| Reconsidering Neurogenetic Indication in the Human Brain: Broad Expression of Doublecortin Transcript in the Hippocampal and Cortical Cell Populations. | Reconsidering Neurogenetic Indication in the Human Brain: Broad Expression of Doublecortin Transcript in the Hippocampal and Cortical Cell Populations.
Cho TH, Kim M, Kim SH, Lee JE, Kim SH, Kim HJ, Hong JE, Yeo IS, Yang HM., Free PMC Article | 10/15/2024 |
| Phenotypic Variability in Novel Doublecortin Gene Variants Associated with Subcortical Band Heterotopia. | Phenotypic Variability in Novel Doublecortin Gene Variants Associated with Subcortical Band Heterotopia.
Procopio R, Fortunato F, Gagliardi M, Talarico M, Sammarra I, Sarubbi MC, Malanga D, Annesi G, Gambardella A., Free PMC Article | 08/15/2024 |
| Novel lissencephaly-associated DCX variants in the C-terminal DCX domain affect microtubule binding and dynamics. | Novel lissencephaly-associated DCX variants in the C-terminal DCX domain affect microtubule binding and dynamics.
Lin JR, Cheng JF, Liu YT, Hsu TR, Lin KM, Chen C, Lin CL, Tsai MH, Tsai JW. | 07/30/2022 |
| Doublecortin undergo nucleocytoplasmic transport via the RanGTPase signaling to promote glioma progression. | Doublecortin undergo nucleocytoplasmic transport via the RanGTPase signaling to promote glioma progression.
Ayanlaja AA, Ji G, Wang J, Gao Y, Cheng B, Kanwore K, Zhang L, Xiong Y, Kambey PA, Gao D., Free PMC Article | 06/12/2021 |
| Study shows the DCX E2K mutant protein retains the ability to interact with and bundle microtubules (MT)s, but these MTs show a reduced sensitivity to nocodazole-induced depolymerization as well as slower alpha-tubulin exchange rates. Also shows increased association of DCX E2K mutant with the actin filament (F-ACT) network. | Pathogenic E2K mutation of doublecortin X (DCX) alters microtubule stabilisation and actin filament association.
Moslehi M, Ng DCH, Bogoyevitch MA. | 06/27/2020 |
| this is the first report revealing that cir-CCDC66 modulates DCX expression through sponging miR-488-3p and thus participates in the onset of Hirschsprung's disease. | Circular RNA CCDC66 targets DCX to regulate cell proliferation and migration by sponging miR-488-3p in Hirschsprung's disease.
Wen Z, Shen Q, Zhang H, Su Y, Zhu Z, Chen G, Peng L, Li H, Du C, Xie H, Xu X, Tang W. | 05/16/2020 |
| Phosphorylation of dublecortin X (DCX) serine 28 (S28) plays a critical role in DCX association with the cytoskeleton in human neuroblastoma cells. | Doublecortin X (DCX) serine 28 phosphorylation is a regulatory switch, modulating association of DCX with microtubules and actin filaments.
Moslehi M, Ng DCH, Bogoyevitch MA. | 11/16/2019 |
| Doublecortin can associate with AP-2 without being bound to microtubules. A DCX-G35D mutation causes a dominant-negative dendrite growth phenotype that is not due to a defect in neurofascin endocytosis. | A dominant dendrite phenotype caused by the disease-associated G253D mutation in doublecortin (DCX) is not due to its endocytosis defect.
Yap CC, Digilio L, Kruczek K, Roszkowska M, Fu XQ, Liu JS, Winckler B., Free PMC Article | 04/20/2019 |
| exchange rates for the C-terminal truncated DCX protein were resistant to the impact of taxol-induced stabilization | Dynamic microtubule association of Doublecortin X (DCX) is regulated by its C-terminus.
Moslehi M, Ng DCH, Bogoyevitch MA., Free PMC Article | 03/9/2019 |
| Age-associated expression of the proliferation and immature neuron markers MKI67 and DCX, respectively, was unrelated, suggesting that neurogenesis-associated processes are independently altered at these points in the development from stem cell to neuron. | Evidence for reduced neurogenesis in the aging human hippocampus despite stable stem cell markers.
Mathews KJ, Allen KM, Boerrigter D, Ball H, Shannon Weickert C, Double KL., Free PMC Article | 05/19/2018 |
| specifically recognizes compacted GDP-like microtubule lattice | Doublecortin Is Excluded from Growing Microtubule Ends and Recognizes the GDP-Microtubule Lattice.
Ettinger A, van Haren J, Ribeiro SA, Wittmann T., Free PMC Article | 06/24/2017 |
| this suggests that the microtubule-interacting doublecortin domain observed in cryo-electron micrographs is the C-terminal domain rather than the N-terminal one. | Crystal Structures of the Human Doublecortin C- and N-terminal Domains in Complex with Specific Antibodies.
Burger D, Stihle M, Sharma A, Di Lello P, Benz J, D'Arcy B, Debulpaep M, Fry D, Huber W, Kremer T, Laeremans T, Matile H, Ross A, Rufer AC, Schoch G, Steinmetz MO, Steyaert J, Rudolph MG, Thoma R, Ruf A., Free PMC Article | 05/13/2017 |
| From this family, we conclude that a DCX mutation causes a pleiotropic phenotype in the female even if X chromosome inactivation pattern is not skewed, and the novel missense mutation in DCX produced relatively mild dysfunction of the doublecortin protein. | Novel DCX mutation-caused lissencephaly in a boy and very mild heterotopia in his mother.
Takeshita S, Higuchi M, Suyama M, Koide W, Maki K, Ushijima K, Ban K, Saito M, Kato M, Saitoh S. | 12/17/2016 |
| We identified a novel DCX mutation c.785A > G, p.Asp262Gly in a family with X-linked lissencephaly and subcortical band heterotopia | A novel DCX missense mutation in a family with X-linked lissencephaly and subcortical band heterotopia syndrome inherited from a low-level somatic mosaic mother: Genetic and functional studies.
Tsai MH, Kuo PW, Myers CT, Li SW, Lin WC, Fu TY, Chang HY, Mefford HC, Chang YC, Tsai JW. | 12/17/2016 |
| In high-risk metastatic Neuroblastoma, TH and DCX mRNA quantification could be used for the assessment of response to treatment and for early detection of progressive disease or relapses. | TH and DCX mRNAs in peripheral blood and bone marrow predict outcome in metastatic neuroblastoma patients.
Yáñez Y, Hervás D, Grau E, Oltra S, Pérez G, Palanca S, Bermúdez M, Márquez C, Cañete A, Castel V. | 07/2/2016 |
| Results point to a critical role of doublecortin in the formation of the neuromuscular junctions. | A critical and previously unsuspected role for doublecortin at the neuromuscular junction in mouse and human.
Bourgeois F, Messéant J, Kordeli E, Petit JM, Delers P, Bahi-Buisson N, Bernard V, Sigoillot SM, Gitiaux C, Stouffer M, Francis F, Legay C. | 02/20/2016 |
| It was conclude that microtubule ends have two distinct features that proteins can recognize independently, namely a structural feature related to curvature and nucleotide state. | Doublecortin recognizes the longitudinal curvature of the microtubule end and lattice.
Bechstedt S, Lu K, Brouhard GJ. | 07/25/2015 |
| DCX-positive cells occur in a wide range of hypothalamic nuclei in humans, mice and sheep. | DCX-expressing cells in the vicinity of the hypothalamic neurogenic niche: a comparative study between mouse, sheep, and human tissues.
Batailler M, Droguerre M, Baroncini M, Fontaine C, Prevot V, Migaud M. | 12/20/2014 |
| human DCX protein was expressed in human adipose stem cells, collagen II was decreased while aggrecan, matrilin 2, and GDF5 were increased during the 14-day pellet culture. | Doublecortin may play a role in defining chondrocyte phenotype.
Ge D, Zhang QS, Zabaleta J, Zhang Q, Liu S, Reiser B, Bunnell BA, Braun SE, O'Brien MJ, Savoie FH, You Z., Free PMC Article | 11/29/2014 |
| We propose that DCDC2 is a tumor suppressor gene of HCC. | Detection of doublecortin domain-containing 2 (DCDC2), a new candidate tumor suppressor gene of hepatocellular carcinoma, by triple combination array analysis.
Inokawa Y, Nomoto S, Hishida M, Hayashi M, Kanda M, Nishikawa Y, Takeda S, Sugimoto H, Fujii T, Yamada S, Kodera Y., Free PMC Article | 09/27/2014 |
| in utero doublecortin knockdown, but not knockout, shows a neocortical neuronal migration phenotype. | Off-target effect of doublecortin family shRNA on neuronal migration associated with endogenous microRNA dysregulation.
Baek ST, Kerjan G, Bielas SL, Lee JE, Fenstermaker AG, Novarino G, Gleeson JG., Free PMC Article | 08/16/2014 |
| Immunoblots revealed that depressed subjects displayed increased expression of doublecortin. | Amygdalar expression of proteins associated with neuroplasticity in major depression and suicide.
Maheu ME, Davoli MA, Turecki G, Mechawar N. | 05/31/2014 |
| coexpression of DCX and SPARC collaboratively diminished radioresistance of glioma cells. | Adenovirus-mediated coexpression of DCX and SPARC radiosensitizes human malignant glioma cells.
Xu Y, Yang L, Jiang X, Yu J, Yang J, Zhang H, Tai G, Yuan X, Liu F. | 04/5/2014 |
| DCX is dispensable for the development of new neurons in adult mice | Evidence that Doublecortin is dispensable for the development of adult born neurons in mice.
Merz K, Lie DC., Free PMC Article | 12/14/2013 |
| one deleterious mutation in the DCX gene was identified in a 5-year-old girl with lissencephaly spectrum | Identification of DCX gene mutation in lissencephaly spectrum with subcortical band heterotopia using whole exome sequencing.
Jang MA, Woo HI, Kim JW, Lee J, Ki CS. | 10/19/2013 |