| DEAD-box helicase 1 inhibited CD8[+] T cell antitumor activity by inducing PD-L1 expression in hepatocellular carcinoma. | DEAD-box helicase 1 inhibited CD8(+) T cell antitumor activity by inducing PD-L1 expression in hepatocellular carcinoma.
Liu J, Yang T, Luo Y, Ma Z, Yu Z, Zhang L, Liu G, Wen J, Lu G, Zhang G, Zhao Y, Luo W, Li Y, Yang N, Zhou J, Lu Y, Chen S, Zeng X., Free PMC Article | 03/13/2024 |
| Role of DDX1 in the oxidative response of ataxia telangiectasia patient-derived fibroblasts. | Role of DDX1 in the oxidative response of ataxia telangiectasia patient-derived fibroblasts.
Garg M, Li L, Godbout R., Free PMC Article | 02/1/2024 |
| Phosphorylation impacts GLE1 nuclear localization and association with DDX1. | Phosphorylation impacts GLE1 nuclear localization and association with DDX1.
Sharma M, Mason AC, Dawson TR, Wente SR. | 01/31/2024 |
| The RNA-Splicing Ligase RTCB Promotes Influenza A Virus Replication by Suppressing Innate Immunity via Interaction with RNA Helicase DDX1. | The RNA-Splicing Ligase RTCB Promotes Influenza A Virus Replication by Suppressing Innate Immunity via Interaction with RNA Helicase DDX1.
Cao L, Hui X, Xu T, Mao H, Lin X, Huang K, Zhao L, Jin M., Free PMC Article | 09/8/2023 |
| Depleting DDX1 sensitizes non-small cell lung cancer cells to chemotherapy by attenuating cancer stem cell traits. | Depleting DDX1 sensitizes non-small cell lung cancer cells to chemotherapy by attenuating cancer stem cell traits.
Yang Q, Xu P, Liu Q, Hu F, Xie X, Jiang L, Bi R, Wang L, Ding F, Xiao H. | 05/13/2023 |
| Interaction of SARS-CoV-2 Nucleocapsid Protein and Human RNA Helicases DDX1 and DDX3X Modulates Their Activities on Double-Stranded RNA. | Interaction of SARS-CoV-2 Nucleocapsid Protein and Human RNA Helicases DDX1 and DDX3X Modulates Their Activities on Double-Stranded RNA.
Lodola C, Secchi M, Sinigiani V, De Palma A, Rossi R, Perico D, Mauri PL, Maga G., Free PMC Article | 03/31/2023 |
| MYC-associated protein X binding with the variant rs72780850 in RNA helicase DEAD box 1 for susceptibility to neuroblastoma. | MYC-associated protein X binding with the variant rs72780850 in RNA helicase DEAD box 1 for susceptibility to neuroblastoma.
Jin Y, Shi J, Wang H, Lu J, Chen C, Yu Y, Wang Y, Yang Y, Ren D, Zeng Q, Ni X, Guo Y. | 01/1/2022 |
| Nucleocytoplasmic shuttling of Gle1 impacts DDX1 at transcription termination sites. | Nucleocytoplasmic shuttling of Gle1 impacts DDX1 at transcription termination sites.
Sharma M, Wente SR., Free PMC Article | 06/12/2021 |
| CircLONP2 enhances colorectal carcinoma invasion and metastasis through modulating the maturation and exosomal dissemination of microRNA-17. | CircLONP2 enhances colorectal carcinoma invasion and metastasis through modulating the maturation and exosomal dissemination of microRNA-17.
Han K, Wang FW, Cao CH, Ling H, Chen JW, Chen RX, Feng ZH, Luo J, Jin XH, Duan JL, Li SM, Ma NF, Yun JP, Guan XY, Pan ZZ, Lan P, Xu RH, Xie D., Free PMC Article | 02/6/2021 |
| These results reveal an important role for DDX1 in the regulation of gene alternative splicing and insulin secretion in pancreatic beta cells. | DDX1 regulates alternative splicing and insulin secretion in pancreatic β cells.
Zhong W, Li Z, Zhou M, Xu T, Wang Y. | 09/15/2018 |
| LGR5 is a critical effector of DDX1 in colorectal cancer cells. | DEAD box protein DDX1 promotes colorectal tumorigenesis through transcriptional activation of the LGR5 gene.
Tanaka K, Ikeda N, Miyashita K, Nuriya H, Hara T., Free PMC Article | 09/8/2018 |
| data have demonstrated that Venezuelan equine encephalitis virus (VEEV)-nsP3 associates with DDX1 and DDX3 in infected cells to facilitate viral multiplication; determined that VEEV-nsP3 interacts with a pre-formed translational complex, comprising of DX3:eIF4A:eIF4G:PABP to potentially aid in translation of viral proteins. | Venezuelan equine encephalitis virus non-structural protein 3 (nsP3) interacts with RNA helicases DDX1 and DDX3 in infected cells.
Amaya M, Brooks-Faulconer T, Lark T, Keck F, Bailey C, Raman V, Narayanan A., Free PMC Article | 11/11/2017 |
| the two structural homologs FAM98A and FAM98B included in a novel complex with DDX1 and C14orf166 are required for PRMT1 expression in colorectal cancer cell lines | FAM98A associates with DDX1-C14orf166-FAM98B in a novel complex involved in colorectal cancer progression.
Akter KA, Mansour MA, Hyodo T, Senga T. | 11/4/2017 |
| DDX1 binds HIV-1 rev response element to promote virus assembly. | A DEAD-box protein acts through RNA to promote HIV-1 Rev-RRE assembly.
Lamichhane R, Hammond JA, Pauszek RF 3rd, Anderson RM, Pedron I, van der Schans E, Williamson JR, Millar DP., Free PMC Article | 09/9/2017 |
| DDX1, a RNA helicase also implicated in DSB repair, interacts with RIF1. Recruitment of DDX1 to DSBs is dependent on RIF1. DDX1 is also required for chromatin loading of BLM to ionizing radiation-induced DSBs. DDX1 and RIF1 have different nucleic acid requirements for accumulation at DSBs, with RNA-DNA hybrids required for DDX1 accrual at DSBs, and single-strand RNA required for accumulation of RIF1 at these sites. | Role for RIF1-interacting partner DDX1 in BLM recruitment to DNA double-strand breaks.
Li L, Poon HY, Hildebrandt MR, Monckton EA, Germain DR, Fahlman RP, Godbout R. | 08/12/2017 |
| Data provide evidence for a role for DDX1 in resolving RNA-DNA structures that accumulate at DNA double-strand breaks located at sites of active transcription thereby facilitating repair by homologous recombination. | DEAD Box 1 Facilitates Removal of RNA and Homologous Recombination at DNA Double-Strand Breaks.
Li L, Germain DR, Poon HY, Hildebrandt MR, Monckton EA, McDonald D, Hendzel MJ, Godbout R., Free PMC Article | 06/24/2017 |
| crystal structure of the SPRY domain of human DDX1 (hDSPRY) is reported at 2.0 A resolution | Structure of the SPRY domain of the human RNA helicase DDX1, a putative interaction platform within a DEAD-box protein.
Kellner JN, Meinhart A., Free PMC Article | 07/2/2016 |
| HIV-1 wild type Tat co-immunoprecipitated with DDX1. | A HIV-1 Tat mutant protein disrupts HIV-1 Rev function by targeting the DEAD-box RNA helicase DDX1.
Lin MH, Sivakumaran H, Jones A, Li D, Harper C, Wei T, Jin H, Rustanti L, Meunier FA, Spann K, Harrich D., Free PMC Article | 10/17/2015 |
| Data indicate a tight binding of DEAD-box protein DDX1 to adenosine diphosphate (ADP), one of the strongest affinities observed for DEAD-box helicases. | Synergistic effects of ATP and RNA binding to human DEAD-box protein DDX1.
Kellner JN, Reinstein J, Meinhart A., Free PMC Article | 06/27/2015 |
| hCLE/C14orf166 associates with DDX1, HSPC117, and FAM98B in a novel transcription-dependent shuttling RNA-transporting complex. | hCLE/C14orf166 associates with DDX1-HSPC117-FAM98B in a novel transcription-dependent shuttling RNA-transporting complex.
Pérez-González A, Pazo A, Navajas R, Ciordia S, Rodriguez-Frandsen A, Nieto A., Free PMC Article | 02/14/2015 |
| archease (also called ZBTB8OS), a protein of unknown function, is required for full activity of the human tRNA ligase complex and, in cooperation with DDX1, facilitates the formation of an RTCB-guanylate intermediate central to mammalian RNA ligation | Analysis of orthologous groups reveals archease and DDX1 as tRNA splicing factors.
Popow J, Jurkin J, Schleiffer A, Martinez J., Free PMC Article | 08/16/2014 |
| subcellular localization of KSRP is regulated by competing interactions with DDX1 or 14-3-3 | DEAD box protein DDX1 regulates cytoplasmic localization of KSRP.
Chou CF, Lin WJ, Lin CC, Luber CA, Godbout R, Mann M, Chen CY., Free PMC Article | 04/12/2014 |
| DDX1 depletion causes accumulation of DNA damage in response to cisplatin and defects in DNA repair of double-stranded breaks. | Roles of ChlR1 DNA helicase in replication recovery from DNA damage.
Shah N, Inoue A, Woo Lee S, Beishline K, Lahti JM, Noguchi E., Free PMC Article | 10/19/2013 |
| DDX1 was shown to be an RNA-activated ATPase, wherein Rev-bound RNA was equally effective at stimulating ATPase activity as protein-free RNA. | DDX1 is an RNA-dependent ATPase involved in HIV-1 Rev function and virus replication.
Edgcomb SP, Carmel AB, Naji S, Ambrus-Aikelin G, Reyes JR, Saphire AC, Gerace L, Williamson JR., Free PMC Article | 05/12/2012 |
| DDX1 acts as a cellular cofactor by promoting oligomerization of Rev on the Rev response element. | Single-molecule studies reveal that DEAD box protein DDX1 promotes oligomerization of HIV-1 Rev on the Rev response element.
Robertson-Anderson RM, Wang J, Edgcomb SP, Carmel AB, Williamson JR, Millar DP., Free PMC Article | 09/17/2011 |