| Differential tyrosine and serine/threonine phosphorylation/dephosphorylation pathways regulate the expression of alpha7 versus alpha3beta4 nicotinic receptor subtypes in mouse hippocampal neurons. | Differential tyrosine and serine/threonine phosphorylation/dephosphorylation pathways regulate the expression of α7 versus α3β4 nicotinic receptor subtypes in mouse hippocampal neurons.
Jiménez-Pompa A, Arribas RL, McIntosh JM, Albillos A. | 11/10/2023 |
| Integrin alpha7 Mutations Are Associated With Adult-Onset Cardiac Dysfunction in Humans and Mice. | Integrin α7 Mutations Are Associated With Adult-Onset Cardiac Dysfunction in Humans and Mice.
Bugiardini E, Nunes AM, Oliveira-Santos A, Dagda M, Fontelonga TM, Barraza-Flores P, Pittman AM, Morrow JM, Parton M, Houlden H, Elliott PM, Syrris P, Maas RP, Akhtar MM, Küsters B, Raaphorst J, Schouten M, Kamsteeg EJ, van Engelen B, Hanna MG, Phadke R, Lopes LR, Matthews E, Burkin DJ., Free PMC Article | 12/17/2022 |
| Association between Decreased ITGA7 Levels and Increased Muscle alpha-Synuclein in an MPTP-Induced Mouse Model of Parkinson's Disease. | Association between Decreased ITGA7 Levels and Increased Muscle α-Synuclein in an MPTP-Induced Mouse Model of Parkinson's Disease.
Han S, Lim S, Yeo S., Free PMC Article | 06/11/2022 |
| ATF1/miR-214-5p/ITGA7 axis promotes osteoclastogenesis to alter OVX-induced bone absorption. | ATF1/miR-214-5p/ITGA7 axis promotes osteoclastogenesis to alter OVX-induced bone absorption.
Liu LL, Xiao YS, Huang WM, Liu S, Huang LX, Zhong JH, Jia P, Liu WY., Free PMC Article | 05/28/2022 |
| Muscle stem cell polarity requires QKI-mediated alternative splicing of Integrin Alpha-7 (Itga7). | Muscle stem cell polarity requires QKI-mediated alternative splicing of Integrin Alpha-7 (Itga7).
Dominici C, Richard S., Free PMC Article | 04/2/2022 |
| miRNAs regulating the expressions of NTF3, GNG2 and ITGA7 are involved in the pathogenesis of abdominal aortic aneurysm in mice. | miRNAs regulating the expressions of NTF3, GNG2 and ITGA7 are involved in the pathogenesis of abdominal aortic aneurysm in mice.
Gan S, Shi W, Tang J. | 05/8/2021 |
| Ptrh2 levels were up-regulated in dystrophin deficient mdx muscle, which correlates with the elevated levels of the a7b1 integrin observed in mdx muscle and Duchenne muscular dystrophy patients. Similar to the a7 integrin, Ptrh2 expression was decreased in laminin-a2 null gastrocnemius muscle | PTRH2 gene mutation causes progressive congenital skeletal muscle pathology.
Doe J, Kaindl AM, Jijiwa M, de la Vega M, Hu H, Griffiths GS, Fontelonga TM, Barraza P, Cruz V, Van Ry P, Ramos JW, Burkin DJ, Matter ML., Free PMC Article | 05/20/2017 |
| Deletion of integrin alpha7 subunit does not aggravate the phenotype of laminin alpha2 chain-deficient mice. laminin-211 and integrin alpha7beta1 have intersecting roles in skeletal muscle. | Deletion of integrin α7 subunit does not aggravate the phenotype of laminin α2 chain-deficient mice.
Gawlik KI, Durbeej M., Free PMC Article | 08/6/2016 |
| Sarcospan-mediated amelioration of muscular dystrophy in mouse model is dependent on the presence of both utrophin and alpha7beta1 integrin. | Sarcospan integration into laminin-binding adhesion complexes that ameliorate muscular dystrophy requires utrophin and α7 integrin.
Marshall JL, Oh J, Chou E, Lee JA, Holmberg J, Burkin DJ, Crosbie-Watson RH., Free PMC Article | 01/16/2016 |
| loss of alpha7 integrin exacerbates a newly discovered muscle phenotype in sarcospan-null mice | Dystrophin and utrophin expression require sarcospan: loss of α7 integrin exacerbates a newly discovered muscle phenotype in sarcospan-null mice.
Marshall JL, Chou E, Oh J, Kwok A, Burkin DJ, Crosbie-Watson RH., Free PMC Article | 06/22/2013 |
| alpha7 integrin prevents muscle disease progression through augmentation and/or stabilization of the existing extracellular matrix in laminin-alpha2-deficient mice and might be a novel drug target for the treatment of MDC1A. | Transgenic overexpression of the α7 integrin reduces muscle pathology and improves viability in the dy(W) mouse model of merosin-deficient congenital muscular dystrophy type 1A.
Doe JA, Wuebbles RD, Allred ET, Rooney JE, Elorza M, Burkin DJ., Free PMC Article | 12/24/2011 |
| This study provides the first demonstration that the presence of the alpha(7)beta(1)-integrin in skeletal muscle increases fiber hypertrophy and new fiber synthesis in the early time course following a single bout of eccentric exercise. | The α7β1-integrin accelerates fiber hypertrophy and myogenesis following a single bout of eccentric exercise.
Lueders TN, Zou K, Huntsman HD, Meador B, Mahmassani Z, Abel M, Valero MC, Huey KA, Boppart MD. | 11/19/2011 |
| Integrin alpha 7 integrin beta1 confers a protective effect in dystrophic muscle through the activation of the ILK, AKT, p70S6K and BAD signaling to promote muscle cell survival. | Activation of AKT signaling promotes cell growth and survival in α7β1 integrin-mediated alleviation of muscular dystrophy.
Boppart MD, Burkin DJ, Kaufman SJ., Free PMC Article | 04/23/2011 |
| These results indicate that the alpha7beta1 integrin, dystrophin, and utrophin complexes act in a concerted manner to maintain the structural and functional integrity of skeletal muscle. | Myotendinous junction defects and reduced force transmission in mice that lack alpha7 integrin and utrophin.
Welser JV, Rooney JE, Cohen NC, Gurpur PB, Singer CA, Evans RA, Haines BA, Burkin DJ., Free PMC Article | 01/21/2010 |
| laminin-111 (alpha(1), beta(1), gamma(1)), which is expressed during embryonic development but absent in normal or dystrophic skeletal muscle, increased alpha(7)-integrin expression in mouse and DMD patient myoblasts | Laminin-111 protein therapy prevents muscle disease in the mdx mouse model for Duchenne muscular dystrophy.
Rooney JE, Gurpur PB, Burkin DJ., Free PMC Article | 01/21/2010 |
| cleavage is a novel mechanism that regulates alpha7 integrin functions in skeletal muscle, and that the generation of such cleavage sites is another evolutionary mechanism for expanding and modifying protein functions. | Genetically determined proteolytic cleavage modulates alpha7beta1 integrin function.
Liu J, Gurpur PB, Kaufman SJ., Free PMC Article | 01/21/2010 |
| exercise-induced muscle injury selectively increases transcription of the alpha7 integrin gene and promotes a rapid change in the alpha7beta integrin at the myotendinous junction | Exercise promotes alpha7 integrin gene transcription and protection of skeletal muscle.
Boppart MD, Volker SE, Alexander N, Burkin DJ, Kaufman SJ., Free PMC Article | 01/21/2010 |
| Results identify non-overlapping functions of integrins alpha3beta1, alpha7beta1 and alpha6beta1 on different laminin isoforms, and suggest a role for these interactions in controlling neurite outgrowth from adult DRG neurons. | Integrin-laminin interactions controlling neurite outgrowth from adult DRG neurons in vitro.
Plantman S, Patarroyo M, Fried K, Domogatskaya A, Tryggvason K, Hammarberg H, Cullheim S. | 01/21/2010 |
| Together our results confirm a role for the alpha7beta1 integrin in placental vascular development and demonstrate for the first time that loss of the alpha7 integrin results in placental defects. | Placental defects in alpha7 integrin null mice.
Welser JV, Lange ND, Flintoff-Dye N, Burkin HR, Burkin DJ., Free PMC Article | 01/21/2010 |
| Thus increasing integrin levels can compensate for defects in the extracellular matrix and cytoskeleton linkage caused by compromises in the dystrophin-glycoprotein complex without triggering apparent overt negative side effects. | Increasing alpha 7 beta 1-integrin promotes muscle cell proliferation, adhesion, and resistance to apoptosis without changing gene expression.
Liu J, Burkin DJ, Kaufman SJ., Free PMC Article | 01/21/2010 |
| Ilk may act as a cytoplasmic effector of alpha 7 beta1-integrin in the pathogenesis of progressive muscular dystrophy. | Deletion of integrin-linked kinase from skeletal muscles of mice resembles muscular dystrophy due to alpha 7 beta 1-integrin deficiency.
Gheyara AL, Vallejo-Illarramendi A, Zang K, Mei L, St-Arnaud R, Dedhar S, Reichardt LF., Free PMC Article | 01/21/2010 |
| An essential role is indicated for integrin alpha 7 in the maintenance of dystrophin-deficient muscles. | Absence of alpha 7 integrin in dystrophin-deficient mice causes a myopathy similar to Duchenne muscular dystrophy.
Guo C, Willem M, Werner A, Raivich G, Emerson M, Neyses L, Mayer U. | 01/21/2010 |
| Alpha7beta1 integrin negatively regulates extracellular signal-regulated kinase activation. | Loss of the alpha7 integrin promotes extracellular signal-regulated kinase activation and altered vascular remodeling.
Welser JV, Lange N, Singer CA, Elorza M, Scowen P, Keef KD, Gerthoffer WT, Burkin DJ. | 01/21/2010 |
| Up-regulation of integrin alpha 7 expression mediated by TGF-beta 1 plays a role in the intraepithelial location of mucosal mast cells in vivo. | TGF-beta 1 regulates adhesion of mucosal mast cell homologues to laminin-1 through expression of integrin alpha 7.
Rosbottom A, Scudamore CL, von der Mark H, Thornton EM, Wright SH, Miller HR. | 01/21/2010 |
| Enhanced axonal regeneration after conditioning lesions involves increased responsiveness to laminin and integrin alpha7beta1 expression. | Involvement of alpha7beta1 integrin in the conditioning-lesion effect on sensory axon regeneration.
Ekström PA, Mayer U, Panjwani A, Pountney D, Pizzey J, Tonge DA. | 01/21/2010 |