| Case Report: Prenatal Recurrent Microcephaly and Corpus Callosum Abnormalities in a Chinese Family with Novel Biallelic SASS6 Mutations. | Case Report: Prenatal Recurrent Microcephaly and Corpus Callosum Abnormalities in a Chinese Family with Novel Biallelic SASS6 Mutations.
Wah YMI, Cao Y, Law CY, Choy KW, Leung TY, Kwan HWA, Poon LC. | 09/12/2023 |
| E2F4's cytoplasmic role in multiciliogenesis is mediated via an N-terminal domain that binds two components of the centriole replication machinery, Deup1 and SAS6. | E2F4's cytoplasmic role in multiciliogenesis is mediated via an N-terminal domain that binds two components of the centriole replication machinery, Deup1 and SAS6.
Hazan R, Mori M, Danielian PS, Guen VJ, Rubin SM, Cardoso WV, Lees JA., Free PMC Article | 02/12/2022 |
| Knockdown of SASS6 reduces growth of MDAMB231 triplenegative breast cancer cells through arrest of the cell cycle at the G2/M phase. | Knockdown of SASS6 reduces growth of MDA‑MB‑231 triple‑negative breast cancer cells through arrest of the cell cycle at the G2/M phase.
Du L, Jing J, Wang Y, Xu X, Sun T, Shi Y, Wang W, Tian B, Han C, Zhao X, Chang H. | 11/27/2021 |
| SAS-6 Association with gamma-Tubulin Ring Complex Is Required for Centriole Duplication in Human Cells. | SAS-6 Association with γ-Tubulin Ring Complex Is Required for Centriole Duplication in Human Cells.
Gupta H, Rajeev R, Sasmal R, Radhakrishnan RM, Anand U, Chandran H, Aparna NR, Agasti S, Manna TK. | 08/14/2021 |
| SASS6 promotes proliferation of esophageal squamous carcinoma cells by inhibiting the p53 signaling pathway. | SASS6 promotes proliferation of esophageal squamous carcinoma cells by inhibiting the p53 signaling pathway.
Xu Y, Zhu K, Chen J, Lin L, Huang Z, Zhang J, Chen Y. | 06/26/2021 |
| The ubiquitin ligase FBXW7 targets the centriolar assembly protein HsSAS-6 for degradation and thereby regulates centriole duplication. | The ubiquitin ligase FBXW7 targets the centriolar assembly protein HsSAS-6 for degradation and thereby regulates centriole duplication.
Badarudeen B, Gupta R, Nair SV, Chandrasekharan A, Manna TK., Free PMC Article | 01/2/2021 |
| CCDC84 Acetylation Oscillation Regulates Centrosome Duplication by Modulating HsSAS-6 Degradation. | CCDC84 Acetylation Oscillation Regulates Centrosome Duplication by Modulating HsSAS-6 Degradation.
Wang T, Zou Y, Huang N, Teng J, Chen J. | 09/19/2020 |
| Expression regulation of PLK-4 and SAS-6 has a central role in centriole biogenesis. (Review) | Centriole assembly at a glance.
Gönczy P, Hatzopoulos GN. | 02/8/2020 |
| the role of SASS6 in the pathogenesis of microcephaly | Novel SASS6 compound heterozygous mutations in a Chinese family with primary autosomal recessive microcephaly.
Zhang Y, Li H, Pang J, Peng Y, Shu L, Wang H. | 03/23/2019 |
| Studies indicate that depletion of any one of the protein kinase polo-like kinase 4 (PLK4) and the two proteins STIL and SAS-6 blocks centriole duplication, and, conversely, overexpression causes centriole amplification. | The PLK4-STIL-SAS-6 module at the core of centriole duplication.
Arquint C, Nigg EA., Free PMC Article | 07/15/2017 |
| expression of wild-type centriolar assembly protein SAS-6 in a SAS-6-depleted background resulted in centriole sizes that are similar to wild type. | SAS-6 engineering reveals interdependence between cartwheel and microtubules in determining centriole architecture.
Hilbert M, Noga A, Frey D, Hamel V, Guichard P, Kraatz SH, Pfreundschuh M, Hosner S, Flückiger I, Jaussi R, Wieser MM, Thieltges KM, Deupi X, Müller DJ, Kammerer RA, Gönczy P, Hirono M, Steinmetz MO. | 08/27/2016 |
| Our present findings revealed that the upregulation of SASS6 expression is involved in the pathogenesis of CRC and is associated with a poor prognosis among patients with colon cancer. | SASS6 overexpression is associated with mitotic chromosomal abnormalities and a poor prognosis in patients with colorectal cancer.
Shinmura K, Kato H, Kawanishi Y, Nagura K, Kamo T, Okubo Y, Inoue Y, Kurabe N, Du C, Iwaizumi M, Kurachi K, Nakamura T, Sugimura H. | 03/26/2016 |
| SAS6 possesses an intrinsic microtubule assembly promoting activity and its outer exposed C-terminal tail may play critical roles in microtubule assembly and stabilizing microtubule attachment with the centriolar cartwheel. | Human SAS-6 C-Terminus Nucleates and Promotes Microtubule Assembly in Vitro by Binding to Microtubules.
Gupta H, Badarudeen B, George A, Thomas GE, Gireesh KK, Manna TK. | 01/30/2016 |
| A homozygous c.185T>C missense mutation in the HsSAS-6 gene is associated with the cause of autosomal recessive primary microcephaly. | A missense mutation in the PISA domain of HsSAS-6 causes autosomal recessive primary microcephaly in a large consanguineous Pakistani family.
Khan MA, Rupp VM, Orpinell M, Hussain MS, Altmüller J, Steinmetz MO, Enzinger C, Thiele H, Höhne W, Nürnberg G, Baig SM, Ansar M, Nürnberg P, Vincent JB, Speicher MR, Gönczy P, Windpassinger C. | 07/25/2015 |
| HsSAS-6 homodimers are targeted to centrosomes where the local environment and high concentration of HsSAS-6 promote oligomerization, thus initiating procentriole formation. | Mechanisms of HsSAS-6 assembly promoting centriole formation in human cells.
Keller D, Orpinell M, Olivier N, Wachsmuth M, Mahen R, Wyss R, Hachet V, Ellenberg J, Manley S, Gönczy P., Free PMC Article | 05/10/2014 |
| Authors propose that CEP135 directly connects the central hub protein, hSAS-6, to the outer microtubules, and suggest that this interaction stabilizes the proper cartwheel structure for further CPAP-mediated centriole elongation. | Human microcephaly protein CEP135 binds to hSAS-6 and CPAP, and is required for centriole assembly.
Lin YC, Chang CW, Hsu WB, Tang CJ, Lin YN, Chou EJ, Wu CT, Tang TK., Free PMC Article | 06/22/2013 |
| STIL cooperates with SAS-6 and PLK4 in the control of centriole number and represents a key centriole duplication factor in human cells. | Cell-cycle-regulated expression of STIL controls centriole number in human cells.
Arquint C, Sonnen KF, Stierhof YD, Nigg EA. | 09/29/2012 |
| hSAS6 depletion hindered STIL targeting to the procentriole, implying that STIL and hSAS6 are mutually dependent for their centriolar localization. | The human microcephaly protein STIL interacts with CPAP and is required for procentriole formation.
Tang CJ, Lin SY, Hsu WB, Lin YN, Wu CT, Lin YC, Chang CW, Wu KS, Tang TK., Free PMC Article | 02/25/2012 |
| The activity of SCF-FBXW5 is negatively regulated by Polo-like kinase 4 (PLK4), which phosphorylates FBXW5 at Ser 151 to suppress its ability to ubiquitylate HsSAS-6. | The SCF-FBXW5 E3-ubiquitin ligase is regulated by PLK4 and targets HsSAS-6 to control centrosome duplication.
Puklowski A, Homsi Y, Keller D, May M, Chauhan S, Kossatz U, Grünwald V, Kubicka S, Pich A, Manns MP, Hoffmann I, Gönczy P, Malek NP. | 10/1/2011 |
| Data show that depletion of hSAS-6 specifically inhibits the formation of CPAP-induced PLSs derived from procentrioles. | CPAP is a cell-cycle regulated protein that controls centriole length.
Tang CJ, Fu RH, Wu KS, Hsu WB, Tang TK. | 01/21/2010 |
| Regulated HsSAS-6 levels normally ensure that each centriole seeds the formation of a single procentriole per cell cycle, thus playing a fundamental role in driving the centrosome duplication cycle and ensuring genome integrity. | Regulated HsSAS-6 levels ensure formation of a single procentriole per centriole during the centrosome duplication cycle.
Strnad P, Leidel S, Vinogradova T, Euteneuer U, Khodjakov A, Gönczy P., Free PMC Article | 01/21/2010 |
| SAS-6 is required for daughter centriole formation in C. elegans. SAS-6 is a coiled-coil protein that is recruited to centrioles at the onset of the centrosome duplication cycle. | SAS-6 defines a protein family required for centrosome duplication in C. elegans and in human cells.
Leidel S, Delattre M, Cerutti L, Baumer K, Gönczy P. | 01/21/2010 |