| Unrevealed roles of extracellular enolase-1 (ENO1) in promoting glycolysis and pro-cancer activities in multiple myeloma via hypoxia-inducible factor 1alpha. | Unrevealed roles of extracellular enolase‑1 (ENO1) in promoting glycolysis and pro‑cancer activities in multiple myeloma via hypoxia‑inducible factor 1α.
Chung IC, Huang WC, Huang YT, Chen ML, Tsai AW, Wu PY, Yuan TT., Free PMC Article | 10/12/2023 |
| The CK1delta/epsilon-AES axis regulates tumorigenesis and metastasis in colorectal cancer. | The CK1δ/ε-AES axis regulates tumorigenesis and metastasis in colorectal cancer.
Wang Z, Zhou L, Wang Y, Peng Q, Li H, Zhang X, Su Z, Song J, Sun Q, Sayed S, Liu S, Lu D., Free PMC Article | 07/31/2021 |
| Results suggest that amino enhancer of split protein (AES) plays an important role in controlling tumor growth and metastasis of prostate cancer (PCa) by regulating both androgen receptor (AR) and Notch signaling pathway. | Amino-terminal enhancer of split gene AES encodes a tumor and metastasis suppressor of prostate cancer.
Okada Y, Sonoshita M, Kakizaki F, Aoyama N, Itatani Y, Uegaki M, Sakamoto H, Kobayashi T, Inoue T, Kamba T, Suzuki A, Ogawa O, Taketo MM., Free PMC Article | 09/30/2017 |
| results indicate that Aes may belong to a novel family of metastasis suppressors with a CpG-island promoter enhancer, and it is regulated transcriptionally | Expression of metastasis suppressor gene AES driven by a Yin Yang (YY) element in a CpG island promoter and transcription factor YY2.
Kakizaki F, Sonoshita M, Miyoshi H, Itatani Y, Ito S, Kawada K, Sakai Y, Taketo MM., Free PMC Article | 02/18/2017 |
| heat shock cognate 70 (HSC70) is an essential component of Aes foci in colorectal cancer cells. | Characterization of Aes nuclear foci in colorectal cancer cells.
Itatani Y, Sonoshita M, Kakizaki F, Okawa K, Stifani S, Itoh H, Sakai Y, Taketo MM., Free PMC Article | 10/1/2016 |
| AES is a transcriptional repressor for HNF-1-alpha in pancreatic beta-cell. | Repression of HNF1α-mediated transcription by amino-terminal enhancer of split (AES).
Han EH, Gorman AA, Singh P, Chi YI. | 03/26/2016 |
| AES binds to PROP1 and represses its expression; PROP1 mutation is a likely cause of combined pituitary hormone deficiency. | A PROP1-binding factor, AES cloned by yeast two-hybrid assay represses PROP1-induced Pit-1 gene expression.
Sugiyama Y, Ikeshita N, Shibahara H, Yamamoto D, Kawagishi M, Iguchi G, Iida K, Takahashi Y, Kaji H, Chihara K, Okimura Y. | 02/15/2014 |
| GRG5/AES interacts with TCF4 and represses Wnt-mediated transcription both in human cells and zebrafish embryos. | GRG5/AES interacts with T-cell factor 4 (TCF4) and downregulates Wnt signaling in human cells and zebrafish embryos.
Costa AM, Pereira-Castro I, Ricardo E, Spencer F, Fisher S, da Costa LT., Free PMC Article | 02/8/2014 |
| alteration of the malignant behavior of cancer cells by AES is related to RND3 regulation. | Suppression of RND3 activity by AES downregulation promotes cancer cell proliferation and invasion.
Xia H, Li M, Chen L, Leng W, Yuan D, Pang X, Chen L, Li R, Tang Q, Bi F. | 11/2/2013 |
| In the presence of NUP98-HOXA9, AES caused an increase in long-term proliferation of primary human CD34+ cells with a marked increase in the numbers of primitive cells. | Amino-terminal enhancer of split (AES) interacts with the oncoprotein NUP98-HOXA9 and enhances its transforming ability.
Sarma NJ, Yaseen NR., Free PMC Article | 12/31/2011 |
| Elevated levels of AES mRNA and protein were confirmed in AML1/ETO-expressing leukemia cells, as well as in other acute myeloid leukemia specimens. | AML1/ETO induces self-renewal in hematopoietic progenitor cells via the Groucho-related amino-terminal AES protein.
Steffen B, Knop M, Bergholz U, Vakhrusheva O, Rode M, Köhler G, Henrichs MP, Bulk E, Hehn S, Stehling M, Dugas M, Bäumer N, Tschanter P, Brandts C, Koschmieder S, Berdel WE, Serve H, Stocking C, Müller-Tidow C. | 07/16/2011 |
| LRP6-ICD interacts with AES exclusively in the nucleus and represses AES mediated TCF/LEF-1 reporter transcription. | Differential modulation of TCF/LEF-1 activity by the soluble LRP6-ICD.
Beagle B, Johnson GV., Free PMC Article | 10/30/2010 |
| Data report that the negative regulatory domain of AES inhibits AES dimerization and AES-mediated inhibition of AR-driven transcription through an interaction with the inhibitory domain. | Structural and functional analysis of amino-terminal enhancer of split in androgen-receptor-driven transcription.
Zhang Y, Gao S, Wang Z. | 05/3/2010 |
| amino enhancer of split has apoptotic activity in neurons and suggest that neuroprotection by histone deacetylase-related protein is mediated by the inhibition of this activity through direct interaction. | Histone deacetylase-related protein inhibits AES-mediated neuronal cell death by direct interaction.
Zhang X, Chen HM, Jaramillo E, Wang L, D'Mello SR., Free PMC Article | 01/21/2010 |
| Results identify Bit1, a mitochondrial protein released into the cytoplasm during apoptosis that forms a complex with AES, a small Groucho/transducin-like enhancer of split (TLE) protein. | A mitochondrial protein, Bit1, mediates apoptosis regulated by integrins and Groucho/TLE corepressors.
Jan Y, Matter M, Pai JT, Chen YL, Pilch J, Komatsu M, Ong E, Fukuda M, Ruoslahti E. | 01/21/2010 |