a Complex of the Intracellular Domain of Interferon λ Receptor 1 (IFNLR1) and the FERM/SH2 Domains of Human JAK1.
Zhang D, Wlodawer A, Lubkowski J., Free PMC Article | 07/1/2017 |
| Results show that IFNLR1 box1 and box2 motifs are required for stable complex formation with JAK1 and the crystal structure of JAK1 reveals IFNLR1 box1 binding site in the FERM domain. Also, structure-based mutagenesis reveals IFNLR1 PxxLxF motif that is essential for binding. Structure of JAK1 with IL10RA box1 indicates conservation among class II receptors. | The Structural Basis for Class II Cytokine Receptor Recognition by JAK1.
Ferrao R, Wallweber HJ, Ho H, Tam C, Franke Y, Quinn J, Lupardus PJ., Free PMC Article | 07/1/2017 |
| Selective expression of IFNlambdaR1 was considered to be a plus point towards the targeted anti-viral activity of IFNlambdas but artificial control on its expression will surely make IFNlambdas a better drug with enhanced activity. | Unraveling the molecular mechanism governing the tissue specific expression of IFNλR1.
Akhtar H, Hamming OJ, Jan SU, Akhtar S, Terczyn' ska-Dyla E, Siupka P, Shafique A, Hartmann R, Sadia H. | 08/13/2016 |
| expression of IL-28RA mRNA may be correlated with the pathogenesis of systemic lupus erythematosus | Increased expression of IL-28RA mRNA in peripheral blood mononuclear cells from patients with systemic lupus erythematosus.
Cheng YY, Sheng YJ, Chang Y, Lin Y, Zhu ZW, Wen LL, Yang C, Liu L, Yang LL, Zhou FS, Zheng XD, Yin XY, Zhang SQ, Cui Y, Yang S, Zhang XJ. | 07/30/2016 |
| Polymorphism within the IL-28R1, but not in IL-28B, is associated with benign prostatic hyperplasia and lower urinary tract symptoms in Chinese. | Association of polymorphism within the interleukin-28 receptor alpha gene, but not in interleukin-28B, with lower urinary tract symptoms (LUTS) in Chinese.
Xiao L, Gao LB, Wei Q. | 07/16/2016 |
| Results show that the distribution of IL10RB and IL28RA genotypes among the Hepatitis C virus-infected and control groups did not differ significantly. | Evaluation of the relationship between IL28B, IL10RB and IL28RA single-nucleotide polymorphisms and susceptibility to hepatitis C virus in Chinese Han population.
Jin G, Kang H, Chen X, Dai D. | 01/17/2015 |
| This study is the first to show the activation of a type III interferon response in low-risk human papillomavirus positive cervical cells and suggests that the lack of this response may be related to lesion progression. | Interferon lambda 1 expression in cervical cells differs between low-risk and high-risk human papillomavirus-positive women.
Cannella F, Scagnolari C, Selvaggi C, Stentella P, Recine N, Antonelli G, Pierangeli A. | 01/10/2015 |
| IL28RA polymorphism (rs10903035) seems to be implicated in the glucose homeostasis because AA genotype increases the likelihood of IR, but this association was different depending on hepatic fibrosis and HCV genotype. | IL28RA polymorphism (rs10903035) is associated with insulin resistance in HIV/HCV-coinfected patients.
Jiménez-Sousa MA, Berenguer J, Fernández-Rodríguez A, Micheloud D, Guzmán-Fulgencio M, Miralles P, Pineda-Tenor D, García-Álvarez M, López JC, Aldámiz-Echevarria T, Carrero A, Resino S. | 09/13/2014 |
| Epigenetic reprogramming of IFNLR1-mediated response potentiates antiviral activity and suppresses tumor growth. | Epigenetic reprogramming of the type III interferon response potentiates antiviral activity and suppresses tumor growth.
Ding S, Khoury-Hanold W, Iwasaki A, Robek MD., Free PMC Article | 08/23/2014 |
| IFN-lambda receptor 1 expression is induced in chronic hepatitis C and correlates with the IFN-lambda3 genotype and with nonresponsiveness to IFN-alpha therapies. | IFN-λ receptor 1 expression is induced in chronic hepatitis C and correlates with the IFN-λ3 genotype and with nonresponsiveness to IFN-α therapies.
Duong FH, Trincucci G, Boldanova T, Calabrese D, Campana B, Krol I, Durand SC, Heydmann L, Zeisel MB, Baumert TF, Heim MH., Free PMC Article | 06/28/2014 |
| The rs12980275 AG/GG genotype and rs10903035 G allele remained independently associated with early pegylated interferon and ribavirin failure of hepatitis C in hepatitis C/HIV coinfected patients. | IL28RA polymorphism is associated with early hepatitis C virus (HCV) treatment failure in human immunodeficiency virus-/HCV-coinfected patients.
Jiménez-Sousa MA, Berenguer J, Rallón N, Guzmán-Fulgencio M, López JC, Soriano V, Fernández-Rodríguez A, Cosín J, Restrepo C, García-Álvarez M, Miralles P, Benito JM, Resino S. | 09/21/2013 |
| Plasmacytoid dendritic cells are major producers of IFN-lambda2 (a type III interferon) in response to viral stimulation and also express functional receptors for this cytokine. | Type III IFNs are produced by and stimulate human plasmacytoid dendritic cells.
Yin Z, Dai J, Deng J, Sheikh F, Natalia M, Shih T, Lewis-Antes A, Amrute SB, Garrigues U, Doyle S, Donnelly RP, Kotenko SV, Fitzgerald-Bocarsly P., Free PMC Article | 12/8/2012 |
| No consistent association is found between IL28RA and multiple sclerosis in a Basque-Spanish population. | Analysis of the IL28RA locus as genetic risk factor for multiple sclerosis.
Lopez de Lapuente A, Alloza I, Goertsches R, Zettl UK, Urcelay E, Arroyo R, Comabella M, Montalban X, Antigüedad A, Vandenbroeck K. | 06/9/2012 |